Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence

Nature Cell Biology

Volumn 8, Issue 5, 2006, Pages 524-531

  Rahmouni, Souad ^a,b   Cerignoli, Fabio ^a   Alonso, Andres ^a   Tsutji, Toshiya ^a   Henkens, Rachel ^b   Zhu, Changjun ^a   Louis Dit sully, Christine ^a   Moutschen, Michel ^b   Jiang, Wei ^a   Mustelin, Tomas ^a,c  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c Universidad de Valladolid y Consejo Superior de Investigaciones Científicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; H1 RELATED PROTEIN TYROSINE PHOSPHATASE; H1-RELATED PROTEIN-TYROSINE PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL AGING; CELL CULTURE; CELL CYCLE S PHASE; CELL DIVISION; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; HELA CELL; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL AGING; CELL DIVISION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RNA, SMALL INTERFERING; S PHASE;

EID: 33744969297     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb1398     Document Type: Article

References (29)

1. Alonso, A. et al. The set of genes encoding protein tyrosine phosphatase family members in the human genome. Cell 117, 699–720 (2004).
2. Andersen, J. N. et al. A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J. 18, 8–13 (2004).
3. Mustelin, T., Vang, T. and Bottini, N. Protein tyrosine phosphatases and the immune response. Nature Rev. Immunol. 5, 43–57 (2005).
4. Alonso, A., Rojas, A., Godzik, A. and Mustelin, T. The dual-specific protein tyrosine phosphatase family. Top. Curr. Genet. 5, 333–358 (2003).
5. Dorfman, K. et al. Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene 13, 925–931 (1996).
6. Ishibashi, T., Bottaro, D. P., Chan, A., Kiki, T. and Aaronson, S. A. Expression cloning of a human dual-specificity phosphatase. Proc. Natl Acad. Sci. USA 89, 12170–12174 (1992).
7. Guan, K. L., Bryoles, S. S. and Dixon, J. E. A Tyr/Ser protein phosphatase encoded by Vaccinia virus. Nature 350, 359–362 (1991).
8. Todd, J. L., Tanner, K. G. and Denu, J. M. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J. Biol. Chem. 274, 13271–13280 (1999).
9. Alonso, A., Saxena, M., Williams, S. and Mustelin, T. Inhibitory role for dual-specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J. Biol. Chem. 276, 4766–4771 (2001).
10. Alonso, A. et al. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nature Immunol. 4, 44–48 (2003).
11. Alonso, A. et al. The minimal essential core of a cysteine-based protein tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. J. Biol. Chem. 279, 35768–35774 (2004).
12. Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).
13. Kang, M. K. et al. Senescence-associated genes in normal human oral keratinocytes. Exp. Cell Res. 287, 272–281 (2003).
14. Stein, G. H., Drullinger, L. F., Robetorye, R. S., Pereira-Smith, O. M. and Smith, J. R. Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc. Natl Acad. Sci. USA 88, 11012–11016 (1991).
15. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. and Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997).
16. Pumiglia, K. M. and Decker, S. J. Cell cycle arrest mediated by the MEK/mitogenactivated protein kinase pathway. Proc. Natl Acad. Sci. USA 94, 448–452 (1997).
17. Wang, W. et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic rasinduced premature senescence. Mol. Cell Biol. 22, 3389–3403 (2002).
18. Alblas, J., Slager-Davidov, R., Steenbergh, P. H., Sussenbach, J. S. and van den Burg, B. The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells. Oncogene 16, 131–139 (1998).
19. Tang, D. et al. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 277, 12710–12717 (2002).
20. Park, J.-I., Strock, C. J., Ball, D. W. and Nelkin, B. D. The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine–paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol. Cell Biol. 23, 543–554 (2003).
21. Lahlou, H. et al. sst2 somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation. J. Biol. Chem. 278, 39356–39371 (2003).
22. Chau, A. S.-S. and Shibuya, E. K. Inactivation of p42 mitogen-activated protein kinase is required for exit from M-phase after cyclin destruction. J. Biol. Chem. 274, 32085–32090 (1999).
23. Tchou, W.-W., Yie, T.-A., Tan, T.-H., Rom, W. N. and Tchou-Wong, K.-M. Role of c-Jun N-terminal kinase 1 (JNK1) in cell cycle checkpoint activated by the protease inhibitor N-acetyl-leucinyl-leucinyl-norleucinal. Oncogene 18, 6974–6980 (1999).
24. Grosch, S. et al. Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. FASEB J. 17, 1316–1318 (2003).
25. Xue, Y., Ramaswamy, N. T., Hong, X. and Pelling, J. C. Association of JNK1 with p21waf1 and p53: modulation of JNK1 activity. Mol. Carcinogen. 36, 38–44 (2003).
26. Jiang, W. et al. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol. Cell 2, 877–885 (1998).
27. Eisen, M. B. and Brown, P.O. DNA arrays for analysis of gene expression. Methods Enzymol. 303, 179–205 (1999).
28. Saxena, M., Williams, S., Taskén, K. and Mustelin, T. Crosstalk between cAMP-dependent kinase and MAP kinase through hematopoietic protein tyrosine phosphatase (HePTP). Nature Cell Biol. 1, 305–311 (1999).
29. Huynh, H. et al. Control of vesicle fusion by a tyrosine phosphatase. Nature Cell. Biol. 6, 831–839 (2004).