The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1

Journal of Biological Chemistry

Volumn 280, Issue 19, 2005, Pages 19078-19086

  Vogt, Andreas ^a,b   Tamewitz, Aletheia ^a   Skoko, John ^a   Sikorski, Rachel P ^a   Giuliano, Kenneth A ^a,c   Lazo, John S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c Cellumen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; LIVING SYSTEMS STUDIES; PHOSPHORESCENCE; TUMORS;

ALKALOIDS; DNA-DAMAGING AGENTS; MOLECULAR INHIBITORS; PHOSPHATASE;

ENZYMES;

ALKALOID; BENZO[C]PHENANTHRIDINE DERIVATIVE; BERBERINE; CANADINE; CHELERYTHRINE; HYDROXYCHELIDONINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 3; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTOPINE; SANGUINARINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 3CH134 PROTEIN; BENZOPHENANTHRIDINE DERIVATIVE; CDC25B PHOSPHATASE; CELL CYCLE PROTEIN; DUAL SPECIFICITY PROTEIN PHOSPHATASE 6; ENZYME INHIBITOR; IMMEDIATE EARLY PROTEIN; ISOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHOSPHOPROTEIN PHOSPHATASE; PLANT EXTRACT;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DRUG DESIGN; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME ACTIVE SITE; FLUORESCENCE MICROSCOPY; GENE LIBRARY; GENETIC TRANSFECTION; HELA CELL; METABOLISM; NEOPLASM; PHOSPHORYLATION; STATISTICAL MODEL; TIME; TUMOR CELL LINE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

TYRO;

ALKALOIDS; BENZOPHENANTHRIDINES; CATALYTIC DOMAIN; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE LIBRARY; HELA CELLS; HUMANS; IMMEDIATE-EARLY PROTEINS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, CHEMICAL; MODELS, STATISTICAL; NEOPLASMS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN-TYROSINE-PHOSPHATASE; TIME FACTORS; TRANSFECTION;

EID: 21344451886     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501467200     Document Type: Article

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