Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Cirit, Murat ^a,b   Grant, Kyle G ^a   Haugh, Jason M ^a  

^a North Carolina State University   (United States)

^b MERRIMACK PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DUAL SPECIFICITY PHOSPHATASE; FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEINASE INHIBITOR; REGULATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG MECHANISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; COMPUTER SIMULATION; DUAL-SPECIFICITY PHOSPHATASES; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTORS; FIBROBLASTS; HUMANS; LEUPEPTINS; MAP KINASE SIGNALING SYSTEM; MESODERM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NIH 3T3 CELLS; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEASOME INHIBITORS; UP-REGULATION;

EID: 84870619521     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050975     Document Type: Article

References (28)

1. Muratani M, Tansey WR, (2003) How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 4: 192-201.
2. Glickman MH, Ciechanover A, (2002) The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction. Physiol Rev 82: 373-428.
3. Adams J, (2004) The proteasome: A suitable antineoplastic target. Nat Rev Cancer 5: 349-360.
4. Yu CR, Rahmani M, Dent P, Grant S, (2004) The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. Exp Cell Res 295: 555-566.
5. Shaul YD, Seger R, (2007) The MEK/ERK cascade: From signaling specificity to divers functions. Biochim Biophys Acta Mol Cell Res 1773: 1213-1226.
6. Yoon S, Seger R, (2006) The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions. Growth Factors 24: 21-44.
7. Dhillon AS, Hagan S, Rath O, Kolch W, (2007) MAP kinase signalling pathways in cancer. Oncogene 26: 3279-3290.
8. Roberts PJ, Der CJ, (2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291-3310.
9. Owens DM, Keyse SM, (2007) Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26: 3203-3213.
10. Lin YW, Chuang SM, Yang JL, (2003) ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway. J Biol Chem 278: 21534-21541.
11. Lornejad-Schafer MR, Schafer C, Richter L, Grune T, Haussinger DH, et al. (2005) Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells. Cell Physiol Biochem 16: 193-206.
12. Chan DW, Liu VWS, Tsao GSW, Yao K-M, Furakawa T, et al. (2008) Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis 29: 1742-1750.
13. Jurek A, Amagasaki K, Gembarska A, Heldin C-H, Lennartsson J, (2009) Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. J Biol Chem 284: 4626-4634.
14. Lønne GK, Masoumi KC, Lennartsson J, Larsson C, (2009) Protein kinase Cδ supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway. J Biol Chem 284: 33456-33465.
15. Kucharska A, Rushworth LK, Staples C, Morrice NA, Keyse SM, (2009) Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signalling 21: 1794-1805.
16. Cirit M, Wang C-C, Haugh JM, (2010) Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network. J Biol Chem 285: 36736-36744.
17. Pera MF, Filipczyk AA, Hawes SM, Laslett AL, (2003) Isolation, characterization, and differentiation of human embryonic stem cells. Methods Enzymol 365: 429-446.
18. Wang C-C, Cirit M, Haugh JM (2009) PI3K-dependent crosstalk interactions converge with Ras as quantifiable inputs integrated by Erk. Mol Syst Biol 5: article no.246.
19. Cirit M, Haugh JM, (2012) Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation. Biochem J 441: 77-85.
20. Brondello J, Brunet A, Pouysségur J, McKenzie FR, (1997) The dual specificity mitogen-activated protein kinase phosphatase-1 and-2 are induced by the p42/p44MAPK cascade. J Biol Chem 272: 1368-1376.
21. Hall A, Marshall CJ, Spurr NK, Weiss RA, (1983) Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature 303: 396-400.
22. Wei Q, Xia Y, (2006) Proteasome inhibition down-regulates endothelial nitric-oxide synthase phosphorylation and function. J Biol Chem 281: 21652-21659.
23. Miyake S, Mullane-Robinson KP, Lill NL, Douillard P, Band H, (1999) Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation: A critical role for Cbl tyrosine kinase-binding domain. J Biol Chem 274: 16619-16628.
24. Chiarugi P, Cirri P, Taddei ML, Talini D, Doria L, et al. (2002) New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases. J Cell Sci 115: 2219-2232.
25. Kazlauskas A, Cooper JA, (1990) Phosphorylation of the PDGF receptor β-subunit creates a tight binding site for phosphatidylinositol-3 kinase. EMBO J 9: 3279-3286.
26. Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, et al. (2003) hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol 13: 308-314.
27. Lock P, I ST, Straffon AFL, Schieb H, Hovens CM, et al. (2006) Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. Biochem Biophys Res Comm 351: 1018-1023.
28. Cirit M, Haugh JM, (2011) Quantitative models of signal transduction networks: How detailed should they be? Commun Integr Biol 4: 353-356.