CC-5079: A small molecule with MKP1, antiangiogenic, and antitumor activity

Journal of Surgical Research

Volumn 164, Issue 1, 2010, Pages 116-125

  Vu, Huan N ^a,c   Miller, Walter J ^a   O'Connor, Sarah A ^a   He, Mei ^a   Schafer, Peter H ^b   Payvandi, Faribourz ^b   Muller, George W ^b   Stirling, David I ^b   Libutti, Steven K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CELGENE CORPORATION   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

angiogenesis; Selcids; small molecule inhibitor

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CC 5079; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PHOSPHODIESTERASE IV INHIBITOR; RNA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG INHIBITION; DRUG TOLERABILITY; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROVASCULATURE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UMBILICAL VEIN; VASCULAR RING;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; AORTA; CELL DIVISION; CELL LINE, TUMOR; CELL MOVEMENT; CHICKENS; CHORIOALLANTOIC MEMBRANE; COLONIC NEOPLASMS; DUAL SPECIFICITY PHOSPHATASE 1; ENDOTHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LYMPHOCYTES; MICE; NITRILES; RATS; UMBILICAL VEINS;

EID: 77958091732     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.01.031     Document Type: Article

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