Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice

Oncotarget

Volumn 3, Issue 2, 2012, Pages 158-171

  Guo, Ke ^a   Tang, Jing Ping ^a   Jie, Li ^a   Al Aidaroos, Abdul Qader O ^a   Hong, Cheng William ^b   Tan, Cheng Peow Bobby ^a   Park, Jung Eun ^a   Varghese, Leyon ^a   Feng, Zhiwei ^c   Zhou, Jianbiao ^d   Chng, Wee Joo ^e   Zeng, Qi ^a,f  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antibody therapy; Intracellular oncoprotein; PRL 3 monoclonal antibody; PRL 3 mouse human chimeric antibody

Indexed keywords

HYBRID PROTEIN; IMMEDIATE EARLY PROTEIN; MONOCLONAL ANTIBODY; PROTEIN TYROSINE PHOSPHATASE; PTP4A3 PROTEIN, MOUSE;

ANIMAL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; COLORECTAL TUMOR; HUMAN; IMMUNOLOGY; LUNG NON SMALL CELL CANCER; LYMPHOCYTE ACTIVATION; MELANOMA; METHODOLOGY; MOLECULARLY TARGETED THERAPY; MOUSE; MOUSE MUTANT; NATURAL KILLER CELL; NUDE MOUSE; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; IMMEDIATE-EARLY PROTEINS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MELANOMA; MICE; MICE, NUDE; MICE, SCID; MOLECULAR TARGETED THERAPY; PROTEIN TYROSINE PHOSPHATASES; RECOMBINANT FUSION PROTEINS;

EID: 84863788995     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.442     Document Type: Article

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