Down-regulation of dual-specificity phosphatase 5 in gastric cancer by promoter CpG island hypermethylation and its potential role in carcinogenesis

American Journal of Pathology

Volumn 182, Issue 4, 2013, Pages 1275-1285

  Shin, So Hyun ^a   Park, Seog Yun ^c   Kang, Gyeong Hoon ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE 5; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATASE; RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CULTURE; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CPG ISLAND; DEPHOSPHORYLATION; DNA METHYLATION; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH MUCOSA;

AZACITIDINE; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; DUAL-SPECIFICITY PHOSPHATASES; EPIGENESIS, GENETIC; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHOSPHORYLATION; PROGNOSIS; PROMOTER REGIONS, GENETIC; REPRODUCIBILITY OF RESULTS; STOMACH NEOPLASMS;

EID: 84875180848     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.01.004     Document Type: Article

References (35)

1. S. Saxonov, P. Berg, and D.L. Brutlag A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters Proc Natl Acad Sci USA 103 2006 1412 1417
2. M. Weber, I. Hellmann, M.B. Stadler, L. Ramos, S. Pääbo, M. Rebhan, and D. Schübeler Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome Nat Genet 39 2007 457 466
3. B.P. Berman, D.J. Weisenberger, J.F. Aman, T. Hinoue, Z. Ramjan, Y. Liu, H. Noushmehr, C.P. Lange, C.M. van Dijk, R.A. Tollenaar, D. Van Den Berg, and P.W. Laird Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains Nat Genet 44 2012 40 46
4. T. Ushijima, and E. Okochi-Takada Aberrant methylations in cancer cells: where do they come from? Cancer Sci 96 2005 206 211
5. P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nat Rev Genet 3 2002 415 428
6. H. Takada, N. Wakabayashi, O. Dohi, K. Yasui, C. Sakakura, S. Mitsufuji, M. Taniwaki, and T. Yoshikawa Tissue factor pathway inhibitor 2 (TFPI2) is frequently silenced by aberrant promoter hypermethylation in gastric cancer Cancer Genet Cytogenet 197 2010 16 24
7. T. Ushijima Detection and interpretation of altered methylation patterns in cancer cells Nat Rev Cancer 5 2005 223 231
8. S. Yamashita, Y. Tsujino, K. Moriguchi, M. Tatematsu, and T. Ushijima Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2′-deoxycytidine treatment and oligonucleotide microarray Cancer Sci 97 2006 64 71
9. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Global cancer statistics, 2002 CA Cancer J Clin 55 2005 74 108
10. K.D. Crew, and A.I. Neugut Epidemiology of gastric cancer World J Gastroenterol 12 2006 354 362
11. M.S. Pino, and D.C. Chung The chromosomal instability pathway in colon cancer Gastroenterology 138 2010 2059 2072
12. C.R. Boland, and A. Goel Microsatellite instability in colorectal cancer Gastroenterology 138 2010 2073 2087.e3
13. B. Leggett, and V. Whitehall Role of the serrated pathway in colorectal cancer pathogenesis Gastroenterology 138 2010 2088 2100
14. M. Esteller, P.G. Corn, S.B. Baylin, and J.G. Herman A gene hypermethylation profile of human cancer Cancer Res 61 2001 3225 3229
15. S.Y. Park, B.H. Kim, J.H. Kim, N.Y. Cho, M. Choi, E.J. Yu, S. Lee, and G.H. Kang Methylation profiles of CpG island loci in major types of human cancers J Korean Med Sci 22 2007 311 317
16. G.H. Kang, S. Lee, J.S. Kim, and H.Y. Jung Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis Lab Invest 83 2003 635 641
17. S.M. Keyse Dual-specificity MAP kinase phosphatases (MKPs) and cancer Cancer Metastasis Rev 27 2008 253 261
18. K. Ueda, H. Arakawa, and Y. Nakamura Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53 Oncogene 22 2003 5586 5591
19. Z. Wang, P.S. Reinach, F. Zhang, K.S. Vellonen, A. Urtti, H. Turner, and J.M. Wolosin DUSP5 and DUSP6 modulate corneal epithelial cell proliferation Mol Vis 16 2010 1696 1704
20. S.Y. Park, E.J. Yoo, N.Y. Cho, N. Kim, and G.H. Kang Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection J Pathol 219 2009 410 416
21. R.J. Wozniak, W.T. Klimecki, S.S. Lau, Y. Feinstein, and B.W. Futscher 5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation Oncogene 26 2007 77 90
22. Z. Zheng, L. Li, X. Liu, D. Wang, B. Tu, L. Wang, H. Wang, and W.G. Zhu 5-Aza-2′-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins FASEB J 26 2012 449 459
23. R.A. Irizarry, C. Ladd-Acosta, B. Wen, Z. Wu, C. Montano, P. Onyango, H. Cui, K. Gabo, M. Rongione, M. Webster, H. Ji, J.B. Potash, S. Sabunciyan, and A.P. Feinberg The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores Nat Genet 41 2009 178 186
24. X. Rao, J. Evans, H. Chae, J. Pilrose, S. Kim, P. Yan, R.L. Huang, H.C. Lai, H. Lin, Y. Liu, D. Miller, J.K. Rhee, Y.W. Huang, F. Gu, J.W. Gray, T.M. Huang, and K.P. Nephew CpG island shore methylation regulates caveolin-1 expression in breast cancer Oncogene 2012 10.1038/onc.2012.474 [Epub ahead of press]
25. L.F. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 410 2001 37 40
26. A.S. Dhillon, S. Hagan, O. Rath, and W. Kolch MAP kinase signalling pathways in cancer Oncogene 26 2007 3279 3290
27. M. Costa, M. Marchi, F. Cardarelli, A. Roy, F. Beltram, L. Maffei, and G.M. Ratto Dynamic regulation of ERK2 nuclear translocation and mobility in living cells J Cell Sci 119 2006 4952 4963
28. V. Volmat, M. Camps, S. Arkinstall, J. Pouysségur, and P. Lenormand The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases J Cell Sci 114 2001 3433 3443
29. M. Mandl, D.N. Slack, and S.M. Keyse Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5 Mol Cell Biol 25 2005 1830 1845
30. I. Wolf, S. Bose, J.C. Desmond, B.T. Lin, E.A. Williamson, B.Y. Karlan, and H.P. Koeffler Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer Breast Cancer Res Treat 105 2007 139 155
31. T. Furukawa, M. Sunamura, F. Motoi, S. Matsuno, and A. Horii Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer Am J Pathol 162 2003 1807 1815
32. S. Xu, T. Furukawa, N. Kanai, M. Sunamura, and A. Horii Abrogation of DUSP6 by hypermethylation in human pancreatic cancer J Hum Genet 50 2005 159 167
33. J.M. Balko, R.S. Cook, D.B. Vaught, M.G. Kuba, T.W. Miller, N.E. Bhola, M.E. Sanders, N.M. Granja-Ingram, J.J. Smith, I.M. Meszoely, J. Salter, M. Dowsett, K. Stemke-Hale, A.M. González-Angulo, G.B. Mills, J.A. Pinto, H.L. Gómez, and C.L. Arteaga Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance Nat Med 18 2012 1052 1059
34. K.L. Jeffrey, M. Camps, C. Rommel, and C.R. Mackay Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses Nat Rev Drug Discov 6 2007 391 403
35. M. Soulsby, and A.M. Bennett Physiological signaling specificity by protein tyrosine phosphatases Physiology (Bethesda) 24 2009 281 289