Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease

Life Sciences

Volumn 90, Issue 7-8, 2012, Pages 237-248

  Wancket, Lyn M ^a   Frazier, W Joshua ^a   Liu, Yusen ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Human; Immunology; Inflammation; MAPK; MKP 1; Mouse

Indexed keywords

ENDOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1;

ADAPTIVE IMMUNITY; ASTHMA; BACTERIAL INFECTION; BREAST CARCINOMA; CATALYSIS; CELL STIMULATION; CENTRAL NERVOUS SYSTEM DISEASE; CYTOKINE PRODUCTION; DISEASE COURSE; ENERGY METABOLISM; HISTONE ACETYLATION; HUMAN; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; LUNG NON SMALL CELL CANCER; MELANOMA; METABOLIC DISORDER; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW; SARCOIDOSIS; TRANSCRIPTION REGULATION;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; DUAL SPECIFICITY PHOSPHATASE 1; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; NEOPLASMS; SARCOIDOSIS;

ANIMALIA;

EID: 84856395989     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.11.017     Document Type: Review

References (170)

1. D. Aeberli, Y. Yang, A. Mansell, L. Santos, M. Leech, and E.F. Morand Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase FEBS Lett 580 2006 974 981 (Pubitemid 43152322)
2. D.R. Alessi, C. Smythe, and S.M. Keyse The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts Oncogene 8 1993 2015 2020 (Pubitemid 23212436)
3. O. Ananieva, J. Darragh, C. Johansen, J.M. Carr, J. McIlrath, and J.M. Park The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling Nat Immunol 9 2008 1028 1036
4. J.S. Arthur, and P. Cohen MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells FEBS Lett 482 2000 44 48
5. J.S. Arthur, A.L. Fong, J.M. Dwyer, M. Davare, E. Reese, and K. Obrietan Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins J Neurosci 24 2004 4324 4332 (Pubitemid 38608143)
6. S. Bhattacharyya, D.E. Brown, J.A. Brewer, S.K. Vogt, and L.J. Muglia Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase Blood 109 2007 4313 4319 (Pubitemid 46743398)
7. P. Bhavsar, M. Hew, N. Khorasani, A. Torrego, P.J. Barnes, and I. Adcock Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma Thorax 63 2008 784 790
8. D. Bokemeyer, A. Sorokin, M. Yan, N.G. Ahn, D.J. Templeton, and M.J. Dunn Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts J Biol Chem 271 1996 639 642
9. D. Bokemeyer, M. Lindemann, and H.J. Kramer Regulation of mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle cells Hypertension 32 1998 661 667 (Pubitemid 28480541)
10. T. Boutros, E. Chevet, and P. Metrakos Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer Pharmacol Rev 60 2008 261 310
11. J.M. Brondello, A. Brunet, J. Pouyssegur, and F.R. McKenzie The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade J Biol Chem 272 1997 1368 1376 (Pubitemid 27034642)
12. J.M. Brondello, J. Pouyssegur, and F.R. McKenzie Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation Science 286 1999 2514 2517
13. J.C. Byon, S.S. Dadke, S. Rulli, A.B. Kusari, and J. Kusari Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) Mol Cell Biochem 218 2001 131 138 (Pubitemid 32294143)
14. T. Calandra, J. Bernhagen, C.N. Metz, L.A. Spiegel, M. Bacher, and T. Donnelly MIF as a glucocorticoid-induced modulator of cytokine production Nature 377 1995 68 71
15. T. Calandra, B. Echtenacher, D.L. Roy, J. Pugin, C.N. Metz, and L. Hultner Protection from septic shock by neutralization of macrophage migration inhibitory factor Nat Med 6 2000 164 170 (Pubitemid 30082360)
16. T.J. Calvert, L.G. Chicoine, Y. Liu, and L.D. Nelin Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin Am J Physiol Heart Circ Physiol 294 2008 H1621 H1629
17. M. Camps, A. Nichols, C. Gillieron, B. Antonsson, M. Muda, and C. Chabert Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase Science 280 1998 1262 1265 (Pubitemid 28269620)
18. W. Cao, C. Bao, E. Padalko, and C.J. Lowenstein Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling J Exp Med 205 2008 1491 1503 (Pubitemid 351831502)
19. E. Carballo, W.S. Lai, and P.J. Blackshear Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin Science 281 1998 1001 1005 (Pubitemid 28399252)
20. C. Casals-Casas, E. Alvarez, M. Serra, C. de la Torre, C. Farrera, and E. Sanchez-Tillo CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation Eur J Immunol 39 2009 1902 1913
21. M.S. Chapman, and J.N. Miner Novel mitogen-activated protein kinase kinase inhibitors Expert Opin Investig Drugs 20 2011 209 220
22. C.H. Charles, A.S. Abler, and L.F. Lau cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein Oncogene 7 1992 187 190
23. C.H. Charles, H. Sun, L.F. Lau, and N.K. Tonks The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine- phosphatase Proc Natl Acad Sci U S A 90 1993 5292 5296 (Pubitemid 23183024)
24. S. Chattopadhyay, R. Machado-Pinilla, C. Manguan-Garcia, C. Belda-Iniesta, C. Moratilla, and P. Cejas MKP1/CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer Oncogene 25 2006 3335 3345 (Pubitemid 43846318)
25. W. Chen, J.L. Martindale, N.J. Holbrook, and Y. Liu Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc Mol Cell Biol 18 1998 5178 5188 (Pubitemid 28388101)
26. P. Chen, D. Hutter, P. Liu, and Y. Liu A mammalian expression system for rapid production and purification of active MAP kinase phosphatases Protein Expr Purif 24 2002 481 488 (Pubitemid 35420073)
27. P. Chen, J. Li, J. Barnes, G.C. Kokkonen, J.C. Lee, and Y. Liu Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages J Immunol 169 2002 6408 6416 (Pubitemid 36903490)
28. P. Cheung, K.G. Tanner, W.L. Cheung, P. Sassone-Corsi, J.M. Denu, and C.D. Allis Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation Mol Cell 5 2000 905 915
29. H. Chi, S.P. Barry, R.J. Roth, J.J. Wu, E.A. Jones, and A.M. Bennett Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses Proc Natl Acad Sci U S A 103 2006 2274 2279 (Pubitemid 43271660)
30. I.J. Cho, N.R. Woo, and S.G. Kim The identification of C/EBPbeta as a transcription factor necessary for the induction of MAPK phosphatase-1 by toll-like receptor-4 ligand Arch Biochem Biophys 479 2008 88 96
31. R. Choudhary, A. Palm-Leis, R.C. Scott III, R.S. Guleria, E. Rachut, and K.M. Baker All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system Am J Physiol Heart Circ Physiol 294 2008 H633 H644
32. Y. Chu, P.A. Solski, R. Khosravi-Far, C.J. Der, and K. Kelly The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation J Biol Chem 271 1996 6497 6501 (Pubitemid 26095464)
33. M.A. Collart, D. Belin, J.D. Vassalli, S. de Kossodo, and P. Vassalli Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors J Exp Med 164 1986 2113 2118 (Pubitemid 17217991)
34. R.J. Davis The mitogen-activated protein kinase signal transduction pathway J Biol Chem 268 1993 14553 14556 (Pubitemid 23206581)
35. C. Denkert, W.D. Schmitt, S. Berger, A. Reles, S. Pest, and A. Siegert Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma Int J Cancer 102 2002 507 513 (Pubitemid 35316006)
36. A.S. Dhillon, S. Hagan, O. Rath, and W. Kolch MAP kinase signalling pathways in cancer Oncogene 26 2007 3279 3290 (Pubitemid 46763021)
37. C. Dong, R.J. Davis, and R.A. Flavell MAP kinases in the immune response Annu Rev Immunol 20 2002 55 72 (Pubitemid 34293420)
38. K. Dorfman, D. Carrasco, M. Gruda, C. Ryan, S.A. Lira, and R. Bravo Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts Oncogene 13 1996 925 931 (Pubitemid 26329078)
39. W. Duan, and W.S. Wong Targeting mitogen-activated protein kinases for asthma Curr Drug Targets 7 2006 691 698 (Pubitemid 43827265)
40. V. Duric, M. Banasr, P. Licznerski, H.D. Schmidt, C.A. Stockmeier, and A.A. Simen A negative regulator of MAP kinase causes depressive behavior Nat Med 16 2010 1328 1332
41. A.G. Eliopoulos, C.D. Dumitru, C.C. Wang, J. Cho, and P.N. Tsichlis Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals EMBO J 21 2002 4831 4840
42. E. Eljaschewitsch, A. Witting, C. Mawrin, T. Lee, P.M. Schmidt, and S. Wolf The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells Neuron 49 2006 67 79 (Pubitemid 43017186)
43. S. Essilfie-Quaye, K. Ito, M. Ito, S.A. Kharitonov, and P.J. Barnes Comparison of Symbicort((R)) versus Pulmicort((R)) on steroid pharmacodynamic markers in asthma patients Respir Med 105 2011 1784 1789
44. W.J. Fan, S. Genade, A. Genis, B. Huisamen, and A. Lochner Dexamethasone-induced cardioprotection: a role for the phosphatase MKP-1? Life Sci 84 2009 838 846
45. M.M. Finucane, G.A. Stevens, M.J. Cowan, G. Danaei, J.K. Lin, and C.J. Paciorek National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants Lancet 377 2011 557 567
46. R.J. Flach, H. Qin, L. Zhang, and A.M. Bennett Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27 J Biol Chem 286 2011 22195 22202
47. C.C. Franklin, and A.S. Kraft Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells J Biol Chem 272 1997 16917 16923 (Pubitemid 27289792)
48. C.C. Franklin, S. Srikanth, and A.S. Kraft Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis Proc Natl Acad Sci U S A 95 1998 3014 3019
49. W.J. Frazier, X. Wang, L.M. Wancket, X.A. Li, X. Meng, and L.D. Nelin Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice J Immunol 183 2009 7411 7419
50. S. Gordon The macrophage Bioessays 17 1995 977 986
51. M. Hammer, J. Mages, H. Dietrich, F. Schmitz, F. Striebel, and P.J. Murray Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10 Eur J Immunol 35 2005 2991 3001 (Pubitemid 41555095)
52. M. Hammer, J. Mages, H. Dietrich, A. Servatius, N. Howells, and A.C. Cato Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock J Exp Med 203 2006 15 20 (Pubitemid 43139639)
53. M. Hammer, B. Echtenachter, H. Weighardt, K. Jozefowski, S. Rose-John, and D.N. Mannel Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models Immunology 131 2010 395 404
54. T.J. Harris, and F. McCormick The molecular pathology of cancer Nat Rev Clin Oncol 7 2010 251 265
55. A. Hernandez-Hernandez, P. Ray, G. Litos, M. Ciro, S. Ottolenghi, and H. Beug Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1 EMBO J 25 2006 3264 3274 (Pubitemid 44141785)
56. Y. Hiroi, J. Hiroi, S. Kudoh, Y. Yazaki, R. Nagai, and I. Komuro Two distinct mechanisms of angiotensin II-induced negative regulation of the mitogen-activated protein kinases in cultured cardiac myocytes Hypertens Res 24 2001 385 394 (Pubitemid 32792438)
57. T.H. Huang, F. Wu, G.B. Loeb, R. Hsu, A. Heidersbach, and A. Brincat Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion J Biol Chem 284 2009 18515 18524
58. G. Huang, Y. Wang, L.Z. Shi, T.D. Kanneganti, and H. Chi Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates Immunity 35 2011 45 58
59. Y. Huo, P. Rangarajan, E.A. Ling, and S.T. Dheen Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia BMC Neurosci 12 2011 49
60. D. Hutter, P. Chen, J. Barnes, and Y. Liu Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation Biochem J 352 Pt 1 2000 155 163
61. D. Hutter, P. Chen, J. Li, J. Barnes, and Y. Liu The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity Mol Cell Biochem 233 2002 107 117 (Pubitemid 34746116)
62. T. Ichikawa, J. Zhang, K. Chen, Y. Liu, F.J. Schopfer, and P.R. Baker Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1 Endocrinology 149 2008 4086 4094
63. R. Issa, S. Xie, N. Khorasani, M. Sukkar, I.M. Adcock, and K.Y. Lee Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells J Immunol 178 2007 7366 7375 (Pubitemid 46847464)
64. F. Jeanneteau, K. Deinhardt, G. Miyoshi, A.M. Bennett, and M.V. Chao The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching Nat Neurosci 13 2010 1373 1379
65. K.L. Jeffrey, M. Camps, C. Rommel, and C.R. Mackay Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses Nat Rev Drug Discov 6 2007 391 403 (Pubitemid 46705202)
66. G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912 (Pubitemid 35425238)
67. H. Kamata, S. Honda, S. Maeda, L. Chang, H. Hirata, and M. Karin Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases Cell 120 2005 649 661 (Pubitemid 40343077)
68. S. Kar, A. Ukil, G. Sharma, and P.K. Das MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms J Leukoc Biol 88 2010 9 20
69. M. Kaur, J.E. Chivers, M.A. Giembycz, and R. Newton Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells Mol Pharmacol 73 2008 203 214 (Pubitemid 350294211)
70. M. Kelly, E. King, C. Rider, C. Gwozd, N. Holden, and J. Eddleston Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide Br J Pharmacol. 2011 Aug 9. doi: 10.1111/j.1476-5381. 2011.01620.x. [Electronic publication ahead of print]
71. S.M. Keyse An emerging family of dual specificity MAP kinase phosphatases Biochim Biophys Acta 1265 1995 152 160
72. S.M. Keyse The role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases Free Radic Res 31 1999 341 349 (Pubitemid 29452860)
73. S.M. Keyse Protein phosphatases and the regulation of mitogen-activated protein kinase signalling Curr Opin Cell Biol 12 2000 186 192 (Pubitemid 30142565)
74. S.M. Keyse Dual-specificity MAP kinase phosphatases (MKPs) and cancer Cancer Metastasis Rev 27 2008 253 261
75. S.M. Keyse, and E.A. Emslie Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase Nature 359 1992 644 647
76. C. Kim, Y. Sano, K. Todorova, B.A. Carlson, L. Arpa, and A. Celada The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression Nat Immunol 9 2008 1019 1027
77. H.M. Ko, S.H. Oh, H.S. Bang, N.I. Kang, B.H. Cho, and S.Y. Im Glutamine protects mice from lethal endotoxic shock via a rapid induction of MAPK phosphatase-1 J Immunol 182 2009 7957 7962
78. S. Kundu, K. Fan, M. Cao, D.J. Lindner, R. Tuthill, and L. Liu Tyrosine phosphatase inhibitor-3 sensitizes melanoma and colon cancer to biotherapeutics and chemotherapeutics Mol Cancer Ther 9 2010 2287 2296
79. Y. Kuwano, H.H. Kim, K. Abdelmohsen, R. Pullmann Jr., J.L. Martindale, and X. Yang MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90 Mol Cell Biol 28 2008 4562 4575 (Pubitemid 351977754)
80. S.P. Kwak, D.J. Hakes, K.J. Martell, and J.E. Dixon Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene J Biol Chem 269 1994 3596 3604
81. K.R. Laderoute, H.L. Mendonca, J.M. Calaoagan, A.M. Knapp, A.J. Giaccia, and P.J. Stork Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity J Biol Chem 274 1999 12890 12897
82. W.S. Lai, J.S. Parker, S.F. Grissom, D.J. Stumpo, and P.J. Blackshear Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts Mol Cell Biol 26 2006 9196 9208 (Pubitemid 44904416)
83. R. Lang, M. Hammer, and J. Mages DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response J Immunol 177 2006 7497 7504 (Pubitemid 44846262)
84. M. Lasa, S.M. Abraham, C. Boucheron, J. Saklatvala, and A.R. Clark Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 Mol Cell Biol 22 2002 7802 7811 (Pubitemid 35217291)
85. L.F. Lau, and D. Nathans Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells EMBO J 4 1985 3145 3151
86. J.S. Lazo, J.J. Skoko, S. Werner, B. Mitasev, A. Bakan, and F. Koizumi Structurally unique inhibitors of human mitogen-activated protein kinase phosphatase-1 identified in a pyrrole carboxamide library J Pharmacol Exp Ther 322 2007 940 947 (Pubitemid 47295790)
87. J. Li, M. Gorospe, D. Hutter, J. Barnes, S.M. Keyse, and Y. Liu Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation Mol Cell Biol 21 2001 8213 8224 (Pubitemid 33051810)
88. M. Li, J.Y. Zhou, Y. Ge, L.H. Matherly, and G.S. Wu The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation J Biol Chem 278 2003 41059 41068 (Pubitemid 37280929)
89. L. Li, S.F. Chen, and Y. Liu MAP kinase phosphatase-1, a critical negative regulator of the innate immune response Int J Clin Exp Med 2 2009 48 67
90. Q. Liao, J. Guo, J. Kleeff, A. Zimmermann, M.W. Buchler, and M. Korc Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells Gastroenterology 124 2003 1830 1845 (Pubitemid 36666779)
91. Y.W. Lin, and J.L. Yang Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling J Biol Chem 281 2006 915 926
92. Y.W. Lin, S.M. Chuang, and J.L. Yang ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway J Biol Chem 278 2003 21534 21541
93. Y. Liu, M. Gorospe, C. Yang, and N.J. Holbrook Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation J Biol Chem 270 1995 8377 8380
94. Y. Liu, E.G. Shepherd, and L.D. Nelin MAPK phosphatases-regulating the immune response Nat Rev Immunol 7 2007 202 212
95. M. Loda, P. Capodieci, R. Mishra, H. Yao, C. Corless, and W. Grigioni Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis Am J Pathol 149 1996 1553 1564 (Pubitemid 26363962)
96. K.R. Mahtani, M. Brook, J.L. Dean, G. Sully, J. Saklatvala, and A.R. Clark Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability Mol Cell Biol 21 2001 6461 6469 (Pubitemid 32927414)
97. K. Maneechotesuwan, X. Yao, K. Ito, E. Jazrawi, O.S. Usmani, and I.M. Adcock Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease PLoS Med 6 2009 e1000076
98. R.G. Manzano, L.M. Montuenga, M. Dayton, P. Dent, I. Kinoshita, and S. Vicent CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential Oncogene 21 2002 4435 4447 (Pubitemid 34774846)
99. B. Metzler, Y. Hu, G. Sturm, G. Wick, and Q. Xu Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells J Biol Chem 273 1998 33320 33326 (Pubitemid 29005708)
100. C.E. Monk, G. Hutvagner, and J.S. Arthur Regulation of miRNA transcription in macrophages in response to Candida albicans PLoS One 5 2010 e13669
101. E. Mortaz, M.V. Rad, M. Johnson, D. Raats, F.P. Nijkamp, and G. Folkerts Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke J Mol Med 86 2008 1045 1056
102. L.D. Nelin, X. Wang, Q. Zhao, L.G. Chicoine, T.L. Young, and D.M. Hatch MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge Am J Physiol Cell Physiol 293 2007 C632 C640
103. A. Nichols, M. Camps, C. Gillieron, C. Chabert, A. Brunet, and J. Wilsbacher Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3 J Biol Chem 275 2000 24613 24621 (Pubitemid 30626560)
104. R. Nieminen, R. Korhonen, T. Moilanen, A.R. Clark, and E. Moilanen Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs Arthritis Rheum 62 2010 1650 1659
105. T. Noguchi, R. Metz, L. Chen, M.G. Mattei, D. Carrasco, and R. Bravo Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth Mol Cell Biol 13 1993 5195 5205 (Pubitemid 23260624)
106. R.M. O'Connell, K.D. Taganov, M.P. Boldin, G. Cheng, and D. Baltimore MicroRNA-155 is induced during the macrophage inflammatory response Proc Natl Acad Sci U S A 104 2007 1604 1609 (Pubitemid 46214637)
107. A. Palm-Leis, U.S. Singh, B.S. Herbelin, G.D. Olsovsky, K.M. Baker, and J. Pan Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes J Biol Chem 279 2004 54905 54917 (Pubitemid 40053237)
108. H. Park, J.Y. Jeon, S.Y. Kim, D.G. Jeong, and S.E. Ryu Identification of novel inhibitors of mitogen-activated protein kinase phosphatase-1 with structure-based virtual screening J Comput Aided Mol Des 25 2011 469 475
109. G. Posern, and R. Treisman Actin' together: serum response factor, its cofactors and the link to signal transduction Trends Cell Biol 16 2006 588 596 (Pubitemid 44636222)
110. P. Puigserver, J. Rhee, J. Lin, Z. Wu, J.C. Yoon, and C.Y. Zhang Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1 Mol Cell 8 2001 971 982 (Pubitemid 34031800)
111. T. Quante, Y.C. Ng, E.E. Ramsay, S. Henness, J.C. Allen, and J. Parmentier Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1 Am J Respir Cell Mol Biol 39 2008 208 217
112. J. Raingeaud, S. Gupta, J.S. Rogers, M. Dickens, J. Han, and R.J. Ulevitch Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine J Biol Chem 270 1995 7420 7426
113. R. Rastogi, W. Du, D. Ju, G. Pirockinaite, Y. Liu, and G. Nunez Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells Am J Respir Crit Care Med 183 2011 500 510
114. H.E. Rauhala, K.P. Porkka, T.T. Tolonen, P.M. Martikainen, T.L. Tammela, and T. Visakorpi Dual-specificity phosphatase 1 and serum/glucocorticoid- regulated kinase are downregulated in prostate cancer Int J Cancer 117 2005 738 745 (Pubitemid 41598824)
115. M. Rincon, and R.J. Davis Regulation of the immune response by stress-activated protein kinases Immunol Rev 228 2009 212 224
116. N. Rodriguez, H. Dietrich, I. Mossbrugger, G. Weintz, J. Scheller, and M. Hammer Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6 J Leukoc Biol 88 2010 579 587
117. T. Roger, A.L. Chanson, M. Knaup-Reymond, and T. Calandra Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1 Eur J Immunol 35 2005 3405 3413 (Pubitemid 43025521)
118. F. Rojo, I. Gonzalez-Navarrete, R. Bragado, A. Dalmases, S. Menendez, and M. Cortes-Sempere Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin Clin Cancer Res 15 2009 3530 3539
119. R.J. Roth, A.M. Le, L. Zhang, M. Kahn, V.T. Samuel, and G.I. Shulman MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice J Clin Invest 119 2009 3817 3829
120. C. Sachsenmaier, A. Radler-Pohl, R. Zinck, A. Nordheim, P. Herrlich, and H.J. Rahmsdorf Involvement of growth factor receptors in the mammalian UVC response Cell 78 1994 963 972 (Pubitemid 24292325)
121. H. Sakaue, W. Ogawa, T. Nakamura, T. Mori, K. Nakamura, and M. Kasuga Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation J Biol Chem 279 2004 39951 39957 (Pubitemid 39258268)
122. K. Salojin, and T. Oravecz Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes J Leukoc Biol 81 2007 860 869 (Pubitemid 46495635)
123. K.V. Salojin, I.B. Owusu, K.A. Millerchip, M. Potter, K.A. Platt, and T. Oravecz Essential role of MAPK phosphatase-1 in the negative control of innate immune responses J Immunol 176 2006 1899 1907 (Pubitemid 43134335)
124. E. Sanchez-Tillo, M. Comalada, J. Xaus, C. Farrera, A.F. Valledor, and C. Caelles JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation J Biol Chem 282 2007 12566 12573 (Pubitemid 47100629)
125. R. Sartori, F. Li, and K.L. Kirkwood MAP kinase phosphatase-1 protects against inflammatory bone loss J Dent Res 88 2009 1125 1130
126. E.G. Shepherd, Q. Zhao, S.E. Welty, T.N. Hansen, C.V. Smith, and Y. Liu The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages J Biol Chem 279 2004 54023 54031 (Pubitemid 40053135)
127. L.E. Shipp, J.V. Lee, C.Y. Yu, M. Pufall, P. Zhang, and D.K. Scott Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids PLoS One 5 2010 e13754
128. M.D. Short, S.M. Fox, C.F. Lam, K.R. Stenmark, and M. Das Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression Mol Biol Cell 17 2006 1995 2008 (Pubitemid 44011613)
129. K.D. Singleton, V.E. Beckey, and P.E. Wischmeyer Glutamine prevents activation of NF-kappaB and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis Shock 24 2005 583 589
130. D.N. Slack, O.M. Seternes, M. Gabrielsen, and S.M. Keyse Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1 J Biol Chem 276 2001 16491 16500
131. M.L. Sohaskey, and J.E. Ferrell Jr. Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes Mol Biol Cell 13 2002 454 468 (Pubitemid 34165075)
132. A.E. Stewart, S. Dowd, S.M. Keyse, and N.Q. McDonald Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation Nat Struct Biol 6 1999 174 181 (Pubitemid 29069781)
133. G. Stoecklin, T. Stubbs, N. Kedersha, S. Wax, W.F. Rigby, and T.K. Blackwell MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay EMBO J 23 2004 1313 1324 (Pubitemid 38525003)
134. B. Su, and M. Karin Mitogen-activated protein kinase cascades and regulation of gene expression Curr Opin Immunol 8 1996 402 411 (Pubitemid 26229663)
135. H. Sun, C.H. Charles, L.F. Lau, and N.K. Tonks MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo Cell 75 1993 487 493 (Pubitemid 23335074)
136. E.R. Sutherland, E. Goleva, M. Strand, D.A. Beuther, and D.Y. Leung Body mass and glucocorticoid response in asthma Am J Respir Crit Care Med 178 2008 682 687
137. C. Suzuki, M. Unoki, and Y. Nakamura Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes J Hum Genet 46 2001 155 157 (Pubitemid 32290646)
138. T. Tanoue, M. Adachi, T. Moriguchi, and E. Nishida A conserved docking motif in MAP kinases common to substrates, activators and regulators Nat Cell Biol 2 2000 110 116
139. M.B. Tanzola, and G.J. Kersh The dual specificity phosphatase transcriptome of the murine thymus Mol Immunol 43 2006 754 762 (Pubitemid 41785404)
140. C.R. Tchen, J.R. Martins, N. Paktiawal, R. Perelli, J. Saklatvala, and A.R. Clark Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence J Biol Chem 285 2010 2642 2652
141. L.A. Tephly, and A.B. Carter Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression Am J Respir Cell Mol Biol 37 2007 366 374 (Pubitemid 350067616)
142. O.S. Usmani, K. Ito, K. Maneechotesuwan, M. Ito, M. Johnson, and P.J. Barnes Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy Am J Respir Crit Care Med 172 2005 704 712 (Pubitemid 41324225)
143. A.F. Valledor, J. Xaus, M. Comalada, C. Soler, and A. Celada Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages J Immunol 164 2000 29 37 (Pubitemid 30012968)
144. A.F. Valledor, L. Arpa, E. Sanchez-Tillo, M. Comalada, C. Casals, and J. Xaus IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation Blood 112 2008 3274 3282
145. A.F. Valledor, E. Sanchez-Tillo, L. Arpa, J.M. Park, C. Caelles, and J. Lloberas Selective roles of MAPKs during the macrophage response to IFN-gamma J Immunol 180 2008 4523 4529
146. S. Vicent, M. Garayoa, J.M. Lopez-Picazo, M.D. Lozano, G. Toledo, and F.B. Thunnissen Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients Clin Cancer Res 10 2004 3639 3649 (Pubitemid 38697597)
147. B. Vogelstein, and K.W. Kinzler The multistep nature of cancer Trends Genet 9 1993 138 141 (Pubitemid 23098782)
148. A. Vogt, P.R. McDonald, A. Tamewitz, R.P. Sikorski, P. Wipf, and J.J. Skoko III A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells Mol Cancer Ther 7 2008 330 340 (Pubitemid 351302526)
149. X. Wang, and Y. Liu Regulation of innate immune response by MAP kinase phosphatase-1 Cell Signal 19 2007 1372 1382 (Pubitemid 46830880)
150. X. Wang, K.D. McCullough, T.F. Franke, and N.J. Holbrook Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival J Biol Chem 275 2000 14624 14631 (Pubitemid 30339753)
151. H.Y. Wang, Z. Cheng, and C.C. Malbon Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer Cancer Lett 191 2003 229 237 (Pubitemid 36255609)
152. X. Wang, X. Meng, J.R. Kuhlman, L.D. Nelin, K.K. Nicol, and B.K. English Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria J Immunol 178 2007 5312 5320 (Pubitemid 46595317)
153. X. Wang, L.D. Nelin, J.R. Kuhlman, X. Meng, S.E. Welty, and Y. Liu The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia Life Sci 83 2008 671 680
154. Z. Wang, N. Cao, D. Nantajit, M. Fan, Y. Liu, and J.J. Li Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation J Biol Chem 283 2008 21011 21023
155. X. Wang, Q. Zhao, R. Matta, X. Meng, X. Liu, and C.G. Liu Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1 J Biol Chem 284 2009 27123 27134
156. J. Wang, H.R. Ford, and A.V. Grishin NF-kappaB-mediated expression of MAPK phosphatase-1 is an early step in desensitization to TLR ligands in enterocytes Mucosal Immunol 3 2010 523 534
157. A.J. Whitmarsh, and R.J. Davis Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways J Mol Med 74 1996 589 607 (Pubitemid 26343761)
158. S.M. Wilson, P. Shen, C.F. Rider, S.L. Traves, D. Proud, and R. Newton Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells J Immunol 183 2009 6788 6799
159. K. Wong, J. Zhang, S. Awasthi, A. Sharma, L. Rogers, and E.F. Matlock Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases J Biol Chem 279 2004 55667 55674 (Pubitemid 40066571)
160. G.S. Wu Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer Cancer Metastasis Rev 26 2007 579 585 (Pubitemid 350115109)
161. J.J. Wu, R.J. Roth, E.J. Anderson, E.G. Hong, M.K. Lee, and C.S. Choi Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity Cell Metab 4 2006 61 73 (Pubitemid 43942257)
162. H. Yang, and G.S. Wu p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements Cancer Biol Ther 3 2004 1277 1282 (Pubitemid 41350966)
163. Q. Yin, X. Wang, J. McBride, C. Fewell, and E. Flemington B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element J Biol Chem 283 2008 2654 2662
164. H. Yu, Q. Li, B. Herbert, R. Zinna, K. Martin, and C.R. Junior Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss Gene Ther 18 2011 344 353
165. H. Yu, Y. Sun, C. Haycraft, V. Palanisamy, and K.L. Kirkwood MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1 Cytokine 56 2011 245 255
166. Y. Zhang, J.M. Reynolds, S.H. Chang, N. Martin-Orozco, Y. Chung, and R.I. Nurieva MKP-1 is necessary for T cell activation and function J Biol Chem 284 2009 30815 30824
167. Q. Zhao, E.G. Shepherd, M.E. Manson, L.D. Nelin, A. Sorokin, and Y. Liu The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38 J Biol Chem 280 2005 8101 8108 (Pubitemid 40349709)
168. Q. Zhao, X. Wang, L.D. Nelin, Y. Yao, R. Matta, and M.E. Manson MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock J Exp Med 203 2006 131 140 (Pubitemid 43139652)
169. C.F. Zheng, and K.L. Guan Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase J Biol Chem 268 1993 16116 16119
170. Q.Y. Zhu, Q. Liu, J.X. Chen, K. Lan, and B.X. Ge MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages J Immunol 185 2010 7435 7442