VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Tang, Jing P ^a   Tan, Cheng P ^a   Li, Jie ^a   Siddique, Md Monowarul ^b   Guo, Ke ^a   Chan, Siew W ^a   Park, Jung E ^a   Tay, Wan N ^a   Huang, Zhi Y ^a   Li, Wen C ^c   Chen, Jian ^c   Zeng, Qi ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b Singapore Health Services   (Singapore)

^c THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE; MONOCLONAL ANTIBODY; PHOSPHOPROTEIN PHOSPHATASE; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG; VH1 LIKE MEMBER Z; DIAGNOSTIC AGENT; DUSP23 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; BREAST CANCER; CANCER STAGING; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CENTROSOME; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; PRIMARY TUMOR; PROTEIN LOCALIZATION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL CYCLE; CELL SEPARATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HYBRIDOMA; METABOLISM; MOUSE; NEOPLASM; RABBIT; TUMOR CELL LINE;

ORYCTOLAGUS CUNICULUS;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; CENTROSOME; DUAL-SPECIFICITY PHOSPHATASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYBRIDOMAS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; NEOPLASMS; RABBITS; TUMOR MARKERS, BIOLOGICAL;

EID: 77952734975     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-128     Document Type: Article

References (15)

1. Bessette DC, Qiu D, Pallen CJ. PRL PTPs: mediators and markers of cancer progression. Cancer Metastasis Rev 2008, 27:231-252. 10.1007/s10555-008-9121-3, 18224294.
2. Tonks NK. Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol 2006, 7:833-846. 10.1038/nrm2039, 17057753.
3. Li J, Guo K, Koh VW, Tang JP, Gan BQ, Shi H, Li HX, Zeng Q. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. Clin Cancer Res 2005, 11:2195-2204. 10.1158/1078-0432.CCR-04-1984, 15788667.
4. Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B. A phosphatase associated with metastasis of colorectal cancer. Science 2001, 294:1343-1346. 10.1126/science.1065817, 11598267.
5. Alonso A, Burkhalter S, Sasin J, Tautz L, Bogetz J, Huynh H, Bremer MC, Holsinger LJ, Godzik A, Mustelin T. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. J Biol Chem 2004, 279:35768-35774. 10.1074/jbc.M403412200, 15201283.
6. Wu Q, Li Y, Gu S, Li N, Zheng D, Li D, Zheng Z, Ji C, Xie Y, Mao Y. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. Int J Biochem Cell Biol 2004, 36:1542-1553. 10.1016/j.biocel.2003.12.014, 15147733.
7. Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H, Kikuchi K. Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. Biochem J 2004, 383:447-55. 10.1042/BJ20040498, 1133737, 15281913.
8. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell 2004, 117:699-11. 10.1016/j.cell.2004.05.018, 15186772.
9. Agarwal R, Burley SK, Swaminathan S. Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex. J Biol Chem 2008, 4: 283(14):8946-8953.
10. Rahmouni S, Cerignoli F, Alonso A, Tsutji T, Henkens R, Zhu C, Louis-dit-Sully C, Moutschen M, Jiang W, Mustelin T. Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol 2006, 8:524-31. 10.1038/ncb1398, 16604064.
11. Liao Q, Guo J, Kleeff J, Zimmermann A, Büchler MW, Korc M, Friess H. Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells. Gastroenterology 2003, 124(7):1830-45. 10.1016/S0016-5085(03)00398-6, 12806617.
12. Nigg EA. Centrosome aberrations: cause or consequence of cancer progression?. Nat Rev Cancer 2002, 2:815-825. 10.1038/nrc924, 12415252.
13. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004, 10:789-899. 10.1038/nm1087, 15286780.
14. Friedl P, Wolf K. Tumor-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003, 3:362-374. 10.1038/nrc1075, 12724734.
15. Sherri L, Rankin MR, Karen MM. A method to assess multiple aspects of the motile behaviour of adherent PC12 cells on applied biological substrates. Journal of Neuroscience Methods 2006, 156:55-63. 10.1016/j.jneumeth.2006.02.011, 16554096.