Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2250-2255

  Park, Hwangseo ^a   Jung, Suk Kyeong ^b   Jeong, Dae Gwin ^b   Ryu, Seong Eon ^b   Kim, Seung Jun ^b  

^a Sejong University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Anti cancer agents; Docking; Inhibitor; PRL 3; Virtual screening

Indexed keywords

ANTINEOPLASTIC AGENT; LIGAND; LIVER PROTEIN; PENTAMIDINE; PHOSPHATASE OF REGENERATING LIVER PROTEIN 3; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; RHODANINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SCORING SYSTEM; SIMULATION; SOLVATION; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; BINDING SITES; CELL LINE; COMPUTER-AIDED DESIGN; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TYROSINE PHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41149089362     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.013     Document Type: Article

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