Downregulation of the Mitochondrial Phosphatase PTPMT1 Is Sufficient to Promote Cancer Cell Death

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Niemi, Natalie M ^a,b   Lanning, Nathan J ^a   Westrate, Laura M ^a   MacKeigan, Jeffrey P ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b VAN ANDEL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALEXIDINE; CARDIOLIPIN; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE LOCALIZED TO THE MITOCHONDRION 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL; IN VITRO STUDY; MITOCHONDRIAL RESPIRATION; OPEN READING FRAME; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION;

ADENOSINE TRIPHOSPHATE; CARDIOLIPINS; CELL DEATH; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HELA CELLS; HUMANS; MITOCHONDRIA; NEOPLASMS; PACLITAXEL; PTEN PHOSPHOHYDROLASE;

EID: 84872246940     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053803     Document Type: Article

References (28)

1. Guan KL, Xiong Y, (2011) Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci 36: 108-116.
2. Soubannier V, McBride HM, (2009) Positioning mitochondrial plasticity within cellular signaling cascades. Biochim Biophys Acta 1793: 154-170.
3. Taylor EB, Rutter J, (2011) Mitochondrial quality control by the ubiquitin-proteasome system. Biochem Soc Trans 39: 1509-1513.
4. Willers IM, Cuezva JM, (2011) Post-transcriptional regulation of the mitochondrial H(+)-ATP synthase: a key regulator of the metabolic phenotype in cancer. Biochim Biophys Acta 1807: 543-551.
5. Pagliarini DJ, Dixon JE, (2006) Mitochondrial modulation: reversible phosphorylation takes center stage? Trends Biochem Sci 31: 26-34.
6. Horbinski C, Chu CT, (2005) Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radic Biol Med 38: 2-11.
7. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, et al. (2005) Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell 19: 197-207.
8. Pagliarini DJ, Worby CA, Dixon JE, (2004) A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem 279: 38590-38596.
9. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, et al. (2011) Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab 13: 690-700.
10. Osman C, Voelker DR, Langer T, (2011) Making heads or tails of phospholipids in mitochondria. J Cell Biol 192: 7-16.
11. Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB, et al. (2005) Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat Chem Biol 1: 223-232.
12. Lutter M, Fang M, Luo X, Nishijima M, Xie X, et al. (2000) Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol 2: 754-761.
13. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
14. Choi SY, Gonzalvez F, Jenkins GM, Slomianny C, Chretien D, et al. (2007) Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis. Cell Death Differ 14: 597-606.
15. Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, et al. (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther 333: 584-592.
16. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, et al. (2006) The colorectal microRNAome. Proc Natl Acad Sci U S A 103: 3687-3692.
17. Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB, Dowhan W, (2001) Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J Biol Chem 276: 38061-38067.
18. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
19. Elis W, Triantafellow E, Wolters NM, Sian KR, Caponigro G, et al. (2008) Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Mol Cancer Res 6: 614-623.
20. McMillin JB, Dowhan W, (2002) Cardiolipin and apoptosis. Biochim Biophys Acta 1585: 97-107.
21. Yip KW, Ito E, Mao X, Au PY, Hedley DW, et al. (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol Cancer Ther 5: 2234-2240.
22. Shen J, Liu X, Yu WM, Liu J, Nibbelink MG, et al. (2011) A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol 31: 4902-4916.
23. Jiang F, Rizavi HS, Greenberg ML, (1997) Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources. Mol Microbiol 26: 481-491.
24. MacKeigan JP, Collins TS, Ting JP, (2000) MEK inhibition enhances paclitaxel-induced tumor apoptosis. J Biol Chem 275: 38953-38956.
25. Shoemaker RH, Monks A, Alley MC, Scudiero DA, Fine DL, et al. (1988) Development of human tumor cell line panels for use in disease-oriented drug screening. Prog Clin Biol Res 276: 265-286.
26. MacKeigan JP, Murphy LO, Blenis J, (2005) Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 7: 591-600.
27. Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, et al. (2011) MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Mol Cell Biol 31: 1357-1368.
28. Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu CL, et al. (2011) Identification of PTPsigma as an autophagic phosphatase. J Cell Sci 124: 812-819.