Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity

Cell

Volumn 147, Issue 1, 2011, Pages 185-198

  Haque, Aftabul ^a,b   Andersen, Jannik N ^a,d   Salmeen, Annette ^c,e   Barford, David ^c   Tonks, Nicholas K ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e DOE JOINT GENOME INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INSULIN RECEPTOR; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; OXIDATION; OXIDATION KINETICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TARGETING;

EID: 80053476859     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2011.08.036     Document Type: Article

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