Molecular mechanisms of the PRL phosphatases

FEBS Journal

Volumn 280, Issue 2, 2013, Pages 505-524

  Rios, Pablo ^a   Li, Xun ^a   Köhn, Maja ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

cancer; cell signalling; dual specificity phosphatases; metastasis; phosphatase of regenerating liver; protein phosphatases

Indexed keywords

AMINO ACID; BETA1 INTEGRIN; CYTOKERATIN 8; DUAL SPECIFICITY PHOSPHATASE; ELONGATION FACTOR 2; EZRIN; GELATINASE A; GELATINASE B; KERATIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PHOSPHOPROTEIN PHOSPHATASE CDC14; POLYCYTIDYLIC ACID RNA BINDING PROTEIN 1; PRL 1 PHOSPHATASE; PRL 2 PHOSPHATASE; PRL 3 PHOSPHATASE; PRL PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; RHO FACTOR; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ACUTE GRANULOCYTIC LEUKEMIA; BREAST CARCINOMA; CANCER INHIBITION; CANCER PROGNOSIS; CARCINOGENICITY; CELL DIFFERENTIATION; CELL MIGRATION; CELL MOTILITY; COLON CARCINOMA; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; EPITHELIUM CELL; GENE; GENE EXPRESSION; HUMAN; IN VIVO STUDY; LIVER METASTASIS; MOLECULAR CLONING; MOLECULAR MECHANICS; MULTIPLE MYELOMA; NONHUMAN; OVARY CARCINOMA; PREDICTIVE VALUE; PRIORITY JOURNAL; PRL1 GENE; PRL2 GENE; PRL3 GENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PRENYLATION; REVIEW; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STOMACH CARCINOMA; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84872781756     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08565.x     Document Type: Review

References (124)

1. Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, et al. (2001) A phosphatase associated with metastasis of colorectal cancer. Science 294, 1343-1346.
2. Al-Aidaroos AQ, &, Zeng Q, (2010) PRL-3 phosphatase and cancer metastasis. J Cell Biochem 111, 1087-1098.
3. Bessette DC, Qiu D, &, Pallen CJ, (2008) PRL PTPs: mediators and markers of cancer progression. Cancer Metastasis Rev 27, 231-252.
4. Wang Y, &, Lazo JS, (2012) Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion. Oncogene 31, 818-827.
5. Hardy S, Wong NN, Muller WJ, Park M, &, Tremblay ML, (2010) Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res 70, 8959-8967.
6. Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, Crowell PL, &, Crowell DN, (1996) Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. Cancer Lett 110, 49-55.
7. Werner SR, Lee PA, DeCamp MW, Crowell DN, Randall SK, &, Crowell PL, (2003) Enhanced cell cycle progression and down regulation of p21Cip1/Waf1 by PRL tyrosine phosphatases. Cancer Lett 202, 201-211.
8. Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E, &, Hong W, (2003) PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Res 63, 2716-2722.
9. Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X, &, Xu Q, (2004) Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. Am J Pathol 164, 2039-2054.
10. Sun JP, Luo Y, Yu X, Wang WQ, Zhou B, Liang F, &, Zhang ZY, (2007) Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem 282, 29043-29051.
11. Guo K, Tang JP, Tan CP, Wang H, &, Zeng Q, (2008) Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice. Cancer Biol Ther 7, 750-757.
12. Ming J, Liu N, Gu Y, Qiu X, &, Wang EH, (2009) PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer. Pathology 41, 118-126.
13. Guo K, Li J, Wang H, Osato M, Tang JP, Quah SY, Gan BQ, &, Zeng Q, (2006) PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res 66, 9625-9635.
14. Nakashima M, &, Lazo JS, (2010) Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics. J Pharmacol Exp Ther 334, 627-633.
15. Semba S, Mizuuchi E, &, Yokozaki H, (2010) Requirement of phosphatase of regenerating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma. Cancer Sci 101, 2254-2261.
16. Mohn KL, Laz TM, Hsu JC, Melby AE, Bravo R, &, Taub R, (1991) The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes. Mol Cell Biol 11, 381-390.
17. Diamond RH, Cressman DE, Laz TM, Abrams CS, &, Taub R, (1994) PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol Cell Biol 14, 3752-3762.
18. Zhao Z, Lee CC, Monckton DG, Yazdani A, Coolbaugh MI, Li X, Bailey J, Shen Y, &, Caskey CT, (1996) Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. Genomics 35, 172-181.
19. Zeng Q, Hong W, &, Tan YH, (1998) Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun 244, 421-427.
20. Stephens BJ, Han H, Gokhale V, &, Von Hoff DD, (2005) PRL phosphatases as potential molecular targets in cancer. Mol Cancer Ther 4, 1653-1661.
21. Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, &, Mustelin T, (2004) Protein tyrosine phosphatases in the human genome. Cell 117, 699-711.
22. Tonks NK, (2005) Redox redux: revisiting PTPs and the control of cell signaling. Cell 121, 667-670.
23. Zeng Q, Si X, Horstmann H, Xu Y, Hong W, &, Pallen CJ, (2000) Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome. J Biol Chem 275, 21444-21452.
24. Si X, Zeng Q, Ng CH, Hong W, &, Pallen CJ, (2001) Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. J Biol Chem 276, 32875-32882.
25. Wang J, Kirby CE, &, Herbst R, (2002) The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. J Biol Chem 277, 46659-46668.
26. Dursina B, Reents R, Delon C, Wu Y, Kulharia M, Thutewohl M, Veligodsky A, Kalinin A, Evstifeev V, Ciobanu D, et al. (2006) Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc 128, 2822-2835.
27. Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, &, Mitchell CA, (2009) The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J 419, 29-49.
28. Fiordalisi JJ, Keller PJ, &, Cox AD, (2006) PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Res 66, 3153-3161.
29. Guo K, Li J, Tang JP, Koh V, Gan BQ, &, Zeng Q, (2004) Catalytic domain of PRL-3 plays an essential role in tumor metastasis: formation of PRL-3 tumors inside the blood vessels. Cancer Biol Ther 3, 945-951.
30. Min SH, Kim DM, Heo YS, Kim HM, Kim IC, &, Yoo OJ, (2010) Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. Life Sci 86, 66-72.
31. Sun JP, Wang WQ, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, &, Zhang ZY, (2005) Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry 44, 12009-12021.
32. Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, &, Ekiel I, (2004) Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. J Biol Chem 279, 11882-11889.
33. Pascaru M, Tanase C, Vacaru AM, Boeti P, Neagu E, Popescu I, &, Szedlacsek SE, (2009) Analysis of molecular determinants of PRL-3. J Cell Mol Med 13, 3141-3150.
34. Jeong DG, Kim SJ, Kim JH, Son JH, Park MR, Lim SM, Yoon TS, &, Ryu SE, (2005) Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. J Mol Biol 345, 401-413.
35. Kim KA, Song JS, Jee J, Sheen MR, Lee C, Lee TG, Ro S, Cho JM, Lee W, Yamazaki T, et al. (2004) Structure of human PRL-3, the phosphatase associated with cancer metastasis. FEBS Lett 565, 181-187.
36. Orsatti L, Innocenti F, Lo Surdo P, Talamo F, &, Barbato G, (2009) Mass spectrometry study of PRL-3 phosphatase inactivation by disulfide bond formation and cysteine into glycine conversion. Rapid Commun Mass Spectrom 23, 2733-2740.
37. Lee SR, Yang KS, Kwon J, Lee C, Jeong W, &, Rhee SG, (2002) Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 277, 20336-20342.
38. Skinner AL, Vartia AA, Williams TD, &, Laurence JS, (2009) Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. Biochemistry 48, 4262-4272.
39. Ishibashi T, Bottaro DP, Chan A, Miki T, &, Aaronson SA, (1992) Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci USA 89, 12170-12174.
40. Li L, Ljungman M, &, Dixon JE, (2000) The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. J Biol Chem 275, 2410-2414.
41. Poon RY, &, Hunter T, (1995) Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science 270, 90-93.
42. Maehama T, &, Dixon JE, (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273, 13375-13378.
43. Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, &, Pavletich NP, (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99, 323-334.
44. Yuvaniyama J, Denu JM, Dixon JE, &, Saper MA, (1996) Crystal structure of the dual specificity protein phosphatase VHR. Science 272, 1328-1331.
45. Gray CH, Good VM, Tonks NK, &, Barford D, (2003) The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J 22, 3524-3535.
46. Song H, Hanlon N, Brown NR, Noble ME, Johnson LN, &, Barford D, (2001) Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol Cell 7, 615-626.
47. Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, &, Dixon JE, (2011) Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci USA 108, 11860-11865.
48. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, &, Okamura Y, (2008) A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci USA 105, 7970-7975.
49. Matsuda M, Takeshita K, Kurokawa T, Sakata S, Suzuki M, Yamashita E, Okamura Y, &, Nakagawa A, (2011) Crystal structure of the cytoplasmic phosphatase and tensin homolog (PTEN)-like region of Ciona intestinalis voltage-sensing phosphatase provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity. J Biol Chem 286, 23368-23377.
50. McParland V, Varsano G, Li X, Thornton J, Baby J, Aravind A, Meyer C, Pavic K, Rios P, &, Köhn M, (2011) The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides. Biochemistry 50, 7579-7590.
51. Zhang ZY, (1998) Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis. Crit Rev Biochem Mol Biol 33, 1-52.
52. Nakamura K, Tanoue K, Satoh T, Takekawa M, Watanabe M, Shima H, &, Kikuchi K, (2002) A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity. J Biochem (Tokyo) 132, 463-470.
53. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, &, Hagiwara M, (2002) A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. J Biol Chem 277, 23909-23918.
54. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, &, Dixon JE, (2006) Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci USA 103, 927-932.
55. Xiao Y, Yeong Chit Chia J, Gajewski JE, Sio Seng Lio D, Mulhern TD, Zhu HJ, Nandurkar H, &, Cheng HC, (2007) PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid-mechanistic analysis of a familial Cowden disease-associated PTEN mutation. Cell Signal 19, 1434-1445.
56. Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, &, Ishioka C, (2000) Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res 60, 3147-3151.
57. Matter WF, Estridge T, Zhang C, Belagaje R, Stancato L, Dixon J, Johnson B, Bloem L, Pickard T, Donaghue M, et al. (2001) Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. Biochem Biophys Res Commun 283, 1061-1068.
58. Kato H, Semba S, Miskad UA, Seo Y, Kasuga M, &, Yokozaki H, (2004) High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. Clin Cancer Res 10, 7318-7328.
59. Wang L, Peng L, Dong B, Kong L, Meng L, Yan L, Xie Y, &, Shou C, (2006) Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome. Ann Oncol 17, 1517-1522.
60. Miskad UA, Semba S, Kato H, &, Yokozaki H, (2004) Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis. Pathobiology 71, 176-184.
61. Polato F, Codegoni A, Fruscio R, Perego P, Mangioni C, Saha S, Bardelli A, &, Broggini M, (2005) PRL-3 phosphatase is implicated in ovarian cancer growth. Clin Cancer Res 11, 6835-6839.
62. Peng L, Ning J, Meng L, &, Shou C, (2004) The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer. J Cancer Res Clin Oncol 130, 521-526.
63. Hassan NM, Hamada J, Kameyama T, Tada M, Nakagawa K, Yoshida S, Kashiwazaki H, Yamazaki Y, Suzuki Y, Sasaki A, et al. (2011) Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues. Asian Pac J Cancer Prev 12, 947-951.
64. Ma Y, &, Li B, (2011) Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix. Med Oncol 28, 775-780.
65. Broyl A, Hose D, Lokhorst H, de Knegt Y, Peeters J, Jauch A, Bertsch U, Buijs A, Stevens-Kroef M, Beverloo HB, et al. (2010) Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Blood 116, 2543-2553.
66. Fagerli UM, Holt RU, Holien T, Vaatsveen TK, Zhan F, Egeberg KW, Barlogie B, Waage A, Aarset H, Dai HY, et al. (2008) Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. Blood 111, 806-815.
67. Zhou J, Bi C, Chng WJ, Cheong LL, Liu SC, Mahara S, Tay KG, Zeng Q, Li J, Guo K, et al. (2011) PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy. PLoS One 6, e19798.
68. Forte E, Orsatti L, Talamo F, Barbato G, De Francesco R, &, Tomei L, (2008) Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3. Biochim Biophys Acta 1783, 334-344.
69. Orsatti L, Forte E, Tomei L, Caterino M, Pessi A, &, Talamo F, (2009) 2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets. Electrophoresis 30, 2469-2476.
70. Mizuuchi E, Semba S, Kodama Y, &, Yokozaki H, (2009) Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression. Int J Cancer 124, 1802-1810.
71. Peng L, Jin G, Wang L, Guo J, Meng L, &, Shou C, (2006) Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. Biochem Biophys Res Commun 342, 179-183.
72. Zheng P, Liu YX, Chen L, Liu XH, Xiao ZQ, Zhao L, Li GQ, Zhou J, Ding YQ, &, Li JM, (2010) Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. J Proteome Res 9, 4897-4905.
73. Peng L, Xing X, Li W, Qu L, Meng L, Lian S, Jiang B, Wu J, &, Shou C, (2009) PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. Mol Cancer 8, 110.
74. Jiang Y, Liu XQ, Rajput A, Geng L, Ongchin M, Zeng Q, Taylor GS, &, Wang J, (2011) Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis. Cancer Res 71, 234-244.
75. Liu Y, Zhou J, Chen J, Gao W, Le Y, Ding Y, &, Li J, (2009) PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly. Cancer Biol Ther 8, 1352-1359.
76. Choi MS, Min SH, Jung H, Lee JD, Lee TH, Lee HK, &, Yoo OJ, (2011) The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability. Biochem Biophys Res Commun 406, 305-309.
77. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3, 89.
78. Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A, Yeung C, Gorlick R, Hewitt SM, &, Helman LJ, (2004) The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 10, 182-186.
79. Fievet BT, Gautreau A, Roy C, Del Maestro L, Mangeat P, Louvard D, &, Arpin M, (2004) Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol 164, 653-659.
80. Neisch AL, &, Fehon RG, (2011) Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling. Curr Opin Cell Biol 23, 377-382.
81. Liang F, Liang J, Wang WQ, Sun JP, Udho E, &, Zhang ZY, (2007) PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem 282, 5413-5419.
82. Heiska L, Melikova M, Zhao F, Saotome I, McClatchey AI, &, Carpen O, (2011) Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environment. Oncogene 30, 4953-4962.
83. Wang H, Vardy LA, Tan CP, Loo JM, Guo K, Li J, Lim SG, Zhou J, Chng WJ, Ng SB, et al. (2010) PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer Cell 18, 52-62.
84. Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, &, Attardi LD, (2008) The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell 30, 303-314.
85. Fontemaggi G, Kela I, Amariglio N, Rechavi G, Krishnamurthy J, Strano S, Sacchi A, Givol D, &, Blandino G, (2002) Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses. J Biol Chem 277, 43359-43368.
86. Xu J, Cao S, Wang L, Xu R, Chen G, &, Xu Q, (2011) VEGF Promotes the transcription of the human PRL-3 gene in HUVEC through transcription factor MEF2C. PLoS One 6, e27165.
87. Thiery JP, &, Sleeman JP, (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7, 131-142.
88. Wang H, Quah SY, Dong JM, Manser E, Tang JP, &, Zeng Q, (2007) PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res 67, 2922-2926.
89. Zheng P, Meng HM, Gao WZ, Chen L, Liu XH, Xiao ZQ, Liu YX, Sui HM, Zhou J, Liu YH, et al. (2011) Snail as a key regulator of PRL-3 gene in colorectal cancer. Cancer Biol Ther 12, 742-749.
90. Cully M, You H, Levine AJ, &, Mak TW, (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6, 184-192.
91. Liu P, Cheng H, Roberts TM, &, Zhao JJ, (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8, 627-644.
92. Bunney TD, &, Katan M, (2010) Phophoinositide signaling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 10, 342-352.
93. Mitra SK, Hanson D, &, Schlaepfer DD, (2005) Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6, 56-68.
94. Liang F, Luo Y, Dong Y, Walls CD, Liang J, Jiang HY, Sanford JR, Wek RC, &, Zhang ZY, (2008) Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase. J Biol Chem 283, 10339-10346.
95. McClatchey AI, (2003) Merlin and ERM proteins: unappreciated roles in cancer development? Nat Rev Cancer 3, 877-883.
96. Lemmon M, (2008) Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol 9, 99-111.
97. Van Meer G, Voelker DR, &, Feigenson GW, (2008) Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol 9, 112-124.
98. Deryugina EI, &, Quigley JP, (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25, 9-34.
99. Lee SK, Han YM, Yun J, Lee CW, Shin DS, Ha YR, Kim J, Koh JS, Hong SH, Han DC, et al. (2011) PRL-3 promotes migration and invasion by up-regulating MMP-7 in human colorectal cancer cells. Int J Cancer. doi:10.1002/ijc.27381.
100. Lai W, Chen S, Wu H, Guan Y, Liu L, Zeng Y, Zhao H, Jiang J, &, Chu Z, (2011) PRL-3 promotes the proliferation of LoVo cells via the upregulation of KCNN4 channels. Oncol Rep 26, 909-917.
101. Min SH, Kim DM, Heo YS, Kim YI, Kim HM, Kim J, Han YM, Kim IC, &, Yoo OJ, (2009) New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53. Oncogene 28, 545-554.
102. Diamond RH, Peters C, Jung SP, Greenbaum LE, Haber BA, Silberg DG, Traber PG, &, Taub R, (1996) Expression of PRL-1 nuclear PTPase is associated with proliferation in liver but with differentiation in intestine. Am J Physiol 271, G121-G129.
103. Peng Y, Genin A, Spinner NB, Diamond RH, &, Taub R, (1998) The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer. J Biol Chem 273, 17286-17295.
104. Dumaual CM, Sandusky GE, Crowell PL, &, Randall SK, (2006) Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues. J Histochem Cytochem 54, 1401-1412.
105. Wang Y, Li ZF, He J, Li YL, Zhu GB, Zhang LH, &, Li YL, (2007) Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis. Int J Colorectal Dis 22, 1179-1184.
106. Achiwa H, &, Lazo JS, (2007) PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. Cancer Res 67, 643-650.
107. Stephens B, Han H, Hostetter G, Demeure MJ, &, Von Hoff DD, (2008) Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells. Mol Cancer Ther 7, 202-210.
108. Luo Y, Liang F, &, Zhang ZY, (2009) PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry 48, 1838-1846.
109. Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, &, Diamond RH, (2001) ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase. J Biol Chem 276, 13718-13726.
110. Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, et al. (2011) PRL-1 promotes ERK1/2 and RhoA activation through a novel interaction with p115 RhoGAP. J Biol Chem 286, 42316-42324.
111. Yu L, Kelly U, Ebright JN, Malek G, Saloupis P, Rickman DW, McKay BS, Arshavsky VY, &, Bowes Rickman C, (2007) Oxidative stress-induced expression and modulation of phosphatase of regenerating liver-1 (PRL-1) in mammalian retina. Biochim Biophys Acta 1773, 1473-1482.
112. Daouti S, Li WH, Qian H, Huang KS, Holmgren J, Levin W, Reik L, McGady DL, Gillespie P, Perrotta A, et al. (2008) A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res 68, 1162-1169.
113. Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, Sternweis PC, &, Cobb MH, (2002) p115 Rho GTPase activating protein interacts with MEKK1. J Cell Physiol 192, 200-208.
114. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, &, Pelicci P, (1996) An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. Proc Natl Acad Sci USA 93, 695-699.
115. Wang Q, Holmes DI, Powell SM, Lu QL, &, Waxman J, (2002) Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene. Cancer Lett 175, 63-69.
116. Akiyama S, Dhavan D, &, Yi T, (2010) PRL-2 increases Epo and IL-3 responses in hematopoietic cells. Blood Cells Mol Dis 44, 209-214.
117. Yagi T, Morimoto A, Eguchi M, Hibi S, Sako M, Ishii E, Mizutani S, Imashuku S, Ohki M, &, Ichikawa H, (2003) Identification of a gene expression signature associated with pediatric AML prognosis. Blood 102, 1849-1856.
118. Radke I, Gotte M, Kersting C, Mattsson B, Kiesel L, &, Wulfing P, (2006) Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer. Br J Cancer 95, 347-354.
119. Playford MP, &, Schaller MD, (2004) The interplay between Src and integrins in normal and tumor biology. Oncogene 23, 7928-7946.
120. Schwering I, Brauninger A, Distler V, Jesdinsky J, Diehl V, Hansmann ML, Rajewsky K, &, Kuppers R, (2003) Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes. Mol Med 9, 85-95.
121. Monaco SE, Angelastro JM, Szabolcs M, &, Greene LA, (2007) The transcription factor ATF5 is widely expressed in carcinomas, and interference with its function selectively kills neoplastic, but not nontransformed, breast cell lines. Int J Cancer 120, 1883-1890.
122. Persengiev SP, &, Green MR, (2003) The role of ATF/CREB family members in cell growth, survival and apoptosis. Apoptosis 8, 225-228.
123. Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN, &, Greene LA, (2006) Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5. Oncogene 25, 907-916.
124. Dluzen D, Li G, Tacelosky D, Moreau M, &, Liu DX, (2011) BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J Biol Chem 286, 7705-7713.