Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 9, 2008, Pages 3545-3550

  Emanuelli, Brice ^a   Eberlé, Delphine ^a   Suzuki, Ryo ^a   Kahn, C Ronald ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

Cytokines; Diabetes; Kinases; Obesity

Indexed keywords

ANISOMYCIN; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MKP 4 ENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; SERINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; DUAL SPECIFICITY PHOSPHATASE; DUSP9 PROTEIN, MOUSE; INSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRESS; UPREGULATION; WHITE ADIPOSE TISSUE; ADIPOCYTE; ANIMAL; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUSCLE CELL; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CELL LINE; DUAL-SPECIFICITY PHOSPHATASES; GENE EXPRESSION REGULATION; HUMANS; INSULIN; INSULIN RESISTANCE; MICE; MUSCLE CELLS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 42149155999     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712275105     Document Type: Article

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