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Volumn 68, Issue 22, 2008, Pages 9255-9264

The mitogen-activated protein kinase phosphatase Vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CELL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PHORBOL 13 ACETATE 12 MYRISTATE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; UNCLASSIFIED DRUG; VACCINIA H1 RELATED PROTEIN;

EID: 56449110281     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1224     Document Type: Article
Times cited : (45)

References (50)
  • 1
    • 33746623315 scopus 로고    scopus 로고
    • Molecular regulation of androgen action in prostate cancer
    • Dehm SM, Tindall DJ. Molecular regulation of androgen action in prostate cancer. J Cell Biochem 2006;99:333-44.
    • (2006) J Cell Biochem , vol.99 , pp. 333-344
    • Dehm, S.M.1    Tindall, D.J.2
  • 2
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004;25:276-308.
    • (2004) Endocr Rev , vol.25 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 3
    • 36849007390 scopus 로고    scopus 로고
    • Androgen signaling and its interactions with other signaling pathways in prostate cancer
    • Kaarbo M, Klokk TI, Saatcioglu F. Androgen signaling and its interactions with other signaling pathways in prostate cancer. Bioessays 2007;29:1227-38.
    • (2007) Bioessays , vol.29 , pp. 1227-1238
    • Kaarbo, M.1    Klokk, T.I.2    Saatcioglu, F.3
  • 4
    • 33845509928 scopus 로고    scopus 로고
    • Early effects of pharmacological androgen deprivation in human prostate cancer
    • Mercader M, Sengupta S, Bodner BK, et al. Early effects of pharmacological androgen deprivation in human prostate cancer. BJU Int 2007;99:60-7.
    • (2007) BJU Int , vol.99 , pp. 60-67
    • Mercader, M.1    Sengupta, S.2    Bodner, B.K.3
  • 5
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001;1:34-45.
    • (2001) Nat Rev Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 6
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 7
    • 3042522892 scopus 로고    scopus 로고
    • Stress-activated protein kinases-tumor suppressors or tumor initiators?
    • Engelberg D. Stress-activated protein kinases-tumor suppressors or tumor initiators? Semin Cancer Biol 2004;14:271-82.
    • (2004) Semin Cancer Biol , vol.14 , pp. 271-282
    • Engelberg, D.1
  • 8
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene 2004;23:2838-49.
    • (2004) Oncogene , vol.23 , pp. 2838-2849
    • Wada, T.1    Penninger, J.M.2
  • 9
    • 34248595035 scopus 로고    scopus 로고
    • Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
    • Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007;26:3203-13.
    • (2007) Oncogene , vol.26 , pp. 3203-3213
    • Owens, D.M.1    Keyse, S.M.2
  • 10
    • 2942581416 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases in the human genome
    • Alonso A, Sasin J, Bottini N, et al. Protein tyrosine phosphatases in the human genome. Cell 2004;117:699-711.
    • (2004) Cell , vol.117 , pp. 699-711
    • Alonso, A.1    Sasin, J.2    Bottini, N.3
  • 11
    • 2042538029 scopus 로고    scopus 로고
    • Structure and regulation of MAPK phosphatases
    • Farooq A, Zhou MM. Structure and regulation of MAPK phosphatases. Cell Signal 2004;16:769-79.
    • (2004) Cell Signal , vol.16 , pp. 769-779
    • Farooq, A.1    Zhou, M.M.2
  • 13
    • 0035895980 scopus 로고    scopus 로고
    • Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation
    • Alonso A, Saxena M, Williams S, Mustelin T. Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J Biol Chem 2001;276:4766-71.
    • (2001) J Biol Chem , vol.276 , pp. 4766-4771
    • Alonso, A.1    Saxena, M.2    Williams, S.3    Mustelin, T.4
  • 14
    • 0037061763 scopus 로고    scopus 로고
    • Dual-specificity protein tyrosine phosphatase VHR downregulates c-Jun N-terminal kinase ( JNK)
    • Todd JL, Rigas JD, Rafty LA, Denu JM. Dual-specificity protein tyrosine phosphatase VHR downregulates c-Jun N-terminal kinase ( JNK). Oncogene 2002;21:2573-83.
    • (2002) Oncogene , vol.21 , pp. 2573-2583
    • Todd, J.L.1    Rigas, J.D.2    Rafty, L.A.3    Denu, J.M.4
  • 15
    • 0033532067 scopus 로고    scopus 로고
    • Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway
    • Todd JL, Tanner KG, Denu JM. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem 1999;274:13271-80.
    • (1999) J Biol Chem , vol.274 , pp. 13271-13280
    • Todd, J.L.1    Tanner, K.G.2    Denu, J.M.3
  • 16
    • 33744969297 scopus 로고    scopus 로고
    • Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
    • Rahmouni S, Cerignoli F, Alonso A, et al. Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol 2006;8:524-31.
    • (2006) Nat Cell Biol , vol.8 , pp. 524-531
    • Rahmouni, S.1    Cerignoli, F.2    Alonso, A.3
  • 17
    • 0037034203 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP
    • Engedal N, Korkmaz CG, Saatcioglu F. C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. Oncogene 2002;21:1017-27.
    • (2002) Oncogene , vol.21 , pp. 1017-1027
    • Engedal, N.1    Korkmaz, C.G.2    Saatcioglu, F.3
  • 18
    • 43249131473 scopus 로고    scopus 로고
    • Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation
    • Lorenzo PI, Saatcioglu F. Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation. Neoplasia 2008;10:418-28.
    • (2008) Neoplasia , vol.10 , pp. 418-428
    • Lorenzo, P.I.1    Saatcioglu, F.2
  • 19
    • 1942442438 scopus 로고    scopus 로고
    • Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer
    • Xi Z, Klokk TI, Korkmaz K, et al. Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer. Cancer Res 2004;64:2365-70.
    • (2004) Cancer Res , vol.64 , pp. 2365-2370
    • Xi, Z.1    Klokk, T.I.2    Korkmaz, K.3
  • 20
    • 0029942883 scopus 로고    scopus 로고
    • CWR22: The first human prostate cancer xenograft withs trongly androgen-dependent and relapsed strains both in vivo and in soft agar
    • Nagabhushan M, Miller CM, Pretlow TP, et al. CWR22: the first human prostate cancer xenograft withs trongly androgen-dependent and relapsed strains both in vivo and in soft agar. Cancer Res 1996;56:3042-6.
    • (1996) Cancer Res , vol.56 , pp. 3042-3046
    • Nagabhushan, M.1    Miller, C.M.2    Pretlow, T.P.3
  • 21
    • 0032831780 scopus 로고    scopus 로고
    • The JNKK2-1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity
    • Zheng C, Xiang J, Hunter T, Lin A. The JNKK2-1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. J Biol Chem 1999;274:28966-71.
    • (1999) J Biol Chem , vol.274 , pp. 28966-28971
    • Zheng, C.1    Xiang, J.2    Hunter, T.3    Lin, A.4
  • 22
    • 34347204166 scopus 로고    scopus 로고
    • Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer
    • Klokk TI, Kilander A, Xi Z, et al. Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Cancer Res 2007;67:5221-30.
    • (2007) Cancer Res , vol.67 , pp. 5221-5230
    • Klokk, T.I.1    Kilander, A.2    Xi, Z.3
  • 23
    • 33646416743 scopus 로고    scopus 로고
    • The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death
    • Zhou JY, Liu Y, Wu GS. The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death. Cancer Res 2006;66:4888-94.
    • (2006) Cancer Res , vol.66 , pp. 4888-4894
    • Zhou, J.Y.1    Liu, Y.2    Wu, G.S.3
  • 24
    • 14044251529 scopus 로고    scopus 로고
    • Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
    • Mandl M, Slack DN, Keyse SM. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol Cell Biol 2005;25:1830-45.
    • (2005) Mol Cell Biol , vol.25 , pp. 1830-1845
    • Mandl, M.1    Slack, D.N.2    Keyse, S.M.3
  • 25
    • 0038701654 scopus 로고    scopus 로고
    • The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK
    • Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ. The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. J Biol Chem 2003;278:10731-6.
    • (2003) J Biol Chem , vol.278 , pp. 10731-10736
    • Willoughby, E.A.1    Perkins, G.R.2    Collins, M.K.3    Whitmarsh, A.J.4
  • 26
    • 0041328210 scopus 로고    scopus 로고
    • Apoptosis levels increase after castration in the CWR22 human prostate cancer xenograft
    • Smitherman AB, Gregory CW, Mohler JL. Apoptosis levels increase after castration in the CWR22 human prostate cancer xenograft. Prostate 2003;57:24-31.
    • (2003) Prostate , vol.57 , pp. 24-31
    • Smitherman, A.B.1    Gregory, C.W.2    Mohler, J.L.3
  • 27
    • 0037232078 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of VHR phosphatase by ZAP-70
    • Alonso A, Rahmouni S, Williams S, et al. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nature Immunol 2003;4:44-8.
    • (2003) Nature Immunol , vol.4 , pp. 44-48
    • Alonso, A.1    Rahmouni, S.2    Williams, S.3
  • 29
    • 1642377561 scopus 로고    scopus 로고
    • ONCOMINE: A cancer microarray database and integrated data-mining platform
    • Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004;6:1-6.
    • (2004) Neoplasia , vol.6 , pp. 1-6
    • Rhodes, D.R.1    Yu, J.2    Shanker, K.3
  • 30
    • 33846255841 scopus 로고    scopus 로고
    • Androgens regulate protein kinase Cδ transcription and modulate its apoptotic function in prostate cancer cells
    • Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cδ transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res 2006;66:11792-801.
    • (2006) Cancer Res , vol.66 , pp. 11792-11801
    • Gavrielides, M.V.1    Gonzalez-Guerrico, A.M.2    Riobo, N.A.3    Kazanietz, M.G.4
  • 31
    • 10744226844 scopus 로고    scopus 로고
    • Interruption of nuclear factor κB signaling by the androgen receptor facilitates 12-O- tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells
    • Altuwaijri S, Lin HK, Chuang KH, et al. Interruption of nuclear factor κB signaling by the androgen receptor facilitates 12-O- tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells. Cancer Res 2003;63:7106-12.
    • (2003) Cancer Res , vol.63 , pp. 7106-7112
    • Altuwaijri, S.1    Lin, H.K.2    Chuang, K.H.3
  • 32
    • 0037112372 scopus 로고    scopus 로고
    • Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
    • Tepper CG, Boucher DL, Ryan PE, et al. Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer Res 2002;62:6606-14.
    • (2002) Cancer Res , vol.62 , pp. 6606-6614
    • Tepper, C.G.1    Boucher, D.L.2    Ryan, P.E.3
  • 33
    • 23944523430 scopus 로고    scopus 로고
    • The emerging role of the PI3-K-Akt pathway in prostate cancer progression
    • Li L, Ittmann MM, Ayala G, et al. The emerging role of the PI3-K-Akt pathway in prostate cancer progression. Prostate Cancer Prostatic Dis 2005;8:108-18.
    • (2005) Prostate Cancer Prostatic Dis , vol.8 , pp. 108-118
    • Li, L.1    Ittmann, M.M.2    Ayala, G.3
  • 34
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFα-induced deathand sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFα-induced deathand sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005;120:649-61.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 35
    • 33846844835 scopus 로고    scopus 로고
    • Androgen induces adaptation to oxidative stress in prostate cancer: Implications for treatment withr adiation therapy
    • Pinthus JH, Bryskin I, Trachtenberg J, et al. Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment withr adiation therapy. Neoplasia 2007;9:68-80.
    • (2007) Neoplasia , vol.9 , pp. 68-80
    • Pinthus, J.H.1    Bryskin, I.2    Trachtenberg, J.3
  • 36
    • 33847219580 scopus 로고    scopus 로고
    • A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity
    • Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene 2007;26:1178-87.
    • (2007) Oncogene , vol.26 , pp. 1178-1187
    • Yu, W.1    Imoto, I.2    Inoue, J.3    Onda, M.4    Emi, M.5    Inazawa, J.6
  • 37
    • 0037058703 scopus 로고    scopus 로고
    • Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma
    • Denkert C, Schmitt WD, Berger S, et al. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Int J Cancer 2002;102:507-13.
    • (2002) Int J Cancer , vol.102 , pp. 507-513
    • Denkert, C.1    Schmitt, W.D.2    Berger, S.3
  • 38
    • 0037430452 scopus 로고    scopus 로고
    • Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer
    • Wang HY, Cheng Z, Malbon CC. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Cancer Lett 2003;191:229-37.
    • (2003) Cancer Lett , vol.191 , pp. 229-237
    • Wang, H.Y.1    Cheng, Z.2    Malbon, C.C.3
  • 39
    • 0037606170 scopus 로고    scopus 로고
    • Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumor-igenicity of pancreatic cancer cells
    • Liao Q, Guo J, Kleeff J, et al. Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumor-igenicity of pancreatic cancer cells. Gastroenterology 2003;124:1830-45.
    • (2003) Gastroenterology , vol.124 , pp. 1830-1845
    • Liao, Q.1    Guo, J.2    Kleeff, J.3
  • 40
    • 33748995966 scopus 로고    scopus 로고
    • Mitogen-Activated Protein Kinase Phosphatase-1 Is Required for Cisplatin Resistance
    • Wang Z, Xu J, Zhou JY, Liu Y, Wu GS. Mitogen-Activated Protein Kinase Phosphatase-1 Is Required for Cisplatin Resistance. Cancer Res 2006;66:8870-7.
    • (2006) Cancer Res , vol.66 , pp. 8870-8877
    • Wang, Z.1    Xu, J.2    Zhou, J.Y.3    Liu, Y.4    Wu, G.S.5
  • 41
    • 34548482720 scopus 로고    scopus 로고
    • DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118
    • Sekine Y, Ikeda O, Hayakawa Y, et al. DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118. Oncogene 2007;26:6038-49.
    • (2007) Oncogene , vol.26 , pp. 6038-6049
    • Sekine, Y.1    Ikeda, O.2    Hayakawa, Y.3
  • 42
    • 44949176019 scopus 로고    scopus 로고
    • Cervix carcinoma is associated withan up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR
    • Henkens R, Delvenne P, Arafa M, et al. Cervix carcinoma is associated withan up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. BMC Cancer 2008;8:147.
    • (2008) BMC Cancer , vol.8 , pp. 147
    • Henkens, R.1    Delvenne, P.2    Arafa, M.3
  • 43
    • 0032877013 scopus 로고    scopus 로고
    • Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis
    • Srikanth S, Franklin CC, Duke RC, Kraft RS. Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis. Mol Cell Biochem 1999;199:169-78.
    • (1999) Mol Cell Biochem , vol.199 , pp. 169-178
    • Srikanth, S.1    Franklin, C.C.2    Duke, R.C.3    Kraft, R.S.4
  • 44
    • 5644295435 scopus 로고    scopus 로고
    • ERK1/2 and p38 pathways are required for P2Y receptor-mediated prostate cancer invasion
    • Chen L, He HY, Li HM, et al. ERK1/2 and p38 pathways are required for P2Y receptor-mediated prostate cancer invasion. Cancer Lett 2004;215:239-47.
    • (2004) Cancer Lett , vol.215 , pp. 239-247
    • Chen, L.1    He, H.Y.2    Li, H.M.3
  • 45
    • 0031036906 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis
    • Magi-Galluzzi C, Mishra R, Fiorentino M, et al. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Lab Invest 1997;76:37-51.
    • (1997) Lab Invest , vol.76 , pp. 37-51
    • Magi-Galluzzi, C.1    Mishra, R.2    Fiorentino, M.3
  • 47
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006;127:679-95.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 48
    • 0037007048 scopus 로고    scopus 로고
    • Large-scale analysis of the human and mouse transcriptomes
    • Su AI, Cooke MP, Ching KA, et al. Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A 2002;99:4465-70.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4465-4470
    • Su, A.I.1    Cooke, M.P.2    Ching, K.A.3
  • 49
    • 0035881732 scopus 로고    scopus 로고
    • Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer
    • Welsh JB, Sapinoso LM, Su AI, et al. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 2001;61:5974-8.
    • (2001) Cancer Res , vol.61 , pp. 5974-5978
    • Welsh, J.B.1    Sapinoso, L.M.2    Su, A.I.3
  • 50
    • 33845884027 scopus 로고    scopus 로고
    • Integrative molecular concept modeling of prostate cancer progression
    • Tomlins SA, Mehra R, Rhodes DR, et al. Integrative molecular concept modeling of prostate cancer progression. Nat Genet 2007;39:41-51.
    • (2007) Nat Genet , vol.39 , pp. 41-51
    • Tomlins, S.A.1    Mehra, R.2    Rhodes, D.R.3


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