Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Zimmerman, Mark W ^a   Homanics, Gregg E ^a   Lazo, John S ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MYC PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 4A3; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON CANCER; COLON CARCINOGENESIS; COLON METASTASIS; COLON MUCOSA; CONTROLLED STUDY; EARLY CANCER; FEMALE; GENE; GENE DELETION; GENE FUNCTION; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PTP4A3 GENE; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

ANIMALS; AZOXYMETHANE; CARCINOGENS; COLON; COLONIC NEOPLASMS; DEXTRAN SULFATE; GENE DELETION; HUMANS; IMMEDIATE-EARLY PROTEINS; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; PROTEIN TYROSINE PHOSPHATASES; PROTO-ONCOGENE PROTEINS C-MYC;

MURINAE; MUS;

EID: 84875506390     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058300     Document Type: Article

References (30)

1. Diamond RH, Cressman DE, Laz TM, Abrams CS, Taub R, (1994) PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol Cell Biol 14: 3752-3762.
2. Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, et al. (2001) A phosphatase associated with metastasis of colorectal cancer. Science 294: 1343-1346.
3. Radke I, Götte M, Kersting C, Mattsson B, Kiesel L, et al. (2006) Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer. Br J Cancer 95: 347-354.
4. Reich R, Hadar S, Davidson B, (2011) Expression and clinical role of protein of regenerating liver (PRL) phosphatases in ovarian carcinoma. Int J Mol Sci 12: 1133-1145.
5. Zhao WB, Li Y, Liu X, Zhang LY, Wang X, (2008) Evaluation of PRL-3 expression, and its correlation with angiogenesis and invasion in hepatocellular carcinoma. Int J Mol Med 22: 187-192.
6. Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, et al. (2011) Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer. BMC Cancer 11.
7. Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, et al. (2002) Molecular characterisation of soft tissue tumours: a gene expression study. Lancet 359: 1301-1307.
8. Guzińska-Ustymowicz K, Pryczynicz A, (2011) PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis. Anticancer Agents Med Chem 11: 99-108.
9. Fiordalisi JJ, Keller PJ, Cox AD, (2006) PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Res 66: 3153-3161.
10. Liang F, Liang J, Wang WQ, Sun JP, Udho E, et al. (2007) PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem 282: 5413-5419.
11. Wang H, Quah SY, Dong JM, Manser E, Tang JP, et al. (2007) PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res 67: 2922-2926.
12. McParland V, Varsano G, Li X, Thornton J, Baby J, et al. (2011) The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides. Biochemistry 50: 7579-7590.
13. Neufert C, Becker C, Neurath MF, (2007) An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protoc 2: 1998-2004.
14. O'Toole SM, Pegg AE, Swenberg JA, (1993) Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine. Cancer Res 53: 3895-3898.
15. Kohno H, Suzuki R, Sugie S, Tanaka T, (2005) Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci 96: 69-76.
16. De Robertis M, Massi E, Poeta ML, Carotti S, Morini S, et al. (2011) The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog 10.
17. Kanneganti M, Mino-Kenudson M, Mizoguchi E (2011) Animal models of colitis-associated carcinogenesis. J Biomed Biotechnol 2011.
18. Guda K, Claffey KP, Dong M, Nambiar PR, Rosenberg DW, (2003) Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors. Mol Carcinog 37: 51-59.
19. Jiang Y, Liu XQ, Rajput A, Geng L, Ongchin M, et al. (2011) Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis. Cancer Res 71: 234-244.
20. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93: 5860-5865.
21. Guo K, Li J, Wang H, Osato M, Tang JP, et al. (2006) PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res 66: 9625-9635.
22. Molleví DG, Aytes A, Padullés L, Martínez-Iniesta M, Baixeras N, et al. (2008) PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness. Br J Cancer 99: 1718-1725.
23. Dong Y, Zhang L, Zhang S, Bai Y, Chen H, et al. (2012) Phosphatase of regenerating liver 2 (PRL2) is essential for placenta development by downregulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt. J Biol Chem (In press).
24. Matter WF, Estridge T, Zhang C, Belagaje R, Stancato L, et al. (2001) Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. Biochem Biophys Res Commun 283: 1061-1068.
25. Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, et al. (2008) The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell 30: 303-314.
26. Massagué J, (2008) TGFβ in Cancer. Cell 134: 215-230.
27. Zhu Y, Richardson JA, Parada LF, Graff JM, (1998) Smad3 mutant mice develop metastatic colorectal cancer. Cell 94: 703-714.
28. Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, et al. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92: 645-656.
29. Liu P, Jenkins NA, Copeland NG, (2003) A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13: 476-484.
30. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC, (1993) Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A 90: 8424-8428.