A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

Molecular Cancer Therapeutics

Volumn 7, Issue 2, 2008, Pages 330-340

  Vogt, Andreas ^a,b   McDonald, Peter R ^a,b   Tamewitz, Aletheia ^a   Sikorski, Rachel P ^a   Wipf, Peter ^b   Skoko III, John J ^a,b   Lazo, John S ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 MERCAPTOETHANOL) 3 METHYL 1,4 NAPHTHOQUINONE; 2,3 BIS(2 HYDROXYETHYLSULFONYL)[1,4]NAPHTHOQUINONE; 6 (2 MORPHOLIN 4 YLETHYLAMINO)QUINOLINE 5,8 DIONE; 7 CHLORO 6 (2 MORPHOLIN 4 YLETHYLAMINO) QUINOLINE 5,8 DIONE; ANTINEOPLASTIC AGENT; DA 3003 1; DEXAMETHASONE; JUN 1111; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NSC 663284; NSC 672121; NSC 95397; PACLITAXEL; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL ASSAY; CELL PROTECTION; CHEMICAL ANALYSIS; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; FLUORESCENCE; HUMAN; HUMAN CELL; IC 50; MAMMAL CELL; PRIORITY JOURNAL; TARGET CELL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CELL SURVIVAL; CYTOPROTECTION; DEXAMETHASONE; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; DUAL SPECIFICITY PHOSPHATASE 1; DUAL SPECIFICITY PHOSPHATASE 6; HELA CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; MODELS, BIOLOGICAL; NAPHTHOQUINONES; PACLITAXEL; QUINONES; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 39749109385     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-2165     Document Type: Article

References (48)