Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

Nature Chemical Biology

Volumn 5, Issue 9, 2009, Pages 680-687

  Molina, Gabriela ^a,c   Vogt, Andreas ^a,b   Bakan, Ahmet ^b   Dai, Weixiang ^b   De Oliveira, Pierre Queiroz ^a   Znosko, Wade ^a   Smithgall, Thomas E ^a,b   Bahar, Ivet ^b   Lazo, John S ^a,b   Day, Billy W ^b   Tsang, Michael ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYLIDENE 3 (CYCLOHEXYLAMINO) 2,3 DIHYDRO 1H INDEN 1 ONE; DUAL SPECIFICITY PHOSPHATASE 6; ENZYME INHIBITOR; FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL LINEAGE; CONTROLLED STUDY; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; GENE EXPRESSION; HEART MUSCLE CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TRANSGENIC ORGANISM; ZEBRA FISH;

DANIO RERIO;

ALLOSTERIC SITE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL LINEAGE; CYCLOHEXYLAMINES; DUAL SPECIFICITY PHOSPHATASE 6; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; INDENES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY; ZEBRAFISH;

EID: 69249210903     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.190     Document Type: Article

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