Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits

Molecular and Cellular Biology

Volumn 29, Issue 6, 2009, Pages 1538-1553

  Gobert, Rosanna Pescini ^a   Joubert, Lara ^a   Curchod, Marie Laure ^a   Salvat, Catherine ^a   Foucault, Isabelle ^a   Jorand Lebrun, Catherine ^a   Lamarine, Marc ^a   Peixoto, Hélène ^a   Vignaud, Chloé ^a   Frémaux, Christèle ^a   Jomotte, Thérèse ^a   Françon, Bernard ^a   Alliod, Chantal ^a   Bernasconi, Lilia ^a   Abderrahim, Hadi ^a   Perrin, Dominique ^a   Bombrun, Agnes ^a   Zanoguera, Francisca ^a   Rommel, Christian ^a,b   Van Huijsduijnen, Rob Hooft ^a  

^a MERCK SERONO S A   (Switzerland)

^b Intellikine Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; GENE; GENE CONTROL; GENOMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; UNINDEXED SEQUENCE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DEXAMETHASONE; DUAL-SPECIFICITY PHOSPHATASES; FORSKOLIN; GENE REGULATORY NETWORKS; GENE SILENCING; GENOME-WIDE ASSOCIATION STUDY; MICE; MYELIN BASIC PROTEINS; NEUROGENESIS; OLIGODENDROGLIA; RATS; SIGNAL TRANSDUCTION; TRETINOIN;

RATTUS;

EID: 62849083302     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01375-08     Document Type: Article

References (45)

1. Agarwala, K. L., S. Ganesh, Y. Tsutsumi, T. Suzuki, K. Amano, and K. Yamakawa. 2001. Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion. Biochem. Biophys. Res. Commun. 285:760-772.
2. Aston, C., L. Jiang, and B. P. Sokolov. 2005. Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol. Psychiatr. 10:309-322.
3. Balavenkatraman, K. K., E. Jandt, K. Friedrich, T. Kautenburger, B. L. Pool-Zobel, A. Ostman, and F. D. Bohmer. 2006. DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. Oncogene 25:6319-6324.
4. Birling, M. C., S. Tait, R. J. Hardy, and P. J. Brophy. 1999. A novel rat tetraspan protein in cells of the oligodendrocyte lineage. J. Neurochem. 73:2600-2608.
5. Cahoy, J. D., B. Emery, A. Kaushal, L. C. Foo, J. L. Zamanian, K. S. Christopherson, Y. Xing, J. L. Lubischer, P. A. Krieg, S. A. Krupenko, W. J. Thompson, and B. A. Barres. 2008. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 28:264-278.
6. Caunt, C. J., S. P. Armstrong, C. A. Rivers, M. R. Norman, and C. A. McArdle. 2008. Spatiotemporal regulation of ERK2 by dual specificity phosphatases. J. Biol. Chem. 283:26612-26623.
7. Chih, B., S. K. Afridi, L. Clark, and P. Scheiffele. 2004. Disorder-associated mutations lead to functional inactivation of neuroligins. Hum. Mol. Genet. 13:1471-1477.
8. Chirivi, R. G., Y. E. Noordman, C. E. Van der Zee, and W. J. Hendriks. 2007. Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. J. Neurochem. 101:829-840.
9. Dugas, J. C., Y. C. Tai, T. P. Speed, J. Ngai, and B. A. Barres. 2006. Functional genomic analysis of oligodendrocyte differentiation. J. Neurosci. 26:10967-10983.
10. Fields, R. D. 2008. White matter in learning, cognition and psychiatric disorders. Trends Neurosci. 31:361-370.
11. Franklin, R. J., and M. R. Kotter. 2008. The biology of CNS remyelination: the key to therapeutic advances. J. Neurol. 255(Suppl. 1):19-25.
12. Gravel, M., J. Peterson, V. W. Yong, V. Kottis, B. Trapp, and P. E. Braun. 1996. Overexpression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination. Mol. Cell Neurosci. 7:453-466.
13. Han, M. H., S. I. Hwang, D. B. Roy, D. H. Lundgren, J. V. Price, S. S. Ousman, G. H. Fernald, B. Gerlitz, W. H. Robinson, S. E. Baranzini, B. W. Grinnell, C. S. Raine, R. A. Sobel, D. K. Han, and L. Steinman. 2008. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 451:1076-1081.
14. Hooft van Huijsduijnen, R. 2003. Drug discovery and development for metabolic diseases. Drug Discov. Today 8:1064-1066.
15. Huang, S., Y. P. Guo, G. May, and T. Enver. 2007. Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev. Biol. 305:695-713.
16. Hudson, L. D. 2003. Pelizaeus-Merzbacher disease and spastic paraplegia type 2: two faces of myelin loss from mutations in the same gene. J. Child Neurol. 18:616-624.
17. Jessen, K. R., and R. Mirsky. 2008. Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia 56:1552-1565.
18. Jung, M., E. Kramer, M. Grzenkowski, K. Tang, W. Blakemore, A. Aguzzi, K. Khazaie, K. Chlichlia, G. von Blankenfeld, H. Kettenmann, et al. 1995. Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo. Eur. J. Neurosci. 7:1245-1265.
19. Kippert, A., K. Trajkovic, D. Fitzner, L. Opitz, and M. Simons. 2008. Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling. BMC Neurosci. 9:40.
20. Kuhlmann, T., V. Miron, Q. Cuo, C. Wegner, J. Antel, and W. Bruck. 2008. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131:1749- 1758.
21. Lappe-Siefke, C., S. Goebbels, M. Gravel, E. Nicksch, J. Lee, P. E. Braun, I. R. Griffiths, and K. A. Nave. 2003. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat. Genet. 33: 366-374.
22. Lein, E. S., M. J. Hawrylycz, N. Ao, M. Ayres, A. Bensinger, A. Bernard, A. F. Boe, M. S. Boguski, K. S. Brockway, E. J. Byrnes, L. Chen, L. Chen, T. M. Chen, M. C. Chin, J. Chong, B. E. Crook, A. Czaplinska, C. N. Dang, S. Datta, N. R. Dee, A. L. Desaki, T. Desta, E. Diep, T. A. Dolbeare, M. J. Donelan, H. W. Dong, J. G. Dougherty, B. J. Duncan, A. J. Ebbert, G. Eichele, L. K. Estin, C. Faber, B. A. Facer, R. Fields, S. R. Fischer, T. P. Fliss, C. Frensley, S. N. Gates, K. J. Glattfelder, K. R. Halverson, M. R. Hart, J. G. Hohmann, M. P. Howell, D. P. Jeung, R. A. Johnson, P. T. Karr, R. Kawal, J. M. Kidney, R. H. Knapik, C. L. Kuan, J. H. Lake, A. R. Laramee, K. D. Larsen, C. Lau, T. A. Lemon, A. J. Liang, Y. Liu, L. T. Luong, J. Michaels, J. J. Morgan, R. J. Morgan, M. T. Mortrud, N. F. Mosqueda, L. L. Ng, R. Ng, G. J. Orta, C. C. Overly, T. H. Pak, S. E. Parry, S. D. Pathak, O. C. Pearson, R. B. Puchalski, Z. L. Riley, H. R. Rockett, S. A. Rowland, J. J. Royall, M. J. Ruiz, N. R. Sarno, K. Schaffnit, N. V. Shapovalova, T. Sivisay, C. R. Slaughterbeck, S. C. Smith, K. A. Smith, B. I. Smith, A. J. Sodt, N. N. Stewart, K. R. Stumpf, S. M. Sunkin, M. Sutram, A. Tam, C. D. Teemer, C. Thaller, C. L. Thompson, L. R. Varnam, A. Visel, R. M. Whitlock, P. E. Wohnoutka, C. K. Wolkey, V. Y. Wong, et al. 2007. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445:168-176.
23. Lewitzky, M., and S. Yamanaka. 2007. Reprogramming somatic cells towards pluripotency by defined factors. Curr. Opin. Biotechnol. 18:467-473.
24. Li, W., B. Zhang, J. Tang, Q. Cao, Y. Wu, C. Wu, J. Guo, E. A. Ling, and F. Liang. 2007. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating α-tubulin. J. Neurosci. 27:2606-2616.
25. Lindberg, R. L., C. J. De Groot, U. Certa, R. Ravid, F. Hoffmann, L. Kappos, and D. Leppert. 2004. Multiple sclerosis as a generalized CNS disease: comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS. J. Neuroimmunol. 152:154-167.
26. Liu, Z., X. Hu, J. Cai, B. Liu, X. Peng, M. Wegner, and M. Qiu. 2007. Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms. Dev. Biol. 302:683-693.
27. Massa, A., F. Barbieri, C. Aiello, R. Iuliano, S. Arena, A. Pattarozzi, A. Corsaro, V. Villa, A. Fusco, G. Zona, R. Spaziante, G. Schettini, and T. Florio. 2004. The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2. Ann. N. Y. Acad. Sci. 1030:264-274.
28. Mi, S., A. Sandrock, and R. H. Miller. 2008. LINGO-1 and its role in CNS repair. Int. J. Biochem. Cell. Biol. 40:1971-1978.
29. Mycko, M. P., R. Papoian, U. Boschert, C. S. Raine, and K. W. Selmaj. 2004. Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis. Clin. Neurol. Neurosurg. 106:223-229.
30. Nicolay, D. J., J. R. Doucette, and A. J. Nazarali. 2007. Transcriptional control of oligodendrogenesis. Glia 55:1287-1299.
31. Oksenberg, J. R., S. E. Baranzini, S. Sawcer, and S. L. Hauser. 2008. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 9:516-526.
32. Pasquali, C., M. L. Curchod, S. Walchli, X. Espanel, M. Guerrier, F. Arigoni, G. Strous, and R. Hooft van Huijsduijnen. 2003. Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Mol. Endocrinol. 17:2228-2239.
33. Pera, I. L., R. Iuliano, T. Florio, C. Susini, F. Trapasso, M. Santoro, L. Chiariotti, G. Schettini, G. Viglietto, and A. Fusco. 2005. The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue. Oncogene 24:3187-3195.
34. Pilecka, I., C. Patrignani, R. Pescini, M.-L. Curchod, D. Perrin, Y. Xue, J. Yasenchak, A. Clark, M. C. Magnone, P. Zaratin, D. Valenzuela, C. Rommel, and R. Hooft van Huijsduijnen. 2007. Protein tyrosine phosphatase H1 (PTP-H1/PTPN3) controls growth hormone receptor signaling and systemic growth. J. Biol. Chem. 282:35405-35415.
35. Reich, D., N. Patterson, P. L. De Jager, G. J. McDonald, A. Waliszewska, A. Tandon, R. R. Lincoln, C. DeLoa, S. A. Fruhan, P. Cabre, O. Bera, G. Semana, M. A. Kelly, D. A. Francis, K. Ardlie, O. Khan, B. A. Cree, S. L. Hauser, J. R. Oksenberg, and D. A. Hafler. 2005. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat. Genet. 37:1113-1118.
36. Sommer, I., and M. Schachner. 1981. Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev. Biol. 83:311-327.
37. Stadelmann, C., and W. Bruck. 2008. Interplay between mechanisms of damage and repair in multiple sclerosis. J. Neurol. 255(Suppl. 1):12-18.
38. Tanoue, T., T. Moriguchi, and E. Nishida. 1999. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP5. J. Biol. Chem. 274:19949-19956.
39. Terada, N., K. Baracskay, M. Kinter, S. Melrose, P. J. Brophy, C. Boucheix, C. Bjartmar, G. Kidd, and B. D. Trapp. 2002. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia 40:350-359.
40. Theodosiou, A., A. Smith, C. Gillieron, S. Arkinstall, and A. Ashworth. 1999. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. Oncogene 18:6981-6988.
41. Wälchli, S., M.-L. Curchod, R. Pescini Gobert, S. Arkinstall, and R. Hooft van Huijsduijnen. 2000. Identification of tyrosine phosphatases that dephosphorylate the insulin receptor: a brute-force approach based on "substratetrapping" mutants. J. Biol. Chem. 275:9792-9796.
42. Wegner, M. 2008. A matter of identity: transcriptional control in oligodendrocytes. J. Mol. Neurosci. 35:3-12.
43. Yin, X., J. Peterson, M. Gravel, P. E. Braun, and B. D. Trapp. 1997. CNP overexpression induces aberrant oligodendrocyte membranes and inhibits MBP accumulation and myelin compaction. J. Neurosci. Res. 50:238-247.
44. Zechel, S., S. Werner, and O. von Bohlen Und Halbach. 2007. Distribution of TRPC4 in developing and adult murine brain. Cell Tissue Res. 328:651-656.
45. Zhang, Y., J. N. Blattman, N. J. Kennedy, J. Duong, T. Nguyen, Y. Wang, R. J. Davis, P. D. Greenberg, R. A. Flavell, and C. Dong. 2004. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature 430:793-797.