Site-specific anticancer effects of dietary flavonoid quercetin

Nutrition and Cancer

Volumn 66, Issue 2, 2014, Pages 177-193

  Sak, Katrin ^a  

^a NGO Praeventio   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; QUERCETIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BLADDER CANCER; BONE CANCER; BRAIN CANCER; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DAMAGE; CELL GROWTH; CELL PROLIFERATION; COLON CANCER; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG METABOLISM; ENDOMETRIUM CANCER; ESOPHAGUS CANCER; ESTROGEN BINDING; GENE INACTIVATION; GLIOMA; HEMATOPOIESIS; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; INCUBATION TIME; INTRACELLULAR SIGNALING; LEUKEMIA; LIVER CANCER; LUNG CANCER; LYMPHOMA; MELANOMA; MOUTH CANCER; OSTEOSARCOMA; OVARY CANCER; OXIDATIVE STRESS; PANCREAS CANCER; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL (TOPIC); PROSTATE CANCER; SALIVARY GLAND CANCER; SIGNAL TRANSDUCTION; SKIN CANCER; STOMACH CANCER; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CELL PROLIFERATION; CLINICAL TRIALS, PHASE I AS TOPIC; DISEASE MODELS, ANIMAL; HUMANS; OXIDATION-REDUCTION; POLYPHENOLS; QUERCETIN;

EID: 84895170428     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2014.864418     Document Type: Article

References (315)

1. Braganhol E, Zamin LL, Canedo AD, Horn F, Tamajusuku AS, et al.: Antiproliferative effect of quercetin in the human U138MG glioma cell line. Anticancer Drugs 17, 663-671, 2006. (Pubitemid 44265867)
2. Guthrie N and Carroll KK: Inhibition of mammary cancer by citrus flavonoids. Adv Exp Med Biol 439, 227-236, 1998. (Pubitemid 28429019)
3. Rusak G, Gutzeit HO, and Müller JL: Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells. Nutr Res 25, 141-153, 2005.
4. Chen YH, Chen HY, Hsu CL, and Yen GC: Induction of apoptosis by the Lactuca indica L. in human leukemia cell line and its active components. J Agric Food Chem 55, 1743-1749, 2007.
5. Lee TJ, Kim OH, Kim YH, Lim JH, Kim S, et al.: Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells. Cancer Lett 240, 234-242, 2006. (Pubitemid 44109922)
6. Suh DK, Lee EJ, Kim HC, and Kim JH: Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. Arch Pharm Res 33, 781-785, 2010.
7. Hannum SM: Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr 44, 1-17, 2004. (Pubitemid 38552288)
8. Rao YK, Geethangili M, Fang SH, and Tzeng YM: Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol 45, 1770-1776, 2007. (Pubitemid 47102515)
9. Yang J and Liu RH: Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. J Agric Food Chem 57, 8581-8586, 2009.
10. Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, et al.: Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virol J 8, 560, 2011.
11. Martinez C, Yanez J, Vicente V, Alcaraz M, Benavente-Garcia O, et al.: Effects of several polyhydroxylated flavonoids on the growth of B16F10 melanoma and Melan-a melanocyte cell lines: influence of the sequential oxidation state of the flavonoid skeleton. Melanoma Res 13, 3-9, 2003. (Pubitemid 36269807)
12. Aherne SA and O'Brien NM: Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells. Nutr Cancer 34, 160-166, 1999. (Pubitemid 29511113)
13. Middleton E Jr and Kandaswami C: The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In: The Flavonoids: Advances in Research Since 1986, Harborne JB, ed. London: Chapman and Hall, 1993, pp. 619-652.
14. Avci CB, Yilmaz S, Dogan ZO, Saydam G, Dodurga Y, et al.: Quercetininduced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology 16, 303-307, 2011.
15. Han Q, Yang R, Li J, Liang W, Zhang Y, et al.: Enhancement of biological activities of nanostructured hydrophobic drug species. Nanoscale 4, 2078-2082, 2012.
16. Lolli G, Cozza G, Mazzorana M, Tibaldi E, Cesaro L, et al.: Inhibition of protein kinase CK2 by flavonoids and tyrphostins: a structural insight. Biochemistry 51, 6097-6107, 2012.
17. Touil YS, Fellous A, Scherman D, and Chabot GG: Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization. Nutr Cancer 61, 310-321, 2009.
18. Zhang H, Zhang M, Yu L, Zhao Y, He N, et al.: Antitumor activities of quercetin and quercetin-5',8-disulfonate in human colon and breast cancer cell lines. Food Chem Toxicol 50, 1589-1599, 2012.
19. Lee SC, Kuan CY, Yang CC, and Yang SD: Bioflavonoids commonly and potently induce tyrosine dephosphorylation/inactivation of oncogenic proline-directed protein kinase FA in human prostate carcinoma cells. Anticancer Res 18, 1117-1121, 1998.
20. Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, et al.: Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem Toxicol 37, 271-285, 1999. (Pubitemid 29335754)
21. Castillo MH, Perkins E, Campbell JH, Doerr R, Hassett JM, et al.: The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin. Am J Surg 158, 351-355, 1989. (Pubitemid 19246239)
22. Koide T, Kamei H, Hashimoto Y, Kojima T, Terabe K, et al.: Influence of flavonoids on cell cycle phase as analyzed by flow-cytometry160. Cancer Biother Radiopharm 12, 111-115, 1997. (Pubitemid 27427933)
23. Aalinkeel R, Bindukumar B, Reynolds JL, Sykes DE, Mahajan SD, et al.: The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. Prostate 68, 1773-1789, 2008.
24. Wang IK, Lin-Shiau SY, and Lin JK: Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 35, 1517-1525, 1999.
25. Lu J, Papp LV, Fang J, Rodriguez-Nieto S, Zhivotovsky B, et al.: Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res 66, 4410-4418, 2006.
26. Kale R, Saraf M, Juvekar A, and Tayade P: Decreased B16F10 melanoma growth and impaired tumour vascularization in BDF1 mice with quercetincyclodextrin binary system. J Pharm Pharmacol 58, 1351-1358, 2006. (Pubitemid 44580565)
27. Said A, Tundis R, Hawas UW, El-Kousy SM, Rashed K, et al.: In vitro antioxidant and antiproliferative activities of flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) leaves. Z Naturforsch C 65, 180-186, 2010.
28. Rodriguez J, Yanez J, Vicente V, Alcaraz M, Benavente-Garcia O, et al.: Effects of several flavonoids on the growth of B16F10 and SKMEL- 1 melanoma cell lines: relationship between structure and activity. Melanoma Res 12, 99-107, 2002. (Pubitemid 34478449)
29. Linsalata M, Orlando A, Messa C, Refolo MG, and Russo F: Quercetin inhibits human DLD-1 colon cancer cell growth and polyamine biosynthesis. Anticancer Res 30, 3501-3507, 2010.
30. Amado NG, Cerqueira DM, Menezes FS, da Silva JF, Neto VM, et al.: Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin cellular localization. Anticancer Drugs 20, 543-552, 2009.
31. Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, et al.: Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett 281, 162-170, 2009.
32. Angst E, Park JL, Moro A, Lu QY, Lu X, et al.: The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas 42, 223-229, 2013.
33. Kuo SM: Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110, 41-48, 1996.
34. Choi JS, Chung HY, Kang SS, Jung MJ, Kim JW, et al.: The structureactivity relationship of flavonoids as scavengers of peroxynitrite. Phytother Res 16, 232-235, 2002. (Pubitemid 34534948)
35. Wang W, Van Alstyne PC, Irons KA, Chen S, Stewart JW, et al.: Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer 48, 106-114, 2004. (Pubitemid 38823552)
36. Kuntz S, Wenzel U, and Daniel H: Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr 38, 133-142, 1999. (Pubitemid 29352529)
37. Loizzo MR, Said A, Tundis R, Hawas UW, Rashed K, et al.: Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds. Plant Foods Hum Nutr 64, 264-270, 2009.
38. Boly R, Gras T, Lamkami T, Guissou P, Serteyn D, et al.: Quercetin inhibits a large panel of kinases implicated in cancer cell biology. Int J Oncol 38, 833-842, 2011.
39. Casagrande F and Darbon JM: Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclindependent kinases CDK2 and CDK1. Biochem Pharmacol 61, 1205-1215, 2001. (Pubitemid 32375112)
40. Chirumbolo S, Marzotto M, Conforti A, Vella A, Ortolani R, et al.: Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical taregts. Clin Mol Allergy 8, 13, 2010.
41. Saragusti AC, Ortega MG, Cabrera JL, Estrin DA, Marti MA, et al.: Inhibitory effect of quercetin on matrix metalloproteinase 9 activity molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction. Eur J Pharmacol 644, 138-145, 2010.
42. Zheng SY, Li Y, Jiang D, Zhao J, and Ge JF: Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A- 549. Mol Med Report 5, 822-826, 2012.
43. Sun ZJ, Chen G, Hu X, Zhang W, Liu Y, et al.: Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin. Apoptosis 15, 850-863, 2010.
44. Tan WF, Lin LP, Li MH, Zhang YX, Tong YG, et al.: Quercetin, a dietaryderived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol 459, 255-262, 2003.
45. Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B, et al.: Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann NY Acad Sci 1259, 95-103, 2012.
46. Borska S, Chmielewska M, Wysocka T, Drag-Zalesinska M, Zabel M, et al.: In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR. Food Chem Toxicol 50, 3375-3383, 2012.
47. Chan ST, Yang NC, Huang CS, Liao JW, and Yeh SL: Quercetin enhances the antitumor activity of trichostatin a through upregulation of p53 protein expression in vitro and in vivo. PLoS One 8, e54255, 2013.
48. Borska S, Drag-Zalesinska M, Wysocka T, Sopel M, Dumanska M, et al.: Antiproliferative and pro-apoptotic effects of quercetin on human pancreatic carcinoma cell lines EPP85-181P and EPP85-181RDB. Folia Histochem Cytobiol 48, 222-229, 2010.
49. Son YO, Lee KY, Kook SH, Lee JC, Kim JG, et al.: Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines. Eur J Pharmacol 502, 195-204, 2004.
50. Gibellini L, Pinti M, Nasi M, Montagna JP, De Biasi S, et al.: Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med 2011, 591356, 2011.
51. Kim Y, Kim WJ, and Cha EJ: Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca-activated K Channels. Korean J Physiol Pharmacol 15, 279-283, 2011.
52. Khonkarn R, Mankhetkorn S, Hennink WE, and Okonogi S: PEG-OCL micelles for quercetin solubilization and inhibition of cancer cell growth. Eur J Pharm Biopharm 79, 268-275, 2011.
53. Haddad AQ, Venkateswaran V, Viswanathan L, Teahan SJ, Fleshner NE, et al.: Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines. Prostate Cancer Prostatic Dis 9, 68-76, 2006. (Pubitemid 43378873)
54. Elattar TM and Virji AS: The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro. Anticancer Res 20, 1733-1738, 2000. (Pubitemid 30628195)
55. O'Prey J, Brown J, Fleming J, and Harrison PR: Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem Pharmacol 66, 2075-2088, 2003. (Pubitemid 37377853)
56. Veeriah S, Hofmann T, Glei M, Dietrich H, Will F, et al.: Apple polyphenols and product formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29). J Agric Food Chem 55, 2892-2900, 2007. (Pubitemid 46668295)
57. Chen SF, Nien S, Wu CH, Liu CL, Chang YC, et al.: Reappraisal of the anticancer efficacy of quercetin in oral cancer cells. J Chin Med Assoc 76, 146-152, 2013.
58. Gokbulut AA, Apohan E, and Baran Y: Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest. Hematology 18, 144-150, 2013.
59. Senthilkumar K, Arunkumar R, Elumalai P, Sharmila G, Gunadharini DN, et al.: Quercetin inhibits invasion, migration and signallingmolecules involved in cell survival and proliferation of prostate cancer cell line (PC- 3). Cell Biochem Funct 29, 87-95, 2011.
60. Michaud-Levesque J, Bousquet-Gagnon N, and Beliveau R: Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Exp Cell Res 318, 925-935, 2012.
61. Jackson SJ and Venema RC: Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells. J Nutr 136, 1178-1184, 2006.
62. Sotoca AM, Ratman D, van der Saag P, Ström A, Gustafsson JA, et al.: Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERalpha/ERbeta ratio. J. Steroid Biochem Mol Biol 112, 171-178, 2008.
63. Vijayababu MR, Arunkumar A, Kanagaraj P, and Arunakaran J: Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells. J Carcinog 5, 10, 2006.
64. Hollman PC, van Trijp JM, Mengelers MJ, de Vries JH, and Katan MB: Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett 114, 139-140, 1997. (Pubitemid 27140094)
65. Haghiac M and Walle T: Quercetin induces necrosis and apoptosis in SCC-9 oral cancer cells. Nutr Cancer 53, 220-231, 2005.
66. Ackland ML, van de Waarsenburg S, and Jones R: Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines. In Vivo 19, 69-76, 2005. (Pubitemid 40450379)
67. Verma AK, Johnson JA, Gould MN, and Tanner MA: Inhibition of 7,12- dimethylbenz(a)anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res 48, 5754-5758, 1988.
68. Ma L, Feugang JM, Konarski P, Wang J, Lu J, et al.: Growth inhibitory effects of quercetin on bladder cancer cell. Front Biosci 11, 2275-2285, 2006. (Pubitemid 43822559)
69. Dihal AA, Woutersen RA, van Ommen B, Rietjens IM, and Stierum RH: Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2. Cancer Lett 238, 248-259, 2006. (Pubitemid 43867910)
70. Elattar TM and Virji AS: The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res 19, 5407-5414, 1999. (Pubitemid 30103382)
71. Debes A, Oerding M, Willers R, Göbel U, and Wessalowski R: Sensitization of human Ewing's tumor cells to chemotherapy and heat treatment by the bioflavonoid quercetin. Anticancer Res 23, 3359-3366, 2003. (Pubitemid 36975436)
72. Rodgers EH and Grant MH: The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells. Chem Biol Interact 116, 213-228, 1998. (Pubitemid 28543195)
73. Newell AM, Yousef GG, Lila MA, Ramírez-Mares MV, and de Mejia EG: Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells. J Ethnopharmacol 130, 536-544, 2010.
74. You HJ, Ahn HJ, and Ji GE: Transformation of rutin to antiproliferative quercetin-3-glucoside by Aspergillus niger. J Agric Food Chem 58, 10886-10892, 2010.
75. Duthie SJ, Johnson W, and Dobson VL: The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimdines) and growth in human cells. Mutat Res 390, 141-151, 1997. (Pubitemid 27230219)
76. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, et al.: Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 54, 4952-4957, 1994. (Pubitemid 24289427)
77. Brisdelli F, Coccia C, Cinque B, Cifone MG, and Bozzi A: Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells. Mol Cell Biochem 296, 137-149, 2007.
78. Pietta PG: Flavonoids as antioxidants. J Nat Prod 63, 1035-1042, 2000.
79. Russo M, Spagnuolo C, Tedesco I, Bilotto S, and Russo GL: The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol 83, 6-15, 2012.
80. Alia M, Ramos S, Mateos R, Granado-Serrano AB, Bravo L, et al.: Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol Appl Pharmacol 212, 110-118, 2006.
81. Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, et al.: The antitumour activities of flavonoids. In Vivo 19, 895-909, 2005.
82. Xie X, Yin J, Jia Q, Wang J, Zou C, et al.: Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncol Rep 26, 687-693, 2011.
83. Avila MA, Cansado J, Harter KW, Velasco JA, and Notario V: Quercetin as a modulator of the cellular neoplastic phenotype: effects on the expression of mutated H-ras and p53 in rodent and human cells. Adv Exp Med Biol 401, 101-110, 1996. (Pubitemid 26326194)
84. De Vincenzo R, Ferlini C, Distefano M, Gaggini C, Riva A, et al.: In vitro evaluation of newly developed chalcone analogues in human cancer cells. Cancer Chemother Pharmacol 46, 305-312, 2000.
85. Ramos AA, Lima CF, Pereira ML, Fernandes-Ferreira M, and Pereira-Wilson C: Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. Toxicol Lett 177, 66-73, 2008.
86. Dajas F: Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol 143, 383-396, 2012.
87. Mu C, Jia P, Yan Z, Liu X, Li X, et al.: Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods Find Exp Clin Pharmacol 29, 179-183, 2007. (Pubitemid 46918296)
88. Wagner C, Fachinetto R, Dalla Corte CL, Brito VB, Severo D, et al.: Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro. Brain Res 1107, 192-198, 2006. (Pubitemid 44205111)
89. Cheel J, Schmeda-Hirschmann G, Jordan M, Theoduloz C, Rodríguez JA, et al.: Free radical scavenging activity and secondary metabolites from in vitro cultures of Sanicula graveolens. Z Naturforsch C 62, 555-562, 2007. (Pubitemid 47403763)
90. Katalinic M, Rusak G, Domacinovic Barovic J, Sinko G, Jelic D, et al.: Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase. Eur J Med Chem 45, 186-192, 2010.
91. Kim SH, Naveen Kumar Ch, Kim HJ, Kim DH, Cho J, et al.: Glucosecontaining flavones-their synthesis and antioxidant and neuroprotective activities. Bioorg Med Chem Lett 19, 6009-6013, 2009.
92. Notoya M, Tsukamoto Y, Nishimura H, Woo JT, Nagai K, et al.:Quercetin, a flavonoid, inhibits the proliferation, differentiation, and mineralization of osteoblasts in vitro. Eur J Pharmacol 485, 89-96, 2004. (Pubitemid 38134401)
93. Skupien K, Oszmianski J, Kostrzewa-Nowak D, and Tarasiuk J: In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells. Cancer Lett 236, 282-291, 2006.
94. Chirumbolo S: Quercetin in cancer prevention and therapy. Integr Cancer Ther 12, 97-102, 2013.
95. Jaramillo S, Lopez S, Varela LM, Rodriguez-Arcos R, Jimenez A, et al.: The flavonol isorhamnetin exhibits cytotoxic effects on human colon cancer cells. J Agric Food Chem 58, 10869-10875, 2010.
96. Bulzomi P, Galluzzo P, Bolli A, Leone S, Acconcia F, et al.: The proapoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals. J Cell Physiol 227, 1891-1898, 2012.
97. Choi CW, Jung HA, Kang SS, and Choi JS: Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. Arch Pharm Res 30, 1-7, 2007.
98. Jakubowicz-Gil J, Rzeski W, Zdzisinska B, Dobrowolski P, Gawron A: Cell death and neuronal arborization upon quercetin treatment in rat neurons. Acta Neurobiol Exp (Wars) 68, 139-146, 2008. (Pubitemid 351871131)
99. Lea MA, Ibeh C, Deutsch JK, Hamid I, and des Bordes C: Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides. Anticancer Res 30, 3629-3635, 2010.
100. Yoshida M, Sakai T, Hosokawa N, Marui N, Matsumoto K, et al.: The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Lett 260, 10-13, 1990. (Pubitemid 20029416)
101. Walle T, Browning AM, Steed LL, Reed SG, and Walle UK: Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans. J Nutr 135, 48-52, 2005. (Pubitemid 40094319)
102. van der Woude H, Gliszczynska-Swigło A, Struijs K, Smeets A, Alink GM, et al.: Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 200, 41-47, 2003. (Pubitemid 37222357)
103. Jeong JH, An JY, Kwon YT, Rhee JG, and Lee YJ: Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem 106, 73-82, 2009.
104. Baran I, Ganea C, Scordino A, Musumeci F, Barresi V, et al.: Effects of menadione, hydrogen peroxide, and quercetin on apoptosis and delayed luminescence of human leukemia Jurkat T-cells. Cell Biochem Biophys 58, 169-179, 2010.
105. Wätjen W, Michels G, Steffan B, Niering P, Chovolou Y, et al.: Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J Nutr, 135, 525-531, 2005. (Pubitemid 40365213)
106. Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, et al.: Potent inhibitory action of red wine polyphenols on human breast cancer cells. J Cell Biochem 78, 429-441, 2000. (Pubitemid 30491071)
107. Hempstock J, Kavanagh JP, and George NJ: Growth inhibition of prostate cell lines in vitro by phyto-oestrogens. Br J Urol 82, 560-563, 1998. (Pubitemid 28477300)
108. Noori-Daloii MR, Momeny M, Yousefi M, Shirazi FG, Yaseri M, et al.: Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol 28, 1395-1404, 2011.
109. Ranelletti FO, Ricci R, Larocca LM, Maggiano N, Capelli A, et al.: Growth-inhibitory effect of quercetin and presence of type-II estrogenbinding sites in human colon-cancer cell lines and primary colorectal tumors. Int J Cancer 50, 486-492, 1992.
110. Caltagirone S, Ranelletti FO, Rinelli A, Maggiano N, Colasante A, et al.: Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer. Am J Respir Cell Mol Biol 17, 51-59, 1997. (Pubitemid 127500820)
111. Niu G, Yin S, Xie S, Li Y, Nie D, et al.: Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells. Acta Biochim Biophys Sin (Shanghai) 43, 30-37, 2011.
112. Ye B, Yang JL, Chen LJ, Wu XX, Yang HS, et al.: Induction of apoptosis by phenylisocyanate derivative of quercetin: involvement of heat shock protein. Anticancer Drugs 18, 1165-1171, 2007. (Pubitemid 47480741)
113. Chen J, Kang J, Da W, and Ou Y: Combination with water-soluble antioxidants increases the anticancer activity of quercetin in human leukemia cells. Pharmazie 59, 859-863, 2004. (Pubitemid 39524584)
114. Wang K, Liu R, Li J, Mao J, Lei Y, et al.: Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy 7, 966-978, 2011.
115. Jung JH, Lee JO, Kim JH, Lee SK, You GY, et al.: Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR downregulation. J Cell Physiol 223, 408-414, 2010.
116. Zhang F, Cui Y, and Cao P: Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells. J Huazhong Univ Sci Technolog Med Sci 28, 369-372, 2008.
117. Liu KC, Yen CY, Wu RS, Yang JS, Lu HF, et al.: The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells. Environ Toxicol Mar 20, 2012.
118. So FV, Guthrie N, Chambers AF, Moussa M, and Carroll KK: Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 26, 167-181, 1996. (Pubitemid 26300196)
119. Scambia G, Panici PC, Ranelletti FO, Ferrandina G, De Vincenzo R, et al.: Quercetin enhances transforming growth factor beta 1 secretion by human ovarian cancer cells. Int J Cancer 57, 211-215, 1994. (Pubitemid 24144211)
120. Balabhadrapathruni S, Thomas TJ, Yurkow EJ, Amenta PS, and Thomas T: Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol Rep 7, 3-12, 2000.
121. Tan J, Wang B, and Zhu L: Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin. Chem Biodivers 6, 1101-1110, 2009.
122. Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, et al.: Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 87, 595-600, 2000. (Pubitemid 30639822)
123. Ramos S, Alia M, Bravo L, and Goya L: Comparative effects of foodderived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J Agric Food Chem 53, 1271-1280, 2005. (Pubitemid 40270427)
124. Kawahara T, Kawaguchi-Ihara N, Okuhashi Y, Itoh M, Nara N, et al.: Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res 29, 4629-4632, 2009.
125. Kim MK, Park KS, Lee C, Park HR, Choo H, et al.: Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety. J Med Chem 53, 8597-8607, 2010.
126. Avila MA, Velasco JA, Cansado J, and Notario V: Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 54, 2424-2428, 1994.
127. Ferry DR, Smith A, Malkhandi J, Fyfe DW, de Takats PG, et al.: Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 2, 659-668, 1996. (Pubitemid 26133468)
128. Liang W, Li X, Li C, Liao L, Gao B, et al.: Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. Mol Med Rep 4, 1017-1023, 2011.
129. Shi M, Wang FS, and Wu ZZ: Synergistic anticancer effect of combined quercetin and recombinant adenoviral vector expressing human wild-type p53, GM-CSF and B7-1 genes on hepatocellular carcinoma cells in vitro. World J Gastroenterol 9, 73-78, 2003. (Pubitemid 36131282)
130. Calias P, Galanopoulos T, Maxwell M, Khayat A, Graves D, et al.: Synthesis of inositol 2-phosphate-quercetin conjugates. Carbohydr Res 292, 83-90, 1996. (Pubitemid 26318357)
131. Granado-Serrano AB, Martín MA, Bravo L, Goya L, and Ramos S: Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERKpathways in a human hepatoma cell line (HepG2). J Nutr 136, 2715-2721, 2006. (Pubitemid 44771763)
132. Zhou J, Liang S, Fang L, Chen L, Tang M, et al.: Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS 13, 93-103, 2009.
133. Scambia G, Ranelletti FA, Benedetti Panici P, Piantelli M, Bonanno G, et al.: Quercetin inhibits the growth of a multidrug-resistant estrogenreceptor- negative MCF-7 human breast-cancer cell line expressing type II estogen-binding sites. Cancer Chemother Pharmacol 28, 255-258, 1991.
134. Howells LM, Britton RG, Mazzoletti M, Greaves P, Broggini M, et al.: Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3′,4′,5′-trimethoxyflavonol, a quercetin analogue. Cancer Prev Res (Phila) 3, 929-939, 2010.
135. Soleas GJ, Grass L, Josephy PD, Goldberg DM, and Diamandis EP: A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin Biochem 35, 119-124, 2002. (Pubitemid 34442691)
136. Chen J and Kang JH. Quercetin and trichostatin Acooperatively kill human leukemia cells. Pharmazie 60, 856-860, 2005. (Pubitemid 41704165)
137. Akbas SH, Timur M, and Ozben T: The effect of quercetin on topotecan cytotoxicity in MCF-7 and MDA-MB 231 human breast cancer cells. J Surg Res 125, 49-55, 2005. (Pubitemid 40523775)
138. Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, and Segura-Aguilar J: Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 26, 107-116, 1999. (Pubitemid 29001498)
139. Jia J and Chen J: Histone hyperacetylation is involved in the quercetininduced human leukemia cell death. Pharmazie 63, 379-383, 2008. (Pubitemid 351756433)
140. Hosseinimehr SJ, Pourmorad F, Shahabimajd N, Shahrbandy K, and Hosseinzadeh R: In vitro antioxidant activity of Polygonium hyrcanicum, Centaurea depressa, Sambucus ebulus, Mentha spicata and Phytolacca americana. Pak J Biol Sci 10, 637-640, 2007. (Pubitemid 46408435)
141. Gacche RN, Shegokar HD, Gond DS, Yang Z, and Jadhav AD: Evaluation of selected flavonoids as antiangiogenic, anticancer, and radical scavenging agents: an experimental and in silico analysis. Cell Biochem Biophys 61, 651-663, 2011.
142. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Eslami B, and Dehpour AA: Antioxidant and antihaemolytic activities of Ferula foetida regel (Umbelliferae). Eur Rev Med Pharmacol Sci 15, 157-164, 2011.
143. Kalim MD, Bhattacharyya D, Banerjee A, and Chattopadhyay S:Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine. BMC Complement Altern Med 10, 77, 2010.
144. Rao AS, Reddy SG, Babu PP, and Reddy AR: The antioxidant and antiproliferative activities of methanolic extracts from Njavara rice bran. BMC Complement Altern Med 10, 4, 2010.
145. Belinha I, Amorim MA, Rodrigues P, de Freitas V, Moradas-Ferreira P, et al.: Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae. J Agric Food Chem 55, 2446-2451, 2007. (Pubitemid 46556237)
146. Loizzo MR, Di Lecce G, Boselli E, Bonesi M, Menichini F, et al.: In vitro antioxidant and hypoglycemic activities of Ethiopian spice blend Berbere. Int J Food Sci Nutr 62, 740-749, 2011.
147. Tumbas VT, Canadanovic-Brunet JM, Cetojevic-Simin DD, Cetkovic GS, Ethilas SM, et al.: Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells. J Sci Food Agric 92, 1273-1281, 2012.
148. Beltran HI, Damian-Zea C, Hernandez-Ortega S, Nieto-Camacho A, and Ramirez-Apan MT: Synthesis and characterization of di-phenyltin (IV)-salicyliden-ortho-aminophenols: analysis of in vitro antitumour/antioxidant activities and molecular structures. J Inorg Biochem 101, 1070-1085, 2007. (Pubitemid 46901144)
149. Roy P, Amdekar S, Kumar A, and Singh V: Preliminary study of the antioxidant properties of flowers and roors of Pyrostegia venusta (Ker Gawl) Miers. BMC Complement Altern Med 11, 69, 2011.
150. Masuoka N, Isobe T, and Kubo I: Antioxidants from Rabdosia japonica. Phytother Res 20, 206-213, 2006.
151. Beevi SS, Narasu ML, and Gowda BB: Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. Plant Foods Hum Nutr 65, 8-17, 2010.
152. Cioffi G, D'Auria M, Braca A, Mendez J, Castillo A, et al.:Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata. J Nat Prod 65, 1526-1529, 2002. (Pubitemid 35386775)
153. Marfak A, Trouillas P, Allais DP, Calliste CA, Duroux JL:Redox reactions obtained by gamma irradiation of quercetin methanol solution are similar to in vivo metabolism. Radiat Res 159, 218-227, 2003. (Pubitemid 36182400)
154. Hanneken A, Lin FF, Johnson J, and Maher P: Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Invest Ophthalmol Vis Sci 47, 3164-3177, 2006. (Pubitemid 351639797)
155. Tokalov SV, Henker Y, Schwab P, Metz P, and Gutzeit HO: Toxicity and cell cycle effects of synthetic 8-prenylnaringenin and derivatives in human cells. Pharmacology 71, 46-56, 2004. (Pubitemid 38410711)
156. Chen JW, Zhu ZQ, Hu TX, and Zhu DY: Structure-activity relationship of natural flavonoids in hydroxyl radical-scavenging effects. Acta Pharmacol Sin 23, 667-672, 2002.
157. Ghanta S, Banerjee A, Poddar A, and Chattopadhyay S: Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni) Bertoni, a natural sweetener. J Agric Food Chem 55, 10962-10967, 2007.
158. Kim EJ, Choi CH, Park JY, Kang SK, and Kim YK: Underlying mechanism of quercetin-induced cell death in human glioma cells. Neurochem Res 33, 971-979, 2008.
159. Choi EJ, Bae SM, and Ahn WS: Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB- 453 cells. Arch Pharm Res 31, 1281-1285, 2008.
160. Seibert H, Maser E, Schweda K, Seibert S, and Gülden M: Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells. Food Chem Toxicol 49, 2398-2407, 2011.
161. Robaszkiewicz A, Balcerczyk A, and Bartosz G. Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biol Int 31, 1245-1250, 2007. (Pubitemid 47030992)
162. Chang YF, Chi CW, and Wang JJ: Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Nutr Cancer 55, 201-209, 2006.
163. Kaiserova H, Simunek T, van der Vijgh WJ, Bast A, and Kvasnickova E: Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase. Biochim Biophys Acta 1772, 1065-1074, 2007. (Pubitemid 47314227)
164. Galati G, Sabzevari O, Wilson JX, and O'Brien PJ: Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177, 91-104. 2002. (Pubitemid 34786247)
165. Agullo G, Gamet-Payrastre L, Fernandez Y, Anciaux N, Demigne C, et al.: Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). Cancer Lett 105, 61-70, 1996. (Pubitemid 26232336)
166. Forni C, Braglia R, Lentini A, Nuccetelli M, Provenzano B, et al.: Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cells. Amino Acids 36, 731-738, 2009.
167. Lee KW, Hur HJ, Lee HJ, and Lee CY: Antiproliferative effects of dietary phenolic substances and hydrogen peroxide. J Agric Food Chem 53, 1990-1995, 2005.
168. Koshy L, Dwarakanath BS, Raj HG, Chandra R, and Mathew TL: Suicidal oxidative stress induced by certain antioxidants. Indian J Exp Biol 41, 1273-1278, 2003. (Pubitemid 37379311)
169. Sergediene E, Jönsson K, Szymusiak H, Tyrakowaska B, Rietjens IM, et al.: Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships. FEBS Lett 462, 392-396, 1999.
170. Hamdy AH, Mettwally WS, El Fotouh MA, Rodriguez B, El-Dewany AI, et al.: Bioactive phenolic compounds from the Egyptian Red Sea seagrass Thalassodendron ciliatum. Z Naturforsch C 67, 291-296, 2012.
171. Jaganathan SK and Mandal M: Antiproliferative effects of honey and of its polyphenols: a review. J Biomed Biotechnol 2009, 830616, 2009.
172. Chou CC, Yang JS, Lu HF, Ip SW, Lo C, et al.: Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch Pharm Res 33, 1181-1191, 2010.
173. Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, et al.: The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol 649, 84-91, 2010.
174. Kaur G, Stetler-Stevenson M, Sebers S, Worland P, Sedlacek H, et al.: Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst 84, 1736-1740, 1992.
175. Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH, et al.: The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis, 25, 647-659, 2004. (Pubitemid 38618516)
176. Chan MM, Fong F, Soprano KJ, Holmes WF, and Heverling H: Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents. J Cell Physiol 194, 63-70, 2003. (Pubitemid 35424228)
177. Indap MA, Radhika S, Motiwale L, and Rao KVK: Quercetin: antitumor activity and pharmacological manipulations for increased therapeutic gains. Ind J Pharmaceut Sci 68, 465-469, 2006. (Pubitemid 44599818)
178. Araujo JR, Goncalves P, and Martel F: Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res 31, 77-87, 2011.
179. Shen J, Zhang W, Wu J, and Zhu Y: The synergistic reversal effect of multidrug resistance by quercetin and hyperthermia in doxorubicin-resistant human myelogenous leukemia cells. Int J Hyperthermia 24, 151-159, 2008. (Pubitemid 351279955)
180. Devipriya S, Vani G, Ramamurthy N, and Shyamaladevi CS: Regulation of intracellular calcium levels and urokinase activity in MDA MB 231 cells by quercetin. Chemotherapy 52, 60-65, 2006.
181. Jakubowicz-Gil J, Paduch R, Gawron A, and Kandefer-Szerszen M: The effect of heat shock, cisplatin, etoposide and quercetin of Hsp27 expression in human normal and tumour cells. Folia Histochem Cytobiol 40, 31-35, 2002. (Pubitemid 34092365)
182. Rzymowska J, Gawron A, Pawlikowska-Pawlega B, Jakubowicz-Gil J, and Wojcierowski J: The effect of quercetin on induction of apoptosis. Folia Histochem Cytobiol 37, 125-126, 1999. (Pubitemid 29179992)
183. Pilatova M, Stupakova V, Varinska L, Sarissky M, Mirossay L, et al.: Effect of selected flavones on cancer and endothelial cells. Gen Physiol Biophys 29, 134-143, 2010.
184. Nagao A, Seki M, and Kobayashi H: Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 63, 1787-1790, 1999. (Pubitemid 129548408)
185. Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, et al.: Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 128, 999-1010, 1999.
186. Kang TB and Liang NC: Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharmacol 54, 1013-1018, 1997.
187. Wang G, Zhang J, Liu L, Sharma S, and Dong Q: Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl. PLoS One 7, e51764, 2012.
188. Borska S, Sopel M, Chmielewska M, Zabel M, and Dziegiel P: Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules, 15, 857-870, 2010.
189. Asea A, Ara G, Teicher BA, Stevenson MA, and Calderwood SK: Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia 17, 347-356, 2001. (Pubitemid 32651842)
190. Prajda N, Singhal RL, Yeh YA, Olah E, Look KY, et al.: Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5- trisphosphate concentration in human ovarian carcinoma cells treated with quercetin. Life Sci 56, 1587-1593, 1995.
191. Csokay B, Prajda N, Weber G, and Olah E: Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 60, 2157-2163, 1997. (Pubitemid 27244397)
192. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Remesy C, et al.: Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53, 1649-1657, 1997. (Pubitemid 27356094)
193. Yeh YA, Herenyiova M, and Weber G: Quercetin: synergistic action with carboxyamidotriazole in human breast carcinoma cells. Life Sci 57, 1285-1292, 1995.
194. Singhal RL, Yeh YA, Praja N, Olah E, Sledge GWJr, et al.: Quercetin down-regulates signal transduction in human breast carcinoma cells. Biochem Biophys Res Commun 208, 425-431, 1995.
195. Nessa MU, Beale P, Chan C, Yu JQ, and Huq F: Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models. Anticancer Res 31, 3789-3797, 2011.
196. Scambia G, Ranelletti FO, Benedetti Panici P, Piantelli M, Rumi C, et al.: Type-II estrogen binding sites in a lymphoblastoid cell line and growthinhibitory effect of estrogen, anti-estrogen and bioflavonoids. Int J Cancer 46, 1112-1116, 1990.
197. Larocca LM, Giustacchini M, Maggiano N, Ranelletti FO, Piantelli M, et al.: Growth-inhibitory effect of quercetin and presence of type II estrogen binding sites in primary human transitional cell carcinomas. J Urol 152, 1029-1033, 1994. (Pubitemid 24246008)
198. Teofili L, Pierelli L, Iovini MS, Leone G, Scambia G, et al.: The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth. Leuk Res 16, 497-503, 1992.
199. Scambia G, Ranelletti FO, Benedetti Panici P, Piantelli M, Bonanno G, et al.: Inhibitory effect of quercetin on primary ovarian and endometrial cancers and synergistic activity with cis-diamminedichloroplatinum (II). Gynecol Oncol 45, 13-19, 1992.
200. Piantelli M, Maggiano N, Ricci R, Larocca LM, Capelli A, et al.: Tamoxifen and quercetin interact with type II estrogen binding sites and inhibit the growth of human melanoma cells. J Invest Dermatol 105, 248-253, 1995.
201. Larocca LM, Teofili L, Leone G, Sica S, Pierelli L, et al.: Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors. Br J Haematol 79, 562-566, 1991.
202. Scambia G, Ranelletti FO, Panici PB, Piantelli M, De Vincenzo R, et al.: Quercetin induces type-II estrogen-binding sites in estrogen-receptornegative (MDA-MB231) and estrogen-receptor-positive (MCF-7) human breast-cancer cell lines. Int J Cancer 54, 462-466, 1993. (Pubitemid 23169686)
203. Markaverich BM, Roberts RR, Alejandro MA, Johnson GA, Middleditch BS, et al.: Bioflavonoid interaction with rat uterine type II binding sites and cell growth inhibition. J Steroid Biochem 30, 71-78, 1988.
204. Nitoda T, Isobe T, and Kubo I: Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells. Phytother Res 22, 867-872, 2008.
205. Psahoulia FH, Moumtzi S, Roberts ML, Sasazuki T, Shirasawa S, et al.: Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 28, 1021-1031, 2007. (Pubitemid 47072186)
206. Nakanoma T, Ueno M, Iida M, Hirata R, and Deguchi N: Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells. Int J Urol 8, 623-630, 2001. (Pubitemid 34017150)
207. Zhang Q, Zhao XH, and Wang ZJ: Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro 23, 797-807, 2009.
208. Zhang Q, Zhao XH, and Wang ZJ: Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol 46, 2042-2053, 2008.
209. Chien SY, Wu YC, Chung JG, Yang JS, Lu HF, et al.: Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Hum Exp Toxicol 28, 493-503, 2009.
210. Knowles LM, Zigrossi DA, Tauber RA, Hightower C, and Milner JA: Flavonoids suppress androgen-independent human prostate tumor proliferation. Nutr Cancer 38, 116-122, 2000. (Pubitemid 32377951)
211. Loa J, Chow P, and Zhang K: Studies of structure-activity relationship on plant polyphenol-induced suppression of human liver cancer cells. Cancer Chemother Pharmacol 63, 1007-1016, 2009.
212. Murtaza I, Marra G, Schlapbach R, Patrignani A, Künzli M, et al.: A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. Biotechnol Appl Biochem 45, 29-36, 2006. (Pubitemid 44032555)
213. Seufi AM, Ibrahim SS, Elmaghraby TK, and Hafez EE: Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences. J Exp Clin Cancer Res 28, 80, 2009.
214. Mertens-Talcott SU and Percival SS: Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett 218, 141-151, 2005. (Pubitemid 40164715)
215. Vijayababu MR, Kanagaraj P, Arunkumar A, Ilangovan R, Aruldhas MM, et al.: Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression. J Cancer Res Clin Oncol 131, 765-771, 2005. (Pubitemid 41577954)
216. Rong Y, Yang EB, Zhang K, and Mack P: Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression. Anticancer Res 20, 4339-4345, 2000. (Pubitemid 32141783)
217. Kuo PC, Liu HF, and Chao JI: Survivin and p53 modulate quercetininduced cell growth inhibition and apoptosis in human lung carcinoma cells. J Biol Chem 279, 55875-55885, 2004.
218. Chen Z, Liu YM, Yang S, Song BA, Xu GF, et al.: Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb. Bioorg Med Chem 16, 1337-1344, 2008. (Pubitemid 351191761)
219. Gao X, Wang B, Wei X, Men K, Zheng F, et al.: Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale 4, 7021-7030, 2012.
220. Spencer JP, Kuhnle GG, Williams RJ, and Rice-Evans S: Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem J 372, 173-181, 2003. (Pubitemid 36609619)
221. Ramirez-Mares MV, Chandra S, and de Mejia EG: In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mutat Res 554, 53-65, 2004. (Pubitemid 39144391)
222. Agullo G, Gamet L, Besson C, Demigne C, and Remesy C: Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells. Cancer Lett 87, 55-63, 1994. (Pubitemid 24352940)
223. Yerlikaya A, Okur E, 350 Eker S, and Erin N: Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line. Mol Med Rep 3, 333-339, 2010.
224. Wenzel U, Herzog A, Kuntz S, and Daniel H: Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics 4, 2160-2174, 2004. (Pubitemid 38880380)
225. Babich H, Reisbaum AG, and Zuckerbraun HL: In vitro response of human gingival epithelial S-G cells to resveratrol. Toxicol Lett 114, 143-153, 2000. (Pubitemid 30125451)
226. Bestwick CS and Milne L: Quercetin modifies reactive oxygen levels but exerts only partial protection against oxidative stress within HL-60 cells. Biochim Biophys Acta 1528, 49-59, 2001. (Pubitemid 32763150)
227. Bansal T, Jaggi M, Khar RK, and Talegaonkar S: Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J Pharm Pharm Sci 12, 46-78, 2009.
228. Alexandrakis M, Letourneau R, Kempuraj D, Kandere-Grzybowska K, Huang M, et al.: Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1). Eur J Haematol 71, 448-454, 2003. (Pubitemid 37467879)
229. Larocca LM, Piantelli M, Teofili L, Leone G, and Ranelletti FO: Concentration and effect of quercetin. Exp Hematol 24, 494-496, 1996.
230. Richter M, Ebermann R, and Marian B: Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. Nutr Cancer 34, 88-99, 1999. (Pubitemid 29382921)
231. van der Woude H, Ter Veld MG, Jacobs N, van der Saag PT, Murk AJ, et al.: The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol Nutr Food Res 49, 763-771, 2005. (Pubitemid 41188584)
232. Britton RG, Horner-Glister E, Pomenya OA, Smith EE, Denton R, et al.: Synthesis and biological evaluation of novel flavonols as potential antiprostate cancer agents. Eur J Med Chem 54, 952-958, 2012.
233. Puoci F, Morelli C, Cirillo G, Curcio M, Parisi OI, et al.: Anticancer activity of a quercetin-based polymer towards HeLa cancer cells. Anticancer Res 32, 2843-2847, 2012.
234. Jagadeeswaran R, Thirunavukkarasu C, Gunasekaran P, Ramamurty N, and Sakthisekaran D: In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Fitoterapia 71, 395-399, 2000. (Pubitemid 30488151)
235. Staedler D, Idrizi E, Kenzaoui BH, and Juillerat-Jeanneret L: Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells. Cancer Chemother Pharmacol 68, 1161-1172, 2011.
236. Paliwal S, Sundaram J, and Mitragotri S: Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound. Br J Cancer 92, 499-502, 2005. (Pubitemid 40395530)
237. Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, et al.: Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol 1, 19-27, 2008.
238. Wang Q, Bao Y, Ahire J, and Chao Y: Co-encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery. Adv Healthc Mater 2, 459-466, 2013.
239. Tan BJ, Liu Y, Chang KL, Lim BK, and Chiu GN: Perorally active nanomicellar formulation of quercetin in the treatment of lung cancer. Int J Nanomedicine 7, 651-661, 2012.
240. Kim MK, Park KS, and Chong Y: Remarkable stability and cytostatic effect of a quercetin conjugate, 3,7-bis-O-pivaloxymethyl (POM) quercetin. Chem Med Chem 7, 229-232, 2012.
241. Krol W, Dworniczak S, Pietsz G, Czuba ZP, Kunicka M, et al.: Synthesis and tumoricidal activity evaluation of new morin and quercetin sulfonic derivatives. Acta Pol Pharm 59, 77-79, 2002. (Pubitemid 34269616)
242. Senthilkumar K, Elumalai P, Arunkumar R, Banudevi S, Gunadharini ND, et al.: Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem 344, 173-184, 2010.
243. Xiao D, Zhu SP, and Gu ZL: Quercetin induced apoptosis in human leukemia HL-60 cells. Zhongguo Yao Li Xue Bao 18, 280-283, 1997. (Pubitemid 27228796)
244. El Bouzidi L, Larhsini M, Markouk M, Abbad A, Hassani L, et al.: Antioxidant and antimicrobial activities of Withania frutescens. Nat Prod Commun 6, 1447-1450, 2011.
245. Teng BS, Lu YH, Wang ZT, Tao XY, and Wei DZ: In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells. Pharmacol Res 54, 186-194, 2006.
246. Hamedeyazdan S, Fathiazad F, Sharifi S, and Nazemiyeh H: Antiproliferative activity of marrubium persicum extract in the MCF-7 human breast cancer cell line. Asian Pac J Cancer Prev 13, 5843-5848, 2012.
247. Suttana W, Mankhetkorn S, Poompimon W, Palagani A, Zhokhov S, et al.: Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. Mol Cancer 9, 99, 2010.
248. Carli CB, de Matos DC, Lopes FC, Maia DC, Dias MB, et al.: Isolated flavonoids against mammary tumour cells LM2. Z Naturforsch C 64, 32-36, 2009.
249. Ezzat SM and Abdel Motaal A: Isolation of new cytotoxic metabolites from Cleome droserifolia growing in Egypt. Z Naturforsch C 67, 266-274, 2012.
250. Rockenbach L, Bavaresco L, Fernandes Farias P, Cappellari AR, Barrios CH, et al.: Alterations in the extracellular catabolism of nucleotides are involved in the antiproliferative effect of quercetin in human bladder cancer T24 cells. Urol Oncol 31, 1204-1211, 2013.
251. Goniotaki M, Hatziantoniou S, Dimas K, Wagner M, and Demetzos C: Encapsulation of naturally occurring flavonoids into liposomes: physicochemical properties and biological activity against human cancer cell lines. J Pharm Pharmacol 56, 1217-1224, 2004. (Pubitemid 39368991)
252. Lyu SY and Park WB: Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. Arch Pharm Res 28, 573-581, 2005.
253. Romanouskaya TV and Grinev VV: Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood. Bull Exp Biol Med 148, 57-59, 2009.
254. Chowdhury SA, Kishino K, Satoh R, Hashimoto K, Kikuchi H, et al.: Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anticancer Res 25, 2055-2063, 2005. (Pubitemid 40904604)
255. Dickancaite E, Nemeikaite A, Kalvelyte A, and Cenas N: Prooxidant character of flavonoid cytotoxicity: structure-activity relationships. Biochem Mol Biol Int 45, 923-930, 1998. (Pubitemid 28422996)
256. Uddin S and Choudhry MA: Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells. Biochem Mol Biol Int 36, 545-550, 1995. (Pubitemid 26173012)
257. Lin CM, Chen CT, Lee HH, and Lin JK: Prevention of cellular ROS damage by isovitexin and related flavonoids. Planta Med 68, 365-367, 2002.
258. Kang TB and Liang NC: Effect of quercetin on activities of protein kinase C and tyrosine protein kinase from HL-60 cells. Zhongguo Yao Li Xue Bao 18, 374-376, 1997.
259. Ishii K, Tanaka S, Kagami K, Henmi K, Toyoda H, et al.: Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. Cancer Invest 28, 220-229, 2010.
260. Austin CA, Patel S, Ono K, Nakane H, and Fisher LM: Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives. Biochem J 282, 883-889, 1992.
261. Ragazzon PA, Bradshaw T, Matthews C, Iley J, and Missailidis S: The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development. Anticancer Res 29, 2273-2283, 2009.
262. Plochmann K, Korte G, Koutsilieri E, Richling E, Riederer P, et al.: Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells. Arch Biochem Biophys 460, 1-9, 2007. (Pubitemid 46482429)
263. Kawaii S, Tomono Y, Katase E, Ogawa K, and Yano M: Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotechnol Biochem 63, 896-899, 1999. (Pubitemid 129562768)
264. Tolomeo M, Grimaudo S, Di Cristina A, Pipitone RM, Dusonchet L, et al.: Galangin increases the cytotoxic activity of imatinib mesylate in imatinibsensitive and imatinib-resistant Bcr-Abl expressing leukemia cells. Cancer Lett 265, 289-297, 2008.
265. Lohezic-Le Devehat F, Tomasi S, Fontanel D, and Boustie J: Flavonols from Scurrula ferruginea Danser (Loranthaceae). Z Naturforsch C 57, 1092-1095, 2002. (Pubitemid 36137357)
266. Kothan S, Dechsupa S, Leger G, Moretti JL, Vergote J, et al.: Spontaneous mitochondrial membrane potential change during apoptotic induction by quercetin in K562 and K562/adr cells. Can J Physiol Pharmacol 82, 1084-1090, 2004. (Pubitemid 40343645)
267. Zanini C, Giribaldi G, Mandili G, Carta F, Crescenzio N, et al.: Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines. J Neurochem 103, 1344-1354, 2007. (Pubitemid 47631803)
268. Huang SL, Hsu CL, and Yen GC: Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells. Life Sci 79, 203-209, 2006.
269. Hakimuddin F, Paliyath G, and Meckling K: Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat 85, 65-79, 2004. (Pubitemid 38437983)
270. Seo HS, Ju JH, Jang K, and Shin I: Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α-negative breast cells. Nutr Res 31, 139-146, 2011.
271. Lee CH, Hong HM, Chang YY, and Chang WW: Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie 94, 1382-1389, 2012.
272. Wang C and Kurzer MS: Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 28, 236-247, 1997. (Pubitemid 27446650)
273. Manthey JA and Guthrie N: Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J Agric Food Chem 50, 5837-5843, 2002. (Pubitemid 35155302)
274. Salama MM, Kandil ZA, and Islam WT: Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt. Nat Prod Res 26, 2057-2062, 2012.
275. So FV, Guthrie N, Chambers AF, and Carroll KK: Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Lett 112, 127-133, 1997. (Pubitemid 27104286)
276. Phromnoi K, Yodkeeree S, Anuchapreeda S, and Limtrakul P: Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids. Acta Pharmacol Sin 30, 1169-1176, 2009.
277. Gulati N, Laudet B, Zohrabian VM, Murali R, and Jhanwar-Uniyal M: The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. Anticancer Res 26, 1177-1181, 2006.
278. Weber G, Singhal RL, Prajda N, Yeh YA, Look KY, et al.: Regulation of signal transduction. Adv Enzyme Regul 35 1-21, 1995.
279. Weber G, Shen F, Prajda N, Yang H, Li W, et al.: Regulation of the signal transduction program by drugs. Adv Enzyme Regul 37, 35-55, 1997. (Pubitemid 27371554)
280. Veeriah S, Kautenburger T, Habermann N, Sauer J, Dietrich H, et al.:Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics. Mol Carcinog 45, 164-174, 2006. (Pubitemid 43358149)
281. Kern M, Tjaden Z, Ngiewih Y, Puppel N, Will F, et al.: Inhibitors of the epidermal growth factor receptor in apple juice extract. Mol Nutr Food Res 49, 317-328, 2005. (Pubitemid 40545524)
282. Bednar W, Holzmann K, and Marian B: Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme. Food Chem Toxicol 45, 508-514, 2007. (Pubitemid 46176360)
283. Kim YK, Kim YS, Choi SU, and Ryu SY: Isolation of flavonol rhamnosides from Loranthus tanakae and cytotoxic effect of them on human tumor cell lines. Arch Pharm Res 27, 44-47, 2004.
284. Kwak JH, Kang MW, Roh JH, Choi SU, and Zee OP: Cytotoxic phenolic compounds from Chionanthus retusus. Arch Pharm Res 32, 1681-1687, 2009.
285. Kaindl U, Eyberg I, Rohr-Udilova N, Heinzle C, and Marian B: The dietary antioxidants resveratrol and quercetin protect cells from exogenous prooxidative damage. Food Chem Toxicol 46, 1320-1326, 2008. (Pubitemid 351258201)
286. Herzog A, Kuntz S, Daniel H, and Wenzel U: Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer 109, 220-229, 2004. (Pubitemid 38240924)
287. Li N, Liu JH, Zhang J, and Yu BY: Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids. J Agric Food Chem 56, 3876-3883, 2008. (Pubitemid 351860197)
288. Tan J, Wang B, and Zhu L: DNA binding, cytotoxicity, apoptotic inducing activity, and molecular modeling study of quercetin zinc(II) complex. Bioorg Med Chem 17, 614-620, 2009.
289. Tan J, Zhu L, and Wang B: From GC-rich DNA binding to the repression of survivin gene for quercetin nickel (II) complex: implications for cancer therapy. Biometals 23, 1075-1084, 2010.
290. Tanigawa S, Fujii M, and Hou DX: Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells. Biosci Biotechnol Biochem 72, 797-804, 2008. (Pubitemid 351463685)
291. Kudo M, Naito Z, Yokoyama M, and Asano G: Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage. Exp Mol Pathol 66, 66-75, 1999. (Pubitemid 29269076)
292. Matsuo M, Sasaki N, Saga K, and Kaneko T: Cytotoxicity of flavonoids toward cultured normal human cells. Biol Pharm Bull 28, 253-259, 2005. (Pubitemid 40880004)
293. Liu CY, Lin YC, Deng JS, Liao JC, Peng WH, et al.: Antioxidant, antiinflammatory, and antiproliferative activities of Taxillus sutchuenensis. Am J Chin Med 40, 335-348, 2012.
294. Tan J, Wang B, and Zhu L: DNA binding and oxidative DNA damage induced by a quercetin copper(II) complex: potential mechanism of its antitumor properties. J Biol Inorg Chem 14, 727-739, 2009.
295. Ludwiczuk A, Saha A, Kuzuhara T, and Asakawa Y: Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae). Phytomedicine 18, 491-498, 2011.
296. Boik JC and Newman RA: A classification model to predict synergism/antagonism of cytotoxicmixtures using protein-drug docking scores. BMC Pharmacol 8, 13, 2008.
297. Chuang-Xin L, Wen-Yu W, Yao C, Xiao-Yan L, and Yun Z: Quercetin enhances the effects of 5-fluorouracil-mediated growth inhibition and apoptosis of esophageal cancer cells by inhibiting NF-κB. Oncol Lett 4, 775-778, 2012.
298. Brown J, O'Prey J, and Harrison PR: Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: involvement of the Akt and stress kinase pathways. Carcinogenesis 24, 171-177, 2003. (Pubitemid 36267083)
299. Ye B, Aponte M, Dai Y, Li L, Ho MC, et al.: Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Lett 251, 43-52, 2007. (Pubitemid 46613833)
300. Shen F, Herenyiova M, and Weber G: Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells. Life Sci 64, 1869-1876, 1999. (Pubitemid 29215188)
301. Lee LT, Huang YT, Hwang JJ, Lee AY, Ke FC, et al.: Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells. Biochem Pharmacol 67, 2103-2114, 2004. (Pubitemid 38595491)
302. Lee DH, Szczepanski M, and Lee YJ: Role of Bax in quercetininduced apoptosis in human prostate cancer cells. Biochem Pharmacol 75, 2345-2355, 2008.
303. Morris JD, Pramanik R, Zhang X, Carey AM, Ragavan N, et al.: Seleniumor quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgenreceptor activity. Cancer Lett 239, 111-122, 2006. (Pubitemid 43946582)
304. Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, et al.: Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer 49, 200-208, 2004. (Pubitemid 39487880)
305. Vijayababu MR, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, et al.: Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 287, 109-116, 2006. (Pubitemid 44057398)
306. Bradette-Hebert ME, Legault J, Lavoie S, and Pichette A: A new labdane diterpene from the flowers of Solidago canadensis. Chem Pharm Bull (Tokyo) 56, 82-84, 2008.
307. Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, et al.: Flavonoids, dietaryderived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57, 2916-2921, 1997. (Pubitemid 27315039)
308. Fotsis T, Pepper MS, Montesano R, Aktas E, Breit S, et al.: Phytoestrogens and inhibition of angiogenesis. Baillieres Clin Endocrinol Metab 12, 649-666, 1998. (Pubitemid 29261276)
309. Castillo-Pichardo L, Martínez-Montemayor MM, Martínez JE, Wall KM, Cubano LA, et al.: Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin Exp Metastasis 26, 505-516, 2009
310. Kim HJ, Kim SK, Kim BS, Lee SH, Park YS, et al.: Apoptotic effect of quercetin on HT-29 colon cancer cells via the AMPK signaling pathway. J Agric Food Chem 58, 8643-8650, 2010.
311. Hosokawa N, Hosokawa Y, Sakai T, Yoshida M, Marui N, et al.: A. Inhibitory effect of quercetin on the synthesis of a possibly cell-cyclerelated 17-kDa protein, in human colon cancer cells. Int J Cancer 45, 1119-1124, 1990. (Pubitemid 20201584)
312. Shan BE, Wang MX, and Li RQ: Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest 27, 604-612, 2009.
313. Cheong E, Ivory K, Doleman J, Parker ML, Rhodes M, et al.: Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest. Carcinogenesis 25, 1945-1952, 2004. (Pubitemid 39405914)
314. Ferrandina G, Almadori G, Maggiano N, Lanza P, Ferlini C, et al.:Growthinhibitory effect of tamoxifen and quercetin and presence of type II estrogen binding sites in human laryngeal cancer cell lines and primary laryngeal tumors. Int J Cancer 77, 747-754, 1998. (Pubitemid 28341393)
315. Scambia G, Ranelletti FO, Panici PB, Piantelli M, Bonanno G, et al.: Inhibitory effect of quercetin on OVCA 433 cells and presence of type II oestrogen binding sites in primary ovarian tumours and cultured cells. Br J Cancer 62, 942-946, 1990.