Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells

Food and Chemical Toxicology

Volumn 49, Issue 9, 2011, Pages 2398-2407

  Seibert, Hasso ^a   Maser, Edmund ^a   Schweda, Kathrin ^a   Seibert, Sabine ^a   Gülden, Michael ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Apigenin; Cytoprotection selectivity index (CSI); Kaempferol; Luteolin; Myricetin; Quercetin

Indexed keywords

APIGENIN; KAEMPFEROL; LUTEOLIN; MYRICETIN; QUERCETIN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; GLIOMA CELL; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN NEOPLASMS; CELL LINE, TUMOR; FLAVONOIDS; GLIOMA; HYDROGEN PEROXIDE; LIPID PEROXIDATION; OXIDATIVE STRESS; RATS;

CHANDIPURA VIRUS; RATTUS;

EID: 79960894101     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.055     Document Type: Article

References (53)

1. Babich H., Liebling E.J., Burger R.F., Zuckerbraun H.L., Schuck A.G. Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals. In Vitro Cell. Dev. Biol. Anim. 2009, 45:226-233.
2. Benda P., Lightbody J., Sato G., Levine L., Sweet W. Differentiated rat glial cell strain in tissue culture. Science 1968, 161:370-371.
3. Bolli A., Marino M., Rimbach G., Fanali G., Fasano M., Ascenzi P. Flavonoid binding to human serum albumin. Biochem. Biophys. Res. Commun. 2010, 398:444-449.
4. Boots A.W., Li H., Schins P.F., Duffin R., Heemskerk J.W.M., Bast A., Haenen G.R.M.M. The quercetin paradox. Toxicol. Appl. Pharmacol. 2007, 222:89-96.
5. Boots A.W., Haenen G.R.M.M., Baast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 2008, 585:325-337.
6. Boulton D., Walle K., Walle T. Extensive binding of the bioflavonoid quercetin to human plasma proteins. J. Pharm. Pharmacol. 1998, 50:243-249.
7. Cai Y.-Z., Sun M., Xing J., Luo Q., Corke H. Structure-radical scavenging activity of phenolic compounds from traditional Chinese medical plants. Life Sciences 2006, 78:2872-2888.
8. Carballal S., Radi R., Kirk C., Barnes S., Freeman B.A., Alvarez B. Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. Biochemistry 2003, 42:9906-9914.
9. Catapano A.L. Antioxidant effect of flavonoids. Angiology 1997, 48:39-44.
10. Cos P., Calomme M., Sindambiwe J.-B., De Brune T., Cimanga K., Pieters L., Vlietinck A.J., van den Berghe D. Cytotoxic and lipid peroxidation-inhibiting activity of flavonoids. Planta Med. 2001, 67:515-519.
11. Cos P., Rajan P., Vedernikova I., Calomme M., Pieters L., Vlietinck A.J., Augustyns K., Haemers A., van den Berghe D. In vitro antioxidant profile of phenolic acis derivatives. Free Radic. Res. 2002, 36:711-716.
12. Cotelle N. Role of flavonoids in oxidative stress. Curr. Top. Med. Chem. 2001, 1:569-590.
13. Crozier A., Jaganath I.B., Clifford M.N. Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009, 26:1001-1043.
14. Desagher S., Glowinski J., Premont J. Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J. Neurosci. 1997, 17:9060-9067.
15. Draper H.H., Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990, 186:421-431.
16. Dringen R., Kussmaul L., Hamprecht B. Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay. Brain Res. Protoc. 1998, 2:223-228.
17. Echeverry C., Arredondo F., Abin-Carriquiry J., Midiwo J.O., Ochieng C., Kerubo L., Dajas F. Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. J. Agric. Food Chem. 2010, 58:2111-2115.
18. Gitika B., Sai Ram M., Sharma S.K., Ilavazhagan G., Banerjee P.K. Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide. Free Radic. Res. 2006, 40:95-102.
19. Gülden M., Jess A., Kammann J., Maser E., Seibert H. Cytotoxic potency of H2O2 in cell cultures: Impact of cell concentration and exposure time. Free Radic. Biol. Med. 2010, 49:1298-1305.
20. Halliwell B. Oxidative stress, nutrition and health. Experimental strategies for optimisation of nutritional antioxidant intake in humans. Free Radic. Res. 1996, 25:57-74.
21. Halliwell B. Are flavonoids antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?. Arch. Biochem. Biophys. 2008, 476:107-112.
22. Hanneken A., Lin F.-F., Johnson J., Maher P. Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Invest. Ophthalmol. Vis. Sci. 2006, 47:3164-3177.
23. Hollman P.C., Katan M.B. Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 1999, 37:937-942.
24. Ishige K., Schubert D., Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic. Biol. Med. 2001, 30:433-446.
25. Jiang Z.-Y., Woollard A.C.S., Wolff S.P. Hydrogen peroxide production during experimental protein glycation. FEBS Lett. 1990, 268:69-71.
26. Kaindl U., Eyberg I., Rohr-Udilova N., Heinzle C., Marian B. The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage. Food Chem. Toxicol. 2008, 46:1320-1326.
27. Kay C.D. The future of flavonoid research. Brit. J. Nutr. 2010, 104:S91-S95.
28. Kuntz S., Wenzel U., Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur. J. Nutr. 1999, 38:133-142.
29. Lambert J.D., Sang S., Yang C.S. Possible controversy over dietary polyphenols: benefits vs risks. Chem. Res. Toxicol. 2007, 20:583-585.
30. Lee K.W., Hur H.J., Lee H.J., Lee C.Y. Antiproliferative effects of phenolic substances and hydrogen peroxide. J. Agric. Food Chem. 2005, 53:1990-1995.
31. Le Marchand L. Cancer preventive effects of flavonoids - a review. Biomed. Pharmacother. 2002, 56:296-301.
32. Linden A., Gülden M., Martin H.-J., Maser E., Seibert H. Peroxide-induced cell death and lipid peroxidation in C6 glioma cells. Toxicol. In Vitro 2008, 22:1371-1376.
33. Long L.H., Clement M.V., Halliwell B. Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem. Biophys. Res. Commun. 2000, 273:50-53.
34. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-274.
35. Mira L., Fernandez M.T., Santos M., Rocha R., Florencio M.H., Jennings K.R. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic. Res. 2002, 36:1199-1208.
36. Mladěnka, P., Macáková,K., Filipský,T., Zatloukalováa, L., Jahodář,, L., Bovicelli, P., Proietti Silvestri, I., Hrdina, R., Saso, L., 2011.In vitro analysis of iron chelating activity of flavonoids. J. Inorg. Biochem., doi:. doi:10.1016/j.jinorgbio.2011.02.003.
37. Moridani M.Y., Galati G., O'Brien P.J. Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells. Chem. Biol. Interact. 2002, 139:251-264.
38. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983, 65:55-63.
39. Nemeikaite-Ceniene A., Imbrasaite A., Sergediene E., Cenas N. Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: role of potential of phenoxyl radical/phenol redox couple. Arch. Biochem. Biophys. 2005, 441:182-190.
40. Panickar K.S., Anderson R.A. Mechanisms underlying the protective effects of myricetin and quercetin following oxygen-glucose deprivation-induced cell swelling and the reduction in glutamate uptake in glial cells. Neuroscience 2011, 183:1-14.
41. Pietta P.-G. Flavonoids as antioxidants. J. Nat. Prod. 2000, 63:1035-1042.
42. Rawel H.M., Meidtner K., Kroll J. Binding of selected phenolic compounds to proteins. J. Agric. Food Chem. 2005, 53:4228-4235.
43. Rice-Evans C.A., Miller N.J., Paganga G. Antioxidant properties of phenolic compounds. Trends Plant Sci. 1997, 2:152-159.
44. Rüweler M., Anker A., Gülden M., Maser E., Seibert H. Inhibition of peroxide-induced radical generation by plant polyphenols in C6 astroglioma cells. Toxicol. In Vitro 2008, 22:1377-1381.
45. Seibert H., Mörchel S., Gülden M. Cytotoxic potency of trialkyltins to C6 glioma cells in vitro: impact of exposure conditions. Cell Biol. Toxicol. 2004, 20:273-283.
46. Seibert H., Jess A., Linden A., Maser E., Perle M., Gülden M. Peroxide-induced oxidative stress and cell death in C6 astroglioma cells. ALTEX 2010, 27:123.
47. Sestili P., Diamantini G., Bedini A., Cerioni L., Tommasini I., Tarzia G., Cantoni O. Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism. Biochem J. 2002, 364:121-128.
48. Sestili P., Martinelli C., Ricci D., Fraternale D., Bucchini A., Giamperi L., Curcio R., Piccoli G., Stocchi V. Cytoprotective effect of preparations from various parts of Punica granatum L. Fruits in oxidatively injured mammalian cells in comparison with their antioxidant capacity in cell free systems. Pharmacol. Res. 2007, 56:18-26.
49. Vlachodimitropoulou E., Sharp P.A., Naftalin R.J. Quercetin-iron chelates are transported via glucose transporters. Free Radic. Biol. Med. 2011, 50:934-944.
50. Wätjen W., Michels G., Steffan B., Niering P., Chovolou Y., Kampkötter A., Tran-Thi Q.-H., Proksch P., Kahl R. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J. Nutr. 2005, 135:525-531.
51. Williams R., Spencer J.P., Rice-Evans C. Flavonoids: antioxidants or signalling molecules?. Free Radic. Biol. Med. 2004, 36:838-849.
52. Van der Woude H., Gliszczynska-Swiglo A., Struijs K., Smeets A., Alink G.M., Rietjens I.M.C.M. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. 2003. Cancer Lett. 2003, 200:41-47.
53. Zhang Q., Zhao X.-H., Wang Z.-J. Cytotoxicity of flavones and flavonols to a human esophagal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol. In Vitro 2009, 23:797-807.