Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells)

Cancer Letters

Volumn 105, Issue 1, 1996, Pages 61-70

  Agullo, Georgine ^a   Gamet Payrastre, Laurence ^a   Fernandez, Yvette ^a   Anciaux, Nathalie ^a   Demigné, Christian ^a   Rémésy, Christian ^a  

^a CEMAGREF   (France)

Author keywords

Colon carcinoma cells; Cytotoxic effects; Flavonoids structure activity; Lactate release

Indexed keywords

DIOSMETIN; FLAVONE; FLAVONOID; FLAVONOL; HYDROXYL GROUP; LACTIC ACID; LUTEOLIN;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL METABOLISM; CELL VIABILITY; COLON ADENOCARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; FATTY ACID DESATURATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0030593485     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04262-0     Document Type: Article

References (34)

1. [1] Miller, A.B., Berrino, F., Hill, M., Pietinen, P., Riboli, E. and Wahrendorf, J. (1994) Diet and the aetiology of cancer, a review. Eur. J. Cancer, 30A, 207-220.
2. [2] Vargas, P.A. and Alberts, D.S. (1992) Primary prevention of colorectal cancer through dietary modification. Cancer, 70, 1230-1235.
3. [3] Starvic, B. (1994) Role of chemopreventers in human diet. Clin. Biochem., 27, 319-332.
4. [4] Wattenberg, L.W. (1990) Inhibition of carcinogenesis by minor anutrient constituents of the diet. Proc. Nutr. Soc., 49, 173-183.
5. [5] Middleton, Jr., E. and Kandaswami, C. (1993) The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In: The Flavonoids: Advances in Research since 1986, pp. 619-652. J.H. Harborne, New York.
6. [6] Deschner, E.E., Ruperto, J., Wong, G. and Newmark, H.L. (1991) Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis, 12, 1193-1196.
7. [7] Barnes, S. (1995) Effect of genistein on in vitro and in vivo models of cancer. J. Nutr., 125, 777S-783S.
8. [8] Constantinou, A. and Huberman, E. (1995) Genistein as an inducer of tumor cell differentiation: possible mechanisms of action. Proc. Soc. Exp. Biol. Med., 208, 109-115.
9. [9] Peterson, G. (1995) Evaluation of the biochemical targets of genistein in tumor cells. J. Nutr., 125, 784S-789S.
10. [10] Hirano, T., Oka, K. and Akiba, M. (1989) Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Res. Commun. Chem. Pathol. Pharmacol., 64, 69-78.
11. [11] Hirano, T., Gotoh, M. and Oka, K. (1994) Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci., 55, 1061-1069.
12. [12] Ferriola, P.C., Cody, V. and Middleton, E. (1989) Protein kinase C inhibition by plant flavonoids. Kinetic mechanism and structure-activity relationships. Biochem. Pharmacol., 38, 1617-1624.
13. [13] Das, A., Wang, J.H. and Lien, E.J. (1994) Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: a structure-system-activity relationship (SSAR) analysis. Prog. Drug Res., 42, 134-164.
14. [14] Miksicek, R.J. (1995) Estrogenic flavonoids: structural requirements for biological activity. Proc. Soc. Exp. Biol. Med., 208, 44-50.
15. [15] Agullo, G., Garnet, L., Besson, C., Demigné, C. and Rémésy, C. (1994) Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and CaCo-2 cells. Cancer Lett., 87, 55-63.
16. [16] Fogh, J., Fogh, J.N. and Orfeo, T. (1977) One hundred and twenty seven cultured human tumor cell-lines producing tumors in nude mice. J. Natl. Cancer Inst., 59, 221-226.
17. [17] Darmon, N., Fernandez, Y., Periquet, A. and Mitjavila, S. (1992) Superoxide anion scavenging capacity measured by a polarographic method. Comparison with a colourimetric method. Free Rad. Res. Commun., 17, 97-107.
18. [18] Hohorst, H. and Bergmeyer, H.U. (1974) L-Lactate determination. In: Methods of Enzymatic Analysis, Vol. 2, pp. 622-637. Editor: H.U. Bergmeyer. Verlag Chemie, Weinheim.
19. [19] Husoy, T., Syversen, T. and Jenssen, J. (1993) Comparison of four in vitro cytotoxicity tests: the MTT assay, NR assay, uridine incorporation and protein measurements. Toxic. In Vitro, 7, 149-154.
20. [20] Bradford, M.M. (1976) A rapid sensitive technique for the quantification of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
21. [21] Belt, J.A., Thomas, J.A., Buchsbaum, R.N. and Racker, E. (1979) Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoids. Biochemistry, 18, 3506-3511.
22. +-ATPase: aspects of the structure-activity relationship and action mechanism. Life Sci., 45, 1111-1117.
23. [23] Grisiola, S., Rubio, V., Feijoo, B. and Mendelson, J. (1975) Inhibition of lactic dehydrogenase and of pyruvate kinase by low concentrations of quercetin. Physiol. Chem. Phys., 7, 473-475.
24. [24] Laughton, M.J., Halliwell, B., Evans, P.J. and Hoult, J.R.S. (1989) Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Biochem. Pharmacol., 38, 2859-2865.
25. [25] Hodnick, W.F., Kung, F.S., Roettger, W.J., Bohmont, C.W. and Pardini, R.S. (1986) Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure activity study. Biochem. Pharmacol., 35, 2345-2357.
26. [26] Jinsart, W., Ternai, B. and Polya, G.M. (1992) Inhibition of rat liver cyclic AMP-dependent protein kinase by flavonoids. Biol. Chem., 373, 205-211.
27. [27] Ohno, T., Kato, C., Shimizu, M., Ito, Y., Tomono, S. and Kawazu, S. (1993) Genistein augments cyclic 3′5′-monophosphate (cAMP) accumulation and insulin release in MIN6 cells. Endocr. Res., 19, 273-285.
28. [28] Ruckstuhl, M. and Landry, Y. (1981) Inhibition of lung cyclic AMP-and cyclic GMP-phosphodiesterases by flavonoids and other chromone-like compounds. Biochem. Pharmacol., 30, 697-702.
29. [29] Kuppusamy, U.R. and Das, N.P. (1992) Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes. Biochem. Pharmacol., 44, 1307-1315.
30. [30] Bourdillat, B., Delautier, D., Labat, C., Benveniste, J., Potier, P. and Brink, C. (1988) Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur. J. Pharmacol., 147, 1-6.
31. [31] Berezt, A., Cazenave, J.P. and Anton, R. (1982) Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: structure-activity relationship. Agents Actions, 12, 382.
32. [32] Di Carlo, G., Autore, G., Izzo, A.A., Maiolino, P., Mascolo, N., Viola, P., Diurno, M. and Capasso, F. (1993) Inhibition of intestinal mobility and secretion by flavonoids in mice and rats: structure-activity relationships. J. Pharm. Pharmacol., 45, 1054-1059.
33. [33] Vairo, G., Argyriou, S., Bordun, A.M., Whitty, G. and Hamilton, J.A. (1990) Inhibition of the signaling pathways for macrophage proliferation by cyclic AMP. J. Biol. Chem., 265, 2692-2701.
34. [34] Hertog, M.G.L., Kromhout, D., Aravanis, C., Blackburn, H., Buzina, R., Fidanza, F., Giampaoli, S., Jansen, A., Menotti, A., Nedeljkovic, S., Pekkarinen, M., Simic, B.S., Toshima, H., Feskens, E.J.M., Hollman, P.C.H. and Katan, M. (1995) Flavonoids intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med., 155, 381-386.