Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (bertoni) bertoni, a natural sweetener

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 26, 2007, Pages 10962-10967

  Ghanta, Srijani ^a   Banerjee, Anindita ^a   Poddar, Avijit ^a   Chattopadhyay, Sharmila ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Antioxidant potential; Flavonoids; Oxidative DNA damage; Stevia rebaudiana

Indexed keywords

ANTIOXIDANT; FLAVONOID; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS; SWEETENING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMISTRY; DNA DAMAGE; DRUG EFFECT; LIPID PEROXIDATION; OXIDATIVE STRESS; PLANT LEAF; STEVIA;

ANTIOXIDANTS; DNA DAMAGE; FLAVONOIDS; LIPID PEROXIDATION; OXIDATIVE STRESS; PHENOLS; PLANT EXTRACTS; PLANT LEAVES; STEVIA; SWEETENING AGENTS;

RATTUS; STEVIA REBAUDIANA;

EID: 38049025701     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf071892q     Document Type: Article

References (28)

1. Hanson, J. R.; De Oliveira, B. H. Stevioside and related sweet diterpenoid glycosides. Nat. Prod. Rep. 1993, 10, 301-309.
2. Kinghorn, A. D.; Soejarto, D. D. Current status of Stevioside as a sweetening agent for human use. In Economic and Medical Plant Research; Wagner, H., Hikino, H., Farmsworth, N. R., Eds.;Academic Press: London, 1985; Vol. 1, pp 1-52.
3. Benford, D. J.; DiNovi, M.; Schlatter, J. Safety Evaluation of Certain Food Additives: Steviol Glycosides. WHO Food Addit. Ser. 2006, 5, 117-144.
4. Frei, B. Nonenzymatic antioxidant defense systems. In Natural Antioxidants in Human Health and Disease; Briviba, K., Sies, H., Eds.; Academic Press: London, 1994; pp 107-116.
5. Rice-Evans, C. The role of antioxidants in biological systems and human studies of disease prevention. In Advances in Applied Lipid Research; Padley, F. B., Ed.; JAI Press Inc.: London, 1996; Vol. 2, pp 183-211.
6. Cui, K.; Luo, X.; Xu, K.; Ven Murthy, M. R. Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2004, 28, 771-799.
7. Halliwell, B. Protection against tissue damage in vivo by desferrioxammine: What is its mechanism of action. Free Radical Biol. Med. 1989, 7, 645-651.
8. Hertog, M. G. L.; Freskens, E. J. M.; Hollman, P. C. H.; Katan, M. B.; Kromhout, D. Dietary antioxidant flavonoids and the risk of coronary heart disease: The Zutphen Elverly Study. Lancet 1993, 342, 1007-1011.
9. Shahidi, F.; Wanasundara, P. K. Phenolic antioxidants. Crit. Rev. Food Sci. Nutr. 1992, 32, 67-103.
10. Pietta, P. G.; Mauri, P. L.; Simonetti, P.; Testolin, G. HPLC and MEKC determination of major flavonoids in selected food pools. Fresenius J. Anal. Chem. 1995, 352, 788-792.
11. Heim, K. E.; Tagliaferro, A. R.; Bobilya, D. J. Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem. 2002, 13, 572-584.
12. Boonkaewwan, C.; Toskulkao, C.; Vongsakul, M. Anti-inflammatory and immunomodulatory activities of Stevioside and its metabolite steviol on THP-1 cells. J. Agric. Food Chem. 2006, 54, 785-789.
13. Xi, Y.; Yamaguchi, T.; Sato, M.; Takeuchi, M. Antioxidant mechanism of Stevia rebaudiana extract and antioxidant activity of inorganic salts. Nippon Kagaku Kaishi 1998, 45, 317-322.
14. Tadhani, M. B.; Patel, V. H.; Subhash, R. In vitro antioxidant activities of Stevia rebaudiana leaves and callus. J. Food Comp. Anal. 2007, 20, 323-329.
15. Rajbhandari, A.; Roberts, M. F. The Flavonoids of Stevia rebaudiana. J. Nat.Prod. 1983, 46, 194-195.
16. Ma, M.; Hong, C.; An, S.; Li, B. Seasonal, Spatial, and Interspecific Variation in Quercetin in Apocynum venetum and Poacynum hendersonii, Chinese Traditional Herbal Teas. J. Agri. Food Chem. 2003, 51, 2390-2393.
17. Barros, L.; Baptista, P.; Correia, D. M.; Morais, J. S.; Ferreira, I. C. F. R. Effects of Conservation Treatment and Cooking on the Chemical Composition and Antioxidant Activity of Portuguese Wild Edible Mushrooms. J. Agri. Food Chem. 2007, 55, 4781-4788.
18. Kumar, A.; Chattopadhyay, S. DNA damage protecting activity and antioxidant potential of pudina extract. Food Chem. 2007, 100, 1377-1384.
19. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237.
20. Halliwell, B.; Gutteridge, M. C. Formation of a thiobarbituric-acid- reactive substance from deoxyribose in the presence of iron salts: The role of superoxide and hydroxyl radicals. FEBS Lett. 1981, 128, 347-352.
21. Tian, B.; Hua, Y. Concentration-dependence of prooxidant and antioxidant effects of aloin and aloe-emodin on DNA. Food Chem. 2005, 91, 413-418.
22. Bors, W.; Heller, W.; Michel, C.; Saran, M. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol. 1990, 186, 343-355.
23. Wiseman, H.; Halliwell, B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J. 1996, 313, 17-29.
24. Kim, H. Y.; Kim, O. H.; Sung, M. K. Effects of Phenol-Depleted and Phenol-Rich Diets on Blood Markers of Oxidative Stress, and Urinary Excretion of Quercetin and Kaempferol in Healthy Volunteers. J. Am. Coll. Nutr. 2003, 22, 217-223.
25. Husain, R. S.; Cillard, J.; Cillard, P. Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 1987, 26, 2489-2491.
26. Cos, P.; Ying, L.; Calomme, M.; Hu, J. P.; Cimanga, K.; Poel, B. V.; Pieters, L.; Vlietinck, A. J.; Berghe, D. V. Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J. Nat. Prod. 1998, 61, 71-76.
27. Hollman, P. C. H.; de Vries, J. H. M.; van Leeuwen, S. D.; Mengelers, M. J. B.; Katan, M. B. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am. J. Clin. Nutr. 1995, 62, 1276-1282.
28. Pannala, A. S.; Chan, T. S.; O'Brien, P. J. O.; Rice-Evans, C. A. Flavonoid B-ring chemistry and antioxidant activity: fast reaction kinetics. Biochem. Biophys. Res. Commun. 2001, 282, 1161-1168.