The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells

Carcinogenesis

Volumn 25, Issue 5, 2004, Pages 647-659

  Nguyen, T T T ^a   Tran, E ^a   Nguyen, T H ^a   Do, P T ^a   Huynh, T H ^a   Huynh, H ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CELL DNA; DIMETHYL SULFOXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN C JUN; PROTEIN KINASE B; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CELL DIVISION; HUMANS; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; QUERCETIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 2442623486     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh052     Document Type: Article

References (67)

1. Bilello,K.S., Murin,S. and Matthay,R.A. (2002) Epidemiology, etiology, and prevention of lung cancer. Clin. Chest Med., 23, 1-25.
2. Alavanja,M.C. (2002) Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions. Oncogene, 21, 7365-7375.
3. Midthun,D.E. and Jett,J.R. (1997) Chemotherapy for advanced lung cancer. When to expect a response. Postgrad. Med., 101, 187-192, 194.
4. Feng,G., Xu,X., Youssef,E.M. and Lotan,R. (2001) Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis. Cancer Res., 61, 7999-8004.
5. Gargiullo,P., Wingo,P.A., Coates,R.J. and Thompson,T.D. (2002) Recent trends in mortality rates for four major cancers, by sex and race/ethnicity - United States. Morb. Mortal. Wkly Rep., 51, 49-53.
6. Block,G., Patterson,B. and Subar,A. (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer, 18, 1-29.
7. Zhou,J.R., Mukherjee,P., Gugger,E.T., Tanaka,T., Blackburn,G.L. and Clinton,S.K. (1998) Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res., 58, 5231-5238.
8. Shao,Z.M., Wu,J., Shen,Z.Z. and Barsky,S.H. (1998) Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res., 58, 4851-4857.
9. Anton,R. (1988) Flavonoids and Traditional Medicine. Alan R.Liss, Inc., New York.
10. Ranelletti,F.O., Ricci,R., Larocca,L.M. et al. (1992) Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors. Int. J. Cancer, 50, 486-492.
11. Ashida,H., Fukuda,I., Yamashita,T. and Kanazawa,K. (2000) Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin. FEBS Lett., 476, 213-217.
12. Agullo,G., Gamet-Payrastre,L., Manenti,S., Viala,C., Remesy,C., Chap,H. and Payrastre,B. (1997) Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem. Pharmacol., 53, 1649-1657.
13. Hagiwara,M., Inoue,S., Tanaka,T., Nunoki,K., Ito,M. and Hidaka,H. (1988) Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem. Pharmacol., 37, 2987-2992.
14. Aligiannis,N., Mitaku,S., Mitrocotsa,D. and Leclerc,S. (2001) Flavonoids as cycline-dependent kinase inhibitors: inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series. Planta Med., 67, 468-470.
15. Gamet-Payrastre,L., Manenti,S., Gratacap,M.P., Tulliez,J., Chap,H. and Payrastre,B. (1999) Flavonoids and the inhibition of PKC and PI 3-kinase. Gen. Pharmacol., 32, 279-286.
16. Constantinou,A., Mehta,R., Runyan,C., Rao,K., Vaughan,A. and Moon,R. (1995) Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships. J. Natl Prod., 58, 217-225.
17. Lee,S.C., Kuan,C.Y., Yang,C.C. and Yang,S.D. (1998) Bioflavonoids commonly and potently induce tyrosine dephosphorylation/inactivation of oncogenic proline-directed protein kinase FA in human prostate carcinoma cells. Anticancer Res., 18, 1117-1121.
18. Suolinna,E.M., Lang,D.R. and Racker,E. (1974) Quercetin, an artificial regulator of the high aerobic glycolysis of tumor cells. J. Natl Cancer Inst., 53, 1515-1519.
19. Yoshizumi,M., Tsuchiya,K., Kirima,K., Kyaw,M., Suzaki,Y. and Tamaki,T. (2001) Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells. Mol. Pharmacol., 60, 656-665.
20. Avila,M.A., Velasco,J.A., Cansado,J. and Notario,V. (1994) Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res., 54, 2424-2428.
21. Xing,N., Chen,Y., Mitchell,S.H. and Young,C.Y. (2001) Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis, 22, 409-414.
22. Scambia,G., Ranelletti,F.O., Benedetti,P.P., Piantelli,M., Rumi,C., Battaglia,F., Larocca,L.M., Capelli,A. and Mancuso,S. (1990) Type-II estrogen binding sites in a lymphoblastoid cell line and growth-inhibitory effect of estrogen, anti-estrogen and bioflavonoids. Int. J. Cancer, 46, 1112-1116.
23. Markaverich,B.M., Roberts,R.R., Alejandro,M.A., Johnson,G.A., Middleditch,B.S. and Clark,J.H. (1988) Bioflavonoid interaction with rat uterine type II binding sites and cell growth inhibition. J. Steroid Biochem., 30, 71-78.
24. Larocca,L.M., Piantelli,M., Leone,G., Sica,S., Teofili,L., Panici,P.B., Scambia,G., Mancuso,S., Capelli,A. and Ranelletti,F.O. (1990) Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids. Br. J. Haematol., 75, 489-495.
25. Hosokawa,N., Hosokawa,Y., Sakai,T., Yoshida,M., Marui,N., Nishino,H., Kawai,K. and Aoike,A. (1990) Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein, in human colon cancer cells. Int. J. Cancer, 45, 1119-1124.
26. Kuo,M.L., Lin,J.K., Huang,T.S. and Yang,N.C. (1994) Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer Lett., 87, 91-97.
27. Ranelletti,F.O., Ricci,R., Larocca,L.M. et al. (1992) Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors. Int. J. Cancer, 50, 486-492.
28. Yoshida,M., Yamamoto,M. and Nikaido,T. (1992) Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res., 52, 6676-6681.
29. Plaumann,B., Fritsche,M., Rimpler,H., Brandner,G. and Hess,R.D. (1996) Flavonoids activate wild-type p53. Oncogene, 13, 1605-1614.
30. Ferrandina,G., Almadori,G., Maggiano,N., Lanza,P., Ferlini,C., Cattani,P., Piantelli,M., Scambia,G. and Ranelletti,F.O. (1998) Growth-inhibitory effect of tamoxifen and quercetin and presence of type II estrogen binding sites in human laryngeal cancer cell lines and primary laryngeal tumors. Int. J. Cancer, 77, 747-754.
31. Teofili,L., Pierelli,L., Iovino,M.S. et al. (1992) The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth. Leuk. Res., 16, 497-503.
32. Wei,Y.Q., Zhao,X., Kariya,Y., Fukata,H., Teshigawara,K. and Uchida,A. (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res., 54, 4952-4957.
33. Ballif,B.A. and Blenis,J. (2001) Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ., 12, 397-408.
34. Krueger,J.S., Keshamouni,V.G., Atanaskova,N. and Reddy,K.B. (2001) Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion. Oncogene, 20, 4209-4218.
35. Montesano,R., Soriano,J.V., Hosseini,G., Pepper,M.S. and Schramek,H. (1999) Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells. Cell Growth Differ., 10, 317-332.
36. Dudley,D.T., Pang,L., Decker,S.J., Bridges,A.J and Saltiel,A.R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl Acad. Sci. USA, 92, 7686-7689.
37. Liu,E., Thant,A.A., Kikkawa,F., Kurata,H., Tanaka,S., Nawa,A., Mizutani,S., Matsuda,S., Hanafusa,H. and Hamaguchi,M. (2000) The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1. Cancer Res., 60, 2361-2364.
38. Chen,Y., Lu,Q., Schneeberger,E.E. and Goodenough,D.A. (2000) Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol. Biol. Cell, 11, 849-862.
39. Moos,P.J. and Fitzpatrick,F.A. (1998) Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits. Cell Growth Differ., 9, 687-697.
40. Fisher,T.C., Milner,A.E., Gregory,C.D., Jackman,A.L., Aherne,G.W., Hartley,J.A., Dive,C. and Hickman,J.A. (1993) bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res., 53, 3321-3326.
41. Boise,L.H., Gonzalez-Garcia,M., Postema,C.E., Ding,L., Lindsten,T., Turka,L.A., Mao,X., Nunez,G. and Thompson,C.B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
42. Franke,T.F., Yang,S.I., Chan,T.O., Datta,K., Kazlauskas,A., Morrison,D.K., Kaplan,D.R. and Tsichlis,P.N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 81, 727-736.
43. Page,C., Lin,H.J., Jin,Y., Castle,V.P., Nunez,G., Huang,M. and Lin,J. (2000) Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer Res., 20, 407-416.
44. Datta,S.R., Dudek,H., Tao,X., Masters,S., Fu,H., Gotoh,Y. and Greenberg,M.E. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91, 231-241.
45. Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J. (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) (see comments). Cell, 87, 619-628.
46. 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol., 18, 629-643.
47. Rom,W.N. and Tchou-Wong,K.M. (2003) Molecular and genetic aspects of lung cancer. Methods Mol. Med., 75, 3-26.
48. Pinkas,J. and Leder,P. (2002) MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res., 62, 4781-4790.
49. Lim,I.J., Phan,T.T., Song,C., Tan,W.T.L. and Longaker,M.T. (2001) Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro. Plast. Reconstr. Surg., 107, 797-808.
50. Huynh,H., Chow,P.K., Ooi,L.L. and Soo,K.C. (2002) A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation. Cell Growth Differ., 13, 115-122.
51. Downward,J. (1999) How BAD phosphorylation is good for survival (news). Nature Cell Biol., 1, E33-E35.
52. Germain,M., Affar,E.B., D'Amours,D., Dixit,V.M., Salvesen,G.S. and Poirier,G.G. (1999) Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J. Biol. Chem., 274, 28379-28384.
53. Kulik,G., Klippel,A. and Weber,M.J. (1997) Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell Biol., 17, 1595-1606.
54. Kolch,W., Kotwaliwale,A., Vass,K. and Janosch,P. (2002) The Role of Raf Kinases in Malignant Transformation. Expert Reviews in Molecular Medicine. Cambridge University Press, UK, pp. 1-18.
55. MacKeigan,J.P., Collins,T.S. and Ting,J.P. (2000) MEK inhibition enhances paclitaxel-induced tumor apoptosis. J. Biol. Chem., 275, 38953-38956.
56. Leighton,T., GInther,C., Fluss,L., Harter,W.K., Cansado,J. and Notario,V. (1992) Phenolic Compounds in Food and Their Effects on Health II. American Chemical Society, Washington.
57. Messina,M.J., Persky,V., Setchell,K.D. and Barnes,S. (1994) Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer, 21, 113-131.
58. Muzio,M., Stockwell,B.R., Stennicke,H.R., Salvesen,G.S. and Dixit,V.M. (1998) An induced proximity model for caspase-8 activation. J. Biol. Chem., 273, 2926-2930.
59. Chao,D.T. and Korsmeyer,S.J. (1998) BCL-2 family: regulators of cell death. Annu. Rev. Immunol., 16, 395-419.
60. O Khwaja,A. (1999) Akt is more than just a Bad kinase (news; comment). Nature, 401, 33-34.
61. Wang,C.Y., Guttridge,D.C., Mayo,M.W. and Baldwin,A.S.,Jr (1999) NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol. Cell. Biol., 19, 5923-5929.
62. Yujiri,T., Sather,S., Fanger,G.R. and Johnson,G.L. (1998) Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science, 282, 1911-1914.
63. Lieu,C.H., Liu,C.C., Yu,T.H., Chen,K.D., Chang,Y.N. and Lai,Y.K. (1998) Role of mitogen-activated protein kinase in taxol-induced apoptosis in human leukemic U937 cells. Cell Growth Differ., 9, 767-776.
64. Kalechman,Y., Longo,D.L., Catane,R., Shani,A., Albeck,M. and Sredni,B. (2000) Synergistic anti-tumoral effect of paclitaxel (Taxol)+AS101 in a murine model of B16 melanoma: association with ras-dependent signal-transduction pathways. Int. J. Cancer, 86, 281-288.
65. Yano,T., Pinski,J., Groot,K. et al. (1992) Stimulation by bombesin and inhibition by bombesin/GRP antagonist RC-3905 of growth of human breast cancer cell lines. Cancer Res., 52, 4545-4547.
66. Markaverich,B.M., Roberts,R.R., Alejandro,M.A. and Clark,J.H. (1984) An endogenous inhibitor of (3H)estradiol binding to nuclear type II estrogen binding sites in normal and malignant tissues. Cancer Res., 44, 1515-1519.
67. Hofmann,J., Doppler,W., Jakob,A., Maly,K., Posch,L., Uberall,F. and Grunicke,H.H. (1988) Enhancement of the antiproliferative effect of cisdiamminedichloroplatinum(II) and nitrogen mustard by inhibitors of protein kinase C. Int. J. Cancer, 42, 382-388.