Antiproliferative effect of quercetin in the human U138MG glioma cell line

Anti-Cancer Drugs

Volumn 17, Issue 6, 2006, Pages 663-671

  Braganhol, Elizandra ^a   Zamin, Lauren L ^a   Delgado Canedo, Andrés ^a   Horn, Fabiana ^b   Tamajusuku, Alessandra S K ^a   Wink, Márcia R ^b   Salbego, Christianne ^a   Battastini, Ana M O ^a,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Biosciences Institute   (Brazil)

^c Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

Author keywords

Cell death; Chemoprevention; Glioma cells; Hippocampal organotypic cultures; Quercetin

Indexed keywords

QUERCETIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER REGRESSION; CELL CYCLE G2 PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; GLIOMA CELL; GROWTH INHIBITION; HIPPOCAMPUS; HUMAN; HUMAN CELL; ISCHEMIA; MITOSIS INDEX; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; G2 PHASE; GLIOMA; HIPPOCAMPUS; HUMANS; MALE; MITOSIS; ORGAN CULTURE TECHNIQUES; QUERCETIN; RATS; RATS, WISTAR; TUMOR CELLS, CULTURED;

EID: 33747626057     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cad.0000215063.23932.02     Document Type: Article

References (40)

1. Avgeropoulos NG, Batchelor TT. New treatment strategies for malignant gliomas. Oncologist 1999; 4:209-224.
2. Holland EC. Gliomagenesis: genetics alterations and mouse models. Nature 2001; 2:120-129.
3. López-Lázaro M. Flavonoids as anticancer agents: structure-activity relationship study. Curr Med Chem 2002; 2:691-714.
4. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52:673-751.
5. Chi C, Kong ANT. Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic Biol Med 2004; 36:1505-1516.
6. Dunnick JK, Hailey JR. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam Appl Toxicol 1992; 19:423-431.
7. Csokay B, Prajda N, Weber G, Olah E. Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 1997; 60:2157-2163.
8. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, Ushida A. Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 1994; 54:4952-4957.
9. Yoshida M, Yamamoto M, Nikaido T. Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res 1992; 52:6676-6681.
10. Ma Z, Hung T, Hoa Huynh T, Tien Do P, Huynh H. Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation. J Endocrinol 2004; 181:493-507.
11. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999; 35:142-147.
12. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999; 13:2905-2927.
13. Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbot NJ, Rice-Evans C. Interaction between flavonoids and the blood-brain barrier: in vitro studies. J Neurochem 2003; 37:173-182.
14. Stoppini L, Bucks PA, Muller DA. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991; 37:173-182.
15. Strasser U, Fisher G. Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation. J Neurosci Methods 1995; 57:177-186.
16. Cimarosti H, Rodnight R, Tavares A, Paiva R, Valentim L, Rocha E, et al. An investigation of neuroprotective effect of lithium in organotypic slice cultures of rat hippocampus exposed to oxygen and glucose deprivation. Neurosci Lett 2001; 315:33-36.
17. Noraberg J, Kristensen BW, Zimmer J. Markers for neuronal degeneration in organotypic slice culture. Protocols 1999; 3:278-290.
18. Valentim LM, Rodnight R, Geyer AB, Horn AP, Tavares A, Cimarosti H, et al. Changes in heat shock protein 27 phosphorylation and immunocontent in response to preconditioning to oxygen and glucose deprivation in organotypic hippocampal cultures. Neuroscience 2003; 118:379-386.
19. Peterson GL. Determination of total protein. Methods Enzymol 1983; 91:95-119.
20. Overton WR, McCoy Jr JP. Reversing the effect of formalin on the binding of propidium iodide to DNA. Cytometry 1994; 16:351-356.
21. Vergote D, Cren-Olivé C, Chopin V, Toillon RA, Rolando C, Hondermarck H, et al. ( - )-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. Breast Cancer Res Treat 2002; 76:195-201.
22. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 1999; 19:8114-8121.
23. Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981; 66:1191-1308.
24. Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003; 3:559S-569S.
25. Tadjalli-Mehr K, Becker N, Rahu M, Stegrevics A, Kurtinaitis J, Hakama M. Randomized trial with fruits and vegetables in prevention of cancer. Acta Oncol 2003; 4:287-293.
26. Arts CWI, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005; 81:317S-325S.
27. Williams RJ, Spencer JPE, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 2004; 36:838-849.
28. Dorta D, Pigoso AA, Mingatto FE, Rodrigues T, Prado IMR, Helena AFC, et al. The interaction of flavonoids with mitochondria: effects on energetic processes. Chem Biol Interact 2005; 152:67-78.
29. Sano T, Lin H, Chen X, Langford LA, Koul D, Bondy ML, et al. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res 1999; 59:1820-1824.
30. Yoshida M, Sakai T, Hosowa N, Marvi N, Matsumoto K, Fujioka A, et al. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Lett 1990; 260:10-13.
31. Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14 ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999; 9:469-479.
32. Avila MA, Cansado J, Harter KW, Velasco JA, Notário V. Quercetin as a modulator of the cellular neoplastic phenotype. Adv Exp Med Biol 1996; 401:101-110.
33. Takano T, Lin JH, Arcuino G, Gao O, Yang J, Nedergaard M. Glutamate release promotes growth of malignant gliomas. Nat Med 2001; 7:1010-1015.
34. Watjen W, Michels G, Steffan B, Niering P, Chovolou Y, Kampkotter A, et al. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J Nutr 2005; 135:525-531.
35. Spencer JPE, Rice-Evans C, Williams RJ. Modulation of pro-survival Akt/protein kinase B and ERK 1/2 signalling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 2003; 278:34783-34793.
36. 2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Phamacol 2005; 69:1839-1851.
37. Ishikawa Y, Kitamura M. Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. Kidney Int 2000; 58:1078-1087.
38. Son Y, Lee KY, Kook S, Lee J, Kim J, Jeon Y, et al. Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines. Eur J Pharmacol 2004; 502:195-204.
39. Lee JC, Kim J, Park JK, Chung GH, Jang YS. The antioxidant, rather than prooxidant, activities of quercetin on normal cell: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Exp Cell Res 2003; 291:386-397.
40. Manach C, Donovan JL. Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic Res 2004; 38:771-785.