Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells

Molecular Medicine Reports

Volumn 4, Issue 5, 2011, Pages 1017-1023

  Liang, Wenna ^a   Li, Xihai ^a   Li, Candong ^a   Liao, Lianming ^a   Gao, Bizheng ^a   Gan, Huijuan ^a   Yang, Zhaoyang ^a   Liao, Linghong ^a   Chen, Xuzheng ^a  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Mitochondria; Osteosarcoma; Quercetin

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; QUERCETIN;

APOPTOSIS; ARTICLE; CELL VIABILITY; CYTOSTASIS; DRUG STRUCTURE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OSTEOSARCOMA CELL; PROTEIN EXPRESSION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SHAPE; CELL SURVIVAL; CYTOCHROMES C; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OSTEOSARCOMA; QUERCETIN; RNA, MESSENGER;

EID: 79960420834     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.533     Document Type: Article

References (29)

1. Rippo MR, Villanova F, Tomassoni Ardori F, et al: Dexamethasone affects Fas- and serum deprivation-induced cell death of human osteoblastic cells through survivin regulation. Int J Immunopathol Pharmacol 23: 1153-1165, 2010.
2. Oertel S, Blattmann C, Rieken S, et al: Radiotherapy in the treatment of primary osteosarcoma-a single center experience. Tumori 96: 582-588, 2010.
3. Won KY, Lee CH, Kim YW and Park YK: Primary giant-cell-rich osteosarcoma of the urinary bladder: usefulness of osteocalcin and osteonectin immunohistochemical staining and literature review. Pathology 43: 161-164, 2011.
4. Gordon EM and Hall FL: Noteworthy clinical case studies in cancer gene therapy: tumor-targeted Rexin-G advances as an efficacious anti-cancer agent. Int J Oncol 36: 1341-1353, 2010.
5. Chen C, Zhou J and Ji C: Quercetin: a potential drug to reverse multidrug resistance. Life Sci 87: 333-338, 2010.
6. Murakami A, Ashida H and Terao J: Multitargeted cancer prevention by quercetin. Cancer Lett 269: 315-325, 2008.
7. Galluzzo P, Martini C, Bulzomi P, et al: Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms. Mol Nutr Food Res 53: 699-708, 2009.
8. Chang YF, Hsu YC, Hung HF, et al: Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutr Cancer 61: 735-745, 2009.
9. Suh DK, Lee EJ, Kim HC and Kim JH: Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. Arch Pharm Res 33: 781-785, 2010.
10. Ferraresi R, Troiano L, Pinti M, et al: Resistance of mtDNA-depleted cells to apoptosis. Cytometry A 73: 528-537, 2008. (Pubitemid 351812850)
11. Wakshlag JJ and Balkman CE: Effects of lycopene on proliferation and death of canine osteosarcoma cells. Am J Vet Res 71: 1362-1370, 2010.
12. Landriscina M, Laudiero G, Maddalena F, et al: Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. Cancer Res 70: 6577-6586, 2010.
13. Cao X, Bennett RL and May WS: c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis. J Biol Chem 283: 14490-14496, 2008.
14. Manfredi G, Kwong JQ, Oca-Cossio JA, et al: BCL-2 improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA. J Biol Chem 278: 5639-5645, 2003. (Pubitemid 36800806)
15. Soriano ME and Scorrano L: The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis. Adv Exp Med Biol 687: 97-114, 2010.
16. Ryu SY, Peixoto PM, Teijido O, Dejean LM and Kinnally KW: Role of mitochondrial ion channels in cell death. Biofactors 36: 255-263, 2010.
17. Autret A and Martin SJ: Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Mol Cell 36: 355-363, 2009.
18. Broadhead ML, Clark JC, Dass CR, Choong PF and Myers DE: Therapeutic targeting of osteoclast function and pathways. Expert Opin Ther Targets 15: 169-181, 2011.
19. Colomer R and Menéndez JA: Mediterranean diet, olive oil and cancer. Clin Transl Oncol 8: 15-21, 2006.
20. Roomi MW, Roomi N, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol Rep 14: 807-815, 2005.
21. Zanini C, Giribaldi G, Mandili G, et al: Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines. J Neurochem 103: 1344-1354, 2007. (Pubitemid 47631803)
22. Vargas AJ and Burd R: Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Nutr Rev 68: 418-428, 2010.
23. Park H, Bergeron E, Senta H, et al: Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways. Biochem Biophys Res Commun 399: 446-451, 2010.
24. Gazitt Y, Kolaparthi V, Moncada K, Thomas C and Freeman J: Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. Int J Oncol 34: 551-561, 2009.
25. Gagiannis S, Müller M, Uhlemann S, et al: Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. Int J Cancer 125: 1551-1557, 2009.
26. Leibowitz B and Yu J: Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther 9: 417-422, 2010.
27. Kaseta MK, Khaldi L, Gomatos IP, et al: Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. J Surg Oncol 97: 259-266, 2008. (Pubitemid 351312167)
28. Eliseev RA, Dong YF, Sampson E, et al: Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene 27: 3605-3614, 2008. (Pubitemid 351793799)
29. Lim ML, Chen B, Beart PM and Nagley P: Relative timing of redistribution of cytochrome c and Smac/DIABLO from mitochondria during apoptosis assessed by double immunocytochemistry on mammalian cells. Exp Cell Res 312: 1174-1184, 2006.