Quercetin Enhances the Antitumor Activity of Trichostatin A through Upregulation of p53 Protein Expression In Vitro and In Vivo

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Chan, Shu Ting ^a   Yang, Nae Cherng ^a   Huang, Chin Shiu ^b   Liao, Jiunn Wang ^c   Yeh, Shu Lan ^a,d  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; HISTONE H4; PROTEIN P53; QUERCETIN; SMALL INTERFERING RNA; TRICHOSTATIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG MEGADOSE; DRUG POTENTIATION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LUNG CANCER; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; HYDROXAMIC ACIDS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; QUERCETIN; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 84872475894     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054255     Document Type: Article

References (47)

1. Henderson C, Mizzau M, Paroni G, Maestro R, Schneider C, et al. (2003) Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J Biol Chem. 278: 12579-12589.
2. Dokmanovic M, Marks PA, (2005) Prospects: histone deacetylase inhibitors. J Cell Biochem 96: 293-304.
3. Seo SK, Jin HO, Woo SH, Kim YS, An S, et al. (2011) Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. J Thorac Oncol 6: 1313-1319.
4. Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, et al. (2006) Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Exp Mol Med 38: 616-624.
5. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H, (2007) The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. J Surg Res 142: 219-226.
6. Chang J, Varghese DS, Gillam MC, Peyton M, Modi B, et al. (2012) Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. Br J Cancer 106: 116-125.
7. Wang X, Li G, Wang A, Zhang Z, Merchan JR, et al. (2011) Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. Mol Carcinog [Epub ahead of print].
8. Karagiannis TC, Lin AJ, Ververis K, Chang L, Tang MM, et al. (2010) Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. Aging (Albany NY) 2: 659-668.
9. Ganslmayer M, Ocker M, Zopf S, Leitner S, Hahn EG, et al. (2004) A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. Oncol Rep 11: 943-950.
10. Mai Z, Blackburn GL, Zhou JR, (2007) Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis 28: 1217-1223.
11. Samuel T, Fadlalla K, Mosley L, Katkoori V, Turner T, et al. (2012) Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells. Anticancer Res 32: 61-71.
12. Shu L, Khor TO, Lee JH, Boyanapalli SS, Huang Y, et al. (2011) Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells, AAPS J. 13: 6-14.
13. Lamson DW, Brignall MS, (2000) Antioxidants and cancer, part 3: quercetin. Altern Med Rev 5: 196-208.
14. Xavier CP, Lima CF, Rohde M, Pereira-Wilson C, (2011) Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. Cancer Chemother Pharmacol 68: 1449-1457.
15. Pfahl M, (1998) Retinoid related molecules: new promises against lung and breast cancer. Expert Opin Investig Drugs 7: 601-606.
16. Divisi D, Di Tommaso S, Salvemini S, Garramone M, Crisci R, (2006) Diet and cancer. Acta Biomed 77: 118-123.
17. Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, et al. (2010) The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol 649: 84-91.
18. Chan ST, Chuang CH, Yeh CL, Liao JW, Liu KL, et al. (2012) Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a]pyrene alone or in combination with β-carotene: in vivo and ex vivo studies. J Nutr Biochem 223: 179-185.
19. Staedler D, Idrizi E, Kenzaoui BH, Juillerat-Jeanneret L, (2011) Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells. Cancer Chemother Pharmacol 68: 1161-1172.
20. Chen J, Kang JH, (2005) Quercetin and trichostatin A cooperatively kill human leukemia cells. Pharmazie 60: 856-860.
21. Tanigawa S, Fujii M, Hou DX, (2008) Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells. Biosci Biotechnol Biochem 2: 797-804.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
23. Cantor JP, Iliopoulos D, Rao AS, Druck T, Semba S, et al. (2007) Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. Int J Cancer 120: 24-31.
24. de Boer VC, Dihal AA, van der Woude H, Arts IC, Wolffram S, et al. (2005) Tissue distribution of quercetin in rats and pigs. J Nutr 135: 1718-1725.
25. Ramos-Vara JA, (2005) Technical aspects of immunohistochemistry. Vet Pathol 42: 405-426.
26. de Kok TM, van Breda SG, Manson MM, (2008) Mechanisms of combined action of different chemopreventive dietary compounds: a review. Eur J Nutr 47: 51-59.
27. Shiau RJ, Chen KY, Wen YD, Chuang CH, Yeh SL, (2010) Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. Eur J Nutr 49: 19-25.
28. Ashcroft M, Vousden KH, (1999) Regulation of p53 stability. Oncogene 18: 7637-43.
29. Roos WP, Kaina B (2012) DNA damage-induced apoptosis: from specific DNA lesions to the DNA damage response and apoptosis. Cancer letters 2012. [Epub ahead of print].
30. Chou CC, Yang JS, Lu HF, Ip SW, Lo C, et al. (2010) Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch Pharm Res 33: 1181-1191.
31. Haupt S, Berger M, Goldberg Z, Haupt Y, (2003) Apoptosis- the p53 network. J Cell Sci 116: 4077-85.
32. Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y, (2009) Tumor suppression by p53: the importance of apoptosis and cellular senescence. J Pathol 219: 3-15.
33. Thangasamy T, Sittadjody S, Lanza-Jacoby S, Wachsberger PR, Limesand KH, et al. (2007) Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase. Nutr Cancer 59: 258-68.
34. Beniston RG, Morgan IM, O'Brien V, Campo MS, (2001) Quercetin, E7 and p53 in papillomavirus oncogenic cell transformation. Carcinogenesis 22: 1069-76.
35. Reed JC, Jurgensmeier JM, Matsuyama S, (1998) Bcl-2 family proteins and mitochondria. Biochim Biophys Acta 1366: 127-137.
36. Soengas MS, Alarcón RM, Yoshida H, Giaccia AJ, Hakem R, et al. (1999) Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159.
37. Miyashita T, Reed JC, (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
38. Bouvard V, Zaitchouk T, Vacher M, Duthu A, Canivet M, et al. (2000) Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene 19: 649-660.
39. Hsu HS, Lin JH, Huang WS, Hsu TW, Su K, et al. (2011) Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27. Cancer 117: 1516-1528.
40. Choi YH, (2005) Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. Int J Oncol 27: 473-479.
41. Amaral JD, Xavier JM, Steer CJ, Rodrigues CM, (2010) The role of p53 in apoptosis. Discov Med 9: 145-52.
42. Zhu WG, Lakshmanan RR, Beal MD, Otterson GA, (2001) DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors, Cancer Res. 61: 1327-1333.
43. Ocker M, Schneider-Stock R, (2007) Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Int J Biochem Cell Biol 39: 1367-1374.
44. Gahr S, Peter G, Wissniowski TT, Hahn EG, Herold C, et al. (2008) The histone-deacetylase inhibitor MS-275 and the CDK-inhibitor CYC-202 promote anti-tumor effects in hepatoma cell lines. Oncol Rep 20: 1249-1256.
45. Gartel AL, Tyner AL, (1999) Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp Cell Res 246: 280-289.
46. Lee E, Furukubo T, Miyabe T, Yamauchi A, Kariya K, (1996) Involvement of histone hyperacetylation in triggering DNA fragmentation of rat thymocytes undergoing apoptosis. FEBS Lett 395: 183-187.
47. Jia J, Chen J, (2008) Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. Pharmazie 63: 379-383.