In vitro antioxidant and antiproliferative activities of Flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) leaves

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 65, Issue 3-4, 2010, Pages 180-186

  Said, Ataa ^a   Tundis, Rosa ^b   Hawas, Usama W ^a   El Kousy, Salah M ^c   Rashed, Khaled ^a   Menichini, Federica ^b   Bonesi, Marco ^b   Huefner, Antje ^d   Loizzo, Monica Rosa ^b   Menichini, Francesco ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b UNIVERSITY OF CALABRIA   (Italy)

^c Menoufia University   (Egypt)

^d UNIVERSITY OF GRAZ   (Austria)

Author keywords

Ailanthus excelsa flavonoids; Antioxidant; Antiproliferative

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; ANTIOXIDANT; BIPHENYL DERIVATIVE; FLAVONOID; PICRIC ACID; SCAVENGER;

AILANTHUS; ARTICLE; CELL DIVISION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; EGYPT; FIBROBLAST; HUMAN; ISOLATION AND PURIFICATION; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; PLANT LEAF; SKIN; TUMOR CELL LINE;

AILANTHUS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CELL DIVISION; CELL LINE, TUMOR; EGYPT; FIBROBLASTS; FLAVONOIDS; FREE RADICAL SCAVENGERS; HUMANS; OXIDATION-REDUCTION; PICRATES; PLANT LEAVES; SKIN;

EID: 77953076893     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2010-3-403     Document Type: Article

References (34)

1. Adamik K. and Brauns F. E. (1957), Ailanthus glen-dulosa (tree-of-heaven) as a pulpwood. TAPPI 40, 522-527.
2. Agullo G., Gamet-Payrastre L., Manenti S., Viala C., Remesy C., Chap H., and Payrastre B. (1997), Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Bio-chem. Pharmacol. 53, 1649-1657.
3. Arcamone F., Cassinelli G., and Casazza A. M. (1980), New antitumor drugs from plants. J. Ethnopharmacol. 2, 149-160.
4. Benzie I. F. and Strains J. J. (1996), The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Anal. Biochem. 239,70-76.
5. British Pharmacopoeia (1988), II. H. M. Stationary Office, London, p. 704.
6. Brusselmans K., Vrolix R., Verhoeven G., and Swinnen J. V. (2005), Induction of cancer cell apoptosis by fla-vonoids is associated with their ability to inhibit fatty acid synthase activity. J. Biol. Chem. 280, 5636-5645.
7. Chen Z. P., Schell J. B., Ho C. T., and Chen K. Y. (1998), Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Lett. 129,173-179.
8. Chen D., Daniel K. G., Chen M. S., Kuhn D. J., Landis-Piwowar K. R., and Dou Q. P. (2005), Dietary flavo-noids as proteasome inhibitors and apoptosis induc-ers in human leukemia cells. Biochem. Pharmacol. 69, 1421-1432.
9. Constantinou A., Mehta R., Runyan C., Rao K., Vaughan A., and Moon R. (1995), Flavonoids as DNA topo-isomerase antagonists and poisons: structure-activity relationships. J. Nat. Prod. 58, 217-225.
10. Cragg G. M. and Newman D. J. (2005), Plants as source of anticancer agents. J. Ethnopharmacol. 100, 72-79.
11. Dhanasekaran S., Suresh B., Sethuraman M., Rajan S., and Dubey R. (1993), Antifertility activity of Ailan-thus excelsa Linn. in female albino rats. Indian J. Exp. Biol. 31, 384-385.
12. Flamini G., Antognoli E., and Morelli I. (2001), Two fla-vonoids and other compounds from the aerial parts of Centaurea bracteata from Italy. Phytochemistry 57, 559-564.
13. Foo L. Y., Lu Y., Molan A. L., Woodfield D. R., and Mc-Nabb W. C. (2000), The phenols and prodelphinidins of white clover flowers. Phytochemistry 54, 539-548.
14. Galati G. and O'Brien P. J. (2004), Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic. Biol. Med. 37, 287-303.
15. Halliwell B. and Gutteridge J. M. C. (1990), Role of free radicals and catalytic metal ions in human disease: an overview. Meth. Enzymol. 186, 1-85.
16. Joshi B. C., Pandey A., Sharma R. P., and Khare A. (2003a), Quassinoids from Ailanthus excelsa. Phyto-chemistry 62, 579-584.
17. Joshi B. C., Pandey A., Chaurasia L., Pal M., SharmaR. P., and Khare A. (2003b). Antifungal activity ofthe stem bark of Ailanthus excelsa. Fitoterapia 74, 689-691.
18. Lepley D. M., Li B., Birt D. F., and Pelling J. C. (1996), The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes. Carcinogenesis 17, 2367-2375.
19. Loizzo M. R., Tundis R., Statti G. A., Menichini F., and Houghton P. J. (2005), In vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from Senecio leucanthemifolius Poiret. J.Pharm. Pharmacol. 57, 897-902.
20. Loizzo M. R., Said A., Tundis R., Rashed K., Statti G. A., Hufner A., and Menichini F. (2007), Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb.) (Simarou-baceae). Phytother. Res. 21, 32-36.
21. Loizzo M. R., Menichini F., Conforti F., Tundis R., Bonesi M., Saab A. M., Statti G. A., de Cindio B., Houghton P. J., Menichini F., and Frega N. G. (2009a), Chemical analysis, antioxidant, antiinflammatory and anticholinesterase activities of Origanum ehrenbergii Boiss. and Origanum syriacum L. essential oils. Food Chem. 117, 174-180.
22. Loizzo M. R., Said A., Tundis R., Hawas U. W., Rashed K., Menichini F., Frega N. G., and Menichini F. (2009b), Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds. Plant Foods Hum. Nutr. 64, 264-270.
23. Nag A. and Matai S. (1994), Ailanthus excelsa Roxb. (Si-maroubacae), a promising source of leaf protein. J. Agric. Food Chem. 42,1115-1117.
24. Nakasugi T. and Komai K. (1998), Antimutagens in the Brazilian folk medicinal plant carqueja (Baccharis trimera Less.). J. Agric. Food Chem. 46, 2560-2564.
25. Narayanan B. A., Geoffroy O., Willingham M. C., Re G. G., and Nixon D. W. (1999), p53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and ap-optosis in ellagic acid treated cancer cells. Cancer Lett. 136, 215-221.
26. Ogura M., Cordell G. A., Kinghorn A. D., and Farns-worth N. R. (1977), Potential anticancer agents VI. Constituents of Ailanthus excelsa (Simaroubaceae). Lloydia 40, 579-584.
27. Panayiotidis M. (2008), Reactive oxygen species (ROS) in multistage carcinogenesis. Cancer Lett. 266, 3-6.
28. Plaumann B., Fritsche M., Rimpler H., Brandner G., and Hess R. D. (1996), Flavonoids activate wild-type p53. Oncogene 13, 1605-1614.
29. Rice-Evans C. A., Miller N. T., and Paganga G. (1997), Antioxidant properties of phenolic compounds. Trends Plant Sci. 4, 304-309.
30. Sanbongi C., Osakabe N., Natsume M., Takizawa T., Gomi S., and Osawa T. (1998), Antioxidative polyphe-nols isolated from Theobroma cacao. J. Agric. Food Chem. 46, 454-457.
31. Scambia G., Panici P. B., Ranelletti F. O., Ferrandina G., De Vincenzo R., Piantelli M., Masciullo V., Bonanno G., Isola G., and Mancuso S. (1994), Quercetin enhances transforming growth factor beta 1 secretion by human ovarian cancer cells. Int. J. Cancer 57, 211-215.
32. Sherman M. M., Borris R. P., Ogura M., Cordell G. A., and Farnsworth N. R. (1980), 35,245,25-Trihydroxy-tirucall-7-ene from Ailanthus excelsa. Phytochemistry 19, 1499-1501.
33. Shrimali M., Jain D. C., Darokar M. P., and Sharma R. P. (2001), Antibacterial activity of Ailanthus excelsa (Roxb.). Phytother. Res. 15, 165-166.
34. Uddin S. and Choudhry M. A. (1995), Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells. Biochem. Mol. Biol. Int. 36, 545-550