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Volumn 19, Issue 5, 2005, Pages 895-910

The antitumor activities of flavonoids

Author keywords

Angiogenesis; Apoptosis; Flavonoids; Focal adhesion kinase; Invasion; Matrix metalloproteinase; Migration; Protein tyrosine kinase; Review

Indexed keywords

5,7,3',4' TETRAHYDROXY 3 GLYCOSYLOXYFLAVONE; ANTHOCYANIDIN; ANTINEOPLASTIC AGENT; APIGENIN; BENZOPYRAN DERIVATIVE; CATECHIN; CHROMAN DERIVATIVE; FISETIN; FLAVAN DERIVATIVE; FLAVONE; FLAVONOID; FLAVONOL; FOCAL ADHESION KINASE; GENISTEIN; ISOFLAVONE; KAEMPFEROL; LUTEOLIN; MATRIX METALLOPROTEINASE; NARINGENIN; PHENYL GROUP; PLANT MEDICINAL PRODUCT; POLYPHENOL; PROANTHOCYANIDIN; PROTEIN KINASE; PROTEIN TYROSINE KINASE; QUERCETIN; TAXIFOLIN; TOCOPHEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; WOGONIN;

EID: 23044455268     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (625)

References (178)
  • 2
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • Harborne JB and Williams CA: Advances in flavonoid research since 1992. Phytochemistry 55: 481-504, 2000.
    • (2000) Phytochemistry , vol.55 , pp. 481-504
    • Harborne, J.B.1    Williams, C.A.2
  • 3
    • 85005732363 scopus 로고
    • Flavonols and flavones in food plants: A review
    • Herrmann K: Flavonols and flavones in food plants: a review. J Food Technol 11: 433-448, 1976.
    • (1976) J. Food Technol. , vol.11 , pp. 433-448
    • Herrmann, K.1
  • 4
    • 0016906546 scopus 로고
    • The flavonoids: A class of semi-essential food components: Their role in human nutrition
    • Kühnau J: The flavonoids: a class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 24: 117-191, 1976.
    • (1976) World Rev. Nutr. Diet. , vol.24 , pp. 117-191
    • Kühnau, J.1
  • 8
    • 33751391867 scopus 로고
    • Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
    • Hertog MGL, Hollman PCH and Katan MB: Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agric Food Chem 40: 2379-2383, 1992.
    • (1992) J. Agric. Food Chem. , vol.40 , pp. 2379-2383
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3
  • 9
    • 0031613667 scopus 로고    scopus 로고
    • Bioavailability and health effects of dietary flavonols in man
    • Hollman PC and Katan MB: Bioavailability and health effects of dietary flavonols in man. Arch Toxicol Suppl 20: 237-248, 1998.
    • (1998) Arch. Toxicol. Suppl. , vol.20 , pp. 237-248
    • Hollman, P.C.1    Katan, M.B.2
  • 10
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
    • Hertog MGL, Hollman PCH, Katan MB and Kromhout D: Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 20: 21-29, 1993.
    • (1993) Nutr. Cancer , vol.20 , pp. 21-29
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3    Kromhout, D.4
  • 11
    • 0033637140 scopus 로고    scopus 로고
    • The impact of plant flavonoids on mammalian biology: Implications for inflammations, heart disease and cancer
    • Middleton E Jr, Kandaswami C and Theoharidis TC: The impact of plant flavonoids on mammalian biology: implications for inflammations, heart disease and cancer. Pharmacol Rev 52: 673-751, 2000.
    • (2000) Pharmacol. Rev. , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharidis, T.C.3
  • 12
    • 0028644238 scopus 로고
    • Free radical scavenging and antioxidant activity of plant flavonoids
    • Kandaswami C and Middleton E Jr: Free radical scavenging and antioxidant activity of plant flavonoids. Adv Experimen Med Biol 366: 351-376, 1994.
    • (1994) Adv. Experimen. Med. Biol. , vol.366 , pp. 351-376
    • Kandaswami, C.1    Middleton Jr., E.2
  • 13
    • 0000952836 scopus 로고    scopus 로고
    • Flavonoids as antioxidants
    • Shahihi E (ed.). ACS Press, Champagne, Illinois
    • Kandaswami C and Middleton E Jr: Flavonoids as antioxidants. In: Natural Antioxidants. Shahihi E (ed.). ACS Press, Champagne, Illinois, pp. 174-203, 1997.
    • (1997) Natural Antioxidants , pp. 174-203
    • Kandaswami, C.1    Middleton Jr., E.2
  • 14
    • 0026583736 scopus 로고
    • Effects of flavonoids on immune and inflammatory cell function
    • Middleton E Jr and Kandaswami C: Effects of flavonoids on immune and inflammatory cell function. Biochem Pharmaco 43: 1167-1179, 1992.
    • (1992) Biochem. Pharmaco. , vol.43 , pp. 1167-1179
    • Middleton Jr., E.1    Kandaswami, C.2
  • 15
    • 84892138934 scopus 로고
    • The impact of plant flavonoids on mammalian biology: Implications for immunity, inflammation and cancer
    • Harborne JB (eds.). Chapman and Hall, London
    • Middleton E Jr and Kandaswami C: The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In: The Flavonoids: Advances in Research. Harborne JB (eds.). Chapman and Hall, London, pp. 619-649, 1993.
    • (1993) The Flavonoids: Advances in Research , pp. 619-649
    • Middleton Jr., E.1    Kandaswami, C.2
  • 16
    • 0028547392 scopus 로고
    • Potential health-promoting properties of citrus flavonoids
    • Middleton E Jr and Kandaswami C: Potential health-promoting properties of citrus flavonoids. Food Tech 48: 115-119, 1994.
    • (1994) Food Tech. , vol.48 , pp. 115-119
    • Middleton Jr., E.1    Kandaswami, C.2
  • 18
    • 0032756794 scopus 로고    scopus 로고
    • Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor
    • Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, Huang CJ, Kandaswami C, Middleton E Jr and Lee MT: Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 128: 999-1010, 1999.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 999-1010
    • Huang, Y.T.1    Hwang, J.J.2    Lee, P.P.3    Ke, F.C.4    Huang, J.H.5    Huang, C.J.6    Kandaswami, C.7    Middleton Jr., E.8    Lee, M.T.9
  • 20
    • 0025719041 scopus 로고
    • Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet
    • Adlercreutz H, Honjo H, Higashi A, Fotsis T, Hamalainen E, Hasegawa T and Okada H: Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr 54: 1093-1100, 1991.
    • (1991) Am. J. Clin. Nutr. , vol.54 , pp. 1093-1100
    • Adlercreutz, H.1    Honjo, H.2    Higashi, A.3    Fotsis, T.4    Hamalainen, E.5    Hasegawa, T.6    Okada, H.7
  • 23
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin D, Varmus HE, Bishop JM, and Vogt P: DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260: 170-173, 1970.
    • (1970) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.4
  • 24
    • 0028069064 scopus 로고
    • Signaling pathways as targets for anticancer drug development
    • Powis G: Signaling pathways as targets for anticancer drug development. Pharmacol Ther 62: 57-95, 1994.
    • (1994) Pharmacol. Ther. , vol.62 , pp. 57-95
    • Powis, G.1
  • 25
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A and Gazit A: Tyrosine kinase inhibition: an approach to drug development. Science 267: 1782-1788, 1995.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 26
    • 0026578427 scopus 로고
    • Protein-tyrosine kinase inhibitors
    • Burke TR: Protein-tyrosine kinase inhibitors. Drugs Future 17: 119-131, 1992.
    • (1992) Drugs Future , vol.17 , pp. 119-131
    • Burke, T.R.1
  • 27
    • 0031795119 scopus 로고    scopus 로고
    • Protein tyrosine kinase: Structure, substrate specificity and drug discovery
    • Al-Obeidi FA, Wu JJ and Lam KS: Protein tyrosine kinase: structure, substrate specificity and drug discovery. Biopolymers 47: 197-223, 1998.
    • (1998) Biopolymers , vol.47 , pp. 197-223
    • Al-Obeidi, F.A.1    Wu, J.J.2    Lam, K.S.3
  • 28
    • 0016821736 scopus 로고
    • The effect of flavonoids on aerobic glycolysis and growth of tumor cells
    • Soulinna EM, Buchsbaum RN and Racker E: The effect of flavonoids on aerobic glycolysis and growth of tumor cells. Cancer Res 35: 1865-1872, 1975.
    • (1975) Cancer Res. , vol.35 , pp. 1865-1872
    • Soulinna, E.M.1    Buchsbaum, R.N.2    Racker, E.3
  • 30
    • 0025980543 scopus 로고
    • Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro
    • Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G and Middleton E Jr: Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. Cancer Lett 56: 147-152, 1991.
    • (1991) Cancer Lett. , vol.56 , pp. 147-152
    • Kandaswami, C.1    Perkins, E.2    Soloniuk, D.S.3    Drzewiecki, G.4    Middleton Jr., E.5
  • 31
    • 0025363503 scopus 로고
    • Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein
    • Constantinou A, Kiguchi K and Huberman E: Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res 50: 2618-2624, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 2618-2624
    • Constantinou, A.1    Kiguchi, K.2    Huberman, E.3
  • 32
    • 0018337941 scopus 로고
    • Antineoplastic activity and cytotoxicity of flavones, isoflavones and flavanones
    • Edwards JM, Raffauf RF and Quesne WL: Antineoplastic activity and cytotoxicity of flavones, isoflavones and flavanones. J Nat Prod 42: 85-91, 1979.
    • (1979) J. Nat. Prod. , vol.42 , pp. 85-91
    • Edwards, J.M.1    Raffauf, R.F.2    Quesne, W.L.3
  • 34
    • 0036327836 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells
    • Lee LT, Huang YT, Hwang JJ, Lee HPP, Ke FC, Nair MP, Kandaswain C and Lee MT: Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res 22: 1615-1628, 2002.
    • (2002) Anticancer Res. , vol.22 , pp. 1615-1628
    • Lee, L.T.1    Huang, Y.T.2    Hwang, J.J.3    Lee, H.P.P.4    Ke, F.C.5    Nair, M.P.6    Kandaswain, C.7    Lee, M.T.8
  • 38
    • 0031017360 scopus 로고    scopus 로고
    • Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity
    • Kyle E, Neckers L, Takimoto C, Curt G and Bergan R: Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 51: 193-200, 1997.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 193-200
    • Kyle, E.1    Neckers, L.2    Takimoto, C.3    Curt, G.4    Bergan, R.5
  • 39
    • 0035135225 scopus 로고    scopus 로고
    • (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the Min/+ mouse
    • Weyant MJ, Carothers AM, Dannenberg AJ and Bertagnolli MM: (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the Min/+ mouse. Cancer Res 61: 118-125, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 118-125
    • Weyant, M.J.1    Carothers, A.M.2    Dannenberg, A.J.3    Bertagnolli, M.M.4
  • 40
    • 2342543194 scopus 로고    scopus 로고
    • Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: Effect on invasive potential of human carcinoma cells
    • Lee LT, Huang YT, Hwang JJ, Lee AYL, Ke FC, Huang CJ, Kandaswami C, Lee PPH and Lee MT: Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells. Biochem Pharmacol 67: 2103-2114, 2004.
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 2103-2114
    • Lee, L.T.1    Huang, Y.T.2    Hwang, J.J.3    Lee, A.Y.L.4    Ke, F.C.5    Huang, C.J.6    Kandaswami, C.7    Lee, P.P.H.8    Lee, M.T.9
  • 41
    • 0029781370 scopus 로고    scopus 로고
    • Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices
    • So FV, Guthrie N, Chambers AF, Moussa M and Carroll LL: Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 26: 167-181, 1996.
    • (1996) Nutr. Cancer , vol.26 , pp. 167-181
    • So, F.V.1    Guthrie, N.2    Chambers, A.F.3    Moussa, M.4    Carroll, L.L.5
  • 42
    • 0023052241 scopus 로고
    • Studies and perspective of protein kinase C
    • Nishizuka Y: Studies and perspective of protein kinase C. Science (Wash DC) 233: 305-312, 1986.
    • (1986) Science (Wash DC) , vol.233 , pp. 305-312
    • Nishizuka, Y.1
  • 43
    • 0023764824 scopus 로고
    • The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    • Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (London) 334: 661-665, 1988.
    • (1988) Nature (London) , vol.334 , pp. 661-665
    • Nishizuka, Y.1
  • 44
    • 0029060391 scopus 로고
    • Protein kinase and lipid signaling for sustained cellular responses
    • Nishizuka Y: Protein kinase and lipid signaling for sustained cellular responses. FASEB J 9: 484-496, 1995.
    • (1995) FASEB J. , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 45
    • 0017575467 scopus 로고
    • Regulation of cyclic AMP level and lactic acid production in Ehrlich ascites tumor cells
    • Graziani Y, Winikoff J and Chayoth R: Regulation of cyclic AMP level and lactic acid production in Ehrlich ascites tumor cells. Biochim Biophys Acta 497: 499-506, 1977.
    • (1977) Biochim. Biophys. Acta , vol.497 , pp. 499-506
    • Graziani, Y.1    Winikoff, J.2    Chayoth, R.3
  • 46
    • 0021042560 scopus 로고
    • Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin
    • Gschwendt M, Horn F, Kittstein W and Marks F: Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin. Biochem Biophys Res Commun 117: 444-447, 1983.
    • (1983) Biochem. Biophys. Res. Commun. , vol.117 , pp. 444-447
    • Gschwendt, M.1    Horn, F.2    Kittstein, W.3    Marks, F.4
  • 48
    • 0023897154 scopus 로고
    • Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases
    • Hagiwara M, Inoue S, Tanaka T, Nunoki K, Ito M and Hidaka H: Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem Pharmacol 37: 2987-2992, 1988.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2987-2992
    • Hagiwara, M.1    Inoue, S.2    Tanaka, T.3    Nunoki, K.4    Ito, M.5    Hidaka, H.6
  • 49
    • 0024550507 scopus 로고
    • Protein kinase C inhibition by plant flavonoids, kinetic mechanism and structure-activity relationships
    • Ferriola PC, Cody V and Middleton E: Protein kinase C inhibition by plant flavonoids, kinetic mechanism and structure-activity relationships. Biochem Pharmacol 38: 1617-1624, 1989.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1617-1624
    • Ferriola, P.C.1    Cody, V.2    Middleton, E.3
  • 51
    • 0030842112 scopus 로고    scopus 로고
    • Relationship between flavonoid structure and inhibition of phosphatidyolinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition
    • Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Remesy C, Chap H and Payrastre B: Relationship between flavonoid structure and inhibition of phosphatidyolinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53: 1649-1657, 1997.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1649-1657
    • Agullo, G.1    Gamet-Payrastre, L.2    Manenti, S.3    Viala, C.4    Remesy, C.5    Chap, H.6    Payrastre, B.7
  • 52
    • 0030712279 scopus 로고    scopus 로고
    • Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells
    • Kang T and Liang N: Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharmacol 54: 1013-1018, 1997.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1013-1018
    • Kang, T.1    Liang, N.2
  • 54
    • 0020635362 scopus 로고
    • The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo
    • Graziani Y, Erikson E and Erikson RL: The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. Eur J Biochem 135: 583-589, 1983.
    • (1983) Eur. J. Biochem. , vol.135 , pp. 583-589
    • Graziani, Y.1    Erikson, E.2    Erikson, R.L.3
  • 55
    • 0032994563 scopus 로고    scopus 로고
    • Differential effects of flavonoids on inhibition of secretion and on accumulation of secretory granules in rat basophilic leukemia cells
    • Alexandrakis M, Singh L, Boucher W, Letourneau R, Theoflopoulos P and Theoharides TC: Differential effects of flavonoids on inhibition of secretion and on accumulation of secretory granules in rat basophilic leukemia cells. Int J Immunopharmacol 21: 379-390, 1999.
    • (1999) Int. J. Immunopharmacol. , vol.21 , pp. 379-390
    • Alexandrakis, M.1    Singh, L.2    Boucher, W.3    Letourneau, R.4    Theoflopoulos, P.5    Theoharides, T.C.6
  • 57
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A and Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212, 1990.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 59
    • 0023145547 scopus 로고
    • The molecular genetics of cancer
    • Bishop JM: The molecular genetics of cancer. Science 235: 305-311, 1987.
    • (1987) Science , vol.235 , pp. 305-311
    • Bishop, J.M.1
  • 60
    • 0025181752 scopus 로고
    • Mechanism of action in NIH3T3 cells of genistein, an inhibitor of EGFR receptor tyrosine activity
    • Linassie C, Pierre M, Peco JR and Pierre J: Mechanism of action in NIH3T3 cells of genistein, an inhibitor of EGFR receptor tyrosine activity. Biochem Pharmacol 39: 187-193, 1990.
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 187-193
    • Linassie, C.1    Pierre, M.2    Peco, J.R.3    Pierre, J.4
  • 62
    • 0025765803 scopus 로고
    • SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins
    • Koch CA, Anderson D, Moran MF, Ellis C and Pawson T: SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252: 668-674, 1991.
    • (1991) Science , vol.252 , pp. 668-674
    • Koch, C.A.1    Anderson, D.2    Moran, M.F.3    Ellis, C.4    Pawson, T.5
  • 64
    • 0025321157 scopus 로고
    • Epidermal growth factor
    • Carpenter G and Cohen S: Epidermal growth factor. J Biol Chem 265: 7709-7712, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7709-7712
    • Carpenter, G.1    Cohen, S.2
  • 65
    • 0035018353 scopus 로고    scopus 로고
    • Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
    • Lu Z, Jiang G, Blume-Jensen P and Hunter T: Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol 21: 4016-4031, 2001.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 4016-4031
    • Lu, Z.1    Jiang, G.2    Blume-Jensen, P.3    Hunter, T.4
  • 66
    • 0025363503 scopus 로고
    • Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein
    • Constantinou A, Kiguchi K and Huberman E: Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res 50: 2618-2624, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 2618-2624
    • Constantinou, A.1    Kiguchi, K.2    Huberman, E.3
  • 67
    • 37049185280 scopus 로고
    • Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells
    • Merlino GT, Xu YH, Ishii S, Clark AJ, Semba K, Yamamoto T and Pastan I: Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224: 417-419, 1994.
    • (1994) Science , vol.224 , pp. 417-419
    • Merlino, G.T.1    Xu, Y.H.2    Ishii, S.3    Clark, A.J.4    Semba, K.5    Yamamoto, T.6    Pastan, I.7
  • 68
    • 0026044563 scopus 로고
    • Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene
    • Peterson G and Barnes S: Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun 179: 661-667, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 661-667
    • Peterson, G.1    Barnes, S.2
  • 69
    • 0028150702 scopus 로고
    • Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells
    • Pagliacci MC, Smacchia M, Migliorati G, Grignani F, Riccardi C and Nicoletti I: Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells. Eur J Cancer 30A: 1675-1682, 1994.
    • (1994) Eur. J. Cancer , vol.30 A , pp. 1675-1682
    • Pagliacci, M.C.1    Smacchia, M.2    Migliorati, G.3    Grignani, F.4    Riccardi, C.5    Nicoletti, I.6
  • 73
    • 0034693854 scopus 로고    scopus 로고
    • Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
    • Parsons JT, Martin KH, Slack JK, Taylor JM and Weed SA: Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19: 5606-5613, 2000.
    • (2000) Oncogene , vol.19 , pp. 5606-5613
    • Parsons, J.T.1    Martin, K.H.2    Slack, J.K.3    Taylor, J.M.4    Weed, S.A.5
  • 75
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesion by tumor suppressor PTEN
    • Tamura M, Gu J, Matsumoto K, Aota SI, Parsons R and Yamada KM: Inhibition of cell migration, spreading, and focal adhesion by tumor suppressor PTEN. Science 280: 1614-1617, 1998.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.I.4    Parsons, R.5    Yamada, K.M.6
  • 78
    • 0023840974 scopus 로고
    • Cytotoxicity of plant flavonoids against Hela cells
    • Mori A, Nishino C, Enoki N and Tawata S: Cytotoxicity of plant flavonoids against Hela cells. Phytochemistry 27: 1017-1020, 1988.
    • (1988) Phytochemistry , vol.27 , pp. 1017-1020
    • Mori, A.1    Nishino, C.2    Enoki, N.3    Tawata, S.4
  • 81
    • 0025365850 scopus 로고
    • Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein, in human colon cancer cells
    • Hosokawa N, Hosokawa Y, Sakai T, Yoshida M, Marui N, Nishino H, Kawai K and Aoike A: Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein, in human colon cancer cells. Int J Cancer 45: 1119-1124, 1990.
    • (1990) Int. J. Cancer , vol.45 , pp. 1119-1124
    • Hosokawa, N.1    Hosokawa, Y.2    Sakai, T.3    Yoshida, M.4    Marui, N.5    Nishino, H.6    Kawai, K.7    Aoike, A.8
  • 82
    • 0024504945 scopus 로고
    • Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum (II) by the ether lipid analogue BN141440, an inhibitor of protein kinase C
    • Hoffman J, Ueberall F, Posch L, Maly K, Herrmann DB and Grunicke H: Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum (II) by the ether lipid analogue BN141440, an inhibitor of protein kinase C. Lipids 24: 312-317, 1989.
    • (1989) Lipids , vol.24 , pp. 312-317
    • Hoffman, J.1    Ueberall, F.2    Posch, L.3    Maly, K.4    Herrmann, D.B.5    Grunicke, H.6
  • 83
    • 0025239010 scopus 로고
    • Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum (II) by quercetin
    • Hoffman J, Fiebig J, Winterhalter HH, Berger BR and Grunicke H: Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum (II) by quercetin. Int J Cancer 45: 536-539, 1990.
    • (1990) Int. J. Cancer , vol.45 , pp. 536-539
    • Hoffman, J.1    Fiebig, J.2    Winterhalter, H.H.3    Berger, B.R.4    Grunicke, H.5
  • 84
    • 0021354865 scopus 로고
    • Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells
    • Kim JH, Kim SH, Alfieri AA and Young CW: Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. Cancer Res 44: 102-106, 1984.
    • (1984) Cancer Res. , vol.44 , pp. 102-106
    • Kim, J.H.1    Kim, S.H.2    Alfieri, A.A.3    Young, C.W.4
  • 85
    • 0026504102 scopus 로고
    • Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite
    • Kioka M, Hosokawa N, Komano T, Hirayoshi K, Nagata K and Ueda K: Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite. FEBS Lett 301: 307-309, 1992.
    • (1992) FEBS Lett. , vol.301 , pp. 307-309
    • Kioka, M.1    Hosokawa, N.2    Komano, T.3    Hirayoshi, K.4    Nagata, K.5    Ueda, K.6
  • 86
    • 0027476039 scopus 로고
    • Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma in vitro
    • Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G and Middleton E: Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma in vitro. Anticancer Drugs 4: 91-96, 1993.
    • (1993) Anticancer Drugs , vol.4 , pp. 91-96
    • Kandaswami, C.1    Perkins, E.2    Soloniuk, D.S.3    Drzewiecki, G.4    Middleton, E.5
  • 87
    • 0026731522 scopus 로고
    • Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids
    • Kandaswami C, Perkins E, Drzewiecki G, Soloniuk DS and Middleton E: Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. Anticancer Drugs 3: 525-530, 1992.
    • (1992) Anticancer Drugs , vol.3 , pp. 525-530
    • Kandaswami, C.1    Perkins, E.2    Drzewiecki, G.3    Soloniuk, D.S.4    Middleton, E.5
  • 88
    • 0021735606 scopus 로고
    • Inhibition by quercetin of the release of density-dependent inhibition of cell growth in RSV-transformed chicken cells
    • Jullien M, Villaudy J, Golde A and Harel L: Inhibition by quercetin of the release of density-dependent inhibition of cell growth in RSV-transformed chicken cells. Cell Biol Int Rep 8: 939-947, 1984.
    • (1984) Cell Biol. Int. Rep. , vol.8 , pp. 939-947
    • Jullien, M.1    Villaudy, J.2    Golde, A.3    Harel, L.4
  • 89
  • 95
    • 0343143817 scopus 로고
    • Synthesis and evaluation of substituted flavones as inhibitors of tyrosine protein kinase
    • Cunningham BDM, Threadgill MD and Hickman HA: Synthesis and evaluation of substituted flavones as inhibitors of tyrosine protein kinase. Br J Cancer 56: 207, 1987.
    • (1987) Br. J. Cancer , vol.56 , pp. 207
    • Cunningham, B.D.M.1    Threadgill, M.D.2    Hickman, H.A.3
  • 98
    • 0028180143 scopus 로고
    • Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468
    • Avila MA, Velasco JA, Cansado J and Notario V: Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 54: 2424-2428, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 2424-2428
    • Avila, M.A.1    Velasco, J.A.2    Cansado, J.3    Notario, V.4
  • 100
    • 0037081274 scopus 로고    scopus 로고
    • Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation
    • Lamy S, Gingras D and Béliveau R: Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res 62: 381-385, 2002.
    • (2002) Cancer Res. , vol.62 , pp. 381-385
    • Lamy, S.1    Gingras, D.2    Béliveau, R.3
  • 101
    • 0034080382 scopus 로고    scopus 로고
    • Tea polyphenols: Prevention of cancer and optimizing health
    • Mukhtar H and Ahmad N: Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 71(suppl): 1698S-1702S, 2000.
    • (2000) Am. J. Clin. Nutr. , vol.71 , Issue.SUPPL.
    • Mukhtar, H.1    Ahmad, N.2
  • 102
    • 0002895975 scopus 로고    scopus 로고
    • General chemical composition of green tea and its infusion
    • Yamamoto T, Juneja LR, Chu D-C and Kim M (eds.). CRC Press New York
    • Chu D-C and Juneja LR: General chemical composition of green tea and its infusion. In: Chemistry and Applications of Green Tea. Yamamoto T, Juneja LR, Chu D-C and Kim M (eds.). CRC Press New York, pp. 13-22, 1997.
    • (1997) Chemistry and Applications of Green Tea , pp. 13-22
    • Chu, D.-C.1    Juneja, L.R.2
  • 103
    • 0026760907 scopus 로고
    • Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines
    • Taniguchi S, Fujiki H, Kobayashi H, Go H, Miyado K, Sadano H and Shimokawa R: Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. Cancer Lett 65: 51-54, 1992.
    • (1992) Cancer Lett. , vol.65 , pp. 51-54
    • Taniguchi, S.1    Fujiki, H.2    Kobayashi, H.3    Go, H.4    Miyado, K.5    Sadano, H.6    Shimokawa, R.7
  • 104
    • 0032547015 scopus 로고    scopus 로고
    • Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts
    • Chen ZP, Schell JB, Ho CT and Chen KY: Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Lett 129(2): 173-179, 1998.
    • (1998) Cancer Lett. , vol.129 , Issue.2 , pp. 173-179
    • Chen, Z.P.1    Schell, J.B.2    Ho, C.T.3    Chen, K.Y.4
  • 105
    • 0347626109 scopus 로고    scopus 로고
    • Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
    • Leone M, Zhai D, Sareth S, Kitada S, Reed JC and Pellecchia M: Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res 63: 8118-8121, 2003.
    • (2003) Cancer Res. , vol.63 , pp. 8118-8121
    • Leone, M.1    Zhai, D.2    Sareth, S.3    Kitada, S.4    Reed, J.C.5    Pellecchia, M.6
  • 106
    • 0033568515 scopus 로고    scopus 로고
    • Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: Structure-activity relationship and mechanisms involved
    • Chung JY., Huang C, Meng X, Dong Z and Yang CS: Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res 59: 4610-4617, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 4610-4617
    • Chung, J.Y.1    Huang, C.2    Meng, X.3    Dong, Z.4    Yang, C.S.5
  • 108
    • 0036669812 scopus 로고    scopus 로고
    • Cancer preventive effects of flavonoids - A review
    • Le Marchand L: Cancer preventive effects of flavonoids - a review. Biomed Pharmacother 56(6): 296-301, 2002.
    • (2002) Biomed. Pharmacother. , vol.56 , Issue.6 , pp. 296-301
    • Le Marchand, L.1
  • 109
    • 0028216956 scopus 로고
    • Soy intake and cancer risk; a review of the in vitro and in vivo data
    • Messina MJ, Persky V, Setchell KDR and Barnes S: Soy intake and cancer risk; a review of the in vitro and in vivo data. Nutr Cancer 21: 114-131, 1994.
    • (1994) Nutr. Cancer , vol.21 , pp. 114-131
    • Messina, M.J.1    Persky, V.2    Setchell, K.D.R.3    Barnes, S.4
  • 112
    • 0025181114 scopus 로고
    • Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations
    • Adlercreutz H: Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand J Clin Lab Invest Suppl 201: 3-21, 1990.
    • (1990) Scand. J. Clin. Lab. Invest. Suppl. , vol.201 , pp. 3-21
    • Adlercreutz, H.1
  • 113
    • 0028898728 scopus 로고
    • Proliferative response of mammary glandular tissue to formononetin
    • Wang W, Tanaka Y, Han Z and Higuchi CM: Proliferative response of mammary glandular tissue to formononetin. Nutr Cancer 23: 131-140, 1995.
    • (1995) Nutr. Cancer , vol.23 , pp. 131-140
    • Wang, W.1    Tanaka, Y.2    Han, Z.3    Higuchi, C.M.4
  • 115
    • 0029894529 scopus 로고    scopus 로고
    • ICE/CED-3 proteases in apoptosis
    • Whyte M: ICE/CED-3 proteases in apoptosis. Trends Cell Biol 6: 245-248, 1996.
    • (1996) Trends Cell Biol. , vol.6 , pp. 245-248
    • Whyte, M.1
  • 116
    • 0033593572 scopus 로고    scopus 로고
    • Cell death in development
    • Vaux DL and Korsmeyer SJ: Cell death in development. Cell 96: 245-254, 1999.
    • (1999) Cell , vol.96 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 117
    • 0031897258 scopus 로고    scopus 로고
    • Proteolytic activities that mediate apoptosis
    • Kidd VJ: Proteolytic activities that mediate apoptosis. Annu Rev Physiol 60: 533-573, 1998.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 533-573
    • Kidd, V.J.1
  • 118
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371(6495): 346-347, 1994.
    • (1994) Nature , vol.371 , Issue.6495 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 119
    • 0030947095 scopus 로고    scopus 로고
    • Programmed cell death in animal development
    • Jacobson MD, Weil M and Raff MC: Programmed cell death in animal development. Cell 88(3): 347-354, 1997.
    • (1997) Cell , vol.88 , Issue.3 , pp. 347-354
    • Jacobson, M.D.1    Weil, M.2    Raff, M.C.3
  • 120
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S: Apoptosis by death factor. Cell 88(3): 355-365, 1997.
    • (1997) Cell , vol.88 , Issue.3 , pp. 355-365
    • Nagata, S.1
  • 121
    • 0034057320 scopus 로고    scopus 로고
    • Apoptosis in cancer
    • Lowe SW and Lin AW: Apoptosis in cancer. Carcinogenesis 21(3): 485-495, 2000.
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 485-495
    • Lowe, S.W.1    Lin, A.W.2
  • 122
    • 0026471968 scopus 로고
    • Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells
    • Traganos F, Ardelt B, Halko M, Bruno S and Darzynkiewicz Z: Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res 52: 6200-6208, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 6200-6208
    • Traganos, F.1    Ardelt, B.2    Halko, M.3    Bruno, S.4    Darzynkiewicz, Z.5
  • 123
    • 0026494972 scopus 로고
    • Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism
    • Tilly JL, Billig H, Kowalski KI and Hsueh AJ: Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Mol Endocrinol 6: 1942-1950, 1992.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1942-1950
    • Tilly, J.L.1    Billig, H.2    Kowalski, K.I.3    Hsueh, A.J.4
  • 124
    • 0027771781 scopus 로고
    • Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines
    • Bergamaschi G, Rosti V, Danova M, Ponchio L, Lucotti C and Cazzola M: Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines. Leukemia 7: 2012-2018, 1993.
    • (1993) Leukemia , vol.7 , pp. 2012-2018
    • Bergamaschi, G.1    Rosti, V.2    Danova, M.3    Ponchio, L.4    Lucotti, C.5    Cazzola, M.6
  • 125
    • 0029597877 scopus 로고
    • Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes
    • Hirano T, Abe K, Gotoh M and Oka K: Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 72(6): 1380-1388, 1995.
    • (1995) Br. J. Cancer , vol.72 , Issue.6 , pp. 1380-1388
    • Hirano, T.1    Abe, K.2    Gotoh, M.3    Oka, K.4
  • 126
    • 0028000264 scopus 로고
    • Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils
    • Yousefi S, Green DR, Blaser K and Simon HU: Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc Natl Acad Sci (USA) 91: 10868-10872, 1994.
    • (1994) Proc. Natl. Acad. Sci. (USA) , vol.91 , pp. 10868-10872
    • Yousefi, S.1    Green, D.R.2    Blaser, K.3    Simon, H.U.4
  • 127
    • 0032856994 scopus 로고    scopus 로고
    • Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
    • Wang IK, Lin-Shiau SY and Lin JK: Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 35(10): 1517-1525, 1999.
    • (1999) Eur. J. Cancer , vol.35 , Issue.10 , pp. 1517-1525
    • Wang, I.K.1    Lin-Shiau, S.Y.2    Lin, J.K.3
  • 129
    • 0842325655 scopus 로고    scopus 로고
    • Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells
    • Shukla S and Gupta S: Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells. Mol Carcinog 39(2): 114-126, 2004.
    • (2004) Mol. Carcinog. , vol.39 , Issue.2 , pp. 114-126
    • Shukla, S.1    Gupta, S.2
  • 130
    • 0035212167 scopus 로고    scopus 로고
    • Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest
    • Ikezoe T, Chen SS, Heber D, Taguchi H and Koeffler HP: Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. Prostate 49(4): 285-292, 2001.
    • (2001) Prostate , vol.49 , Issue.4 , pp. 285-292
    • Ikezoe, T.1    Chen, S.S.2    Heber, D.3    Taguchi, H.4    Koeffler, H.P.5
  • 131
    • 0030930265 scopus 로고    scopus 로고
    • Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells
    • Liang YC, Lin-Shiau SY, Chen CF and Lin JK: Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells. J Cell Biochem 67(1): 55-65, 1997.
    • (1997) J. Cell Biochem. , vol.67 , Issue.1 , pp. 55-65
    • Liang, Y.C.1    Lin-Shiau, S.Y.2    Chen, C.F.3    Lin, J.K.4
  • 132
    • 0034694870 scopus 로고    scopus 로고
    • Bioflavonoid quercetin inhibits mitosis and apoptosis of glomerular cells in vitro and in vivo
    • Ishikawa Y and Kitamura M: Bioflavonoid quercetin inhibits mitosis and apoptosis of glomerular cells in vitro and in vivo. Biochem Biophys Res Commun 279(2): 629-634, 2000.
    • (2000) Biochem. Biophys. Res. Commun. , vol.279 , Issue.2 , pp. 629-634
    • Ishikawa, Y.1    Kitamura, M.2
  • 133
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS and Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327-336, 1991.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 134
    • 0027400462 scopus 로고
    • Antimetastatic prostacyclin analog
    • Schneider MR and Schirner M: Antimetastatic prostacyclin analog. Drugs Future 18: 29-48, 1993.
    • (1993) Drugs Future , vol.18 , pp. 29-48
    • Schneider, M.R.1    Schirner, M.2
  • 135
    • 0030044480 scopus 로고    scopus 로고
    • Matrix metalloproteinases 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer
    • Liabakk NB, Talbot I, Smith RA, Wilkinson K and Balkwill F: Matrix metalloproteinases 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res 56: 190-196, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 190-196
    • Liabakk, N.B.1    Talbot, I.2    Smith, R.A.3    Wilkinson, K.4    Balkwill, F.5
  • 137
    • 0027251836 scopus 로고
    • A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
    • Davies B, Brown PD, East N, Crimmin MJ and Balkwill FR: A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 53: 2087-2091, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 2087-2091
    • Davies, B.1    Brown, P.D.2    East, N.3    Crimmin, M.J.4    Balkwill, F.R.5
  • 138
    • 0028178968 scopus 로고
    • Expression and activity of MMPs and their regulators in ovarian cancer
    • Naylor MS, Stamp GW, Davies BD and Balkwill FR: Expression and activity of MMPs and their regulators in ovarian cancer. Int J Cancer 58: 50-56, 1994.
    • (1994) Int. J. Cancer , vol.58 , pp. 50-56
    • Naylor, M.S.1    Stamp, G.W.2    Davies, B.D.3    Balkwill, F.R.4
  • 141
    • 0031663622 scopus 로고    scopus 로고
    • Roles of the matrix metalloproteinases in mammary gland development and cancer
    • Benaud C, Dickson RB and Thompson EW: Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Res Treat 50: 97-116, 1998.
    • (1998) Breast Cancer Res. Treat. , vol.50 , pp. 97-116
    • Benaud, C.1    Dickson, R.B.2    Thompson, E.W.3
  • 142
    • 0029824947 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system
    • Hua J and Muschel R: Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system. Cancer Res 56: 5279-5284, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 5279-5284
    • Hua, J.1    Muschel, R.2
  • 143
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remolding
    • Matrisian LM: Metalloproteinases and their inhibitors in matrix remolding. Trends Genet 6: 121-125, 1990.
    • (1990) Trends Genet. , vol.6 , pp. 121-125
    • Matrisian, L.M.1
  • 144
    • 0026536653 scopus 로고
    • Cancer cell invasion and metastasis
    • Liotta LA: Cancer cell invasion and metastasis. Medicine Sci Am 266: 54-59, 62-63, 1992.
    • (1992) Medicine Sci. Am. , vol.266 , Issue.54-59 , pp. 62-63
    • Liotta, L.A.1
  • 145
    • 0036569084 scopus 로고    scopus 로고
    • RECKing MMP function: Implications for cancer development
    • Rhee JS and Coussens LM: RECKing MMP function: implications for cancer development. Trends Cell Biol 12(5): 209-211, 2002.
    • (2002) Trends Cell Biol. , vol.12 , Issue.5 , pp. 209-211
    • Rhee, J.S.1    Coussens, L.M.2
  • 146
    • 1242337456 scopus 로고    scopus 로고
    • Matrix metalloproteinases in colorectal cancer: Is it worth talking about?
    • Wagenaar-Miller RA, Gorden L and Matrisian LM: Matrix metalloproteinases in colorectal cancer: is it worth talking about? Cancer Metastasis Rev 23(1-2): 119-135, 2004.
    • (2004) Cancer Metastasis Rev. , vol.23 , Issue.1-2 , pp. 119-135
    • Wagenaar-Miller, R.A.1    Gorden, L.2    Matrisian, L.M.3
  • 147
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers AF and Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89(17): 1260-1270, 1997.
    • (1997) J. Natl. Cancer Inst. , vol.89 , Issue.17 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 148
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2(3): 161-174, 2002.
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 149
    • 0031848158 scopus 로고    scopus 로고
    • Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites
    • Beattie GJ and Smyth JF: Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites. Clin Cancer Res 4(8): 1899-1902, 1998.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.8 , pp. 1899-1902
    • Beattie, G.J.1    Smyth, J.F.2
  • 151
    • 0038054004 scopus 로고    scopus 로고
    • Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages
    • Lin N, Sato T, Takayama Y, Mimaki Y, Sashida Y, Yano M and Ito A: Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol 65(12): 2065-2071, 2003.
    • (2003) Biochem. Pharmacol. , vol.65 , Issue.12 , pp. 2065-2071
    • Lin, N.1    Sato, T.2    Takayama, Y.3    Mimaki, Y.4    Sashida, Y.5    Yano, M.6    Ito, A.7
  • 152
    • 0038022616 scopus 로고    scopus 로고
    • Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases
    • Kim MH: Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. J Cell Biochem 89(3): 529-538, 2003.
    • (2003) J. Cell Biochem. , vol.89 , Issue.3 , pp. 529-538
    • Kim, M.H.1
  • 153
    • 0037459043 scopus 로고    scopus 로고
    • Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: Role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9
    • Moon SY, Cho GO, Jung SY, Gal SW, Kwon TY, Lee YC, Madamanchi NR and Kim CH: Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun 301(4): 1069-1078, 2003.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , Issue.4 , pp. 1069-1078
    • Moon, S.Y.1    Cho, G.O.2    Jung, S.Y.3    Gal, S.W.4    Kwon, T.Y.5    Lee, Y.C.6    Madamanchi, N.R.7    Kim, C.H.8
  • 154
    • 0742286824 scopus 로고    scopus 로고
    • Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway
    • Zhang XM, Huang SP and Xu Q: Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway. Cancer Chemother Pharmacol 53(1): 82-88, 2004.
    • (2004) Cancer Chemother. Pharmacol. , vol.53 , Issue.1 , pp. 82-88
    • Zhang, X.M.1    Huang, S.P.2    Xu, Q.3
  • 155
    • 0032212387 scopus 로고    scopus 로고
    • Genistein exerts multiple suppressive effects on human breast carcinoma cells
    • Shao ZM, Wu J, Shen ZZ and Barsky SH: Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 58(21): 4851-4857, 1998.
    • (1998) Cancer Res. , vol.21 , Issue.58 , pp. 4851-4857
    • Shao, Z.M.1    Wu, J.2    Shen, Z.Z.3    Barsky, S.H.4
  • 156
    • 0031855920 scopus 로고    scopus 로고
    • Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines
    • Shao ZM, Wu J, Shen ZZ and Barsky SH: Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines. Anticancer Res 18(3A): 1435-1439, 1998.
    • (1998) Anticancer Res. , vol.18 , Issue.3 A , pp. 1435-1439
    • Shao, Z.M.1    Wu, J.2    Shen, Z.Z.3    Barsky, S.H.4
  • 157
    • 16544382310 scopus 로고    scopus 로고
    • Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro
    • Magee PJ, McGlynn H and Rowland IR: Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. Cancer Lett 208(1): 35-41, 2004.
    • (2004) Cancer Lett. , vol.208 , Issue.1 , pp. 35-41
    • Magee, P.J.1    McGlynn, H.2    Rowland, I.R.3
  • 158
    • 7644242802 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids
    • Ende C and Gebhardt R: Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids. Planta Med 70(10): 1006-1008, 2004.
    • (2004) Planta Med. , vol.70 , Issue.10 , pp. 1006-1008
    • Ende, C.1    Gebhardt, R.2
  • 159
    • 3242884081 scopus 로고    scopus 로고
    • Inhibition of metalloproteinase activity by fruit extracts
    • Tate P, God J, Bibb R, Lu Q and Larcom LL: Inhibition of metalloproteinase activity by fruit extracts. Cancer Lett 212(2): 153-158, 2004.
    • (2004) Cancer Lett. , vol.212 , Issue.2 , pp. 153-158
    • Tate, P.1    God, J.2    Bibb, R.3    Lu, Q.4    Larcom, L.L.5
  • 161
    • 0035865023 scopus 로고    scopus 로고
    • Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate
    • Garbisa S, Sartor L, Biggin S, Salvato B, Benelli R and Albini A: Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 91(4): 822-832, 2001.
    • (2001) Cancer , vol.91 , Issue.4 , pp. 822-832
    • Garbisa, S.1    Sartor, L.2    Biggin, S.3    Salvato, B.4    Benelli, R.5    Albini, A.6
  • 163
    • 0028567131 scopus 로고
    • Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein
    • Scholar EM and Toews ML: Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein. Cancer Lett 87(2): 159-162, 1994.
    • (1994) Cancer Lett. , vol.87 , Issue.2 , pp. 159-162
    • Scholar, E.M.1    Toews, M.L.2
  • 164
    • 0032482434 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties
    • Zhang L, Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C and Hung MC: Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Oncogene 16(22): 2855-2863, 1998.
    • (1998) Oncogene , vol.16 , Issue.22 , pp. 2855-2863
    • Zhang, L.1    Zhang, L.2    Lau, Y.K.3    Xi, L.4    Hong, R.L.5    Kim, D.S.6    Chen, C.F.7    Hortobagyi, G.N.8    Chang, C.9    Hung, M.C.10
  • 170
    • 7444272077 scopus 로고    scopus 로고
    • Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity
    • Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C and Fotsis T: Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity. Cancer Res 64: 7936-7946, 2004.
    • (2004) Cancer Res. , vol.64 , pp. 7936-7946
    • Bagli, E.1    Stefaniotou, M.2    Morbidelli, L.3    Ziche, M.4    Psillas, K.5    Murphy, C.6    Fotsis, T.7
  • 172
    • 0021068289 scopus 로고
    • Stimulation of rat peritoneal mast cell migration by tumor-derived peptides
    • Poole TJ and Zetter BR: Stimulation of rat peritoneal mast cell migration by tumor-derived peptides. Cancer Res 43: 5857-5861, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 5857-5861
    • Poole, T.J.1    Zetter, B.R.2
  • 173
    • 0001392978 scopus 로고
    • The mast cell, its amines, and tumor growth in rodents and man
    • Scott KG: The mast cell, its amines, and tumor growth in rodents and man. Ann NY Acad Sci 103: 285-312, 1963.
    • (1963) Ann. NY Acad. Sci. , vol.103 , pp. 285-312
    • Scott, K.G.1
  • 174
    • 0002797150 scopus 로고
    • Neuroimmunology of tumor growth: The role of mast cells
    • Theoharides TC: Neuroimmunology of tumor growth: the role of mast cells. Int J Immunopathol Pharmacol 1: 89-98, 1988.
    • (1988) Int. J. Immunopathol. Pharmacol. , vol.1 , pp. 89-98
    • Theoharides, T.C.1
  • 175
    • 0004947061 scopus 로고
    • Inhibition of endotoxin-induced expression of intercellular adhesion molecule-1 and of leukocyte adhesion to endothelial cells by the plant flavonoid quercetin
    • Anné S, Agarwal R, Nair MP, Schwartz SA, Ballow M, Kandaswami C and Middleton E Jr: Inhibition of endotoxin-induced expression of intercellular adhesion molecule-1 and of leukocyte adhesion to endothelial cells by the plant flavonoid quercetin. J Allergy Clin Immunol 93: 276, 1994.
    • (1994) J. Allergy Clin. Immunol. , vol.93 , pp. 276
    • Anné, S.1    Agarwal, R.2    Nair, M.P.3    Schwartz, S.A.4    Ballow, M.5    Kandaswami, C.6    Middleton Jr., E.7
  • 176
    • 0025865284 scopus 로고
    • Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1
    • Walsh LJ, Trinchieri G, Waldorf HA, Whitaker D and Murphy GF: Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci (USA) 88(10): 4220-4224, 1991.
    • (1991) Proc. Natl. Acad. Sci. (USA) , vol.88 , Issue.10 , pp. 4220-4224
    • Walsh, L.J.1    Trinchieri, G.2    Waldorf, H.A.3    Whitaker, D.4    Murphy, G.F.5
  • 178
    • 0038022616 scopus 로고    scopus 로고
    • Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases
    • Myoung H Kim: Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. J Cell Biochem 89(3): 529-538, 2003.
    • (2003) J. Cell Biochem. , vol.89 , Issue.3 , pp. 529-538
    • Myoung, H.K.1


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