Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides

Anticancer Research

Volumn 30, Issue 9, 2010, Pages 3629-3635

  Lea, Michael A ^a   Ibeh, Chinwe ^a   Deutsch, Jill K ^a   Hamid, Imran ^a   DesBordes, Charles ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Caco 2; Colon cancer; Differentiation; Flavonols; Growth; Peroxide

Indexed keywords

ALKALINE PHOSPHATASE; BAICALEIN; FLAVONOID GLYCOSIDE; HYDROGEN PEROXIDE; ISOQUERCITRIN; MYRICETIN; QUERCETIN; QUERCETIN 4' GLUCOSIDE; QUERCETIN RUTINOSIDE; QUERCITRIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FLAVONOL DERIVATIVE; GLYCOSIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON CANCER; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; BIOSYNTHESIS; CACO 2 CELL LINE; CHEMISTRY; COLON TUMOR; DRUG EFFECTS; ENZYMOLOGY; HT 29 CELL LINE;

ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONIC NEOPLASMS; FLAVONOLS; GLYCOSIDES; HT29 CELLS; HUMANS; QUERCETIN;

EID: 77958570942     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Lea MA, Ibeh C, Han L and desBordes C: Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res 30: 311-318, 2010.
2. Bischoff SC: Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11: 733-740, 2008.
3. Cao G, Sofic E and Prior RL: Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships. Free Radical Biol Med 22: 749-760, 1997.
4. Long LH, Clement MV and Haliwell B: Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)- epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem Biophys Res Commun 273: 50-53, 2000.
5. Halliwell B: Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Archiv Biochem Biophys 476: 107-112. 2008.
6. Lea MA, Shareef A, Sura M and desBordes C: Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules. Cancer Chemother Pharmacol 54: 57-63, 2004. (Pubitemid 38858366)
7. Lea MA, Ibeh C, Shah N and Moyer MP: Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. Anticancer Res 27: 741-748, 2007.
8. Nourooz-Zadeh J, Tajaddini-Sarmadi J and Wolff SP: Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal Biochem 220: 403-409, 1994.
9. Manach C, Scalbert A, Morand C, Remesy C, and Jimenez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr 79: 727-747, 2004.
10. Kampa M, Nifli A-P, Notas G and Castanas E: Polyphenols and cancer cell growth. Rev Physiol Biochem Pharmacol 159: 79-113, 2007.
11. Lamoral-Theys D, Pottier L, Dufrasne F, Neve J, Dubois J, Kornienko A, Kiss R and Ingrassia L: Natural polyphenols that display anticancer properties through inhibition of protein kinase activity. Current Med Chem 17: 812-825, 2010.
12. Witt O, Schulze S, Kanbach K, Roth C and Pekrun A: Tumor cell differentiation by butyrate and environmental stress. Cancer Lett 171: 173-182, 2001.
13. Orchel A, Dzierzewicz Z, Parfiniewicz B, Weglarz L and Wilczok T: Butyrate-induced differentiation of colon cancer cells is PKC and JNK dependent. Dig Dis Sci 50: 490-498, 2005. (Pubitemid 40543737)
14. Bischoff SC: Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11: 733-740, 2008.
15. Murakami A, Ashida H and Terao J: Multitargeted cancer prevention by quercetin. Cancer Lett 269: 315-325, 2008.
16. Depeint F, Gee JM, Williamson G and Johnson IT: Evidence for consistent patterns between flavonoid structures and cellular activities. Proc Nutr Soc 61: 97-103, 2002.
17. Arts ICW, Sesink ALA, Faassen-Peters M and Hollman PC: The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent excretion of dietary quercetin glycosides. Br J Nutr 91: 841-847, 2004.
18. Boyer J, Brown D and Liu RH: Uptake of quercetin and quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers. J Agric Food Chem 52: 7172-7179, 2004.
19. Noratto G, Porter W, Byrne D and Cisneros-Zevallos L: Identifying peach and plum polyphenols with chemopreventive potential against estrogen-independent breast cancer cells. J Agric Food Chem 57: 5219-5226, 2009.
20. Loo G: Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation. J Nutr Biochem 14: 64-73, 2003.
21. Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP and Gescher AJ: Dietary polyphenolic phytochemicals - Promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer 120: 451-458, 2006.
22. Lea MA, Ibeh C, desBordes C, Vizzotto, M,Cisneros-Zevallos L, Byrne DH, Okie W and Moyer MP: Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. Anticancer Res 28: 2067-2076, 2008.