Anticancer activity of a quercetin-based polymer towards HeLa cancer cells

Anticancer Research

Volumn 32, Issue 7, 2012, Pages 2843-2847

  Puoci, Francesco ^a   Morelli, Catia ^a   Cirillo, Giuseppe ^a   Curcio, Manuela ^a   Parisi, Ortensia Ilaria ^a   Maris, Pamela ^a   Sisci, Diego ^a   Picci, Nevio ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Anticancer activity; Antioxidants; HeLa cells; Polymeric drugs; Quercetin; Radical grafting

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; POLYMER; QUERCETIN; TRYPAN BLUE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG STABILITY; FEMALE; FOLIN CIOCALTEU TEST; FUNCTION TEST; GEL PERMEATION CHROMATOGRAPHY; HELA CELL; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; POLYMERIZATION; PRIORITY JOURNAL; SCAVENGING SYSTEM; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CHROMATOGRAPHY, GEL; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; HELA CELLS; HUMANS; POLYMETHACRYLIC ACIDS; QUERCETIN; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84865689619     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Cirillo G, Kraemer K, Fuessel S, Puoci F, Curcio M, Spizzirri UG, Altimari I and Iemma F: Biological activity of a gallic acid - gelatin conjugate. Biomacromolecules 11: 3309-3315, 2010.
2. Pasanphan W, Buettner GR and Chirachanchai S: Chitosan conjugated with deoxycholic acid and gallic acid: a novel biopolymer-based additive antioxidant for polyethylene. J Appl Polym Sci 109: 38-46, 2008.
3. Menichetti S, Viglianisi C, Liguori F, Cogliati C, Boragno L, Stagnaro P, Losio S and Sacchi MC: Ethylene-based copolymers with tunable content of polymerizable hindered phenols as non-releasing macromolecular additives. J Polym Sci Polym Chem 46: 6393-6406, 2008.
4. Singh A and Kaplan DL: In vitro enzyme-induced vinyl polymerization. Adv Polym Sci 194: 211-222, 2006.
5. Dahe GJ, Teotia RS, Kadam SS and Bellare JR: The biocompatibility and separation performance of antioxidative polysulfone/vitamin E TPGS composite hollow fiber membranes. Biomaterials 32: 352-365, 2011.
6. Halliwell B: Free radicals and antioxidants - Quo vadis? Trends Pharmacol Sci 32: 125-130, 2011.
7. Nenkat Ratnam D, Ankola DD, Bhardwaj V, Sahana DK and Ravi Kumar MNV: Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective. J Control Rel 113: 189-207, 2006. (Pubitemid 43983041)
8. Chen X, McRae S, Parelkar S and Emrick T: Polymeric phosphorylcholine- camptothecin conjugates prepared by controlled free radical polymerization and click chemistry. Bioconjugate Chem 20: 2331-2341, 2009.
9. Ferguson EL and Duncan R: Dextrin-phospholipase A2: synthesis and evaluation as a bioresponsive anticancer conjugate. Biomacromolecules 10: 1358-1364, 2009.
10. Puoci F, Iemma F, Curcio M, Parisi OI, Cirillo G, Spizzirri UG and Picci N: Synthesis of methacrylic - ferulic acid co-polymer with antioxidant properties by single-step free radical polymerization. J Agric Food Chem 56: 10646-10650, 2008.
11. Herveas Perez JP, Lopez-Cabarcos E and Lopez-Ruiz B: The application of methacrylate-based polymers to enzyme biosensors. Biomol Eng 23: 233-245, 2006. (Pubitemid 44291561)
12. Kook D, Wolf AH, Yu AL, Neubauer AS, Priglinger SG, Kampik A and Welge-Lussen UC: The protective effect of quercetin against oxidative stress in the human RPE. Invest Ophthalmol Vis Sci 49: 1712-1720, 2008.
13. Moon YJ, Wang X and Morris ME: Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 20: 187-210, 2006. (Pubitemid 43087702)
14. Xing N, Chen Y, Mitchell SH and Young CY: Quercetin inhibits expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis 22: 409-414, 2001. (Pubitemid 32203819)
15. Kim WK, Bang MH, Kim ES, Kang NE, Jung KC, Cho HJ and Park JHY: Quercetin decreases the expression of ERBB2 and ERBB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem 16: 155-162, 2005. (Pubitemid 40312168)
16. Chen W, Wang X, Zhuang J, Zhang L and Lin Y: Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis 28: 2114-2121, 2007. (Pubitemid 47543370)
17. Jung JH, Lee JO, Kim JH, Lee SK, You GY, Park SH, Park JM, Kim EK, Suh PG, An JK and Kim HS: Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR downregulation. J Cell Physiol 223: 408-414, 2010.
18. Makris DP and Rossiter JT: Heat-induced, metal-catalyzed oxidative degradation of quercetin and rutin (quercetin-3-O-rhamnosylglucoside) in aqueous model systems. J Agric Food Chem 48: 3830-3838, 2000.
19. Van der Woude H, Gliszczyńska-Swigło A, Struijs K, Smeets A, Alink GM and Rietjens IM: Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 200: 41-47, 2003.
20. Boulton DW, Walle KU and Walle T: Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism. J Pharm Pharmacol 51: 353-359, 1999. (Pubitemid 29192790)
21. Careri M, Corradini C, Elviri L, Nicoletti I and Zagnoni I: Direct HPLC analysis of quercetin and trans-resveratrol in red wine, grape, and winemaking byproducts. J Agric Food Chem 51: 5226-5231, 2003.
22. Bai F, Huang B, Yang X and Huang W: Synthesis of monodisperse poly(methacrylic acid) microspheres by distillation-precipitation polymerization. Eur Polym J 43: 3923-3932, 2007. (Pubitemid 47332459)
23. Pan Y, Zhu J, Wang H, Zhang X, Zhang Y, He C, Ji X and Li H: Antioxidant activity of ethanolic extract of Cortex fraxini and use in peanut oil. Food Chem 103: 913-918, 2007. (Pubitemid 46283239)
24. Magalhaes ML, Segundo MA, Reis S and Lima JLFC: Methodological aspects about in vitro evaluation of antioxidant properties. Anal Chim Acta 613: 1-19, 2009.
25. Kobayashi S and Higashimura H: Oxidative polymerization of phenols revisited. Prog Polym Sci 28: 1015-1048, 2003.