Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential

European Journal of Pharmacology

Volumn 459, Issue 2-3, 2003, Pages 255-262

  Tan, Wen Fu ^a   Lin, Li Ping ^a   Li, Mei Hong ^a   Zhang, Yi Xiang ^a   Tong, Yun Guang ^a   Xiao, Dong ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Angiogenesis; Matrix metalloproteinase 2; Microvascular dermal endothelial cell (Human); Quercetin; Umbilical vein endothelial cell (Human)

Indexed keywords

ANGIOGENESIS INHIBITOR; FLAVONOID; GELATIN; GELATINASE A; PROTEIN TYROSINE KINASE; QUERCETIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; DIET; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROVASCULARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; ZYMOGRAPHY;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; CHICK EMBRYO; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; QUERCETIN;

EID: 0037449461     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02848-0     Document Type: Article

References (36)

1. Ashton A.W., Yokota R., John G., Zhaoi S., Suadicanii S.O. Inhibition of endothelial cell migration, intercellular Communication, and vascular tube formation by thromboxane A2. J. Biol. Chem. 274:1999;35562-35570.
2. Battegay E.J. Angiogensis: Mechanistic insights, neovascular diseases, and therapeutic prospects. J. Mol. Med. 73:1995;333-346.
3. Castillo M.H., Perkins E., Campbell J.H., Doerr R., Hassett J.M. The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin. Am. J. Surg. 158:1989;351-355.
4. Corvazier E., Maclouf J. Interference of some flavonoids and non-steroidal anti-inflammatory drugs with oxidative metabolism of arachidonic acid by human platelets and neutrophils. Biochem. Biophys. Acta. 835:1985;315-321.
5. Fang J., Shing Y., Wiederschain D., Yan L., Butterfield C., Jackson G., Harper J., Tamvakopoulos G., Moses M.A. Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proc. Natl. Acad. Sci. U. S. A. 97:1999;3884-3889.
6. Ferry D.R., Smith A., Malkhandi J., Fyfe D.W., Takats P.G. Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res. 2:1996;659-668.
7. Garcia C.R., Gonzalez C.A., Agudo A., Riboli E. Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes Control. 10:1999;71-75.
8. Gourley M., Williamson J.S. Angiogenesis: New targets for the developmemt of anticancer chemotherapies. Curr. Pharm. Des. 6:2000;417-439.
9. Gugler R., Leschik M., Dengler H.J. Disposition of quercetin in man after single oral and intravenous doses. Eur. J. Clin. Pharmacol. 9:1975;229-234.
10. Havesteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32:1983;1141-1148.
11. Huang S., Robinson J.B., Deguzman A., Bucana C.D., Fidler I.J. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 60:2000;5334-5339.
12. Igura K., Ohta T., Kuroda Y., Kaji K.A. Reveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 171:2001;11-16.
13. Itoh T., Tanioka M., Yoshida H., Yoshioka T., Nishimoto H., Itohara S. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 58:1998;1048-1051.
14. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:1973;2745-2756.
15. Jiang Y., Goldberg I.D., Shi Y.E. Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene. 21:2002;2245-2252.
16. Kim S.H., Yeo G.S., Lim Y.S., Kang C.D., Kim C.M., Chung B.S. Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells. Exp. Mol. Med. 30:1998;87-92.
17. Klagsbrun M., Moses M.A. Molecular angiogenesis. Chem. Biol. 6:1999;217-224.
18. Koyama S., Takagi H., Otani A., Suzuma K., Nishimura K., Honda Y. Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of rentinal microcapillary endothelial cells. Br. J. Pharmacol. 127:1999;537-545.
19. Levy J., Teuerstein I., Marbach M., Radian S., Sharoni Y. Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: Inhibition by quercetin. Biochem. Biophys. Res. Commun. 123:1984;1227-1233.
20. Marchand L.L., Murphy S.P., Hankin J.H., Wilken L.R., Kolonel L.N. Intake of flavonoids and lung cancer. J. Natl. Cancer Inst. 92:2000;154-159.
21. Mignatti P., Rifkin D.B. Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein. 49:1996;117-137.
22. Molnar J., Beladi I., Domonkos K., Foldeak S., Boda K. Antitumor activity of flavonoids on NK/Ly ascites tumor cells. Neoplasma. 28:1981;11-18.
23. Morris A.D., Leonce S., Guilbaud N., Tucker G.C., Perez V., Jan M., Cordi A.A., Pierre A., Atassi G. Eriochrome Black T, structurally related to suramin, inhibits angiogenesis and tumor growth in vivo. Anticancer Drugs. 8:1997;746-755.
24. Morrow D.M., Fitzsimmons P.E., Chopra M., McGlynn H. Dietary supplementation with the anti-tumour promoter quercetin: Its effects on matrix metalloproteinase gene regulation. Mutat. Res. 480-481:2001;269-276.
25. Mouria M., Gukovskaya A.S., Jung Y., Buechler P., Hines O.J., Reber H.A., Pandol S.J. Food-derived polyphenols inhibits pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer. 98:2002;761-769.
26. Nguyen M., Arkell J., Jackson C. Human endothelial gelatinases and angiogenesis. Int. J. Biochem. Cell Biol. 33:2001;960-970.
27. Qing C., Zhang J.S., Ding J. In vitro cytotoxicity of salvicine, a novel diterpenoid quinone. Acta. Pharmacol. Sin. 20:1999;297-302.
28. Scambia G., Ranelletti F.O., Panici P.B., Piantelli M., Bonanno G., Vincenzo R., Ferrandina G., Rumi C., Larocca L.M., Mancuso S. Inhibitory effect of quercetin on OVA 433 cells and presence of type II oestrogen binding sites in primary ovarian tumors and cultured cells. Br. J. Cancer. 62:1990;942-946.
29. Scambia G., Ranelletti F.O., Panici P.B., Piantelli M., Vincenzo R., Ferrandina G., Bonanno G., Capelli A., Mancuso S. Quercetin induces type-II estrogen-binding sites in estrogen-receptor-negative (MDA-MB231) and estrogen-receptor-positive (MCF-7) human breast cancer cell lines. Int. J. Cancer. 54:1993;462-466.
30. Schnaper H.W., Grant D.S., Stetler W.G., Fridman R., Orazi G., Murphy A.N., Bird R.E., Hoythya M., Fuerst T.R., French D.L. Type IV collagenase and TIMPs modulate endothelial cell morphogenesis in vitro. J. Cell Physiol. 156:1993;235-246.
31. Sunwoo J.B., Chen Z., Dong G., Yeh N., Crowl B.C., Sausville E., Adams J., Elliott P., Van W.C. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin. Cancer Res. 7:2001;1419-1428.
32. Vincent L., Chen W., Hong L., Mirshahi F., Mishal Z., Mirshahi T., Vannier J.P., Soria J., Soria C. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: Contribution to its antiangiogenic effect. FEBS Lett. 475:2001;159-166.
33. Xiao D., Zhu S.P., Gu Z.L. Quercetin induced apoptosis in human leukemia HL-60 cell. Acta. Pharmacol. Sin. 18:1998;280-283.
34. Xiao D., Tan W., Li M., Ding J. Antiangiogenic potential of 10-hydroxycamptothecin. Life Sci. 69:2001;1619-1628.
35. Yanagihara K., Ito A., Toge T., Numoto M. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res. 53:1993;5815-5821.
36. Yoshida M., Sakai T., Hosokawa N., Marui N., Matsumoto K., Fujioka A., Nishino H., Aoike A. The effect of quercetin of cell cycle progression and growth of human gastric cancer cells. FEBS Lett. 260:1990;10-13.