Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt

Oncology Reports

Volumn 26, Issue 3, 2011, Pages 687-693

  Xie, Xianbiao ^a   Yin, Junqiang ^a   Jia, Qiang ^b   Wang, Jin ^a   Zou, Changye ^a   Brewer, Kari J ^c   Colombo, Chiara ^c   Wang, Yaofei ^a   Huang, Gang ^a   Shen, Jingnan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guizhou Academy of Sciences   (China)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Akt; Apoptosis; Methotrexate; Mito chondria; Osteosarcoma; Quercetin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CYTOCHROME C; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; QUERCETIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHOTREXATE; MITOCHONDRIA; OSTEOSARCOMA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN;

EID: 79960009760     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1328     Document Type: Article

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