Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression

Journal of Cancer Research and Clinical Oncology

Volumn 131, Issue 11, 2005, Pages 765-771

  Vijayababu, M R ^a   Kanagaraj, P ^a   Arunkumar, A ^a   Ilangovan, R ^a   Aruldhas, M M ^a   Arunakaran, J ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Bax; Bcl 2; Caspase 3; Cdc2; Cell cycle; Cyclins; p21 Cip1; pRb; Prostate cancer; Quercetin

Indexed keywords

ANDROGEN; CASPASE 3; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P130; PROTEIN P21; QUERCETIN; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE G2 PHASE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; QUERCETIN; RETINOBLASTOMA PROTEIN; TUMOR MARKERS, BIOLOGICAL;

EID: 27644568638     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-005-0005-4     Document Type: Article

References (35)

1. Agarwal R (2000) Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem Pharmacol 60:1051-1059
2. Aquilina JW, Lipsky JJ, Bostwick DG (1999) Androgen deprivation as strategy for prostate cancer chemoprevention. J Nutr Cancer Inst 89:689-696
3. Balabhadrapathruni S, Thomas TJ, Yurkow EJ, Amenta PS, Thomas T (2000) Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol Rep 7:3-12
4. Buchkovich K, Duffy LA, Harlow E (1989) The Retinoblastoma protein is phosphorlyated during specific phases of the cell cycle. Cell 58:1097-1105
5. Casagrande F, Darbon JM (2001) Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol 61:1205-1215
6. Catz SD, Johnson JL (2003) Bcl-2 in prostate cancer; a minireview. Apoptosis 8:29-37
7. Choi JA, Kim JY, Lee JY, Kang CM, Kwon HJ, Yoo YD, Kim TW, Lee YS, Lee SJ (2001) Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int J Oncol 19:837-844
8. Csokay B, Prajda N, Weber G, Olah E (1997) Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 60:2157-2163
9. Dyson N (1998) The regulation of E2F by pRB-family proteins. Genes Dev 12:2245-2262
10. Ewen ME (1994) The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev 13:45-66
11. Ferriola PC, Cody V, Middleton E Jr (1989) Protein-kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationship. Biochem Pharmacol 38:1617-1624
12. Gali-Muhtasib H, Bakkar N (2002) Modulating cell cycle: current applications and prospects for future drug development. Curr Can Drug Targets 2:309-336
13. Gioeli D, Mandell JW, Petroni GR, Frierson Jr HF, Weber MJ (1999) Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res 59:279-284
14. Grana X, Reddy P (1999) Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinase (CDKs), growth-suppressor genes, cyclin-dependent kinase inhibitors (CDKIs). Oncogene 11:211-219
15. Howard CM, Claudio PP, Luca AD, Stiegler P, Jori FP, Safdar NM, Caputi M, Khalili K, Giordano A (2000) Inducible pRb/p130 expression and growth-suppressive mechanisms: evidence of pRb130, p27kip1, and cyclin E negative feedback regulatory loop. Cancer Res 60:2737-2744
16. Knowles LM, Zigrossi DA, Tauber RA, Hightower C, Milner JA (2000) Flavonoids suppress androgen-independent human prostate tumor proliferation. Nutr Can 38:116-122
17. Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E (1991) The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J 10:4279-4290
18. Li X, Marami M, Yu J, Nan B, Roth JA, Kagawa S, Fang B, Dennerr L, Marcelli M (2001) Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer. Cancer Res 61:186-191
19. Lin BT-Y, Gruenwald S, Morla AO, Lee W-H, Wang JYJ (1991) Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J 10:857-864
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin-phenol reagent. J Biol Chem 193:265-270
21. Malumbres M, Barbacid M (2001) To cycle or not to cycle: a critical decision in cancer. Nature Rev Cancer 1:222-231
22. Martin JL, Pattison SL (2000) Insulin-like growth factor binding protein-3 is regulated by dihydrotestosterone and stimulates deoxyribonucleic acid synthesis and cell proliferation in LNCaP prostate carcinoma cell. Endocrinology 141:2401-2409
23. Mittnacht S (1998) Control of pRB phosphorylation. Curr Opin Genet Dev 8:21-27
24. Morgan DO (1995) Principles of CDK regulation. Nature 374:131-134
25. Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH, Huynh H (2004) The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25:647-659
26. Paggi MG, Baldi A, Bonetto F, Giordano A (1996) Retinoblastoma protein family in cell cycle and cancer: a review. J Cell Biochem 62:418-430
27. Paggi MG, Felson A, Giordano A (2003) Growth control by the retinoblastoma gene family. In: El Deiry WS (ed) Tumor suppressor genes (Vol 1). Humana Press, New Jersey, pp 3-19
28. Pavletich NP (1999) Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators and Cip and INK4 inhibitors. J Mol Biol 287:821-828
29. Quinn M, Babb P (2002) Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part 1. International comparisons. BJU Int 90:162-173
30. Srivastava RK, Srivastava AR, Korsmeyers J, Nesterva M, Cho-chung YS, Longo DL (1998) Involvement of microtubules in the regulation of Bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent kinase. Mol Cell Biol 18:3509-3517
31. Taraphdar AK, Roy M, Bhattacharya RK (2001) Natural products as inducers of apoptosis: implication for cancer therapy and prevention. Curr Sci 80:1387-1396
32. Vijayababu MR, Kanagaraj P, Arunkumar A, Srinivasan N, Michael Aruldhas M, Arunakaran J (2004) Effects of quercetin on IGF system components in PC-3 cells. In: XXII symposium of the society for reproductive biology and comparative endocrinology (SRBCE), Chennai, pp 30-31
33. Wang S, DeGroff VL, Clinton SK (2003) Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase. J Nutr 133:2367-2376
34. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704
35. Yuan H, Pan Y, Young CY (2004) Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells. Cancer Lett 213(2):155-63