Induction of apoptosis by quercetin: Different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells

Molecular and Cellular Biochemistry

Volumn 296, Issue 1-2, 2007, Pages 137-149

  Brisdelli, Fabrizia ^a   Coccia, Cristina ^a   Cinque, Benedetta ^a   Cifone, Maria Grazia ^a   Bozzi, Argante ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Apoptosis; Caspases; Cytochrome c; Glutathione; Quercetin; ROS

Indexed keywords

CASPASE; CYTOCHROME C; GLUTATHIONE; QUERCETIN; REACTIVE OXYGEN METABOLITE;

ACUTE LYMPHOCYTIC LEUKEMIA; ANIMAL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL STRAIN K 562; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; SECRETION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; K562 CELLS; LEUKEMIA, LYMPHOCYTIC, ACUTE; QUERCETIN; REACTIVE OXYGEN SPECIES;

EID: 34447530779     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9307-3     Document Type: Article

References (67)

1. Cook NC, Samman S: Flavonoids. Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 7: 66-76, 1996
2. Goldberg DM, Tsang E, Karumanchiri A, Diamandis E, Soleas G, Ng E: Method to assay the concentrations of phenolic constituents of biological interest in wines. Anal Chem 68: 1688-1694, 1996
3. Manach C, Williamson G, Morand C, Scalbert A, Remesy C: Bioavailability and bioefficacy of polyphenols in humans. I Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S-242S, 2005
4. Ross JA, Kasum CM: Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22: 19-34, 2002
5. Murota K, Terao J: Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch Biochem Biophys 417: 12-17, 2003
6. Spencer JPE, Kuhnle GGC, Williams RJ, Rice-Evans C: Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem J 372: 173-181, 2003
7. Awad HM, Boersma MG, Boeren S, van der Woude H, van Zanden J, van Bladeren PJ, Vervoort J, Rietjens IM: Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system. FEBS Lett 520: 30-34, 2002
8. Awad HM, Boersma MG, Boeren S, van Bladeren PJ, Vervoort J, Rietjens IM: Quenching of quercetin quinone/quinone methides by different thiolate scavangers: stability and reversibility of conjugate formation. Chem Res Toxicol 16: 822-831, 2003
9. Otake Y, Walle T: Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos 30: 103-105, 2002
10. Otake Y, Hsieh F, Walle T: Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab Dispos 30: 576-581, 2002
11. Jakubowicz-Gil J, Paduch R, Piersiak T, Lowniak K, Gawron A, Kandefer-Szerszen M: The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells. Biochem Pharmacol 69: 1343-1350, 2005
12. Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL: Quercetin and anti-CD95 (Fas/Apo1) enhance apoptosis in HPB-ALL cell line. FEBS Lett 462: 322-328, 1999
13. Wang IK, Lin-Shiau SY, Lin JK: Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukemia HL-60 cells. Eur J Cancer 35: 1517-1525, 1999
14. Kuo SM: Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110: 41-48, 1996
15. McGahon AJ, Martin SJ, Bissonnette RP, Mahboubi A, Shi Y, Mogil RJ, Nishioka WK, Green DR: The end of and the (cell) line: methods for the study of apoptosis in vitro. (Review). Methods Cell Biol 46: 153-185, 1995
16. Köhlex C, Orrenius S, Zhivatovsky B: Evaluation of caspase activity in apoptotic cells. J Immunol Methods 265: 97-110, 2002
17. Anderson ME: Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113: 548-555, 1985
18. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
19. Carlberg I, Mannervik B: Purification and characterization of flavoenzyme glutathione reductase from rat liver. J Biol Chem 250: 5475-5480, 1975
20. Paglia BE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1: 158-169, 1967
21. Habig WH, Pabot MJ, Jarkoby WB: Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139, 1974
22. LeBel CP, Ishiropoulos H, Bondy SC: Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive species formation and oxidative stress. Chem Res Toxicol 5: 227-231, 1992
23. Bedi A, Barber JP, Bedi GC, el-Deiry WS, Sidranski D, Vala MS, Akhtar AJ, Hilton J, Jones RJ: BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents. Blood 86: 1148-1158, 1995
24. Cortez D, Kadlec L, Pendergast AM: Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. Mol Cell Biol 15: 5531-5541, 1995
25. Riordan FA, Bravery CA, Mengubas K, Ray N, Borthwick NJ, Akbar AN, Hart SM, Hoffbrand AV, Metha AB, Wickremasinghe RG: Herbimycin A accelerates the induction of apoptosis following etoposide treatment or gamma-irradiation of BCR/ABL-positive leukemia cells. Oncogene 16: 1533-1542, 1998
26. Knijn A, Brisdelli F, Ferretti A, Iorio E, Marcheggiani D, Bozzi A: Metabolic alterations in K562 cells exposed to taxol and tyrphostin AG957: 1H NMR and biochemical studies. Cell Biol Int 29: 890-897, 2005
27. Scalbert A, Williamson G: Dietary intake and bioavailability of polyphenols. J Nutr 130: 2073S-2085S, 2000
28. Williamson G, Manach C: Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 bioavailable intervention studies. Am J Clin Nutr 81: 243S-255S, 2005
29. Hsu H, Xiong J, Goeddel DV: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 88: 495-504, 1995
30. Raff M: Cell suicide for beginners. Nature 396: 119-122, 1998
31. Crompton M: The mitochondrial permeability transition pore and its role in cell death. Biochem J 341: 233-249, 1999
32. Kroemer G, Reed JC: Mitochondrial control of cell death. Nat Med 6: 513-519, 2000
33. Galati G, Teng S, Moridani MY, Chan TS, O'Brien PJ: Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact 17: 311-349, 2000
34. Williams RJ, Spencer JPE, Rice-Evans C: Flavonoids: antioxidants or signalling molecules?. Free Radic Biol Med 36: 838-849, 2004
35. Park C, So H-S, Shin C-H, Baek S-H, Moon B-S, Shin S-H, Lee HS, Lee DW, Park R: Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol 66: 1287-1295, 2003
36. Cotgreave IA, Gerdes RG: Recent trends in glutathione biochemistry-glutathione-protein interactions: a molecular link between oxidative stress and cell proliferation?. Biochem Biophys Res Commun 242: 1-9, 1998
37. Van den Dobbelsteen DJ, Nobel CS, Schlegel J, Cotgreave IAOrrenius S, Slater AF: Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem 271: 15420-15427, 1996
38. Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S, Meyn RE: Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci USA 95: 2956-2960, 1998
39. Luzi C, Brisdelli F, Cinque B, Cifone G, Bozzi A: Differential sensitivity to resveratrol-induced apoptosis of chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells. Biochem Pharmacol 68: 2019-2030, 2004
40. Middleton E Jr, Kandaswami C: Potential health promoting properties of citrus flavonoids. Food Technol 48: 115-119, 1994
41. Hakimuddin F, Paliyath G, Meckling K: Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat 85: 65-79, 2004
42. Di Carlo G, Mascolo N, Ice AA, Capasso F: Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci 65: 337-353, 1999
43. Duthie GG, Duthie SJ, Kyle JAM: Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutr Res Rev 13: 79-106, 2000
44. Mertens-Talcott SU, Talcott ST, Percival SS: Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 133: 2669-2674, 2003
45. Lee TJ, Kim OH, Kim YH, Lim JH, Kim S, Park JW, Kwon TK: Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells. Cancer Lett 240: 234-242, 2006
46. Richter M, Ebermann R, Marian B: Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. Nutr Cancer 34: 88-99, 1999
47. Yoshida M, Yamamoto M, Nikaido T: Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res 52: 6676-6681, 1992
48. Radtke J, Linseisen J, Wolfram G: Fasting plasma concentrations of selected flavonoids as markers of their ordinary dietary intake. Eur J Nutr 41: 203-209, 2002
49. Erlund I, Marniemi J, Hakala P, Alfthan G, Meririnne E, Aro A: Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations. Eur J Clin Nutr 57: 37-42, 2003
50. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science 275: 1132-1136, 1997
51. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997
52. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132, 1997
53. Antonsson B, Martinou JC: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000
54. Qanungo S, Wang M, Nieminen AL: N-acetyl-L-cysteine enhances apoptosis through inhibition of Nuclear Factor-kB in hypoxic murine embryonic fibroblasts. J Biol Chem 279: 50455-50464, 2004
55. Chen Y, Zheng R, Jia Z, Ju Y: Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med 9: 19-21, 1990
56. Torel J, Cillard J, Cillard P: Antioxidant activity of flavonoids and reactivity with peroxy radical. Phytochemistry 25: 383-385, 1986
57. Husain SR, Cillard J, Cillard P: Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 26: 2489-2491, 1987
58. Sestili P, Guidarelli A, Dacha M, Cantoni O: Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. Free Radic Biol Med 25: 196-200, 1998
59. Negre-Salvayre A, Salvayre R: Quercetin prevents the cytotoxicity of oxidised LDL on lymphoid cell lines. Free Radic Biol Med 12: 101-106, 1992
60. Duthie SJ, Collins AR, Duthie GG, Dobson VL: Quercetin and myricetin protect against hydrogen peroxide induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes. Mutat Res 393: 223-231, 1997
61. Skaper SD, Fabris M, Ferrar V, Carbonare MD, Leon A: Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Radic Biol Med 22: 669-678, 1997
62. Kim WK, Bang MH, Kim ES, Kang NE, Jung KC, Cho HJ, Park JH: Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem 16: 155-162, 2005
63. Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QP: Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukaemia cells. Biochem Pharmacol 69: 1421-1432, 2005
64. Dorta DJ, Pigoso AA, Mingatto FE, Rodrigues T, Prado IMR, Helena AFC, Uyemura SA, Santos AC, Curti C: The interaction of flavonoids with mitochondria: effects on energetic processes. Chem Biol Interact 152: 67-78, 2005
65. Manach C, Morand C, Crespy V, Demingne C, Texier O, Regerat F, Remesy C: Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett 426: 331-336, 1998
66. Boulton DW, Walle UK, Walle T: Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism. J Pharm Pharmacol 51: 353-359, 1999
67. Long LH, Clement MV, Halliwell B: Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem Biophys Res Commun 273: 50-53, 2000