Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells

Archives of Pharmacal Research

Volumn 31, Issue 10, 2008, Pages 1281-1285

  Choi, Eun Jeong ^a   Bae, Su Mi ^a   Ahn, Woong Shick ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; Cell cycle arrest; Human breast cancer MDA MB 453 cells; Quercetin

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; QUERCETIN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; BREAST TUMOR; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; GENETICS; HUMAN; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMANS; NEOPLASM PROTEINS; QUERCETIN;

EID: 55149124980     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-2107-0     Document Type: Article

References (38)

1. A. W. Abu-Qare M. B. Abou-Donia 2001 Biomarkers of apoptosis: Release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′- deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene J. Toxicol. Environ. Health B Crit. Rev. 4 313 332
2. M. L. Agarwal A. Agarwal W. R. Taylor G. R. Stark 1995 p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts Proc. Nati. Acad. Sci. USA. 92 8493 8497
3. F. Alcocer D. Whitley J. F. Salazar-Gonzalez W. D. Jordan M. T. Sellers D. E. Eckhoff K. Suzuki C. Macrae K. I. Bland 2002 Quercetin inhibits human vascular smooth muscle cell proliferation and migration Surgery 131 198 204
4. Y. F. Chang C. W. Chi J. J. Wang 2006 Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells Nutr. Cancer 55 201 209
5. E. J. Choi K. M. Chee B. H. Lee 2003 Anti-and prooxidant effects of chronic quercetin administration in rats Eur. J. Pharmacol. 482 281 285
6. A. R. Collins 2005 Antioxidant intervention as a route to cancer prevention Eur. J. 41 1923 1930
7. N. Cotelle 2001 Role of flavonoids in oxidative stress Curr. Top. Med. Chem. 1 569 590
8. E. N. Frankel J. Kanner J. B. German E. Parks J. E. Kinsella 1993 Inhibition of oxidation of human lowdensity lipoprotein by phenolic substances in red wine Lancet 341 454 457
9. M. G. Hertog H. B. Bueno-de-Mesquita A. M. Fehily P. M. Sweetnam P. C. Elwood D. Kromhout 1996 Fruit and vegetable consumption and cancer mortality in the Caerphilly Study Cancer Epidemiol. Biomark. Prev. 5 673 677
10. M. G. Hertog 1996 Epidemiological evidence on potential health properties of flavonoids Proc. Nutr. Soc. 55 385 397
11. M. G. Hertog P. C. Hollman M. B. Katan D. Kromhout 1993 Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands Nutr. Cancer 20 21 29
12. S. L. Huang C. L. Hsu G. C. Yen 2006 Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells Life Sci. 79 203 209
13. C. Kandaswami E. Middleton Jr. 1994 Free radical scavenging and antioxidant activity of plant flavonoids Adv. Exp. Med. Biol. 366 351 376
14. C. Kandaswami L. T. Lee P. P. Lee J. J. Hwang F. C. Ke Y. T. Huang M. T. Lee 2005 The antitumor activities of flavonoids In Vivo 19 895 909
15. W. K. Kim M. H. Bang E. S. Kim N. E. Kang K. C. Jung H. J. Cho J. H. Park 2005 Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells J. Nutr. Biochem. 16 155 162
16. D. Kook A. H. Wolf A. L. Yu A. S. Neubauer S. G. Priglinger A. Kampik U. C. Welge-Lüssen 2008 The protective effect of quercetin against oxidative stress in the human RPE in Vitro Invest. Ophthalmol. Vis. Sci. 49 1712 1720
17. P. M. Kris-Etherton C. L. Keen 2002 Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health Curr. Opin. Lipidol. 13 41 49
18. D. W. Lamson M. S. Brignall 2000 Antioxidants and cancer, part 3: quercetin Altern. Med. Rev. 5 196 208
19. D. Lepik V. Jaks L. Kadaja S. Varv T. Maimets 2003 Electroporation and carrier DNA cause p53 activation, cell cycle arrest, and apoptosis Anal. Biochem. 318 1 52 59
20. J. H. Lim J. W. Park D. S. Min J. S. Chang Y. H. Lee Y. B. Park K. S. Choi T. K. Kwon 2007 NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells Apoptosis 12 411 421
21. H. Liu C. Zhang W. Zeng 2006 Estrogenic and antioxidant effects of a phytoestrogen daidzein on ovarian germ cells in embryonic chickens Domest. Anim. Endocrinol. 31 258 268
22. M. Lopez-Lazaro 2002 Flavonoids as anticancer agents: structureactivity relationship study Curr. Med. Chem. Anticancer Agents. 2 691 714
23. D. Metodiewa A. K. Jaiswal N. Cenas E. Dickancaité J. Segura-Aguilar 1999 Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product Free Radic. Biol. Med. 26 107 116
24. M. Notoya Y. Tsukamoto H. Nishimura J. T. Woo K. Nagai I. S. Lee H. Hagiwara 2004 Quercetin, a flavonoid, inhibits the proliferation, differentiation, and mineralization of osteoblasts in vitro Eur. J. Pharmacol. 48 89 96
25. S. A. Oakea S. S. Lin M. C. Bassik 2006 The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins Curr. Mol. Med. 6 99 109
26. M. Park H. D. Chae J. Yun M. Jung Y. S. Kim S. H. Kim M. H. Han D. Y. Shin 2000 Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest Cancer Res. 60 542 545
27. M. A. Parker J. K. Anderson D. A. Corliss V. E. Abraria R. L. Sidman K. I. Park Y. D. Teng D. A. Cotanche E. Y. Snyder 2005 Expression profile of an operationallydefined neural stem cell clone Exp. Neurol. 194 320 332
28. S. K. Pathak R. A. Sharma J. K. Mellon 2003 Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review) Int. J. Oncol. 22 5 13
29. A. G. Porter R. U. Janicke 1999 Emerging roles of caspase-3 in apoptosis Cell Death Differ. 6 99 104
30. A. A. Ramos C. F. Lima M. L. Pereira M. Fernandes-Ferreira C. Pereira-Wilson 2008 Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay Toxicol. Lett. 177 66 73
31. A. V. Rao S. Agarwal 2000 Role of antioxidant lycopene in cancer and heart disease J. Am. Coll. Nutr. 19 563 569
32. W. Ren Z. Qiao H. Wang L. Zhu L. Zhang 2003 Flavonoids: Promising anticancer agents Med. Res. Rev. 23 519 534
33. G. L. Russo 2007 Ins and outs of dietary phytochemicals in cancer chemoprevention Biochem. Pharmacol. 74 533 544
34. S. C. Sahu G. C. Gray 1996 Pro-oxidant activity of flavonoids: Effects on glutathione and glutathione S-transferase in isolated rat liver nuclei Cancer Lett. 104 193 196
35. S. C. Shen Y. C. Chen F. L. Hsu W. R. Lee 2003 Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade J. Cell Biochem. 89 1044 1055
36. R. P. Singh R. Agarwal 2006 Natural flavonoids targeting deregulated cell cycle progression in cancer cells Curr. Drug Targets. 7 345 354
37. M. F. van Delft D. C. Huang 2006 How the Bcl-2 family of proteins interact to regulate apoptosis Cell Res. 16 203 213
38. J. Zhang R. A. Stanley A. Adaim L. D. Melton M. A. Skinner 2006 Free radical scavenging and cytoprotective activities of phenolic antioxidants Mol. Nutr. Food Res. 50 996 1005