The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition

European Journal of Pharmacology

Volumn 649, Issue 1-3, 2010, Pages 84-91

  Vidya Priyadarsini, R ^a   Senthil Murugan, R ^a   Maitreyi, S ^b   Ramalingam, K ^b   Karunagaran, D ^b   Nagini, S ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

Author keywords

Apoptosis; Cell cycle; NF B; P53; Quercetin

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYCLIN D1; CYTOCHROME C; I KAPPA B; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLSERINE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN P21; PROTEIN P50; PROTEIN P53; QUERCETIN; REACTIVE OXYGEN METABOLITE; SURVIVIN; SYNAPTOTAGMIN I; UBIQUITIN PROTEIN LIGASE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE PROTEINS; CELL MEMBRANE; CELL NUCLEUS; CELL SURVIVAL; DOWN-REGULATION; FEMALE; G2 PHASE; HELA CELLS; HUMANS; MITOCHONDRIA; NF-KAPPA B; OSMOLAR CONCENTRATION; QUERCETIN; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 78049294193     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.020     Document Type: Article

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