메뉴 건너뛰기




Volumn 48, Issue 2, 2010, Pages 222-229

Antiproliferative and pro-apoptotic effects of quercetin on human pancreatic carcinoma cell lines EPP85-181P and EPP85-181RDB

Author keywords

Antiproliferative effect; Apoptosis; Daunorubicin; Human pancreatic carcinoma cell lines; Quercetin

Indexed keywords

DAUNORUBICIN; QUERCETIN;

EID: 77957223875     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10042-08-0109-1     Document Type: Article
Times cited : (27)

References (58)
  • 1
    • 10044246299 scopus 로고    scopus 로고
    • Review of flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology
    • Erlund I. Review of flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res. 2004;24:551-874.
    • (2004) Nutr Res , vol.24 , pp. 551-874
    • Erlund, I.1
  • 2
    • 0029610477 scopus 로고
    • Review of the biology of Quercetin and related bioflavonoids
    • Formica JV, Regelson W. Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol. 1995;33: 1061-1080.
    • (1995) Food Chem Toxicol , vol.33 , pp. 1061-1080
    • Formica, J.V.1    Regelson, W.2
  • 3
    • 38849203188 scopus 로고    scopus 로고
    • Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation
    • Bureau G, Longpre F, Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res. 2008;86:403-410.
    • (2008) J Neurosci Res , vol.86 , pp. 403-410
    • Bureau, G.1    Longpre, F.2    Martinoli, M.G.3
  • 5
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003;3:768-780.
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 6
    • 0034928799 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by dietary polyphenolic compounds
    • Yang CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 2001;21:381-406.
    • (2001) Annu Rev Nutr , vol.21 , pp. 381-406
    • Yang, C.S.1    Landau, J.M.2    Huang, M.T.3    Newmark, H.L.4
  • 7
    • 17844361910 scopus 로고    scopus 로고
    • Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro
    • van Erk MJ, Roepman P, van der Lende TR et al. Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005;44:143-156.
    • (2005) Eur J Nutr , vol.44 , pp. 143-156
    • van Erk, M.J.1    Roepman, P.2    van der Lende, T.R.3
  • 8
    • 68149138453 scopus 로고    scopus 로고
    • Quercetin inhibits IL-1 betainduced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways
    • Ying B, Yang T, Song X et al. Quercetin inhibits IL-1 betainduced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Mol Biol Rep. 2008;36: 1825-1832.
    • (2008) Mol Biol Rep , vol.36 , pp. 1825-1832
    • Ying, B.1    Yang, T.2    Song, X.3
  • 9
    • 55149124980 scopus 로고    scopus 로고
    • Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells
    • Choi EJ, Bae SM, Ahn WS. Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch Pharm Res. 2008;31:1281-1285.
    • (2008) Arch Pharm Res , vol.31 , pp. 1281-1285
    • Choi, E.J.1    Bae, S.M.2    Ahn, W.S.3
  • 10
    • 70149104225 scopus 로고    scopus 로고
    • Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells
    • Zamin LL, Filippi-Chiela EC, Dillenburg-Pilla P, Horn F, Salbego C, Lenz G. Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells. Cancer Sci., 2009;100:1655-1662.
    • (2009) Cancer Sci , vol.100 , pp. 1655-1662
    • Zamin, L.L.1    Filippi-Chiela, E.C.2    Dillenburg-Pilla, P.3    Horn, F.4    Salbego, C.5    Lenz, G.6
  • 11
    • 67349181288 scopus 로고    scopus 로고
    • Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells
    • Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C. Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett. 2009;281:162-170.
    • (2009) Cancer Lett , vol.281 , pp. 162-170
    • Xavier, C.P.1    Lima, C.F.2    Preto, A.3    Seruca, R.4    Fernandes-Ferreira, M.5    Pereira-Wilson, C.6
  • 12
    • 0037409044 scopus 로고    scopus 로고
    • Flavonoid effects on normal and leukemic cells
    • Liesveld JL, Abboud CN, Lu C et al. Flavonoid effects on normal and leukemic cells. Leuk Res. 2003;27:517-527.
    • (2003) Leuk Res , vol.27 , pp. 517-527
    • Liesveld, J.L.1    Abboud, C.N.2    Lu, C.3
  • 13
    • 5044239935 scopus 로고    scopus 로고
    • Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines
    • Son YO, Lee KY, Kook SH et al. Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines. Eur J Pharmacol. 2004;502:195-204.
    • (2004) Eur J Pharmacol , vol.502 , pp. 195-204
    • Son, Y.O.1    Lee, K.Y.2    Kook, S.H.3
  • 14
    • 0030962254 scopus 로고    scopus 로고
    • Relationship between lethal effects and topoisomerase II-mediated doublestranded DNA breaks produced by anthracyclines with different sequence specificity
    • Binaschi M, Capranico G, Dal Bo L, Zunino F. Relationship between lethal effects and topoisomerase II-mediated doublestranded DNA breaks produced by anthracyclines with different sequence specificity. Mol Pharmacol. 1997;51:1053-1059.
    • (1997) Mol Pharmacol , vol.51 , pp. 1053-1059
    • Binaschi, M.1    Capranico, G.2    Dal, B.L.3    Zunino, F.4
  • 15
    • 34548321264 scopus 로고    scopus 로고
    • Role of anthracyclines in the era of targeted therapy
    • Cortes-Funes H, Coronado C. Role of anthracyclines in the era of targeted therapy. Cardiovasc Toxicol. 2007;7:56-60.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 56-60
    • Cortes-Funes, H.1    Coronado, C.2
  • 16
    • 34548301545 scopus 로고    scopus 로고
    • Protection by flavonoids against anthracycline cardiotoxicity: From chemistry to clinical trials
    • Bast A, Haenen GR, Bruynzeel AM, Van der Vijgh WJ. Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials. Cardiovasc Toxicol. 2007;7:154-159.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 154-159
    • Bast, A.1    Haenen, G.R.2    Bruynzeel, A.M.3    Van der Vijgh, W.J.4
  • 17
    • 0032566691 scopus 로고    scopus 로고
    • Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    • Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998;281:2042-2045.
    • (1998) Science , vol.281 , pp. 2042-2045
    • Le Good, J.A.1    Ziegler, W.H.2    Parekh, D.B.3    Alessi, D.R.4    Cohen, P.5    Parker, P.J.6
  • 18
    • 2442623486 scopus 로고    scopus 로고
    • The role of activated MEK-ERK pathway in quercetininduced growth inhibition and apoptosis in A549 lung cancer cells
    • Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH, Huynh H. The role of activated MEK-ERK pathway in quercetininduced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis. 2004;25:647-659.
    • (2004) Carcinogenesis , vol.25 , pp. 647-659
    • Nguyen, T.T.1    Tran, E.2    Nguyen, T.H.3    Do, P.T.4    Huynh, T.H.5    Huynh, H.6
  • 19
    • 58649101636 scopus 로고    scopus 로고
    • Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis
    • Warren CA, Paulhill KJ, Davidson LA et al. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J Nutr. 2009;139:101-105.
    • (2009) J Nutr , vol.139 , pp. 101-105
    • Warren, C.A.1    Paulhill, K.J.2    Davidson, L.A.3
  • 20
    • 42649100263 scopus 로고    scopus 로고
    • Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway
    • Kim YH, Lee DH, Jeong JH, Guo ZS, Lee YJ. Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol. 2008;75:1946-1958.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1946-1958
    • Kim, Y.H.1    Lee, D.H.2    Jeong, J.H.3    Guo, Z.S.4    Lee, Y.J.5
  • 21
    • 42149151524 scopus 로고    scopus 로고
    • Underlying mechanism of quercetin-induced cell death in human glioma cells
    • Kim EJ, Choi CH, Park JY, Kang SK, Kim YK. Underlying mechanism of quercetin-induced cell death in human glioma cells. Neurochem Res. 2008;33:971-979.
    • (2008) Neurochem Res , vol.33 , pp. 971-979
    • Kim, E.J.1    Choi, C.H.2    Park, J.Y.3    Kang, S.K.4    Kim, Y.K.5
  • 22
    • 1542605222 scopus 로고    scopus 로고
    • Catherine Rice-Evans. Flavonoids: Antioxidants or signalling molecules?
    • Robert J. Williams JPES, Catherine Rice-Evans. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med. 2004;37:838-849.
    • (2004) Free Radic Biol Med , vol.37 , pp. 838-849
    • Robert, J.1    Williams, J.P.E.S.2
  • 23
    • 58049191302 scopus 로고    scopus 로고
    • Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats
    • Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci. 2009;84:75-80.
    • (2009) Life Sci , vol.84 , pp. 75-80
    • Ghosh, A.1    Mandal, A.K.2    Sarkar, S.3    Panda, S.4    Das, N.5
  • 24
    • 74249099331 scopus 로고    scopus 로고
    • Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat
    • Gupta C, Vikram A, Tripathi DN, Ramarao P, Jena GB: Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat. Phytother Res. 2009;24:119-128.
    • (2009) Phytother Res , vol.24 , pp. 119-128
    • Gupta, C.1    Vikram, A.2    Tripathi, D.N.3    Ramarao, P.4    Jena, G.B.5
  • 25
    • 1542285131 scopus 로고    scopus 로고
    • The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines in in vitro conditions
    • Borska S, Gebarowska E, Wysocka T, Drag-Zalesinska M, Zabel M. The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines in in vitro conditions. Folia Morphol (Warsz). 2004;63:103-105.
    • (2004) Folia Morphol (Warsz) , vol.63 , pp. 103-105
    • Borska, S.1    Gebarowska, E.2    Wysocka, T.3    Drag-Zalesinska, M.4    Zabel, M.5
  • 26
    • 18244376403 scopus 로고    scopus 로고
    • Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters
    • Di Pietro A, Conseil G, Perez-Victoria JM et al. Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. Cell Mol Life Sci. 2002;59:307-322.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 307-322
    • Di Pietro, A.1    Conseil, G.2    Perez-Victoria, J.M.3
  • 27
    • 0026504102 scopus 로고
    • Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite
    • Kioka N, Hosokawa N, Komano T, Hirayoshi K, Nagata K, Ueda K. Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite. FEBS Lett. 1992;301:307-309.
    • (1992) FEBS Lett , vol.301 , pp. 307-309
    • Kioka, N.1    Hosokawa, N.2    Komano, T.3    Hirayoshi, K.4    Nagata, K.5    Ueda, K.6
  • 28
    • 33646568511 scopus 로고    scopus 로고
    • Mechanisms and strategies to overcome multiple drug resistance in cancer
    • Ozben T. Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett. 2006;580:2903-2909.
    • (2006) FEBS Lett , vol.580 , pp. 2903-2909
    • Ozben, T.1
  • 29
    • 34250667583 scopus 로고    scopus 로고
    • Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma
    • Saczko J, Kulbacka J, Chwilkowska et al. Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma. Folia Histochem Cytobiol. 2007;45:93-98.
    • (2007) Folia Histochem Cytobiol , vol.45 , pp. 93-98
    • Saczko, J.1    Kulbacka, J.2    Chwilkowska3
  • 30
    • 0033861060 scopus 로고    scopus 로고
    • Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells
    • Lage H, Jordan A, Scholz R, Dietel M. Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells. Int J Hyperthermia. 2000;16:291-303.
    • (2000) Int J Hyperthermia , vol.16 , pp. 291-303
    • Lage, H.1    Jordan, A.2    Scholz, R.3    Dietel, M.4
  • 31
    • 0025341331 scopus 로고
    • New colorimetric cytotoxicity assay for anticancer-drug screening
    • Skehan P, Storeng R, Scudiero D et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 1990;82:1107-1112.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1107-1112
    • Skehan, P.1    Storeng, R.2    Scudiero, D.3
  • 32
    • 0038309713 scopus 로고    scopus 로고
    • Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis
    • Yasuhara S, Zhu Y, Matsui T. Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem. 2003;51:873-885.
    • (2003) J Histochem Cytochem , vol.51 , pp. 873-885
    • Yasuhara, S.1    Zhu, Y.2    Matsui, T.3
  • 33
    • 0030961394 scopus 로고    scopus 로고
    • The DNA 'comet assay' as a rapid screening technique to control irradiated food
    • Cerda H, Delincee H, Haine H, Rupp H. The DNA 'comet assay' as a rapid screening technique to control irradiated food. Mutat Res. 1997;375:167-181.
    • (1997) Mutat Res , vol.375 , pp. 167-181
    • Cerda, H.1    Delincee, H.2    Haine, H.3    Rupp, H.4
  • 35
    • 67649946192 scopus 로고    scopus 로고
    • Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway
    • Shan BE, Wang MX, Li RQ. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009;27:604-612.
    • (2009) Cancer Invest , vol.27 , pp. 604-612
    • Shan, B.E.1    Wang, M.X.2    Li, R.Q.3
  • 36
    • 61749103704 scopus 로고    scopus 로고
    • Protective effect of quercetin in primary neurons against Abeta(1-42): Relevance to Alzheimer's disease
    • Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. J Nutr Biochem. 2009;20:269-275.
    • (2009) J Nutr Biochem , vol.20 , pp. 269-275
    • Ansari, M.A.1    Abdul, H.M.2    Joshi, G.3    Opii, W.O.4    Butterfield, D.A.5
  • 37
    • 38849134933 scopus 로고    scopus 로고
    • Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine
    • Lee KW, Kang NJ, Heo YS et al. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res. 2008;68:946-955.
    • (2008) Cancer Res , vol.68 , pp. 946-955
    • Lee, K.W.1    Kang, N.J.2    Heo, Y.S.3
  • 38
    • 67649440675 scopus 로고    scopus 로고
    • The antioxidant effects of quercetin metabolites on the prevention of high glucose-induced apoptosis of human umbilical vein endothelial cells
    • Chao CL, Hou YC, Chao PD, Weng CS, Ho FM. The antioxidant effects of quercetin metabolites on the prevention of high glucose-induced apoptosis of human umbilical vein endothelial cells. Br J Nutr. 2009;101:1165-1170.
    • (2009) Br J Nutr , vol.101 , pp. 1165-1170
    • Chao, C.L.1    Hou, Y.C.2    Chao, P.D.3    Weng, C.S.4    Ho, F.M.5
  • 39
    • 65649137735 scopus 로고    scopus 로고
    • Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases
    • Jagtap S, Meganathan K, Wagh V, Winkler J, Hescheler J, Sachinidis A. Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases. Curr Med Chem. 2009;16:1451-1462.
    • (2009) Curr Med Chem , vol.16 , pp. 1451-1462
    • Jagtap, S.1    Meganathan, K.2    Wagh, V.3    Winkler, J.4    Hescheler, J.5    Sachinidis, A.6
  • 40
    • 0034724758 scopus 로고    scopus 로고
    • Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA
    • Johnson MK, Loo G. Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA. Mutat Res. 2000;459:211-218.
    • (2000) Mutat Res , vol.459 , pp. 211-218
    • Johnson, M.K.1    Loo, G.2
  • 41
    • 0035451074 scopus 로고    scopus 로고
    • Dietary supplementation with the anti-tumour promoter quercetin: Its effects on matrix metalloproteinase gene regulation
    • Morrow DM, Fitzsimmons PE, Chopra M, McGlynn H. Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001;480-481:269-276.
    • (2001) Mutat Res
    • Morrow, D.M.1    Fitzsimmons, P.E.2    Chopra, M.3    McGlynn, H.4
  • 42
    • 33846093647 scopus 로고    scopus 로고
    • Molecular mechanisms of anthracyclines action
    • Szulawska A, Czyz M: [Molecular mechanisms of anthracyclines action]. Postepy Hig Med Dosw. 2006;60:78-100.
    • (2006) Postepy Hig Med Dosw , vol.60 , pp. 78-100
    • Szulawska, A.1    Czyz, M.2
  • 44
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr. 2002;22:19-34.
    • (2002) Annu Rev Nutr , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 45
    • 16244408972 scopus 로고    scopus 로고
    • (-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis
    • Choi YJ, Jeong YJ, Lee YJ, Kwon HM, Kang YH. (-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis. J Nutr. 2005;135:707-713.
    • (2005) J Nutr , vol.135 , pp. 707-713
    • Choi, Y.J.1    Jeong, Y.J.2    Lee, Y.J.3    Kwon, H.M.4    Kang, Y.H.5
  • 46
    • 56049123402 scopus 로고    scopus 로고
    • The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
    • Aalinkeel R, Bindukumar B, Reynolds JL et al. The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. Prostate 2008;68:1773-1789.
    • (2008) Prostate , vol.68 , pp. 1773-1789
    • Aalinkeel, R.1    Bindukumar, B.2    Reynolds, J.L.3
  • 47
    • 57349169369 scopus 로고    scopus 로고
    • Quercetin sensitizes human hepatoma cells to TRAILinduced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation
    • Kim JY, Kim EH, Park SS, Lim JH, Kwon TK, Choi KS. Quercetin sensitizes human hepatoma cells to TRAILinduced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. J Cell Biochem. 2008;105:1386-1398.
    • (2008) J Cell Biochem , vol.105 , pp. 1386-1398
    • Kim, J.Y.1    Kim, E.H.2    Park, S.S.3    Lim, J.H.4    Kwon, T.K.5    Choi, K.S.6
  • 48
    • 33749007655 scopus 로고    scopus 로고
    • Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma
    • Rosner K, Ropke C, Pless V, Skovgaard GL. Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma. Biosci Biotechnol Biochem. 2006;70:2169-2177.
    • (2006) Biosci Biotechnol Biochem , vol.70 , pp. 2169-2177
    • Rosner, K.1    Ropke, C.2    Pless, V.3    Skovgaard, G.L.4
  • 49
    • 33745655837 scopus 로고    scopus 로고
    • Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
    • Vijayababu MR, Arunkumar A, Kanagaraj P, Arunakaran J. Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells. J Carcinog. 2006;5:10.
    • (2006) J Carcinog , vol.5 , pp. 10
    • Vijayababu, M.R.1    Arunkumar, A.2    Kanagaraj, P.3    Arunakaran, J.4
  • 50
    • 12844268624 scopus 로고    scopus 로고
    • Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells
    • Mertens-Talcott SU, Percival SS. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 2005;218:141-151.
    • (2005) Cancer Lett , vol.218 , pp. 141-151
    • Mertens-Talcott, S.U.1    Percival, S.S.2
  • 51
    • 39149143709 scopus 로고    scopus 로고
    • The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage
    • Kaindl U, Eyberg I, Rohr-Udilova N, Heinzle C, Marian B. The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage. Food Chem Toxicol. 2008;46:1320-1326.
    • (2008) Food Chem Toxicol , vol.46 , pp. 1320-1326
    • Kaindl, U.1    Eyberg, I.2    Rohr-Udilova, N.3    Heinzle, C.4    Marian, B.5
  • 52
    • 67651042484 scopus 로고    scopus 로고
    • Essential role of Nrf2 in keratinocyte protection from UVA by quercetin
    • Kimura S, Warabi E, Yanagawa T et al. Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009.
    • (2009) Biochem Biophys Res Commun
    • Kimura, S.1    Warabi, E.2    Yanagawa, T.3
  • 53
    • 0038064452 scopus 로고    scopus 로고
    • Inactivation of creatine kinase induced by quercetin with horseradish peroxidase and hydrogen peroxide. pro-oxidative and anti-oxidative actions of quercetin
    • Miura T, Muraoka S, Fujimoto Y. Inactivation of creatine kinase induced by quercetin with horseradish peroxidase and hydrogen peroxide. pro-oxidative and anti-oxidative actions of quercetin. Food Chem Toxicol. 2003;41:759-765.
    • (2003) Food Chem Toxicol , vol.41 , pp. 759-765
    • Miura, T.1    Muraoka, S.2    Fujimoto, Y.3
  • 54
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism
    • Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol in vitro. 2006;20:187-210.
    • (2006) Toxicol In Vitro , vol.20 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 55
    • 0242576442 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells
    • O'Prey J, Brown J, Fleming J, Harrison PR. Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem Pharmacol. 2003;66:2075-2088.
    • (2003) Biochem Pharmacol , vol.66 , pp. 2075-2088
    • O'Prey, J.1    Brown, J.2    Fleming, J.3    Harrison, P.R.4
  • 56
    • 77957178533 scopus 로고
    • Toxicity and carcinogenicity studies of quercetin, a natural component of foods
    • Dunnick JK, Hailey JR. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam Appl Toxicol. 1992;19:423-431.
    • (1992) Fundam Appl Toxicol , vol.19 , pp. 423-431
    • Dunnick, J.K.1    Hailey, J.R.2
  • 57
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45:2179-2205.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 58
    • 32944472519 scopus 로고    scopus 로고
    • Safety of quercetin for clinical application (Review)
    • Okamoto T: Safety of quercetin for clinical application (Review). Int J Mol Med. 2005;16:275-278.
    • (2005) Int J Mol Med , vol.16 , pp. 275-278
    • Okamoto, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.