Signaling circuits in early B-cell development

Advances in Immunology

Volumn 122, Issue , 2014, Pages 129-175

  Reth, Michael ^a,b   Nielsen, Peter ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

B cell development; Il7 receptor; MAP kinase; PI3 kinase; PreB receptor; Signaling

Indexed keywords

INTERLEUKIN 7 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PRE B CELL RECEPTOR;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL EXPANSION; CELL MATURATION; CELL SURVIVAL; DEVELOPMENTAL STAGE; DOWN REGULATION; GENE LOCUS; GENE MUTATION; GENE REARRANGEMENT; HUMAN; IMMUNOGLOBULIN GENE; INTRACELLULAR SIGNALING; KNOCKOUT MOUSE; LEUKEMIA; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

B-CELL DEVELOPMENT; IL7 RECEPTOR; MAP KINASE; PI3 KINASE; PREB RECEPTOR; SIGNALING;

ANIMALS; B-LYMPHOCYTE SUBSETS; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; HUMANS; PRE-B CELL RECEPTORS; PRECURSOR CELLS, B-LYMPHOID; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84893414788     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800267-4.00004-3     Document Type: Chapter

References (259)

1. Aguzzi A., Brandner S., Sure U., Rüedi D., Isenmann S. Transgenic and knock-out mice: Models of neurological disease. Brain Pathology 1994, 4:3-20.
2. Aiba Y., Kameyama M., Yamazaki T., Tedder T.F., Kurosaki T. Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 2008, 111:1497-1503.
3. Alkhatib A., Werner M., Hug E., Herzog S., Eschbach C., Faraidun H., et al. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. The Journal of Experimental Medicine 2012, 209:395-406.
4. Alt F.W., Yancopoulos G.D., Blackwell T.K., Wood C., Thomas E., Boss M., et al. Ordered rearrangement of immunoglobulin heavy chain variable region segments. The EMBO Journal 1984, 3:1209-1219.
5. Amin R.H., Schlissel M.S. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nature Immunology 2008, 9:613-622.
6. Andreu E.J., Lledó E., Poch E., Ivorra C., Albero M.P., Martínez-Climent J.A., et al. BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells. Cancer Research 2005, 65:3264-3272.
7. Arinobu Y., Mizuno S.-I., Chong Y., Shigematsu H., Iino T., Iwasaki H., et al. Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 2007, 1:416-427.
8. Bankovich A.J., Raunser S., Juo Z.S., Walz T., Davis M.M., Garcia K.C. Structural insight into pre-B cell receptor function. Science 2007, 316:291-294.
9. Baracho G.V., Miletic A.V., Omori S.A., Cato M.H., Rickert R.C. Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Current Opinion in Immunology 2011, 23:178-183.
10. Batista F.D., Treanor B., Harwood N.E. Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation. Immunological Reviews 2010, 237:191-204.
11. Bednarski J.J., Sleckman B.P. Integrated signaling in developing lymphocytes: The role of DNA damage responses. Cell Cycle 2012, 11:4129-4134.
12. Boboila C., Boboila C., Alt F.W., Alt F.W., Schwer B., Schwer B. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Advances in Immunology 2012, 116:1-49.
13. Boiko A.D., Porteous S., Razorenova O.V., Krivokrysenko V.I., Williams B.R., Gudkov A.V. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes & Development 2006, 20:236-252.
14. Bortnick A., Allman D. What is and what should always have been: Long-lived plasma cells induced by T cell-independent antigens. The Journal of Immunology 2013, 190:5913-5918.
15. Bradl H., Jäck H.M. Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines. The Journal of Immunology 2001, 167:6403-6411.
16. Brightbill H., Schlissel M.S. The effects of c-Abl mutation on developing B cell differentiation and survival. International Immunology 2009, 21:575-585.
17. Brooks S.R., Kirkham P.M., Freeberg L., Carter R.H. Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric. The Journal of Immunology 2004, 172:7556-7564.
18. Burgering B.M.T., Medema R.H. Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. Journal of Leukocyte Biology 2003, 73:689-701.
19. Calamito M., Juntilla M.M., Thomas M., Northrup D.L., Rathmell J., Birnbaum M.J., et al. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 2010, 115:4043-4050.
20. Ceredig R., Andersson J., Melchers F., Rolink A. Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors. European Journal of Immunology 1999, 29:2797-2807.
21. Chalupny N.J., Kanner S.B., Schieven G.L., Wee S.F., Gilliland L.K., Aruffo A., et al. Tyrosine phosphorylation of CD19 in pre-B and mature B cells. The EMBO Journal 1993, 12:2691-2696.
22. Chen H.-C., Byrd J.C., Muthusamy N. Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival. The Journal of Immunology 2006, 176:2208-2218.
23. Chen Z., Xiao Y., Zhang J., Li J., Liu Y., Zhao Y., et al. Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. PLoS One 2011, 6:e20475.
24. Cobaleda C., Jochum W., Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 2007, 449:473-477.
25. Conley M.E., Dobbs A.K., Quintana A.M., Bosompem A., Wang Y.-D., Coustan-Smith E., et al. Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K. Journal of Experimental Medicine 2012, 209:463-470.
26. Corfe S.A., Paige C.J. The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation. Seminars in Immunology 2012, 24:198-208.
27. Coughlin J.J., Stang S.L., Dower N.A., Stone J.C. RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. The Journal of Immunology 2005, 175:7179-7184.
28. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789.
29. Dang T.P. Notch, apoptosis and cancer. Advances in Experimental Medicine and Biology 2012, 727:199-209.
30. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
31. de Alboran I.M., O'Hagan R.C., Gärtner F., Malynn B., Davidson L., Rickert R., et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 2001, 14:45-55.
32. Degner-Leisso S.C., Feeney A.J. Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes. Seminars in Immunology 2010, 22:346-352.
33. Deininger M.W., Goldman J.M., Melo J.V. The molecular biology of chronic myeloid leukemia. Blood 2000, 96:3343-3356.
34. Delgado P., Cubelos B., Calleja E., Martínez-Martín N., Ciprés A., Mérida I., et al. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nature Immunology 2009, 10:880-888.
35. Delogu A., Schebesta A., Sun Q., Aschenbrenner K., Perlot T., Busslinger M. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 2006, 24:269-281.
36. Dengler H., Baracho G., Omori S., Bruckner S., Arden K., Castrillon D., et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nature Immunology 2008, 9:1388-1398.
37. Dias S., Silva H., Cumano A., Vieira P. Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. The Journal of Experimental Medicine 2005, 201:971-979.
38. Dolence J.J., Gwin K., Frank E., Medina K.L. Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B-cell precursors. European Journal of Immunology 2011, 41:324-334.
39. Duy C., Yu J.J., Nahar R., Swaminathan S., Kweon S.-M., Polo J.M., et al. BCL6 is critical for the development of a diverse primary B cell repertoire. The Journal of Experimental Medicine 2010, 207:1209-1221.
40. Elantak L., Espeli M., Boned A., Bornet O., Bonzi J., Gauthier L., et al. Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation. The Journal of Biological Chemistry 2012, 287:44703-44713.
41. Engels N., Wollscheid B., Wienands J. Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha. European Journal of Immunology 2001, 31:2126-2134.
42. Eschbach C., Bach M.P., Fidler I., Pelanda R., Köhler F., Rajewsky K., et al. Efficient generation of B lymphocytes by recognition of self-antigens. European Journal of Immunology 2011, 41:2397-2403.
43. Espeli M., Mancini S.J.C., Breton C., Poirier F., Schiff C. Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. Blood 2009, 113:5878-5886.
44. Famulok M., Mayer G. Aptamer modules as sensors and detectors. Accounts of Chemical Research 2011, 44:1349-1358.
45. Fayard E., Tintignac L.A., Baudry A., Hemmings B.A. Protein kinase B/Akt at a glance. Journal of Cell Science 2005, 118:5675-5678.
46. Feldhahn N., Klein F., Mooster J.L., Hadweh P., Sprangers M., Wartenberg M., et al. Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells. The Journal of Experimental Medicine 2005, 201:1837-1852.
47. Ferreiros-Vidal I., Carroll T., Taylor B., Terry A., Liang Z., Bruno L., et al. Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood 2013, 121:1769-1782.
48. Ferry H., Cornall R.J. Analysis of B-cell immune tolerance induction using transgenic mice. Methods in Molecular Biology 2004, 271:239-260.
49. Finetti F., Savino M.T., Baldari C.T. Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters. Immunological Reviews 2009, 232:115-134.
50. Fleming H.E., Paige C.J. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity 2001, 15:521-531.
51. Flemming A., Brummer T., Reth M., Jumaa H. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nature Immunology 2003, 4:38-43.
52. Frame S., Cohen P. GSK3 takes centre stage more than 20 years after its discovery. The Biochemical Journal 2001, 359:1-16.
53. Fruman D.A., Snapper S.B., Yballe C.M., Davidson L., Yu J.Y., Alt F.W., et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 1999, 283:393-397.
54. Fu C., Turck C.W., Kurosaki T., Chan A.C. BLNK: A central linker protein in B cell activation. Immunity 1998, 9:93-103.
55. Fugmann S.D. The origins of the Rag genes-From transposition to V(D)J recombination. Seminars in Immunology 2010, 22:10-16.
56. Fujimoto M., Poe J.C., Hasegawa M., Tedder T.F. CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. Immunologic Research 2000, 22:281-298.
57. Fuxa M., Skok J.A. Transcriptional regulation in early B cell development. Current Opinion in Immunology 2007, 19:129-136.
58. Galler G.R., Mundt C., Parker M., Pelanda R., Martensson I.-L., Winkler T.H. Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components. The Journal of Experimental Medicine 2004, 199:1523-1532.
59. Gauwerky C.E., Haluska F.G., Tsujimoto Y., Nowell P.C., Croce C.M. Evolution of B-cell malignancy: Pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene. Proceedings of the National Academy of Sciences of the United States of America 1988, 85:8548-8552.
60. Georgopoulos K., Bigby M., Wang J.H., Molnar A., Wu P., Winandy S., et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994, 79:143-156.
61. Gerits N., Kostenko S., Moens U. In vivo functions of mitogen-activated protein kinases: Conclusions from knock-in and knock-out mice. Transgenic Research 2007, 16:281-314.
62. Giles A.J., Bender T.P., Ravichandran K.S. The adaptor protein Shc plays a key role during early B cell development. The Journal of Immunology 2009, 183:5468-5476.
63. Giltiay N.V., Chappell C.P., Clark E.A. B-cell selection and the development of autoantibodies. Arthritis Research & Therapy 2012, 14(Suppl. 4):S1.
64. Gold M.R. B cell development: Important work for ERK. Immunity 2008, 28:488-490.
65. Gregory M.A., Qi Y., Hann S.R. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. The Journal of Biological Chemistry 2003, 278:51606-51612.
66. Guloglu F.B., Roman C.A.J. Precursor B cell receptor signaling activity can be uncoupled from surface expression. The Journal of Immunology 2006, 176:6862-6872.
67. Habib T., Park H., Tsang M., de Alboran I.M., Nicks A., Wilson L., et al. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. The Journal of Cell Biology 2007, 179:717-731.
68. Hardy R.R., Hayakawa K. B cell development pathways. Annual Review of Immunology 2001, 19:595-621.
69. Hardy R.R., Li Y.S., Allman D., Asano M., Gui M., Hayakawa K. B-cell commitment, development and selection. Immunological Reviews 2000, 175:23-32.
70. Hauser J., Verma-Gaur J., Grundstrom T. Broad feedback inhibition of pre-B-cell receptor signaling components. Molecular Immunology 2013, 54:247-253.
71. Hayashi K., Yamamoto M., Nojima T., Goitsuka R., Kitamura D. Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity 2003, 18:825-836.
72. Heltemes-Harris L.M., Willette M.J.L., Ramsey L.B., Qiu Y.H., Neeley E.S., Zhang N., et al. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. The Journal of Experimental Medicine 2011, 208:1135-1149.
73. Herzog S., Jumaa H. Self-recognition and clonal selection: Autoreactivity drives the generation of B cells. Current Opinion in Immunology 2012, 24:166-172.
74. Herzog S., Hug E., Meixlsperger S., Paik J.-H., DePinho R.A., Reth M., et al. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nature Immunology 2008, 9:623-631.
75. Hess J., Werner A., Wirth T., Melchers F., Jäck H.M., Winkler T.H. Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:1745-1750.
76. Hirokawa S., Sato H., Kato I., Kudo A. EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells. European Journal of Immunology 2003, 33:1824-1829.
77. Hoelbl A., Kovacic B., Kerenyi M.A., Simma O., Warsch W., Cui Y., et al. Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 2006, 107:4898-4906.
78. Holmes M.L., Carotta S., Corcoran L.M., Nutt S.L. Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment. Genes & Development 2006, 20:933-938.
79. Huang H., Tindall D.J. Dynamic FoxO transcription factors. Journal of Cell Science 2007, 120:2479-2487.
80. Inabe K., Kurosaki T. Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement. Blood 2002, 99:584-589.
81. Infantino S., Benz B., Waldmann T., Jung M., Schneider R.J., Reth M. Arginine methylation of the B cell antigen receptor promotes differentiation. The Journal of Experimental Medicine 2010, 207:711-719.
82. Jhaveri S., Rajendran M., Ellington A.D. In vitro selection of signaling aptamers. Nature Biotechnology 2000, 18:1293-1297.
83. Jiang Q., Li W.Q., Aiello F.B., Mazzucchelli R., Asefa B., Khaled A.R., et al. Cell biology of IL-7, a key lymphotrophin. Cytokine & Growth Factor Reviews 2005, 16:513-533.
84. Johnson K., Hashimshony T., Sawai C.M., Pongubala J.M.R., Skok J.A., Aifantis I., et al. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity 2008, 28:335-345.
85. Johnson K., Reddy K.L., Singh H. Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development. Advances in Experimental Medicine and Biology 2009, 650:133-147.
86. Jumaa H., Bossaller L., Portugal K., Storch B., Lotz M., Flemming A., et al. Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature 2003, 423:452-456.
87. Jumaa H., Hendriks R.W., Reth M. B cell signaling and tumorigenesis. Annual Review of Immunology 2005, 23:415-445.
88. Jumaa H., Mitterer M., Reth M., Nielsen P.J. The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage. European Journal of Immunology 2001, 31:2164-2169.
89. Karasuyama H., Kudo A., Melchers F. The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. The Journal of Experimental Medicine 1990, 172:969-972.
90. Karasuyama H., Rolink A., Melchers F. A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. The Journal of Experimental Medicine 1993, 178:469-478.
91. Karasuyama H., Rolink A., Melchers F. Surrogate light chain in B cell development. Advances in Immunology 1996, 63:1-41.
92. Kawano Y., Ouchida R., Wang J.-Y., Yoshikawa S., Yamamoto M., Kitamura D., et al. A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5. Molecular and Cellular Biology 2012, 32:4462-4471.
93. Kazi J.U., Vaapil M., Agarwal S., Bracco E., Påhlman S., Rönnstrand L. The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling. Cellular Signalling 2013, 25:1852-1860.
94. Kersseboom R., Middendorp S., Dingjan G.M., Dahlenborg K., Reth M., Jumaa H., et al. Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. The Journal of Experimental Medicine 2003, 198:91-98.
95. Kersseboom R., Ta V.B.T., Zijlstra A.J.E., Middendorp S., Jumaa H., van Loo P.F., et al. Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement. The Journal of Immunology 2006, 176:4543-4552.
96. Khiem D., Cyster J.G., Schwarz J.J., Black B.L. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:17067-17072.
97. Kikuchi K., Lai A.Y., Hsu C.-L., Kondo M. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. The Journal of Experimental Medicine 2005, 201:1197-1203.
98. Kirstetter P., Thomas M., Dierich A., Kastner P., Chan S. Ikaros is critical for B cell differentiation and function. European Journal of Immunology 2002, 32:720-730.
99. Kitamura D., Kudo A., Schaal S., Müller W., Melchers F., Rajewsky K. A critical role of lambda 5 protein in B cell development. Cell 1992, 69:823-831.
100. Kitamura D., Roes J., Kühn R., Rajewsky K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 1991, 350:423-426.
101. Knoll M., Yanagisawa Y., Simmons S., Engels N., Wienands J., Melchers F., et al. The non-Ig parts of the VpreB and lambda5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. The Journal of Immunology 2012, 188:6010-6017.
102. Köhler F., Hug E., Eschbach C., Meixlsperger S., Hobeika E., Kofer J., et al. Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. Immunity 2008, 29:912-921.
103. Köhler F., Storch B., Kulathu Y., Herzog S., Kuppig S., Reth M., et al. A leucine zipper in the N terminus confers membrane association to SLP-65. Nature Immunology 2005, 6:204-210.
104. Kraus M., Alimzhanov M.B., Rajewsky N., Rajewsky K. Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell 2004, 117:787-800.
105. Krop I., Shaffer A.L., Fearon D.T., Schlissel M.S. The signaling activity of murine CD19 is regulated during cell development. The Journal of Immunology 1996, 157:48-56.
106. Kuiper R.P., Schoenmakers E.F.P.M., van Reijmersdal S.V., Hehir-Kwa J.Y., van Kessel A.G., van Leeuwen F.N., et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007, 21:1258-1266.
107. Kulathu Y., Hobeika E., Turchinovich G., Reth M. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. The EMBO Journal 2008, 27:1333-1344.
108. Kuo T.C., Schlissel M.S. Mechanisms controlling expression of the RAG locus during lymphocyte development. Current Opinion in Immunology 2009, 21:173-178.
109. Küppers R., Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001, 20:5580-5594.
110. Lam K.P., Kühn R., Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997, 90:1073-1083.
111. Lanig H., Bradl H., Jäck H.-M. Three-dimensional modeling of a pre-B-cell receptor. Molecular Immunology 2004, 40:1263-1272.
112. Lee T., Yao G., Nevins J., You L. Sensing and integration of Erk and PI3K signals by Myc. PLoS Computational Biology 2008, 4:e1000013.
113. Lennartsson J., Rönnstrand L. Stem cell factor receptor/c-Kit: From basic science to clinical implications. Physiological Reviews 2012, 92:1619-1649.
114. Levy Y., Benlagha K., Buzyn A., Colombel M., Brouet J.C., Lassoued K. IL-7 sensitizes human pre-B cells but not pro-B cells to Fas/APO-1 (CD95)-mediated apoptosis. Clinical and Experimental Immunology 1997, 110:329-335.
115. Li L.-X., Goetz C.A., Katerndahl C.D.S., Sakaguchi N., Farrar M.A. A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness. The Journal of Immunology 2010, 184:1728-1736.
116. Li W., Liu Q., Pang Y., Jin J., Wang H., Cao H., et al. Core fucosylation of mu heavy chains regulates assembly and intracellular signaling of precursor B cell receptors. The Journal of Biological Chemistry 2012, 287:2500-2508.
117. Lim I.K. TIS21 (/BTG2/PC3) as a link between ageing and cancer: Cell cycle regulator and endogenous cell death molecule. Journal of Cancer Research and Clinical Oncology 2006, 132:417-426.
118. Lin Y.C., Benner C., Mansson R., Heinz S., Miyazaki K., Miyazaki M., et al. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nature Immunology 2012, 13:1196-1204.
119. Lin Y.C., Jhunjhunwala S., Benner C., Heinz S., Welinder E., Mansson R., et al. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nature Immunology 2010, 11:635-643.
120. Liu P., Sharrock R.A. Directed dimerization: An in vivo expression system for functional studies of type II phytochromes. The Plant Journal 2013, 75:915-926.
121. Lu R., Medina K.L., Lancki D.W., Singh H. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes & Development 2003, 17:1703-1708.
122. Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:9448-9453.
123. Ma S., Pathak S., Mandal M., Trinh L., Clark M.R., Lu R. Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression. Molecular and Cellular Biology 2010, 30:4149-4158.
124. Maehama T., Dixon J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. The Journal of Biological Chemistry 1998, 273:13375-13378.
125. Malin S., McManus S., Cobaleda C., Novatchkova M., Delogu A., Bouillet P., et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nature Immunology 2010, 11:171-179.
126. Mandal M., Powers S.E., Ochiai K., Georgopoulos K., Kee B.L., Singh H., et al. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nature Immunology 2009, 10:1110-1117.
127. Mandel E.M., Grosschedl R. Transcription control of early B cell differentiation. Current Opinion in Immunology 2010, 22:161-167.
128. Mangolini M., de Boer J., Walf-Vorderwülbecke V., Pieters R., den Boer M.L., Williams O. STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia. Blood 2013, 122:542-549.
129. Manning B.D., Cantley L.C. United at last: The tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochemical Society Transactions 2003, 31:573-578.
130. Manning B.D., Cantley L.C. AKT/PKB signaling: Navigating downstream. Cell 2007, 129:1261-1274.
131. Manz J., Denis K., Witte O., Brinster R., Storb U. Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains. The Journal of Experimental Medicine 1988, 168:1363-1381.
132. Marchisio M.A., Rudolf F. Synthetic biosensing systems. The International Journal of Biochemistry & Cell Biology 2011, 43:310-319.
133. Marshall A.J., Fleming H.E., Wu G.E., Paige C.J. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. The Journal of Immunology 1998, 161:6038-6045.
134. Martensson I.-L., Keenan R.A., Licence S. The pre-B-cell receptor. Current Opinion in Immunology 2007, 19:137-142.
135. McKenna H.J., Stocking K.L., Miller R.E., Brasel K., De Smedt T., Maraskovsky E., et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000, 95:3489-3497.
136. Medina K.L., Pongubala J.M.R., Reddy K.L., Lancki D.W., Dekoter R., Kieslinger M., et al. Assembling a gene regulatory network for specification of the B cell fate. Developmental Cell 2004, 7:607-617.
137. Medvedovic J., Medvedovic J., Ebert A., Ebert A., Tagoh H., Tagoh H., et al. Pax5: A master regulator of B cell development and leukemogenesis. Advances in Immunology 2011, 111:179-206.
138. Melchers F., Haasner D., Streb M., Rolink A. B-lymphocyte lineage-committed, IL-7 and stroma cell-reactive progenitors and precursors, and their differentiation to B cells. Advances in Experimental Medicine and Biology 1992, 323:111-117.
139. Melchers F., Rolink A., Grawunder U., Winkler T.H., Karasuyama H., Ghia P., et al. Positive and negative selection events during B lymphopoiesis. Current Opinion in Immunology 1995, 7:214-227.
140. Merkenschlager M. Ikaros in immune receptor signaling, lymphocyte differentiation, and function. FEBS Letters 2010, 584:4910-4914.
141. Mertsching E., Grawunder U., Meyer V., Rolink T., Ceredig R. Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: Expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen. European Journal of Immunology 1996, 26:28-33.
142. Metzger H. Transmembrane signaling: The joy of aggregation. The Journal of Immunology 1992, 149:1477-1487.
143. Milne C.D., Fleming H.E., Zhang Y., Paige C.J. Mechanisms of selection mediated by interleukin-7, the preBCR, and hemokinin-1 during B-cell development. Immunological Reviews 2004, 197:75-88.
144. Mombaerts P., Iacomini J., Johnson R.S., Herrup K., Tonegawa S., Papaioannou V.E. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992, 68:869-877.
145. Mourcin F., Breton C., Tellier J., Narang P., Chasson L., Jorquera A., et al. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood 2011, 117:6552-6561.
146. Mullighan C.G. The molecular genetic makeup of acute lymphoblastic leukemia. Hematology/the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2012, 2012:389-396.
147. Mullighan C.G., Goorha S., Radtke I., Miller C.B., Coustan-Smith E., Dalton J.D., et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007, 446:758-764.
148. Mullighan C.G., Miller C.B., Radtke I., Phillips L.A., Dalton J., Ma J., et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008, 453:110-114.
149. Mundt C., Licence S., Shimizu T., Melchers F., Mårtensson I.L. Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice. The Journal of Experimental Medicine 2001, 193:435-445.
150. Müller K., Engesser R., Schulz S., Steinberg T., Tomakidi P., Weber C.C., et al. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Research 2013, 41:e124.
151. Naderi S., Gutzkow K.B., Låhne H.U., Lefdal S., Ryves W.J., Harwood A.J., et al. cAMP-induced degradation of cyclin D3 through association with GSK-3beta. Journal of Cell Science 2004, 117:3769-3783.
152. Nagasawa T. Microenvironmental niches in the bone marrow required for B-cell development. Nature Reviews. Immunology 2006, 6:107-116.
153. Nagata K., Nakamura T., Kitamura F., Kuramochi S., Taki S., Campbell K.S., et al. The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 1997, 7:559-570.
154. Nakayama J., Yamamoto M., Hayashi K., Satoh H., Bundo K., Kubo M., et al. BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3. Blood 2009, 113:1483-1492.
155. Nemazee D. Receptor editing in B cells. Advances in Immunology 2000, 74:89-126.
156. Nera K.-P., Kohonen P., Narvi E., Peippo A., Mustonen L., Terho P., et al. Loss of Pax5 promotes plasma cell differentiation. Immunity 2006, 24:283-293.
157. Nilsson J.A., Cleveland J.L. Myc pathways provoking cell suicide and cancer. Oncogene 2003, 22:9007-9021.
158. Nitschke L., Kosco M.H., Köhler G., Lamers M.C. Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens. Proceedings of the National Academy of Sciences of the United States of America 1993, 90:1887-1891.
159. Nussenzweig M.C., Shaw A.C., Sinn E., Danner D.B., Holmes K.L., Morse H.C., et al. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science 1987, 236:816-819.
160. Nutt S.L., Kee B.L. The transcriptional regulation of B cell lineage commitment. Immunity 2007, 26:715-725.
161. Nutt S.L., Heavey B., Rolink A.G., Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999, 401:556-562.
162. O'Reilly L.A., Kruse E.A., Puthalakath H., Kelly P.N., Kaufmann T., Huang D.C.S., et al. MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. The Journal of Immunology 2009, 183:261-269.
163. O'Riordan M., Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 1999, 11:21-31.
164. Ochiai K., Maienschein-Cline M., Mandal M., Triggs J.R., Bertolino E., Sciammas R., et al. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nature Immunology 2012, 13:300-307.
165. Oellerich T., Bremes V., Neumann K., Bohnenberger H., Dittmann K., Hsiao H.-H., et al. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. The EMBO Journal 2011, 30:3620-3634.
166. Ohnishi K., Melchers F. The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling. Nature Immunology 2003, 4:849-856.
167. Ohnishi K., Melchers F., Shimizu T. Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages. European Journal of Immunology 2005, 35:957-963.
168. Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000, 13:817-827.
169. Okkenhaug K. Signaling by the phosphoinositide 3-kinase family in immune cells. Annual Review of Immunology 2013, 31:675-704.
170. Okkenhaug K., Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nature Reviews. Immunology 2003, 3:317-330.
171. Otero D.C., Rickert R.C. CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition. The Journal of Immunology 2003, 171:5921-5930.
172. Paige J.S., Nguyen-Duc T., Song W., Jaffrey S.R. Fluorescence imaging of cellular metabolites with RNA. Science 2012, 335:1194.
173. Paige J.S., Wu K.Y., Jaffrey S.R. RNA mimics of green fluorescent protein. Science 2011, 333:642-646.
174. Palmesino E., Moepps B., Gierschik P., Thelen M. Differences in CXCR4-mediated signaling in B cells. Immunobiology 2006, 211:377-389.
175. Park T.J., Kim J.Y., Park S.H., Kim H.S., Lim I.K. Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. Experimental Cell Research 2009, 315:3152-3162.
176. Parker M.J., Licence S., Erlandsson L., Galler G.R., Chakalova L., Osborne C.S., et al. The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription. The EMBO Journal 2005, 24:3895-3905.
177. Pelanda R., Braun U., Hobeika E., Nussenzweig M.C., Reth M. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. The Journal of Immunology 2002, 169:865-872.
178. Pelanda R., Schaal S., Torres R.M., Rajewsky K. A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity 1996, 5:229-239.
179. Pelanda R., Schwers S., Sonoda E., Torres R.M., Nemazee D., Rajewsky K. Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 1997, 7:765-775.
180. Poe J.C., Minard-Colin V., Kountikov E.I., Haas K.M., Tedder T.F. A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. The Journal of Immunology 2012, 189:2318-2325.
181. Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996, 381:751-758.
182. Rajewsky K., Gu H., Kühn R., Betz U.A., Müller W., Roes J., et al. Conditional gene targeting. The Journal of Clinical Investigation 1996, 98:600-603.
183. Ramadani F., Bolland D.J., Garcon F., Emery J.L., Vanhaesebroeck B., Corcoran A.E., et al. The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. Science signaling 2010, 3:ra60.
184. Reth M., Petrac E., Wiese P., Lobel L., Alt F.W. Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. The EMBO Journal 1987, 6:3299-3305.
185. Reth M.G., Ammirati P., Jackson S., Alt F.W. Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature 1985, 317:353-355.
186. Reynaud D., Demarco I.A., Reddy K.L., Schjerven H., Bertolino E., Chen Z., et al. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nature Immunology 2008, 9:927-936.
187. Ritchie K.A., Brinster R.L., Storb U. Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice. Nature 1984, 312:517-520.
188. Roes J., Rajewsky K. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. The Journal of Experimental Medicine 1993, 177:45-55.
189. Rohrschneider L.R., Fuller J.F., Wolf I., Liu Y., Lucas D.M. Structure, function, and biology of SHIP proteins. Genes & Development 2000, 14:505-520.
190. Rolink A., Haasner D., Melchers F., Andersson J. The surrogate light chain in mouse B-cell development. International Reviews of Immunology 1996, 13:341-356.
191. Rolink A.G., ten Boekel E., Yamagami T., Ceredig R., Andersson J., Melchers F. B cell development in the mouse from early progenitors to mature B cells. Immunology Letters 1999, 68:89-93.
192. Rolink A.G., Winkler T., Melchers F., Andersson J. Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. The Journal of Experimental Medicine 2000, 191:23-32.
193. Rossi B., Espeli M., Schiff C., Gauthier L. Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation. The Journal of Immunology 2006, 177:796-803.
194. Roulland S., Roulland S., Faroudi M., Faroudi M., Mamessier E., Mamessier E., et al. Early steps of follicular lymphoma pathogenesis. Advances in Immunology 2011, 111:1-46.
195. Sandoval G.J., Graham D.B., Bhattacharya D., Sleckman B.P., Xavier R.J., Swat W. Cutting edge: Cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. The Journal of Immunology 2013, 190:2485-2489.
196. Schamel W.W.A., Reth M. Monomeric and oligomeric complexes of the B cell antigen receptor. Immunity 2000, 13:5-14.
197. Schmidt E.V., Pattengale P.K., Weir L., Leder P. Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: A pre-B-cell lymphoma model. Proceedings of the National Academy of Sciences of the United States of America 1988, 85:6047-6051.
198. Schmidt M., Fernandez de Mattos S., van der Horst A., Klompmaker R., Kops G.J.P.L., Lam E.W.-F., et al. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Molecular and Cellular Biology 2002, 22:7842-7852.
199. Schram B.R., Tze L.E., Ramsey L.B., Liu J., Najera L., Vegoe A.L., et al. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. The Journal of Immunology 2008, 180:4728-4741.
200. Schuh W., Meister S., Herrmann K., Bradl H., Jäck H.-M. Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor. Molecular Immunology 2008, 45:362-375.
201. Schuh W., Meister S., Roth E., Jäck H.-M. Cutting edge: Signaling and cell surface expression of a mu H chain in the absence of lambda 5: A paradigm revisited. The Journal of Immunology 2003, 171:3343-3347.
202. Schweighoffer E., Vanes L., Mathiot A., Nakamura T., Tybulewicz V.L.J. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 2003, 18:523-533.
203. Shaw A.C., Swat W., Ferrini R., Davidson L., Alt F.W. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. The Journal of Experimental Medicine 1999, 189:123-129.
204. Shimizu T., Mundt C., Licence S., Melchers F., Martensson I.-L. VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. The Journal of Immunology 2002, 168:6286-6293.
205. Shinjo F., Hardy R.R., Jongstra J. Monoclonal anti-lambda 5 antibody FS1 identifies a 130 kDa protein associated with lambda 5 and Vpre-B on the surface of early pre-B cell lines. International Immunology 1994, 6:393-399.
206. Shinkai Y., Alt F.W. RAG-2-deficient mice lack mature lymphocytes owing to inability to intiate V(D)J rearrangement. Cell 1992, 68:855-867.
207. Sigvardsson M., O'Riordan M., Grosschedl R. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 1997, 7:25-36.
208. Sitnicka E., Brakebusch C., Martensson I.-L., Svensson M., Agace W.W., Sigvardsson M., et al. Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. The Journal of Experimental Medicine 2003, 198:1495-1506.
209. So L., Fruman D.A. PI3K signalling in B- and T-lymphocytes: New developments and therapeutic advances. The Biochemical Journal 2012, 442:465-481.
210. Song G., Ouyang G., Bao S. The activation of Akt/PKB signaling pathway and cell survival. Journal of Cellular and Molecular Medicine 2005, 9:59-71.
211. Spanopoulou E. Cellular and molecular analysis of lymphoid development using Rag-deficient mice. International Reviews of Immunology 1996, 13:257-288.
212. Spanopoulou E., Roman C.A., Corcoran L.M., Schlissel M.S., Silver D.P., Nemazee D., et al. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes & Development 1994, 8:1030-1042.
213. Srinivasan L., Sasaki Y., Calado D.P., Zhang B., Paik J.-H., DePinho R.A., et al. PI3 kinase signals BCR-dependent mature B cell survival. Cell 2009, 139:573-586.
214. Storb U., Roth P., Kurtz B.K. Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. Immunologic Research 1994, 13:291-298.
215. Storch B., Meixlsperger S., Jumaa H. The Ig-alpha ITAM is required for efficient differentiation but not proliferation of pre-B cells. European Journal of Immunology 2007, 37:252-260.
216. Su Y.-W., Flemming A., Wossning T., Hobeika E., Reth M., Jumaa H. Identification of a pre-BCR lacking surrogate light chain. The Journal of Experimental Medicine 2003, 198:1699-1706.
217. Su Y.-W., Hao Z., Hirao A., Yamamoto K., Lin W.-J., Young A., et al. 14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:1555-1560.
218. Su Y.-W., Herzog S., Lotz M., Feldhahn N., Müschen M., Jumaa H. The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion. European Journal of Immunology 2004, 34:3614-3622.
219. Su Y.W., Jumaa H. LAT links the pre-BCR to calcium signaling. Immunity 2003, 19:295-305.
220. Subrahmanyam R., Du H., Ivanova I., Chakraborty T., Ji Y., Zhang Y., et al. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nature Immunology 2012, 13:1205-1212.
221. Sun B., Mallampati S., Gong Y., Wang D., Lefebvre V., Sun X. Sox4 is required for the survival of pro-B cells. The Journal of Immunology 2013, 190:2080-2089.
222. Suzuki T., K-Tsuzuku J., Ajima R., Nakamura T., Yoshida Y., Yamamoto T. Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes & Development 2002, 16:1356-1370.
223. Ta V.B.T., de Bruijn M.J.W., ter Brugge P.J., van Hamburg J.P., Diepstraten H.J.A., van Loo P.F., et al. Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway. Blood 2010, 115:1385-1393.
224. Thévenin C., Nutt S.L., Busslinger M. Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis. The Journal of Experimental Medicine 1998, 188:735-744.
225. Thompson E.C., Cobb B.S., Sabbattini P., Meixlsperger S., Parelho V., Liberg D., et al. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity 2007, 26:335-344.
226. Tiegs S.L., Russell D.M., Nemazee D. Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine 1993, 177:1009-1020.
227. Tokoyoda K., Egawa T., Sugiyama T., Choi B.-I., Nagasawa T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 2004, 20:707-718.
228. Tolar P., Sohn H.W., Pierce S. The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer. Nature Immunology 2005, 6:1168-1176.
229. Trageser D., Iacobucci I., Nahar R., Duy C., von Levetzow G., Klemm L., et al. Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. Journal of Experimental Medicine 2009, 206:1739-1753.
230. Tsubata T., Reth M. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. The Journal of Experimental Medicine 1990, 172:973-976.
231. Tsuzuki S., Seto M. TEL (ETV6)-AML1 (RUNX1) initiates self-renewing fetal pro-B cells in association with a transcriptional program shared with embryonic stem cells in mice. Stem Cells 2013, 31:236-247.
232. Tze L.E., Schram B.R., Lam K.-P., Hogquist K.A., Hippen K.L., Liu J., et al. Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biology 2005, 3:e82.
233. Tzivion G., Dobson M., Ramakrishnan G. FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochimica et Biophysica Acta 2011, 1813:1938-1945.
234. Übelhart R., Bach M.P., Eschbach C., Wossning T., Reth M., Jumaa H. N-linked glycosylation selectively regulates autonomous precursor BCR function. Nature Immunology 2010, 11:759-765.
235. van der Vos K.E., Coffer P.J. The extending network of FOXO transcriptional target genes. Antioxidants & Redox Signaling 2011, 14:579-592.
236. van Loo P.F., Dingjan G.M., Maas A., Hendriks R.W. Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. Immunity 2007, 27:468-480.
237. Venkitaraman A.R., Cowling R.J. Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor. European Journal of Immunology 1994, 24:2168-2174.
238. Verbeek S., van Lohuizen M., van der Valk M., Domen J., Kraal G., Berns A. Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. Molecular and Cellular Biology 1991, 11:1176-1179.
239. Vervoorts J., Lüscher-Firzlaff J., Lüscher B. The ins and outs of MYC regulation by posttranslational mechanisms. The Journal of Biological Chemistry 2006, 281:34725-34729.
240. Vettermann C., Jäck H.-M. The pre-B cell receptor: Turning autoreactivity into self-defense. Trends in Immunology 2010, 31:176-183.
241. Vettermann C., Herrmann K., Albert C., Roth E., Bösl M.R., Jäck H.-M. A unique role for the lambda5 nonimmunoglobulin tail in early B lymphocyte development. The Journal of Immunology 2008, 181:3232-3242.
242. Victora G.D., Nussenzweig M.C. Germinal centers. Annual Review of Immunology 2012, 30:429-457.
243. Vigorito E., Bardi G., Glassford J., Lam E.W.-F., Clayton E., Turner M. Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. The Journal of Immunology 2004, 173:3209-3214.
244. Vogt P.K., Jiang H., Aoki M. Triple layer control: Phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 2005, 4:908-913.
245. Waskow C., Paul S., Haller C., Gassmann M., Rodewald H.-R. Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Immunity 2002, 17:277-288.
246. Welinder E., Ahsberg J., Sigvardsson M. B-lymphocyte commitment: Identifying the point of no return. Seminars in Immunology 2011, 23:335-340.
247. Wen R., Chen Y., Bai L., Fu G., Schuman J., Dai X., et al. Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Molecular and Cellular Biology 2006, 26:9364-9376.
248. Wienands J., Schweikert J., Wollscheid B., Jumaa H., Nielsen P.J., Reth M. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. The Journal of Experimental Medicine 1998, 188:791-795.
249. Wilker P.R., Kohyama M., Sandau M.M., Albring J.C., Nakagawa O., Schwarz J.J., et al. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nature Immunology 2008, 9:603-612.
250. Winkler G.S. The mammalian anti-proliferative BTG/Tob protein family. Journal of Cellular Physiology 2010, 222:66-72.
251. Xie L., Ushmorov A., Leithäuser F., Guan H., Steidl C., Färbinger J., et al. FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Blood 2012, 119:3503-3511.
252. Yamagata K., Daitoku H., Takahashi Y., Namiki K., Hisatake K., Kako K., et al. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Molecular Cell 2008, 32:221-231. http://www.molecule.org/supplemental/S1097-2765(08)00658-8.
253. Yang J., Reth M. Oligomeric organization of the B-cell antigen receptor on resting cells. Nature 2010, 467:465-469.
254. Yang J., Reth M. The dissociation activation model of B cell antigen receptor triggering. FEBS Letters 2010, 584:4872-4877.
255. Yao Z., Cui Y., Watford W.T., Bream J.H., Yamaoka K., Hissong B.D., et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:1000-1005.
256. Yasuda T., Kurosaki T. Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle 2008, 7:3634-3640.
257. Yasuda T., Sanjo H., Pages G., Kawano Y., Karasuyama H., Pouyssegur J., et al. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 2008, 28:499-508.
258. Zhang L., Reynolds T.L., Shan X., Desiderio S. Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 2011, 34:163-174.
259. Zhang X., Tang N., Hadden T.J., Rishi A.K. Akt, FoxO and regulation of apoptosis. Biochimica et Biophysica Acta 2011, 1813:1978-1986.