A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

Nature Immunology

Volumn 13, Issue 3, 2012, Pages 300-307

  Ochiai, Kyoko ^a   Maienschein Cline, Mark ^a   Mandal, Malay ^a   Triggs, Joseph R ^a   Bertolino, Eric ^a   Sciammas, Roger ^a   Dinner, Aaron R ^a   Clark, Marcus R ^a   Singh, Harinder ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE ANTIGEN; IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 7; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAG1 PROTEIN; RAG2 PROTEIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX5;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE INDUCTION; GENETIC CODE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-7; MICE; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 84857195761     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2210     Document Type: Article

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