Ikaros is critical for B cell differentiation and function

European Journal of Immunology

Volumn 32, Issue 3, 2002, Pages 720-730

  Kirstetter, Peggy ^a   Thomas, Mireille ^a   Dierich, Andrée ^a   Kastner, Philippe ^a   Chan, Susan ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

B cell; Differentiation; Ikaros; Knockout

Indexed keywords

BETA GALACTOSIDASE; CELL SURFACE MARKER; RAG1 PROTEIN; RAG2 PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; FETUS DEVELOPMENT; GENE TARGETING; GENETIC CODE; GENETIC TRANSCRIPTION; HOMOZYGOSITY; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; STEM CELL;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; BETA-GALACTOSIDASE; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA-BINDING PROTEINS; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, RAG-1; GENES, REPORTER; GENOTYPE; HOMEODOMAIN PROTEINS; IKAROS TRANSCRIPTION FACTOR; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULIN M; IMMUNOLOGIC DEFICIENCY SYNDROMES; LAC OPERON; MICE; MICE, TRANSGENIC; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036201410     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200203)32:3<720::AID-IMMU720>3.0.CO;2-P     Document Type: Article

References (28)

1. B cell development pathways
2. Transcriptional regulation of early B-lymphocyte differentiation
3. The Ikaros gene is required for the development of all lymphoid lineages
4. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
5. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
6. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
7. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
8. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
9. Ikaros sets thresholds for T cell activation and regulates chromosome propagation
10. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
11. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors
12. Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules
13. Early B-lymphocyte precursors and their regulation by sex steroids
14. Apoptosis and its modulation during B lymphopoiesis in mouse bone marrow
15. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
16. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
17. B cell commitment, development and selection
18. Down-regulation of terminal deoxynucleotidyl transferase by Ig heavy chain in B lineage cells
19. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
20. Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation
21. + thymocytes by Ikaros proteins in direct competition with an Ets activator
22. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding
23. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
24. Aiolos regulates B cell activation and maturation to effector state
25. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
26. Visualization of CD4/CD8 T cell commitment
27. A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis
28. Phenotype analysis of cycling and postcycling thymocytes: Evaluation of detection methods for BrdUrd and surface proteins