Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A

Immunity

Volumn 11, Issue 1, 1999, Pages 21-31

  O'Riordan, Mary ^a   Grosschedl, Rudolf ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW; CELL MATURATION; COMPLEX FORMATION; CONTROLLED STUDY; FETUS; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM;

EID: 0033166301     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80078-3     Document Type: Article

References (59)

1. Adams, B., Dorfler, P., Aguzzi, A., Kozmik, Z., Urbanek, P., Maurer-Fogy, I., and Busslinger, M. (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 6, 1589-1607.
2. Bain, G., Maandag, E.C., Izon, D.J., Amsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schlissel, M.S., Feeney, A.J., van Roon, M., et al. (1994). E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79, 885-892.
3. Benezra, R. (1994). An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 79, 1057-1067.
4. Bruhn, L., Munnerlyn, A., and Grosschedl, R. (1997). ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev. 11, 640-653.
5. Busslinger, M., and Nutt, S. (1998). Role of the transcription factor BSAP (Pax-5) in B-cell development. In Molecular Biology of B-cell and T-cell Development, J.G. Monroe and E.V. Rothenberg, eds. (Totowa, NJ: Humana Press), pp. 83-110.
6. Busslinger, M., Klix, N., Pfeffer, P., Graninger, P.G., and Kozmik, Z. (1996). Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc. Natl. Acad. Sci. USA 93, 6129-6134.
7. Chen, J., Shinkai, Y., Young, F., and Alt, F.W. (1994). Probing immune functions in RAG-deficient mice. Curr. Opin. Immunol. 6, 313-319.
8. Choi, J.K., Shen, C.P., Radomska, H.S., Eckhardt, L.A., and Kadesch, T. (1996). E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15, 5014-5021.
9. Crozatier, M., Valle, D., Dubois, L., Ibnsouda, S., and Vincent, A. (1996). Collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain. Curr. Biol. 6, 707-718.
10. Fitzsimmons, D., Hodsdon, W., Wheat, W., Maira, S.M., Wasylyk, B., and Hagman, J. (1996). Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter. Genes Dev. 10, 2198-2211.
11. Garel, S., Marin, F., Mattei, M.G., Vesque, C., Vincent, A., and Charnay, P. (1997). Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system. Dev. Dyn. 210, 191-205.
12. Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, T.B., Smith-Gill, S.J., Brink, R.A., Pritchard-Briscoe, H., Wotherspoon, J.S., Loblay, R.H., Raphael, K., et al. (1988). Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334, 676-682.
13. Hagman, J., Travis, A., and Grosschedl, R. (1991). A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. EMBO J. 10, 3409-3417.
14. Hagman, J., Belanger, C., Travis, A., Turck, C.W., and Grosschedl, R. (1993). Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev. 7, 760-773
15. Hagman, J., Gutch, M.J., Lin, H., and Grosschedl, R. (1995). EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains. EMBO J. 14, 2907-2916.
16. Hardy, R.R., and Hayakawa, K. (1995). B-lineage differentiation stages resolved by multiparameter flow cytometry. Ann. NY Acad. Sci. 764, 19-24.
17. Henikoff, S. (1996). Dosage-dependent modification of position-effect variegation in Drosophila. Bioessays 18, 401-409.
18. Hernandez-Munain, C., and Krangel, M.S. (1995). C-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer [published erratum appears in Mol. Cell. Biol. 1995 Aug;15(8):4659]. Mol. Cell. Biol. 15, 3090-3099.
19. Jacobs, Y., Xin, X.Q., Dorshkind, K., and Nelson, C. (1994). Pan/E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and Pan/E2A proteins are not detected in myeloid cells. Mol. Cell. Biol. 14, 4087-4096.
20. Kee, B.L., and Murre, C. (1998). Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J. Exp. Med. 188, 699-713.
21. Klug, C.A., Morrison, S.J., Masek, M., Hahm, K., Smale, S.T., and Weissman, I.L. (1998). Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc. Natl. Acad. Sci. USA 95, 657-662.
22. Kozmik, Z., Wang, S., Dorfler, P., Adams, B., and Busslinger, M. (1992). The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol. 12, 2662-2672.
23. Kudo, A., Sakaguchi, N., and Melchers, F. (1987). Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes [published erratum appears in EMBO J. 1987 Dec 20; 6(13):4242]. EMBO J. 6, 103-107.
24. Lassar, A.B., Davis, R.L., Wright, W.E., Kadesch, T., Murre, C., Voronova, A., Baltimore, D., and Weintraub, H. (1991). Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell 66, 305-315.
25. Li, Y.S., Hayakawa, K., and Hardy, R.R. (1993). The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178, 951-960.
26. Lin, H., and Grosschedl, R. (1995). Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263-267.
27. Mansouri, A., Hallonet, M., and Gruss, P. (1996). Pax genes and their roles in cell differentiation and development. Curr. Opin. Cell. Biol. 8, 851-857.
28. Mason, D.Y., Jones, M., and Goodnow, C.C. (1992). Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. Int. Immunol. 4, 163-175.
29. Molkentin, J.D., Black, B.L., Martin, J.F., and Olson, E.N. (1995). Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83, 1125-1136.
30. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., and Papaioannou, V.E. (1992). Rag-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
31. Murre, C., McCaw, P.S., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., et al. (1989). Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-544.
32. Murre, C., McCaw, P.S., and Baltimore, D. (1989). A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56, 777-783.
33. Murre, C., Voronova, A., and Baltimore, D. (1991). B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol. Cell. Biol. 11, 1156-1160.
34. Murre, C., Bain, G., van Dijk, M.A., Engel, I., Furnari, B.A., Massari, M.E., Matthews, J.R., Quong, M.W., Rivera, R.R., and Stuiver, M.H. (1994). Structure and function of helix-loop-helix proteins. Biochim. Biophys. Acta 1218, 129-135.
35. Nutt, S.L., Urbanek, P., Rolink, A., and Busslinger, M. (1997). Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev. 11, 476-491.
36. Nutt, S.L., Morrison, A.M., Dorfler, P., Rolink, A., and Busslinger, M. (1998). Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J. 17, 2319-2333.
37. Nutt, S.L., Vambrie, S., Steinlein, P., Kozmik, Z., Rolink, A., Weith, A., and Busslinger, M. (1999). Independent regulation of the two Pax5 alleles during B-cell development. Nat. Genet. 21, 390-395.
38. Reya, T., and Grosschedl, R. (1998). Transcriptional regulation of B-cell differentiation. Curr. Opin. Immunol. 10, 158-165.
39. Rolink, A., and Melchers, F. (1993). B lymphopoiesis in the mouse. Adv. Immunol. 53, 123-156.
40. Rolink, A., ten Boekel, E., Melchers, F., Fearon, D.T., Krop, I., and Andersson, J. (1996). A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183, 187-194.
41. Schlissel, M., Voronova, A., and Baltimore, D. (1991). Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5, 1367-1376.
42. Scott, E.W., Simon, M.C., Anastasi, J., and Singh, H. (1994). Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265, 1573-1577.
43. Shen, C.P., and Kadesch, T. (1995). B-cell-specific DNA binding by an E47 homodimer. Mol. Cell. Biol. 15, 4518-4524.
44. Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., et al. (1992). Rag-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
45. Sigvardsson, M., O'Riordan, M., and Grosschedl, R. (1997). EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 7, 25-36.
46. Singh, H. (1996). Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates. Curr. Opin. Immunol. 8, 160-165.
47. Sloan, S.R., Shen, C.P., McCarrick-Walmsley, R., and Kadesch, T. (1996). Phosphorylation of E47 as a potential determinant of B-cell-specific activity. Mol. Cell. Biol. 16, 6900-6908.
48. Spanopoulou, E., Roman, C.A., Corcoran, L.M., Schlissel, M.S., Silver, D.P., Nemazee, D., Nussenzweig, M.C., Shinton, S.A., Hardy, R.R., and Baltimore, D. (1994). Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042.
49. Tian, J., Okabe, T., Miyazaki, T., Takeshita, S., and Kudo, A. (1997). Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters as well as the KI and KII sites upstream of the Jkappa genes. Eur. J. Immunol. 27, 750-755.
50. Torres, R.M., Flaswinkel, H., Reth, M., and Rajewsky, K. (1996). Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272, 1804-1808.
51. Urbanek, P., Wang, Z.Q., Fetka, I., Wagner, E.F., and Busslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.
52. Wakatsuki, Y., Neurath, M.F., Max, E.E., and Strober, W. (1994). The B cell-specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 179, 1099-1108.
53. Wallin, J.J., Gackstetter, E.R., and Koshland, M.E. (1998). Dependence of BSAP repressor and activator functions on BSAP concentration. Science 279, 1961-1964.
54. Wang, M.M., and Reed, R.R. (1993). Molecular cloning of the olfactory neuronal transcription factor OIf-1 by genetic selection in yeast. Nature 364, 121-126.
55. Wang, H., Diamond, R.A., and Rothenberg, E.V. (1998). Cross-lineage expression of Ig-beta (B29) in thymocytes: Positive and negative gene regulation to establish T cell identity. Proc. Natl. Acad. Sci. USA 95, 6831-6836.
56. Wasserman, R., Li, Y.S., and Hardy, R.R. (1995). Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement. J. Immunol. 155, 644-651.
57. Wehr, R., and Gruss, P. (1996). Pax and vertebrate development. Int. J. Dev. Biol. 40, 369-377.
58. Yao, T.P., Oh, S.P., Fuchs, M., Zhou, N.D., Ch'ng, L.E., Newsome, D., Bronson, R.T., Li, E., Livingston, D.M., and Eckner, R. (1998). Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93, 361-372.
59. Zhuang, Y., Soriano, P., and Weintraub, H. (1994). The helix-loop-helix gene E2A is required for B cell formation. Cell 79, 875-884.