The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage

European Journal of Immunology

Volumn 31, Issue 7, 2001, Pages 2164-2169

  Jumaa, Hassan ^a   Mitterer, Michael ^a   Reth, Michael ^a   Nielsen, Peter J ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

5; Deficient; Signaling; Surrogate; VpreB

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; MUTANT PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL MATURATION; CONTROLLED STUDY; CROSS BREEDING; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; SPLEEN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD; ANTIGENS, CD43; B-LYMPHOCYTES; BONE MARROW; CARRIER PROTEINS; CELL DIFFERENTIATION; GENE DELETION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; SIALOGLYCOPROTEINS; SPLEEN; STEM CELLS;

EID: 0034932149     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200107)31:7<2164::AID-IMMU2164>3.0.CO;2-S     Document Type: Article

References (36)

1. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
2. Murine B Lymphopoiesis - Towards a United Model
3. Role of the surrogate light chain and the pre B-cell receptor in mouse B-cell development
4. Clonal selection and learning in the antibody system
5. B cell development: Signal transduction by antigen receptors and their surrogates
6. Antibody regulation of B cell development
7. RAG-1 deficient mice have no mature B and T lymphocytes
8. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
9. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
10. A critical role of lambda 5 protein in B cell development
11. Regulation of an early developmental checkpoint in the B cell pathway by lg beta
12. Antigen receptor signalling - Integration of protein tyrosine kinase functions
13. Genetic analysis of B cell antigen receptor signaling
14. Lymphocytes with a complex: Adapter proteins in antigen receptor signaling
15. Tec family kinases in lymphocyte signaling and function
16. Tec kinases: A family with multiple roles in immunity
17. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
18. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
19. Defective B cell development and function in Btk-deficient mice
20. Impaired expansion of mouse B cell progenitors lacking Btk
21. Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein Slp76
22. Requirement For the Leukocyte-Specific Adapter Protein Slp-76 For Normal T-cell Development
23. Essential role of LAT in T cell development
24. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
25. Requirements for B cell linker protein (BLNK) in B cell development
26. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
27. An essential role for BLNK in human B cell development
28. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - Functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
29. Interaction of SLP adaptors with the SH2 domain of Tec family kinases
30. Precursor B Cells of Mouse Bone Marrow Express Two Different Complexes With the Surrogate Light Chain On the Surface
31. BLNK: Connecting Syk and Btk to calcium signals
32. Regulation of the phospholipase C-gamma 2 pathway in B cells
33. Phospholipase C gamma 2 is essential in the functions of B cell and several Fc receptors
34. Essential role of phospholipase C-gamma 2 in B cell development and function
35. B cell development in the mouse from early progenitors to mature B cells
36. B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5(+) B cells