Three-dimensional modeling of a pre-B-cell receptor

Molecular Immunology

Volumn 40, Issue 17, 2004, Pages 1263-1272

  Lanig, Harald ^a   Bradl, Harald ^a   Jäck, Hans Martin ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

B cell maturation; Molecular modeling; Structure prediction; Unique tails; VpreB; 5

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN LIGHT CHAIN; POLYPEPTIDE; PROTEIN LAMBDA5; PROTEIN VPREB; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; COMPUTER AIDED DESIGN; COMPUTER MODEL; CONFORMATION; LIGAND BINDING; MOLECULAR MODEL; PREDICTION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

EID: 1142285367     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2003.11.030     Document Type: Article

References (36)

1. Altschul S.F., Madden T.L., Schaffer A.A., Zhang Z., Miller W., Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acid Res. 25:1997;3389-3402.
2. Bradl H., Jack H.M. Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines. J. Immunol. 167:2001;6403-6411.
3. Bradl H., Wittmann J., Milius D., Vettermann C., Jack H.M. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of λ5 and stroma cell-associated heparan sulfate. J. Immunol. 171:2003;2338-2348.
4. Burrows P.D., Stephan R.P., Wang Y.H., Lassoued K., Zhang Z., Cooper M.D. The transient expression of pre-B cell receptors gouverns B cell development. Semin. Immunol. 14:2002;343-349.
5. Case, D.A., Pearlman, D.A., Caldwell, J.W., Cheatham III, T.E., Ross, W.S., Simmerling, C.L., Darden, T.A., Merz, K.M., Stanton, R.V., Cheng, A.L., Vincent, J.J., Crowley, M., Ferguson, D.M., Radmer, R.J., Seibel, G.L., Singh, U.C., Weiner, P.K., Kollman P.A., 1997. AMBER 5, University of California, San Francisco, CA, USA.
6. Combet C., Blanchet C., Geourjon C., Deléage G. NPS@: network protein sequence analysis. Trends Biochem. Sci. 3:2000;147-150.
7. Cornell W.D., Cieplak P., Bayly C.I., Gould I.R., Merz K.M. Jr., Ferguson D.M., Spellmeyer D.C., Fox T., Caldwell J.W., Kollman P.A. J. Am. Chem. Soc. 117:1995;5179-5197.
8. Edelman G.M. Antibody structure and moleculare immunology. Scan. J. Immunol. 34:1991;1-22.
9. Gauld S.B., Dal Porto J.M., Cambier J.C. B cell antigen receptor signaling: roles in cell development and disease. Science. 296:2002;1641-1642.
10. Gauthier L., Rossi B., Roux F., Termine E., Schiff C. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc. Natl. Acad. Sci. U.S.A. 99:2002;13014-13019.
11. Graille M., Stura E.A., Corper A.L., Sutton B.J., Taussig M.J., Charbonnier J.B., Silverman G.J. Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity. Proc. Natl. Acad. Sci. U.S.A. 97:2000;5399-5404.
12. Grawunder U., Leu T.M., Schatz D.G., Werner A., Rolink A.G., Melchers F., Winkler T.H. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity. 3:1995;601-608.
13. Guelpa-Fonlupt V., Bossy D., Alzari P., Fumoux F., Fougereau M., Schiff C. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. Mol. Immunol. 31:1994;1099-1108.
14. Hess J., Werner A., Wirth T., Melchers F., Jack H.M., Winkler T.H. Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor. Proc. Natl. Acad. Sci. U.S.A. 98:2001;1745-1750.
15. Hooft R.W.W., Vriend G., Sander C., Abola E.E. Errors in protein structures. Nature. 381:1996;272-272.
16. Jorgensen W.L., Chandrasekhar J., Madura J.D., Impey R.W., Klein M.L. J. Chem. Phys. 79:1983;926-935.
17. Kabsch W., Sander C. Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers. 22:1983;2577-2637.
18. Karasuyama H., Kudo A., Melchers F. The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J. Exp. Med. 172:1990;969-972.
19. Keyna U., Beck-Engeser G.B., Jongstra J., Applequist S.E., Jäck H.M. Surrogate light chain-dependent selection of Ig heavy chain V regions. J. Immunol. 155:1995;5536-5542.
20. Kurosaki T. Regulation of B cell fates by BCR signaling components. Curr. Opin. Immunol. 3:2002;341-347.
21. Löffert D., Ehlich A., Muller W., Rajewsky K. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:1996;133-144.
22. Martensson I.L., Rolink A., Melchers F., Mundt C., Licence S., Shimizu T. The pre-B cell receptor and its role in proliferation and Ig heavy chain allelic exclusion. Semin. Immunol. 14:2002;335-342.
23. Meffre E., Casellas R., Nussenzweig M.C. Antibody regulation of B cell development. Nat. Immunol. 1:2000;379-385.
24. Melchers F., Karasuyama H., Haasner D., Bauer S., Kudo A., Sakaguchi N., Jameson B., Rolink A. The surrogate light chain in B-cell development. Immunol. Today. 14:1993;60-68.
25. Melchers F. Fit for life in the immune system? Surrogate L chain tests H chains that test L chains. Proc. Natl. Acad. Sci. U.S.A. 96:1999;2571-2573.
26. Minegishi Y., Hendershot L.M., Conley M.E. Novel mechanisms control the folding and assembly of lambda5/14.1 and VpreB to produce an intact surrogate light chain. Proc. Natl. Acad. Sci. U.S.A. 96:1999;3041-3046.
27. Misener V., Jongstra-Bilen J., Young A.J., Atkinson M.J., Wu G.E., Jongstra J. Association of Ig L chain-like protein lambda 5 with a 16-kilodalton protein in mouse pre-B cell lines is not dependent on the presence of Ig H chain protein. J. Immunol. 145:1990;905-909.
28. Muljo S.A., Schlissel M.S. Pre-B and pre-T receptors: conservation of strategies in regulating early lymphocyte development. Immunol. Rev. 175:2000;80-93.
29. Ohnishi K., Melchers F. The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signalling. Nat. Immunol. 4:2003;849-856.
30. Pillai S., Baltimore D. Formation of disulphide-linked mu 2 omega 2 tetramers in pre-B cells by the 18 K omega-immunoglobulin light chain. Nature. 329:1987;172-174.
31. Porter R.R. Structural studies of immunoglobulins. Scan. J. Immunol. 34:1991;381-389.
32. Rolink A., Karasuyama H., Grawunder U., Haasner D., Kudo A., Melchers F. B cell development in mice with a defective lambda 5 gene. Eur. J. Immunol. 23:1993;1284-1288.
33. Schlissel M.S., Morrow T. Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153:1994;1645-1657.
34. Schwede T., Diemand A., Guex N., Peitsch M.C. Protein structure computing in the genomic era. Res. Microbiol. 151:2000;107-112.
35. Thompson J.D., Gibson T.J., Plewniak F., Jeanmougin F., Higgins D.G. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acid Res. 25:1997;4876-4882.
36. Vriend G. WHAT IF: a molecular modeling and drug design program. J. Mol. Graph. 8:1990;52-56.