Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Chen, Zhengshan ^a   Xiao, Yanna ^a   Zhang, Junjun ^a   Li, Jing ^a   Liu, Yuxuan ^b   Zhao, Yingying ^b   Ma, Changchun ^a   Luo, Jin ^a   Qiu, Yamei ^a   Huang, Guowei ^a   Korteweg, Christine ^a   Gu, Jiang ^a,b  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IKAROS TRANSCRIPTION FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAG1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FOXP1; TRANSCRIPTION FACTOR PAX5BETA; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; FOXP1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, HUMAN; REPRESSOR PROTEIN; TCF3 PROTEIN, HUMAN;

ARTICLE; B LYMPHOCYTE; CANCER CELL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN GENE; PROTEIN EXPRESSION; RECOMBINATION ACTIVATING GENE 1; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; RNA INTERFERENCE; TUMOR CELL LINE;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IKAROS TRANSCRIPTION FACTOR; NF-KAPPA B; NUCLEAR PROTEINS; RECOMBINATION, GENETIC; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 79957807804     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020475     Document Type: Article

References (44)

1. Chen Z, Qiu X, Gu J, (2009) Immunoglobulin expression in non-lymphoid lineage and neoplastic cells. Am J Pathol 174: 1139-1148.
2. Qiu X, Zhu X, Zhang L, Mao Y, Zhang J, et al. (2003) Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells. Cancer Res 63: 6488-6495.
3. Zheng H, Li M, Ren W, Zeng L, Liu HD, et al. (2007) Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells. Mol Immunol 44: 2221-2227.
4. Chen Z, Huang X, Ye J, Pan P, Cao Q, et al. (2010) Immunoglobulin G is present in a wide variety of soft tissue tumors and correlates well with proliferation markers and tumor grades. Cancer 116: 1953-1963.
5. Huang J, Sun X, Mao Y, Zhu X, Zhang P, et al. (2008) Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons. Int J Biochem Cell Biol 40: 1604-1615.
6. Geng LY, Shi ZZ, Dong Q, Cai XH, Zhang YM, et al. (2007) Expression of SNC73, a transcript of the immunoglobulin alpha-1 gene, in human epithelial carcinomas. World J Gastroenterol 13: 2305-2311.
7. Huang J, Zhang L, Ma T, Zhang P, Qiu X, (2009) Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse testis and epididymis. J Histochem Cytochem 57: 339-349.
8. Zhang S, Mao Y, Huang J, Ma T, Zhang L, et al. (2010) Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands. Cell Mol Life Sci 67: 985-994.
9. Chen Z, Gu J, (2007) Immunoglobulin G expression in carcinomas and cancer cell lines. Faseb J 21: 2931-2938.
10. Jung D, Giallourakis C, Mostoslavsky R, Alt FW, (2006) Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol 24: 541-570.
11. Fugmann SD, Lee AI, Shockett PE, Villey IJ, Schatz DG, (2000) The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol 18: 495-527.
12. Oettinger MA, Schatz DG, Gorka C, Baltimore D, (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248: 1517-1523.
13. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, et al. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68: 869-877.
14. Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, et al. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68: 855-867.
15. McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, et al. (1995) Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83: 387-395.
16. van Gent DC, McBlane JF, Ramsden DA, Sadofsky MJ, Hesse JE, et al. (1995) Initiation of V(D)J recombination in a cell-free system. Cell 81: 925-934.
17. Kuo TC, Schlissel MS, (2009) Mechanisms controlling expression of the RAG locus during lymphocyte development. Curr Opin Immunol 21: 173-178.
18. Lauring J, Schlissel MS, (1999) Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines. Mol Cell Biol 19: 2601-2612.
19. Fuller K, Storb U, (1997) Identification and characterization of the murine Rag1 promoter. Mol Immunol 34: 939-954.
20. Wei XC, Kishi H, Jin ZX, Zhao WP, Kondo S, et al. (2002) Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2. J Immunol 169: 873-881.
21. Wei XC, Dohkan J, Kishi H, Wu CX, Kondo S, et al. (2005) Characterization of the proximal enhancer element and transcriptional regulatory factors for murine recombination activating gene-2. Eur J Immunol 35: 612-621.
22. Hsu LY, Lauring J, Liang HE, Greenbaum S, Cado D, et al. (2003) A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19: 105-117.
23. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, et al. (2008) Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol 9: 927-936.
24. Amin RH, Schlissel MS, (2008) Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol 9: 613-622.
25. Hu H, Wang B, Borde M, Nardone J, Maika S, et al. (2006) Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol 7: 819-826.
26. Verkoczy L, Ait-Azzouzene D, Skog P, Martensson A, Lang J, et al. (2005) A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity 22: 519-531.
27. Kishi H, Jin ZX, Wei XC, Nagata T, Matsuda T, et al. (2002) Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells. Blood 99: 576-583.
28. Iacobucci I, Lonetti A, Messa F, Cilloni D, Arruga F, et al. (2008) Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance. Blood 112: 3847-3855.
29. Wang B, Lin D, Li C, Tucker P, (2003) Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J Biol Chem 278: 24259-24268.
30. Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, et al. (2000) Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 20: 8969-8982.
31. Coffer PJ, Burgering BM, (2004) Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 4: 889-899.
32. Alikhani M, Roy S, Graves DT, (2010) FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis 16: 408-415.
33. de Pooter RF, Kee BL, (2010) E proteins and the regulation of early lymphocyte development. Immunol Rev 238: 93-109.
34. Quong MW, Romanow WJ, Murre C, (2002) E protein function in lymphocyte development. Annu Rev Immunol 20: 301-322.
35. Sun XH, Baltimore D, (1991) An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell 64: 459-470.
36. Massari ME, Murre C, (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20: 429-440.
37. Kee BL, Arias J, Montminy MR, (1996) Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J Biol Chem 271: 2373-2375.
38. Choi JK, Shen CP, Radomska HS, Eckhardt LA, Kadesch T, (1996) E47 activates the Ig-heavy chain and TdT loci in non-B cells. Embo J 15: 5014-5021.
39. Romanow WJ, Langerak AW, Goebel P, Wolvers-Tettero IL, van Dongen JJ, et al. (2000) E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol Cell 5: 343-353.
40. Goebel P, Janney N, Valenzuela JR, Romanow WJ, Murre C, et al. (2001) Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells. J Exp Med 194: 645-656.
41. Myatt SS, Lam EW, (2007) The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 7: 847-859.
42. Banham AH, Beasley N, Campo E, Fernandez PL, Fidler C, et al. (2001) The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res 61: 8820-8829.
43. Deng YQ, Zheng J, Li GH, Zhu XH, Zhang P, et al. (2006) [Immunoglobulin expression in colon cancer cell line HT-29 and its biological activities]. Zhonghua Zhong Liu Za Zhi 28: 88-91.
44. Zheng H, Li M, Liu H, Ren W, Hu DS, et al. (2007) Immunoglobulin alpha heavy chain derived from human epithelial cancer cells promotes the access of S phase and growth of cancer cells. Cell Biol Int 31: 82-87.