Erk Kinases Link Pre-B Cell Receptor Signaling to Transcriptional Events Required for Early B Cell Expansion

Immunity

Volumn 28, Issue 4, 2008, Pages 499-508

  Yasuda, Tomoharu ^a   Sanjo, Hideki ^a   Pagès, Gilles ^b   Kawano, Yohei ^c   Karasuyama, Hajime ^c   Pouysségur, Jacques ^b   Ogata, Masato ^d   Kurosaki, Tomohiro ^a  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

^b CENTRE ANTOINE LACASSAGNE   (France)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

MOLIMMUNO

Indexed keywords

B LYMPHOCYTE RECEPTOR; BREAKPOINT CLUSTER REGION PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; TRANSCRIPTION FACTOR ELK 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL CYCLE PROGRESSION; CELL EXPANSION; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; MOUSE; NONHUMAN; PHASE TRANSITION; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; GENE DELETION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PRE-B CELL RECEPTORS; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 41549103208     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.02.015     Document Type: Article

References (52)

1. Bell S.E., Vigorito E., McAdam S., Reynolds H.M., Caraux A., Colucci F., and Turner M. PLCγ2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells. Eur. J. Immunol. 34 (2004) 2237-2247
2. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., and Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286 (1999) 1358-1362
3. Buchwalter G., Gross C., and Wasylyk B. Ets ternary complex transcription factors. Gene 324 (2004) 1-14
4. Cesari F., Brecht S., Vintersten K., Vuong L.G., Hofmann M., Klingel K., Schnorr J.J., Arsenian S., Schild H., Herdegen T., et al. Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation. Mol. Cell. Biol. 24 (2004) 294-305
5. Chen H.C., Byrd J.C., and Muthusamy N. Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival. J. Immunol. 176 (2006) 2208-2218
6. Costello P.S., Nicolas R.H., Watanabe Y., Rosewell I., and Treisman R. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Nat. Immunol. 5 (2004) 289-298
7. Craxton A., Draves K.E., Gruppi A., and Clark E.A. BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. J. Exp. Med. 202 (2005) 1363-1374
8. Dequiedt F., Van Lint J., Lecomte E., Van Duppen V., Seufferlein T., Vandenheede J.R., Wattiez R., and Kettmann R. Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J. Exp. Med. 201 (2005) 793-804
9. Fleming H.E., and Paige C.J. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity 15 (2001) 521-531
10. Flemming A., Brummer T., Reth M., and Jumaa H. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat. Immunol. 4 (2003) 38-43
11. Gonzalez G.A., and Montminy M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59 (1989) 675-680
12. Grumont R.J., Strasser A., and Gerondakis S. B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-κB regulated c-myc transcription. Mol. Cell 10 (2002) 1283-1294
13. Habib T., Park H., Tsang M., de Alboran I.M., Nicks A., Wilson L., Knoepfler P.S., Andrews S., Rawlings D.J., Eisenman R.N., and Iritani B.M. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J. Cell Biol. 179 (2007) 717-731
14. Hardy R.R., and Hayakawa K. B cell development pathways. Annu. Rev. Immunol. 19 (2001) 595-621
15. Hatano N., Mori Y., Oh-hora M., Kosugi A., Fujikawa T., Nakai N., Niwa H., Miyazaki J., Hamaoka T., and Ogata M. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8 (2003) 847-856
16. Hendriks R.W., and Middendorp S. The pre-BCR checkpoint as a cell-autonomous proliferation switch. Trends Immunol. 25 (2004) 249-256
17. Hobeika E., Thiemann S., Storch B., Jumaa H., Nielsen P.J., Pelanda R., and Reth M. Testing gene function early in the B cell lineage in mb1-cre mice. Proc. Natl. Acad. Sci. USA 103 (2006) 13789-13794
18. 2-terminal kinase 1, and p38 mitogen-activated protein kinase. J. Exp. Med. 188 (1998) 1297-1306
19. Jumaa H., Hendriks R.W., and Reth M. B cell signaling and tumorigenesis. Annu. Rev. Immunol. 23 (2005) 415-445
20. Kawano Y., Yoshikawa S., Minegishi Y., and Karasuyama H. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J. Immunol. 177 (2006) 2242-2249
21. Kitamura D., Roes J., Kuhn R., and Rajewsky K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350 (1991) 423-426
22. Kraus M., Pao L.I., Reichlin A., Hu Y., Canono B., Cambier J.C., Nussenzweig M.C., and Rajewsky K. Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igß cytoplasmic tail. J. Exp. Med. 194 (2001) 455-469
23. Kuhn R., Schwenk F., Aguet M., and Rajewsky K. Inducible gene targeting in mice. Science 269 (1995) 1427-1429
24. Kurosaki T. Regulation of B-cell signal transduction by adaptor proteins. Nat. Rev. Immunol. 2 (2002) 354-363
25. Maki K., Sunaga S., Komagata Y., Kodaira Y., Mabuchi A., Karasuyama H., Yokomuro K., Miyazaki J.I., and Ikuta K. Interleukin 7 receptor-deficient mice lack γδ T cells. Proc. Natl. Acad. Sci. USA 93 (1996) 7172-7177
26. Meffre E., Casellas R., and Nussenzweig M.C. Antibody regulation of B cell development. Nat. Immunol. 1 (2000) 379-385
27. Middendorp S., Dingjan G.M., and Hendriks R.W. Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice. J. Immunol. 168 (2002) 2695-2703
28. Muljo S.A., and Schlissel M.S. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol. 4 (2003) 31-37
29. Muto A., Tashiro S., Nakajima O., Hoshino H., Takahashi S., Sakoda E., Ikebe D., Yamamoto M., and Igarashi K. The transcriptional programme of antibody class switching involves the repressor Bach2. Nature 429 (2004) 566-571
30. Nagata K., Nakamura T., Kitamura F., Kuramochi S., Taki S., Campbell K.S., and Karasuyama H. The Ig α/Igß heterodimer on μ-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7 (1997) 559-570
31. Negishi I., Motoyama N., Nakayama K., Nakayama K., Senju S., Hatakeyama S., Zhang Q., Chan A.C., and Loh D.Y. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376 (1995) 435-438
32. Oh-hora M., Johmura S., Hashimoto A., Hikida M., and Kurosaki T. Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-γ2 to Ras in B cell receptor signaling. J. Exp. Med. 198 (2003) 1841-1851
33. Pagès G., Guerin S., Grall D., Bonino F., Smith A., Anjuere F., Auberger P., and Pouysségur J. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286 (1999) 1374-1377
34. Pelengaris S., Khan M., and Evan G. c-MYC: More than just a matter of life and death. Nat. Rev. Cancer 2 (2002) 764-776
35. Reichlin A., Hu Y., Meffre E., Nagaoka H., Gong S., Kraus M., Rajewsky K., and Nussenzweig M.C. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin β. J. Exp. Med. 193 (2001) 13-23
36. Reimold A.M., Iwakoshi N.N., Manis J., Vallabhajosyula P., Szomolanyi-Tsuda E., Gravallese E.M., Friend D., Grusby M.J., Alt F., and Glimcher L.H. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412 (2001) 300-307
37. Roose J.P., Mollenauer M., Ho M., Kurosaki T., and Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol. Cell. Biol. 27 (2007) 2732-2745
38. Roovers K., and Assoian R.K. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22 (2000) 818-826
39. Roux P.P., and Blenis J. ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68 (2004) 320-344
40. Saijo K., Schmedt C., Su I.H., Karasuyama H., Lowell C.A., Reth M., Adachi T., Patke A., Santana A., and Tarakhovsky A. Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development. Nat. Immunol. 4 (2003) 274-279
41. Sandmann T., Jensen L.J., Jakobsen J.S., Karzynski M.M., Eichenlaub M.P., Bork P., and Furlong E.E. A temporal map of transcription factor activity: Mef2 directly regulates target genes at all stages of muscle development. Dev. Cell 10 (2006) 797-807
42. Schweighoffer E., Vanes L., Mathiot A., Nakamura T., and Tybulewicz V.L. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 18 (2003) 523-533
43. Sears R., Nuckolls F., Haura E., Taya Y., Tamai K., and Nevins J.R. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14 (2000) 2501-2514
44. Su Y.W., and Jumaa H. LAT links the pre-BCR to calcium signaling. Immunity 19 (2003) 295-305
45. Turner M., Mee P.J., Costello P.S., Williams O., Price A.A., Duddy L.P., Furlong M.T., Geahlen R.L., and Tybulewicz V.L. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 (1995) 298-302
46. van Zelm M.C., van der Burg M., de Ridder D., Barendregt B.H., de Haas E.F., Reinders M.J., Lankester A.C., Revesz T., Staal F.J., and van Dongen J.J. Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J. Immunol. 175 (2005) 5912-5922
47. Wen R., Chen Y., Schuman J., Fu G., Yang S., Zhang W., Newman D.K., and Wang D. An important role of phospholipase Cγ1 in pre-B-cell development and allelic exclusion. EMBO J. 23 (2004) 4007-4017
48. Yamamoto T., Ebisuya M., Ashida F., Okamoto K., Yonehara S., and Nishida E. Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. Curr. Biol. 16 (2006) 1171-1182
49. Yang B.S., Hauser C.A., Henkel G., Colman M.S., Van Beveren C., Stacey K.J., Hume D.A., Maki R.A., and Ostrowski M.C. Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol. Cell. Biol. 16 (1996) 538-547
50. Youn H.D., and Liu J.O. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity 13 (2000) 85-94
51. Zhang C.Y., Wu Y.L., and Boxer L.M. Impaired proliferation and survival of activated B cells in transgenic mice that express a dominant-negative cAMP-response element-binding protein transcription factor in B cells. J. Biol. Chem. 277 (2002) 48359-48365
52. Zhao G., Shi L., Qiu D., Hu H., and Kao P.N. NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function. Exp. Cell Res. 305 (2005) 312-323