B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β

Journal of Immunology

Volumn 169, Issue 2, 2002, Pages 865-872

  Pelanda, Roberta ^a   Braun, Uschi ^a   Hobeika, Elias ^a   Nussenzweig, Michel C ^a   Reth, Michael ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD79B ANTIGEN; IMMUNOGLOBULIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; DISULFIDE BOND; GENE REARRANGEMENT; GENETIC RECOMBINATION; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RESIDUE ANALYSIS; STEM CELL;

EID: 0037100435     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.2.865     Document Type: Article

References (67)

1. Cross-lineage expression of Ig-β (B29) in thymocytes: Positive and negative gene regulation to establish T cell identity
2. B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties
3. Molecular components of the B-cell antigen receptor complex of the IgM class
4. Identification of the genes encoding the IgM-α and Ig-β components of the IgM antigen receptor complex by amino-terminal sequencing
5. Molecular cloning and expression pattern of a human gene homologous to the murine mb-I gene
6. The B-cell antigen receptor of the five immunoglobulin classes
7. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-I genes
8. Signalling function of the B-cell antigen receptors
9. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
10. Regulation of signalling through B-lymphocyte antigen receptors by cell-cell interaction molecules
11. B-cell antigen receptor signaling in immature-stage B cells: Integrating intrinsic and extrinsic signals
12. Intermediary signaling effectors coupling the B-cell receptor to the nucleus
13. The B-cell antigen receptor: Formation of signaling complexes and the function of adaptor proteins
14. The structure of the μ/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction
15. Regulation of an early developmental checkpoint in the B cell pathway by Igβ
16. Mutations in Igα (CD79a) result in a complete block in B-cell development
17. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin β
18. Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igβ cytoplasmic tail
19. Aberrant B cell development and immune response in mice with a compromised BCR complex
20. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
21. Analysis of the B-cell progenitor compartment at the level of single cells
22. Regulation of hemopoiesis by bone marrow stromal cells and their products
23. Molecular interactions between stromai cells and B lymphocyte precursors
24. Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes
25. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation
26. Functional immnoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
27. Surrogate light chain-dependent selection of Ig heavy chain V regions
28. H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor
29. The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule
30. A complex of glycoproteins is associated with VpreB/λ5 surrogate light chain on the surface of μ heavy chain-negative early precursor B cell lines
31. CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain
32. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin chain gene
33. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
34. Structure of the murine mb-I gene encoding a putative sIgM-associated molecule
35. Cre recombinase-controlled expression of the mb-I allele
36. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line
37. A prematurely expressed Igκ transgene, but not VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice
38. Monoclonal antibodies specific for murine IgM. I. Characterization of antigenic determinants on the four constant domains of the μ heavy chain
39. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
40. Antigen receptor tail clue
41. Nonsense-mediated mRNA decay
42. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
43. Identification of the earliest B lineage stage in mouse bone marrow
44. CD2 expression in murine B cell lineage
45. Expression and ontogeny of CD2 on murine B cells
46. IL-2 receptor a chain (CD25, TAC) expression defines a crucial stage in pre-B cell development
47. Splenic T zone development is B cell dependent
48. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
49. The Igα/Igβ heterodimer on μ-negative proB cells is competent for transducing signals to induce early B cell differentiation
50. Control of immunoglobulin gene rearrangements in developing B cells
51. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion
52. H gene segment rearrangements in lymphoid cells
53. Assembly of the truncated immunoglobulin heavy chain Dμ into antigen receptor-like complexes in pre-B cells but not in B cells
54. + cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow
55. A critical role of λ5 protein in B cell development
56. RAG-1-deficient mice have no mature B and T lymphocytes
57. Counterselection against Dμ is mediated through immunoglobulin (Ig)α-Igβ
58. Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice
59. The cytoplasmic domains of immunoglobulin (Ig)α and Igβ can independently induce the precursor B cell transition and allelic exclusion
60. The immunoglobulin (Ig)α and Igβ cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice
61. Pre-B and pre-T-cell receptors: Conservation of strategies in regulating early lymphocyte development
62. Transcriptional regulation of early B-lymphocyte differentiation
63. The role of the preBCR, the interleukin-7 receptor, and homotypic interactions during B-cell development
64. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway
65. Fidelity and infidelity in commitment to B-lymphocyte lineage development