Structural insight into pre-B cell receptor function

Science

Volumn 316, Issue 5822, 2007, Pages 291-294

  Bankovich, Alexander J ^a   Raunser, Stefan ^b   Juo, Z Sean ^a   Walz, Thomas ^b   Davis, Mark M ^a   Garcia, K Christopher ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN; LYMPHOCYTE RECEPTOR;

ANTIBODY; BIOCHEMICAL COMPOSITION; CELL ORGANELLE;

ANTIGEN RECOGNITION; ARTICLE; COMPLEMENTARITY DETERMINING REGION; HUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ANIMALS; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, B-CELL; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247354176     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1139412     Document Type: Article

References (30)

1. C. C. Goodnow, J. Sprent, B. Fazekas de St Groth, C. G. Vinuesa, Nature 435, 590 (2005).
2. S. Tonegawa, Nature 302, 575 (1983).
3. N. Sakaguchi, F. Melchers, Nature 324, 579 (1986).
4. A. Kudo, F. Melchers, EMBO J. 6, 2267 (1987).
5. H. Lanig, H. Bradl, H. M. Jack, Mol. Immunol. 40, 1263 (2004).
6. F. Melchers et al., Immunol. Today 14, 60 (1993).
7. Y. Minegishi, L. M. Hendershot, M. E. Conley, Proc. Natl. Acad. Sci. U.S.A. 96, 3041 (1999).
8. T. Tsubata, M. Reth, J. Exp. Med. 172, 973 (1990).
9. L. M. Hendershot, J. Cell Biol. 111, 829 (1990).
10. S. Pillai, D. Baltimore, Nature 329, 172 (1987).
11. E. ten Boekel, F. Melchers, A. G. Rolink, Immunity 7, 357 (1997).
12. D. J. Decker, N. E. Boyle, J. A. Koziol, N. R. Klinman J. Immunol. 146, 350 (1991).
13. J. Hess et al., Proc. Natl. Acad. Sci. U.S.A. 98, 1745 (2001).
14. H. Karasuyama et al., Cell 77, 133 (1994).
15. U. Keyna, G. B. Beck-Engeser, J. Jongstra, S. E. Applequist, H. M. Jack, J. Immunol. 155, 5536 (1995).
16. M. Milili, C. Schiff, M. Fougereau, C. Tonnelle Eur. J. Immunol. 26, 63 (1996).
17. Y. Minegishi et al., J. Exp. Med. 187, 71 (1998).
18. D. Kitamura et al., Cell 69, 823 (1992).
19. H. Bradl, J. Wittmann, D. Milius, C. Vettermann, H. M. Jack, J. Immunol. 171, 2338 (2003).
20. L. Gauthier, B. Rossi, F. Roux, E. Termine, C. Schiff Proc. Natl. Acad. Sci. U.S.A. 99, 13014 (2002).
21. K. Ohnishi, F. Melchers, Nat. Immunol. 4, 849 (2003).
22. L. D. Wang, M. R. Clark, Immunology 110, 411 (2003).
23. P. Bork, L. Holm, C. Sander, J. Mol. Biol. 242, 309 (1994).
24. A. Kudo, S. Bauer, F. Melchers, Prog. Immunol. 7, 339 (1989).
25. B. Al-Lazikani, A. M. Lesk, C. Chothia, J. Mol. Biol. 273, 927 (1997).
26. M. Zemlin et ol., J. Mol. Biol. 334, 733 (2003).
27. J. L. Xu, M. M. Davis, Immunity 13, 37 (2000).
28. M. M. Davis, Semin. Immunol. 16, 239 (2004).
29. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
30. We thank M. Conley for providing human SLC cDNA; M. Krogsgaard for assistance with SPR; M. Boulanger, P. Strop, and X. Wang for assistance with x-ray crystallography; and M. Winslow and L. Colf for critical reading of the manuscript. This work was supported by grants from NIH, Keck Foundation, and Howard Hughes Medical Institute (K.C.G.) and the Stanford Immunology Program Training Grant (A.J.B.). The molecular EM facility at Harvard Medical School was established with a generous donation from the Giovanni Armenise Harvard Center for Structural Biology and is maintained with funds from NIH (to T.W.). Coordinates and structure factors have been deposited in the PDB (www.rcsb.org) with accession number 2H32.