메뉴 건너뛰기




Volumn 95, Issue 11, 2000, Pages 3489-3497

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; PROTEIN TYROSINE KINASE;

EID: 0034210658     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.11.3489.011k45_3489_3497     Document Type: Article
Times cited : (740)

References (48)
  • 1
    • 0025836321 scopus 로고
    • Stratton lecture 1990: Clinical implications of positive and negative hematopoietic stem cell regulators
    • Moore MA. Stratton lecture 1990: clinical implications of positive and negative hematopoietic stem cell regulators [review]. Blood. 1991;78:1.
    • (1991) Blood , vol.78 , pp. 1
    • Moore, M.A.1
  • 2
    • 0027136259 scopus 로고
    • Hematopoietic regulators: Redundancy or subtlety?
    • Metcalf D. Hematopoietic regulators: redundancy or subtlety? Blood. 1993;82:3515.
    • (1993) Blood , vol.82 , pp. 3515
    • Metcalf, D.1
  • 3
    • 0032519768 scopus 로고    scopus 로고
    • c-kit Ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
    • Lyman SD, Jacobsen SEW. c-kit Ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101.
    • (1998) Blood , vol.91 , pp. 1101
    • Lyman, S.D.1    Jacobsen, S.E.W.2
  • 4
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
    • Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 1991;65:1143.
    • (1991) Cell , vol.65 , pp. 1143
    • Matthews, W.1    Jordan, C.T.2    Wiegand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 5
    • 0027955112 scopus 로고
    • + human bone marrow cells and is involved in the proliferation of early progenitor/ stem cells
    • + human bone marrow cells and is involved in the proliferation of early progenitor/ stem cells. Proc Natl Acad Sci U S A. 1994;91: 459.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 459
    • Small, D.1    Levenstein, M.2    Kim, E.3
  • 6
    • 0027146421 scopus 로고
    • Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells
    • Lyman SD, James L, Vanden Bos T, et al. Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell. 1993;75:1157.
    • (1993) Cell , vol.75 , pp. 1157
    • Lyman, S.D.1    James, L.2    Vanden Bos, T.3
  • 7
    • 0029006853 scopus 로고
    • FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units
    • Hudak S, Hunte B, Culpepper J, et al. FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units. Blood. 1985;85: 2747.
    • (1985) Blood , vol.85 , pp. 2747
    • Hudak, S.1    Hunte, B.2    Culpepper, J.3
  • 9
    • 0028928832 scopus 로고
    • FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver
    • Muench MO, Roncarolo MG, Menon S, et al. FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood. 1995;85:963.
    • (1995) Blood , vol.85 , pp. 963
    • Muench, M.O.1    Roncarolo, M.G.2    Menon, S.3
  • 11
    • 0029912731 scopus 로고    scopus 로고
    • Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3
    • Ramsfjell V, Borge OJ, Veiby OP, et al. Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. Blood. 1996;88:4481.
    • (1996) Blood , vol.88 , pp. 4481
    • Ramsfjell, V.1    Borge, O.J.2    Veiby, O.P.3
  • 12
    • 0028952954 scopus 로고
    • The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors
    • Hirayama F, Lyman SD, Clark SC, Ogawa M. The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood. 1995;85:1762.
    • (1995) Blood , vol.85 , pp. 1762
    • Hirayama, F.1    Lyman, S.D.2    Clark, S.C.3    Ogawa, M.4
  • 13
    • 0029670722 scopus 로고    scopus 로고
    • Flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
    • Hunte BE, Hudak S, Campbell D, Xu Y, Rennick D. Flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors. J Immunol. 1996;156:489.
    • (1996) J Immunol. , vol.156 , pp. 489
    • Hunte, B.E.1    Hudak, S.2    Campbell, D.3    Xu, Y.4    Rennick, D.5
  • 14
    • 0029793903 scopus 로고    scopus 로고
    • Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells
    • Veiby OP, Lyman SD, Jacobsen SEW. Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. Blood. 1996;88:1256.
    • (1996) Blood , vol.88 , pp. 1256
    • Veiby, O.P.1    Lyman, S.D.2    Jacobsen, S.E.W.3
  • 15
    • 0029957070 scopus 로고    scopus 로고
    • Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7
    • Ray RJ, Paige CJ, Furlonger C, Lyman SD, Rottapel R. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7. Eur J Immunol. 1996; 26:1504.
    • (1996) Eur J Immunol. , vol.26 , pp. 1504
    • Ray, R.J.1    Paige, C.J.2    Furlonger, C.3    Lyman, S.D.4    Rottapel, R.5
  • 17
    • 0032032358 scopus 로고    scopus 로고
    • FLT-3 ligand and marrow stroma-derived factors promote CD3γ, CD3δ, CD3ζ, and RAG-2 gene expression in primary human CD34+LIN-DR- marrow progenitors
    • Gaffney PM, Lund J, Miller JS. FLT-3 ligand and marrow stroma-derived factors promote CD3γ, CD3δ, CD3ζ, and RAG-2 gene expression in primary human CD34+LIN-DR- marrow progenitors. Blood. 1998;91:1662.
    • (1998) Blood , vol.91 , pp. 1662
    • Gaffney, P.M.1    Lund, J.2    Miller, J.S.3
  • 18
    • 0031132519 scopus 로고    scopus 로고
    • Differential effects of Flk-2/ Flt-3 ligand and stem cell factor on murine thymic progenitor cells
    • Moore TA, Zlotnik A. Differential effects of Flk-2/ Flt-3 ligand and stem cell factor on murine thymic progenitor cells. J Immunol. 1997;158:4187.
    • (1997) J Immunol. , vol.158 , pp. 4187
    • Moore, T.A.1    Zlotnik, A.2
  • 19
    • 0028803283 scopus 로고
    • Plasma/ serum levels of flt3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia
    • Lyman SD, Seaberg M, Hanna R, et al. Plasma/ serum levels of flt3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia. Blood. 1995;86:4091.
    • (1995) Blood , vol.86 , pp. 4091
    • Lyman, S.D.1    Seaberg, M.2    Hanna, R.3
  • 20
    • 0029856349 scopus 로고    scopus 로고
    • Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia
    • Wodnar-Filipowicz A, Lyman SD, Gratwohl A, Tichelli A, Speck B, Nissen C. Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia. Blood. 1996;88:4493.
    • (1996) Blood , vol.88 , pp. 4493
    • Wodnar-Filipowicz, A.1    Lyman, S.D.2    Gratwohl, A.3    Tichelli, A.4    Speck, B.5    Nissen, C.6
  • 21
    • 0029795529 scopus 로고    scopus 로고
    • Hematologic effects of flt3 ligand in vivo in mice
    • Brasel K, McKenna HJ, Morrissey PJ, et al. Hematologic effects of flt3 ligand in vivo in mice. Blood. 1996;88:2004.
    • (1996) Blood , vol.88 , pp. 2004
    • Brasel, K.1    McKenna, H.J.2    Morrissey, P.J.3
  • 22
    • 0030736703 scopus 로고    scopus 로고
    • Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice
    • Brasel K, McKenna HJ, Charrier K, Morrissey PJ, Williams DE, Lyman SD. Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice. Blood. 1997;90:3781.
    • (1997) Blood , vol.90 , pp. 3781
    • Brasel, K.1    McKenna, H.J.2    Charrier, K.3    Morrissey, P.J.4    Williams, D.E.5    Lyman, S.D.6
  • 23
    • 0029661945 scopus 로고    scopus 로고
    • Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified
    • Maraskovsky E, Brasel K, Teepe M, et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med. 1996;184:1953.
    • (1996) J Exp Med. , vol.184 , pp. 1953
    • Maraskovsky, E.1    Brasel, K.2    Teepe, M.3
  • 24
    • 0031225999 scopus 로고    scopus 로고
    • Developmental pathways of dendritic cells in vivo: Distinct function, phenotype, and localization of dendritic cell subsets in FLt3 ligand-treated mice
    • Pulendran B, Lingappa J, Kennedy MK, et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. J Immunol. 1997;159:2222.
    • (1997) J Immunol. , vol.159 , pp. 2222
    • Pulendran, B.1    Lingappa, J.2    Kennedy, M.K.3
  • 25
    • 0031214007 scopus 로고    scopus 로고
    • FLT3 ligand induces the generation of functionally active dendritic cells in mice
    • Shurin MR, Pandharipande PP, Zorina TD, et al. FLT3 ligand induces the generation of functionally active dendritic cells in mice. Cell Immunol. 1997; 179:174.
    • (1997) Cell Immunol. , vol.179 , pp. 174
    • Shurin, M.R.1    Pandharipande, P.P.2    Zorina, T.D.3
  • 27
    • 14444284333 scopus 로고    scopus 로고
    • Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model
    • Chen K, Braun S, Lyman S, et al. Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model. Cancer Res. 1997;57:3511.
    • (1997) Cancer Res. , vol.57 , pp. 3511
    • Chen, K.1    Braun, S.2    Lyman, S.3
  • 28
  • 29
    • 0029097145 scopus 로고
    • Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
    • Mackarehtschian K, Hardin JD, Moore KA, Boast S, Goff SP, Lemischka IR. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 1995;3:147.
    • (1995) Immunity , vol.3 , pp. 147
    • Mackarehtschian, K.1    Hardin, J.D.2    Moore, K.A.3    Boast, S.4    Goff, S.P.5    Lemischka, I.R.6
  • 30
    • 0018625422 scopus 로고
    • Hereditary anemias of the mouse: A review for geneticists
    • Russell ES. Hereditary anemias of the mouse: a review for geneticists. Adv Genet. 1979;20:357.
    • (1979) Adv Genet. , vol.20 , pp. 357
    • Russell, E.S.1
  • 31
    • 0027988545 scopus 로고
    • Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    • Peschon JJ, Morrissey PJ, Grabstein KH, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med. 1994;180:1955.
    • (1994) J Exp Med. , vol.180 , pp. 1955
    • Peschon, J.J.1    Morrissey, P.J.2    Grabstein, K.H.3
  • 32
    • 0033068180 scopus 로고    scopus 로고
    • CD8α - and CD8α - Subclasses of dendritic cells direct the development of distinct T helper cells in vivo
    • Maldonado-Lopez R, De Smedt T, Michel P, et al. CD8α - and CD8α - subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med. 1999;189:587.
    • (1999) J Exp Med. , vol.189 , pp. 587
    • Maldonado-Lopez, R.1    De Smedt, T.2    Michel, P.3
  • 33
    • 0030294238 scopus 로고    scopus 로고
    • A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production
    • Kronin V, Winkel K, Suss G, et al. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J Immunol. 1996;157:3819.
    • (1996) J Immunol. , vol.157 , pp. 3819
    • Kronin, V.1    Winkel, K.2    Suss, G.3
  • 34
    • 0030761480 scopus 로고    scopus 로고
    • Flt3 ligand in cooperation with transforming growth factor-beta 1 potentiates in vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions
    • Strobl H, Bello-Fernandez C, Riedl E, et al. Flt3 ligand in cooperation with transforming growth factor-beta 1 potentiates in vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions. Blood. 1997;90:1425.
    • (1997) Blood , vol.90 , pp. 1425
    • Strobl, H.1    Bello-Fernandez, C.2    Riedl, E.3
  • 35
    • 0031937948 scopus 로고    scopus 로고
    • The influence of interleukin (IL)-4, IL-13, and Flt3 ligand on human dendritic cell differentiation from cord blood CD34+ progenitor cells
    • Rosenzwajg M, Camus S, Guigon M, Gluckman JC. The influence of interleukin (IL)-4, IL-13, and Flt3 ligand on human dendritic cell differentiation from cord blood CD34+ progenitor cells. Exp Hematol. 1998;26:63.
    • (1998) Exp Hematol. , vol.26 , pp. 63
    • Rosenzwajg, M.1    Camus, S.2    Guigon, M.3    Gluckman, J.C.4
  • 36
    • 0030456366 scopus 로고    scopus 로고
    • Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor
    • Saunders D, Lucas K, Ismaili J, et al. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J Exp Med. 1996;184: 2185.
    • (1996) J Exp Med. , vol.184 , pp. 2185
    • Saunders, D.1    Lucas, K.2    Ismaili, J.3
  • 37
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor
    • Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor. J Exp Med. 1992;176:1693.
    • (1992) J Exp Med. , vol.176 , pp. 1693
    • Inaba, K.1    Inaba, M.2    Romani, N.3
  • 38
    • 0026446156 scopus 로고
    • GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
    • Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature. 1992;360:258.
    • (1992) Nature , vol.360 , pp. 258
    • Caux, C.1    Dezutter-Dambuyant, C.2    Schmitt, D.3    Banchereau, J.4
  • 39
    • 0026674846 scopus 로고
    • TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages
    • Santiago-Schwarz F, Belilos E, Diamond B, Carsons SE. TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J Leukoc Biol. 1992;52:274.
    • (1992) J Leukoc Biol. , vol.52 , pp. 274
    • Santiago-Schwarz, F.1    Belilos, E.2    Diamond, B.3    Carsons, S.E.4
  • 40
    • 0026702360 scopus 로고
    • Interactions of tumor necrosis factor with granulocyle-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow
    • Reid CDL, Stackpoole A, Meager A, Tickerpace J. Interactions of tumor necrosis factor with granulocyle-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol. 1992;149:2681.
    • (1992) J Immunol. , vol.149 , pp. 2681
    • Reid, C.D.L.1    Stackpoole, A.2    Meager, A.3    Tickerpace, J.4
  • 41
    • 0031013082 scopus 로고    scopus 로고
    • The influence of granulocyte/ macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs
    • Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K. The influence of granulocyte/ macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol. 1997;27:40.
    • (1997) Eur J Immunol. , vol.27 , pp. 40
    • Vremec, D.1    Lieschke, G.J.2    Dunn, A.R.3    Robb, L.4    Metcalf, D.5    Shortman, K.6
  • 42
    • 0030456368 scopus 로고    scopus 로고
    • A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
    • Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med. 1996;184:2417.
    • (1996) J Exp Med. , vol.184 , pp. 2417
    • Borkowski, T.A.1    Letterio, J.J.2    Farr, A.G.3    Udey, M.C.4
  • 43
    • 0032530754 scopus 로고    scopus 로고
    • Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: Implications for anti-cancer and anti-viral therapy
    • Shaw SG, Maung AA, Steptoe RJ, Thomson AW, Vujanovic NL. Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy. J Immunol. 1998;161:2817.
    • (1998) J Immunol. , vol.161 , pp. 2817
    • Shaw, S.G.1    Maung, A.A.2    Steptoe, R.J.3    Thomson, A.W.4    Vujanovic, N.L.5
  • 44
    • 0029009398 scopus 로고
    • Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement
    • Wasserman R, Li YS, Hardy RR. Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement. J Immunol. 1995;155:644.
    • (1995) J Immunol. , vol.155 , pp. 644
    • Wasserman, R.1    Li, Y.S.2    Hardy, R.R.3
  • 45
    • 0028318788 scopus 로고
    • Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs
    • Hannum C, Culpepper J, Campbell D, et al. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature. 1994; 368:643.
    • (1994) Nature , vol.368 , pp. 643
    • Hannum, C.1    Culpepper, J.2    Campbell, D.3
  • 46
    • 0029074587 scopus 로고
    • Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    • Miettinen PJ, Berger JE, Meneses J, et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995;376:337.
    • (1995) Nature , vol.376 , pp. 337
    • Miettinen, P.J.1    Berger, J.E.2    Meneses, J.3
  • 47
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • published erratum appears in Science 1995 Aug 18; 269:909
    • Sibilia M, Wagner EF. Strain-dependent epithelial defects in mice lacking the EGF receptor [published erratum appears in Science 1995 Aug 18; 269:909]. Science. 1995;269:234.
    • (1995) Science , vol.269 , pp. 234
    • Sibilia, M.1    Wagner, E.F.2
  • 48
    • 0029064203 scopus 로고
    • Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
    • Threadgill DW, Dlugosz AA, Hansen LA, et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 1995;269:230.
    • (1995) Science , vol.269 , pp. 230
    • Threadgill, D.W.1    Dlugosz, A.A.2    Hansen, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.