Cutting edge: Signaling and cell surface expression of a μH chain in the absence of λ5: A paradigm revisited

Journal of Immunology

Volumn 171, Issue 7, 2003, Pages 3343-3347

  Schuh, Wolfgang ^a   Meister, Silke ^a   Roth, Edith ^a   Jäck, Hans Martin ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 7; MEMBRANE PROTEIN; POLYPEPTIDE; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL DEATH; CELL GROWTH; CELL MATURATION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; FLOW CYTOMETRY; GENOTYPE; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SOUTHERN BLOTTING; STEM CELL; STROMA CELL; TRANSGENIC MOUSE;

EID: 0141886227     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.7.3343     Document Type: Article

References (28)

1. Alt, F. W., G. D. Yancopoulos, T. K. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, and D. Baltimore. 1984. Ordered rearrangement of immunoglobulin H chain variable region segments. EMBO J. 3:1209.
2. Meffre, E., R. Casellas, and M. C. Nussenzweig. 2000. Antibody regulation of B cell development. Nat. Immunol. 1:379.
3. Muljo, S. A., and M. S. Schlissel. 2000. Pre-B and pre-T cell receptors: conservation of strategies in regulating early lymphocyte development. Immunol. Rev. 175:80.
4. Burrows, P. D., R. P. Stephan, Y. H. Wang, K. Lassoued, Z. Zhang, and M. D. Cooper. 2002. The transient expression of pre-B cell receptors governs B cell development. Semin. Immunol. 14:343.
5. Martensson, I. L., A. Rolink, F. Melchers, C. Mundt, S. Licence, and T. Shimizu. 2002. The pre-B cell receptor and its role in proliferation and Ig H chain allelic exclusion. Semin. Immunol. 14:335.
6. Kline, G. H., L. Harrwell, G. B. Beck-Engeser, U. Keyna, S. Zaharevitz, N. R. Klinman, and H.-M. Jäck. 1998. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional μ H chains. J. Immunol. 161:1608.
7. Decker, D. J., N. E. Boyle, A. Koziol, and N. R. Klinman. 1991. The expression of the IgH chain repertoire in developing bone marrow B lineage cells. J. Immunol. 146:350.
8. Rolink, A., U. Karasuyama, U. Grawunder, D. Haasner, A. Kudo, and F. Melchers. 1993. B cell development in mice with a defective λ5 gene. Eur. J. Immunol. 23:1284.
9. Gong, S., and M. C. Nussenzweig. 1996. Regulation of an early developmental checkpoint in the B cell pathway by Igβ. Science 272:411.
10. Shimizu,T., C. Mundt, S. Licence, F. Melchers, and I. L. Martensson. 2002. VpreB1/ VpreB2/λ5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J. Immunol. 168:6286.
11. Pelanda, R., U. Braun, E. Hobeika, M. C. Nussenzweig, and M. Reth. 2002. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β. J. Immunol. 169:865.
12. Grawunder, U., T. M. Leu, D. G. Schatz, A. Werner, A. G. Rolink, F. Melchers, and T. H. Winkler. 1995. Down-regulation of RAG1 and RAG2 gene expression in pre-B cells after functional immunoglobulin H chain rearrangement. Immunity 3:601.
13. Hess, J., A. Werner, T. Wirth, F. Melchers, H.-M. Jäck, and T. H. Winkler. 2001. Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor. Proc. Natl. Acad. Sci. USA 98:1745.
14. Kitamura, D., A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky. 1992. A critical role of λ5 protein in B cell development. Cell 69:823.
15. Pelanda, R., S. Schaal, R. M. Torres, K. Rajewsky. 1996. A prematurely expressed Ig(κ) transgene, but not V(κ)J(κ) gene segment targeted into the Ig(κ) locus, can rescue B cell development in λ5-deficient mice. Immunity 5:229.
16. Stephan, R. P., E. Elgavish, H. Karasuyama, H. Kubagawa, and M. D. Cooper. 2001. Analysis of VpreB expression during B lineage differentiation in A5-deficient mice. J. Immunol. 167:3734.
17. Bradl, H., and H.-M. Jäck. 2001. Surrogate L chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines. J. Immunol. 167:6403.
18. Karasuyama, H., A. Rolink, Y. Shinkai, F. Young, F. W. Alt, and F. Melchers. 1994. The expression of Vpre-B/A5 surrogate L chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77:133.
19. Papavasiliou, F., M. Jankovic, and M. C. Nussenzweig. 1996. Surrogate or conventional L chains are required for membrane immunoglobulin μ to activate the precursor B cell transition. J. Exp. Med. 184.2025.
20. Mielenz, D., A. Ruschel, C. Vettermann, and H.-M. Jäck. Immunoglobulin μ heavy chains do not mediate tyrosine phosphorylation of Igα from the ER/Cis-Golgi. J. Immunol. 171:3091.
21. Keyna, U., G. B. Beck-Engeser, J. Jongstra, S. E. Applequist, and H.-M. Jäck. 1995. Surrogate L chain-dependent selection of IgH chain V regions. J. Immunol. 155:5536.
22. Seidl, T., A. Rolink, and F. Melchers. 2001. The VpreB protein of the surrogate Lchain can pair with some μ H-chains in the absence of λ5 protein. Eur. J. Immunol. 31:1999.
23. Haas, I. G. 1991. Bip - a heat shock protein involved in immunoglobulin chain assembly. Curr. Top. Microbiol. Immunol. 167:71.
24. Liu, C. Y., and R. J. Kaufmann. 2003. The unfolded protein response. Science 116: 1861.
25. H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.
26. Pollok B. A., R. Anker, P. Eldridge, L. Hendershot, and D. Levitt. 1987. Molecular basis of the cell surface expression of immunoglobulin μ chain without L chain in human B lymphocytes. Proc. Natl. Acad. Sci. USA 84:9199.
27. Minegishi, Y., and M. E. Conley. 2001. Negative selection at the pre-BCR checkpoint elicited by human μ H chains with unusual CDR3 regions. Immunity 14:631.
28. Gauthier, L., B. Rossi, F. Roux, E. Termine, and C. Schiff. 2002. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc. Natl. Acad. Sci. USA 99:13014.