SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

Journal of Experimental Medicine

Volumn 188, Issue 4, 1998, Pages 791-795

  Wienands, Jürgen ^a,b   Schweikert, Jutta ^a   Wollscheid, Bernd ^a   Jumaa, Hassan ^b   Nielsen, Peter J ^b   Reth, Michael ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Antigen receptor; SLP 65; Src homology 2 domain; Tyrosine phosphorylation

Indexed keywords

ADAPTOR PROTEIN; AMINO ACID; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN RECEPTOR; PERVANADATE; PROTEIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA, COMPLEMENTARY; ENZYME INHIBITORS; GRB2 ADAPTOR PROTEIN; HUMANS; HYDROGEN PEROXIDE; IMMUNOGLOBULIN DELTA-CHAINS; IMMUNOGLOBULIN MU-CHAINS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; RABBITS; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VANADATES;

EID: 0032541388     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.4.791     Document Type: Article

References (26)

1. DeFranco, A.L. 1997. The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunol. 9:296-308.
2. Kurosaki, T. 1997. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9:309-318.
3. Reth, M., and J. Wienands. 1997. Initiation and processing of signals from the B cell antigen receptor. Annu. Rev. Immunol. 15:453-479.
4. Crespo, P., K.E. Schuebel, A.A. Ostrom, J.S. Gutkind, and X.R. Bustelo. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 385:169-172.
5. Wienands, J., O. Larbolette, and M. Reth. 1996. Evidence for a preformed transducer complex organized by the B cell antigen receptor. Proc. Natl. Acad. Sci. USA. 93:7865-7870.
6. Tsunoda, S., J. Sierralta, Y. Sun, R. Bodner, E. Suzuki, A. Becker, M. Socolich, and C.S. Zuker. 1997. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature. 388:243-249.
7. Posas, F., and H. Saito. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of PBS2p MAPKK. Science. 276:1702-1705.
8. Baumann, G., D. Maier, F. Freuler, C. Tschopp, K. Baudisch, and J. Wienands. 1994. In vitro characterization of major ligands for Src homology 2 domains derived from tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells. Eur. J. Immunol. 42: 1799-1807.
9. Jumaa, H., and P.J. Nielsen. 1997. The splicing factor SRp20 modifies splicing of its own mRNA and ASF/F2 antagonizes this regulation. EMBO (Eur. Mol. Biol. Organ.) J. 16:5077-5085.
10. Tanaka, M., and W. Herr. 1997. Differential transcnptional activation by Oct-1 and Oct-2: independent activation domains induce Oct-2 phosphorylation. Cell. 60:375-386.
11. Wilson, I.A., H.L. Niman, R.A. Houghten, A.R. Cherenson, M.L. Connolly, and R.A. Lerner. 1984. The structure of an antigenic determinant in a protein. Cell. 37:767-778.
12. Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO (Eur. Mol. Biol. Organ.) J. 13:3748-3756.
13. Yamanashi, Y., and D. Baltimore. 1997. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell. 88:205-211.
14. Langdon, W.Y., J.W. Hartley, S.P. Klinken, S.K. Ruscetti, and H.C.D. Morse. 1989. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA. 86:1168-1172.
15. Jackman, J.K., D.G. Motto, Q. Sun, M. Tanemoto, C.W. Turck, G.A. Peltz, G.A. Koretzky, and P.R. Findell. 1995. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J. Biol. Chem. 270: 7029-7032.
16. Tuosto, L., F. Michel, and O. Acuto. 1996. p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 184:1161-1166.
17. Wu, J., D.G. Motto, G.A. Koretzky, and A. Weiss. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 4:593-602.
18. Onodera, H., D.G. Motto, G.A. Korctzky, and D.M. Rothstein. 1996. Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase. J. Biol. Chem. 271:22225-22230.
19. Musci, M.A., L.R. Hendricks-Taylor, D.G. Motto, M. Paskind, J. Kamens, C.W. Turck, and G.A. Koretzky. 1997. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J. Biol. Chem. 272:11674-11677.
20. da Silva, A.J., Z. Li, G. de Vera, E. Canto, P. Findell, and C.E. Rudd. 1997. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc. Natl. Acad. Sci. USA. 94:7493-7498.
21. Fu, C., and A.C. Chan. 1997. Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase C-γ, Grb2, and Vav after B cell antigen receptor activation. J. Biol. Chem. 272:27362-27368.
22. Lam, K.P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 90:1073-1083.
23. Neuberger, M. 1997. Antigen receptor signaling gives lymphocytes a long life. Cell. 90:971-973.
24. Motto, D.G., S.E. Ross, J. Wu, L.R. Hendricks-Taylor, and G.A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J. Exp. Med. 183:1937-1943.
25. Fang, N., D.G. Motto, S.E. Ross, and G.A. Koretzky. 1996. Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. J. Immunol. 157:3769-3773.
26. Clements, J.L., B. Yang, S.E. Ross-Barta, S.L. Eliason, R.F. Hrstka, R.A. Williamson, and G.A. Koretzky. 1998. Requirement for the leukocyte-specific adaptor protein SLP-76 for normal T cell development. Science. 281:416-419.